Warren Buffett once said that when you find the first cockroach in the kitchen, it's definitely not the only one in the kitchen! --There must be other cockroaches you haven't found yet.

The phrase could not be more aptly applied to Changchun Changsheng Biological Company. The rabies vaccine quality gate was the first cockroach discovered in Changsheng Biological Company, and as expected, Pepsin was the second cockroach discovered. Is there a third or fourth ...... really dare not think about it.

Vaccine counterfeiting is murder for profit. The rabies vaccine is life-saving after exposure to rabies, and it is inconceivable that a person who thought he could live with the rabies vaccine, but ended up dying because of a fake vaccine, would make any indictment of the world at the end of his life.

The DPT vaccine is a triple vaccine that prevents whooping cough, diphtheria, and tetanus, three diseases that are now relatively rare. These three diseases are potent infectious diseases that have a certain mortality rate for serious infections, and even more so for children without immunity. What kind of anger will parents voice if their children are injected with these flunked DPT vaccines and their children suffer from illnesses as a result?

As a doctor, I used to repeat countless times to parents like Mrs. Xianglin: "You must get vaccinated, and the more vaccines you get, the better." The quality and safety of vaccines are guaranteed as the regulation of vaccines is getting stricter and stricter." ...... However, countless times such popularization of science, in front of the Changsheng biological vaccine incident, all seem powerless and pale!

Changchun Changsheng Biotechnology Co. Ltd. received a penalty decision, and was fined a total of 3.44 million yuan. With such a serious vaccine quality incident, this number of fines is even lighter than a mosquito bite. Let's see how other people catch product quality. The baby talcum powder produced by Johnson & Johnson in the United States was fined $4.7 billion by a court ruling not long ago because it contained the carcinogen asbestos!

Drugs and vaccines involve the safety of everyone's life, who doesn't have a child, which child does not need to be vaccinated? It is hoped that the relevant departments will step up supervision and punishment, and for those enterprises that dare to fake vaccines, it is not too much to penalize them with a huge loss of assets!

(Image from the web)

You listen to the words, say you are interested in medical science, welcome to follow my headline: hanging pediatrics

I. Episodic and inevitable nature of the outbreak of the incident concern

Previously on the "vaccine" problem previously not unreported, not no lawsuit, not injured, but slowly no sound, thanks to the public referee network, we can see through the legal search, the case involves a number of companies involved in bribery, bribery, vaccine infringement, but previously no attention, the reasons for this, inextricably linked. .

Lang Xianping once spoke in Guangdong TV's "Finance and Economics" many years ago: the vaccine market is the most FB market in China, and after so many years, the problem still exists.

This event has sparked a wide-ranging discussion related to several factors:

On the one hand, the accumulation of contradictions, through the referee network and so on can be seen, previously there are many disputes around, if the current through the referee, through the previous media reports no relevant cases, it is estimated that the point of contradiction triggered will not be so big. On the other hand, the recent hit movie "I said the God of medicine", in fact, in the medical knowledge, medical concerns and other aspects of the padding. On the other hand, this time, the vaccine involved is universal and related to people's livelihood, and air, everyone is equal, there is no special supply, so a lot of big V is also a victim, a lot of big V forwarding, the use of fans to trigger the attention of the public. In addition, there are also the FB issues involved after the vaccine that was revealed, which touches on the current point of conflict even more. Therefore, the vaccine is only an external, internal is a manifestation of social contradictions, a livelihood perspective of the appeal.

Second, was the punishment reasonable at the time? Criminal offense involved? (A twisted application of the law)

As it stands now, the Jilin Food and Drug Administration's fine at the outset was unreasonable, more than three million dollars to penalize such a serious matter, of course, too little, and inevitably sparked heated debate.

Article 74 of the Drug Administration Law stipulates that anyone who produces or sells substandard drugs shall be liable to confiscation of the illegally produced or sold drugs and the illegal proceeds, and shall be fined at not less than double and not more than triple the amount of the value of the illegally produced or sold drugs; if the circumstances are serious, he shall be ordered to stop production, suspend business and rectify the situation, or revoke the document certifying the approval of the drugs, or revoke the drug production license, the drug business license, or the license to make preparations for medical institutions. If the case constitutes a crime, criminal liability shall be investigated in accordance with the law. Article 75 stipulates that enterprises or other units engaged in the production or sale of counterfeit medicines and the production or sale of substandard medicines under serious circumstances shall not allow the persons directly responsible for them and other persons directly responsible to engage in pharmaceutical production or business activities within 10 years.

In accordance with the provisions of the Drug Administration Law, there are general and serious circumstances and those that constitute a crime.

Jilin Food and Drug Administration at the beginning of the punishment is in accordance with the first class to be punished, that is, it is considered to be a general situation, after the Drug Administration found the problem, upgraded to serious, and so on into a hot issue triggered by the public discussion, and then upgraded to a criminal offense. The reason for this process is not explained.

The case has now been taken over by the Public Security Opportunity, what will be the sentence?

Article 140 of the Criminal Law stipulates that: If a producer or seller adulterates or adulterates a product, passes it off as genuine, substitutes it for a good one, or passes off an unqualified product as a qualified product, ...... if the sales amount is more than 500,000 yuan but less than 2 million yuan, he shall be sentenced to fixed-term imprisonment of not less than seven years, and shall be fined not less than 50 per cent and not more than two times the amount of the sales amount Article 150 of ...... stipulates: If a unit commits a crime as stipulated in Articles 140 to 148 of this Section, the unit shall be sentenced to a fine, and its directly responsible supervisors and other directly responsible persons shall be punished in accordance with the provisions of the respective article.

As of now, it is more likely that the sentence will be in accordance with 140 of the Penal Code, what are the exact facts and how exactly will they be characterized, I hope that when the next hotspot comes, there will be people who will continue to pay attention to it, and it will not go up in smoke just because of a burst of hot public opinion attention, and then continue to be people getting hurt, and lawsuits being filed, and the problem continues ......

Pharmaceutical safety is greater than heaven! A fine of over 3 million dollars clearly does not achieve the effect of punishment. Unscrupulous companies like these should be fined until they lose all their money, and they should be shut down permanently. Moreover, investigations should be carried out to hold the heads of the companies legally responsible.

Compared with the previous Sanlu milk powder incident, the vaccine incident of Changchun Changsheng has caused even worse impacts. Vaccines are supposed to be the ramparts that help mankind fight off diseases, so how can they dare to be sloppy?

Besides, these vaccinations are given to the future of our country, to parents' babies, to innocent children, and the crime against them is unforgivable!

Just exposed "rabies vaccine production record falsification" incident was informed by the State Drug Administration 3 days later, Changchun Changsheng and exposed the "DPT vaccine unqualified". Why this poorly stained enterprise can repeatedly get the tender? The reasons behind it are thought-provoking.

These profit-motivated and heartless people should be severely punished, and vaccine counterfeiting is almost equivalent to intentional homicide in a serious sense. Not only has it posed a hidden danger to vaccinated children, but it has also shaken the public's trust in domestically produced vaccines. Allegedly, some people have already taken their children to Hong Kong for vaccination.

In addition to penalties, it is now imperative to give an account of the whereabouts of those problematic vaccines, and also, do those children who have received substandard DPT vaccines need to be vaccinated? Previously inoculated with the problematic vaccine in the children have not caused disease or even death, these need to have a fair and transparent statement.

Finally, the phenomenon of pharmaceutical counterfeiting must be treated with zero tolerance. It must not be tolerated and punished severely.

If I may say so, it should be penalized heavily, and should even be put out of business outright.

Why would I say that?

Because vaccines are no small matter, it is about the complete health of millions of people, especially those children who have been vaccinated by the manufacturer.

Vaccine counterfeiting involves not only crime, but even indirect killing!

Imagine how many substandard or even counterfeit vaccines would have been circulating on the market if the problem had not been detected in time by the State's flight inspection.

Imagine: what would be the consequences if those who had been vaccinated by that manufacturer became ill because of these ineffective vaccines?

Just imagine: if such behavior is not severely punished, how serious the social impact will be if more unscrupulous manufacturers with a sense of fluke follow the trend and imitate it?

If a society cannot even ensure the basic health problems of its citizens, what kind of harmony and what kind of revitalization can it talk about, and will it still have a future?

What future can there be for a people who do not have the right values and who cannot guarantee a heart that does not do evil?

Of course, the above is just my personal perception.

If you have a different notion, feel free to leave a comment.

Let more people know a little bit more!

What do you think of "Changsheng Biologicals fined 3.44 million yuan by Jilin Food and Drug Administration after failing DPT vaccine"?

The incident in which Changsheng Biological's adsorbed cell-free DPT vaccine was penalized because it was found to be "non-compliant with the requirements of the [potency determination] item" is far less egregious than the falsification of the rabies vaccine's "production records", but it will attract greater attention because it will be considered a "real potency" problem and because the vaccination targets are all infants and young children. Although far less egregious in nature than the falsification of the rabies vaccine's "production records", it will attract more attention and have a greater adverse impact because it will be considered a "real validity" issue, and because the target group for vaccination is all infants and young children.

Why? It needs to start with the DPT vaccine itself.

Adsorption of cell-free combined DPT vaccine and the establishment of the immune barrier

The Adsorbed Acellular Pertussis Combination Vaccine (AAPCV) consists of an acellular pertussis vaccine (pertussis toxoid, filamentous hemagglutinin, and Bordetella pertussis adhesin), diphtheria toxoid, and tetanus toxoid to protect against pertussis, diphtheria, and tetanus, three nasty bacterial infectious diseases.

In my country, these three bacterial infections were common in the 1970s and caused serious health hazards when contracted. The first two are acute respiratory infectious diseases that are quite contagious and mainly infect children.

whooping coughAs the name suggests, severe spasmodic cough can last for 2 to 3 months after infection with Bordetella pertussis.

tetanusInfection with Corynebacterium diphtheriae (below) results in the formation of a white pseudomembrane in the larynx, and the child often develops a barking croup.

Both of these infections have a high rate of severe case fatality.

tetanus (lockjaw)As the name suggests, it usually develops as a result of infection with Clostridium tetani from a break in the skin, and the causative agent is tetanus toxoid, a toxin that primarily attacks motor neurons and therefore manifests itself in paroxysmal or tonic spasms (as shown below, which are calledopitoshtonous (med.), muscular spasm of the body associated with tetanus and meningitis).In Chinese medicine, it is also known as the so-called wind disease, hence the name tetanus. At one time, tetanus was an almost incurable disease, especially in newborns, also known as "seven-day wind", with a high mortality rate.

However, these three diseases are now almost unseen.

This is due to the high coverage of vaccinations with specific vaccines.Since the vaccine against these three diseases is suitable for making a combined vaccine, this triple vaccine is commonly used worldwide and plays a vital role in preventing these three diseases.

In view of the immense danger of these three diseases, they are all major public health problems.

Therefore, this triple vaccine belongs to class I in our country, i.e., it is purchased by the public treasury and inoculated free of charge to the appropriate population by the disease control authorities.

When the majority of the population is vaccinated and builds up specific immunity, it is as if a firewall, medically known as an immune barrier, is built against these infectious diseases, so that these germs have no chance to flourish (epidemics).

However, when some people in the population are not vaccinated for one reason or another, or when the vaccines they receive are not effective enough to stimulate the development of immunity, a hole in the great wall of the immune barrier appears, and when the hole is large enough, the germs that have been screened out of the population have a chance to return and cause epidemics of disease.

As a result, the usual category 1 vaccination is administered both for oneself and for the community.

In recent years, it has been common to see epidemics of whooping cough in some areas abroad, caused by the destruction of the immune barrier due to the refusal of many people to be vaccinated out of religious or anti-vaccine movement compulsion for fear of the side effects of vaccination.

Why Changsheng Biologicals DPT vaccine failure has worse effects

As mentioned above, the effective prevention of these infectious diseases relies on the establishment of an immune barrier in the population by high-coverage effective vaccination, which, when imperfectly established, gives the disease an opportunity to return.

This DPT3 vaccine incident of Changsheng Biologicals is clearly a validity issue, which means that even if these vaccines are administered, there is a possibility that effective immune reactivity may not be developed, and thus the immune defense barrier of the society may be undermined. Therefore, the nature of the problem is even worse than that of the rabies vaccine, which is mainly used for personal prevention, and the impact is even worse.

Adsorbed acellular DPT vaccine is not a new vaccine

The term "adsorbent acellular" refers mainly to the vaccine production process and refers to pertussis vaccines.

In the early days, pertussis vaccines used so-called whole-cell pertussis vaccines with intact bacterial organisms. It was found in vaccination practice that this whole-cell vaccine, although its effectiveness was guaranteed, sometimes had significant side effects and even serious neurological complications.

As a result, scientists began exploring a vaccine without the intact bacterial organism, which is the acellular pertussis vaccine.

The acellular pertussis vaccine was first used in Japan in 1981 and has been shown in epidemiologic investigations to confer the same level of protection as the whole-cell vaccine.

Subsequently, many biological product units in China obtained production capacity and approvals one after another and continued to form a triple vaccine with diphtheria and tetanus toxoid vaccines.

As you can see, this vaccine is not a new process new vaccine, but a proven old vaccine.

At present, Wuhan Biological Products Co., Ltd. has the largest production base of adsorbed cell-free DPT vaccine in the world.

Changsheng Bio, along with its earlier parent company Changchun Gaoxin, are both offshoots of the Changchun Institute of Biological Products.

Changchun Institute of Biological Products is one of the earliest research institutes in China's biological products industry, together with Beijing, Shanghai, Wuhan, Chengdu and Lanzhou Biological Products Research Institute, known as China's six major biological products research institutes.

Although Changsheng Biologicals and Changchun High-Tech have been privatized into private enterprises, they are, after all, from the Changchun Biological Products Research Institute, one of China's leading research institutes in biological products, and there should not be any problem in mastering the production of adsorbed acellular DPT vaccine, which is a mature vaccine.

And yet, it is."敢"Something is wrong, and it's a critical validity issue.

What are the reasons? In conjunction with the "falsification of production records" for rabies vaccines, the probability is that the problem lies not in technology but in other areas: management, profit, or something else?

Hitting or even destroying the public's confidence and trust in vaccines, especially domestically produced vaccines, is the biggest danger of the vaccine incident

Just Changsheng Biologicals, a company with vaccine production and sales as its main business, in just a few days there were two consecutive outbreaks of vital vaccine problems - falsified production records of rabies vaccine and unqualified quality of DPT vaccine - and this kind of undesirable events strike the most serious blow to the public's confidence in vaccines and trust in domestically produced vaccines, and to reshape these It is not known how much effort it will take to reshape the confidence and trust of the relevant departments and popularizers of science.

Yesterday, the news about vaccine fraud finally broke in the circle of friends.

After a series of journalists in-depth reports, are not a big fire, but instead the self media a "king of vaccines", the Changchun Changsheng labeled wolf hard hit a hand.

On July 15, a batch of Changsheng Biotechnology'srabies vaccineDuring an inspection by the State Drug Administration, it was found to have falsified production records.

On July 19, Changsheng Bio was exposed againAdsorbed acellular DPT vaccineFailed the test.

It is important to note that the rabies batch of vaccine was found not to have been put on the market yet, and theoretically would not affect patients who need to receive this vaccine, whereas the penalty announcement for the combined vaccine for DPT has this sentence:

The illegal proceeds of the drugs totaled 858,840.00 yuan, and the value of the goods totaled 861,349.20 yuan.

This batch of vaccines with non-compliant potency indicatorsTotal 252.6 thousandThe first nine months were spent on theAll sold toShandong Province CDC.

One batch of substandard rabies vaccine could potentially lead to the deaths of multiple rabies patients;

A batch of substandard DPT vaccine could potentially undo years of gains in preventing whooping cough, diphtheria and tetanus.

There's a line from I Am Not a Drugstore:The only disease in this world is the disease of poverty.

I used to be unable to understand why some people had to pay thousands of dollars more for imported vaccines. Now these falsified records show you what it means to be "worth every penny".Without the money for expensive vaccines, you have to expect to touch an effective vaccine on your own, like touching a prize.

It just doesn't make sense. It's not supposed to be like this.

- 2 -

A small vaccine carries the life and death of a generation.

Every time something happens to a vaccine, it shakes the public's confidence once more:

What else is there to believe in?

More and more parents are afraid of vaccination and do not even take their children for vaccination; some parents are anxious and helpless and blindly take their children for catch-up vaccination; and unscrupulous marketing numbers trumpet the benefits of not vaccinating and take advantage of the opportunity to make a fortune by selling fake medicines.

This can lead to very serious effects.Failure to vaccinate leaves you vulnerable in the face of pandemic infectious diseases, and a large number of children who don't get vaccinated, or who have failed vaccinations, can be infected with Hepatitis B, measles, and even the H1N1 flu.

(Photo transferred from Chinese Photographers Association website - Guo Xianzhong: a four-year-old paralyzed after a Group A Stream Vaccine)

Vaccines must be given as required, otherwise it is tantamount to exposing your child to the risk of disease or even becoming the source of certain epidemic infections.

Someone asked.Why do these people make so much money and still do evil?

Because for them, it may not be doing evil.

As a consumer, a user, and a direct victim of vaccine failure, it is inevitable that one will be angry at these fakers:

Vaccine counterfeiting, the audacity to put the public's health and safety at risk and to undermine disease prevention and control is simply unpardonable.

But from some people's point of view, it seems that the amount of money to be spent on compensating these victims and recalling potentially faulty vaccines is too much of a project and too much of a loss for the company:I'm a victim too.So even though the fine was imposed there was no first recall and it was allowed to circulate to more cities.

Fines are really just a drop in the bucket compared to profits, believe me.

There is a tolerance for adverse reactions to vaccines and injections, and as long as they don't result in direct deaths, they won't be blamed. It's over, the people who ran the production lines don't have to be fired, and the people who were responsible for underreporting, falsifying records, and the management who nodded their heads or closed their eyes won't be implicated either.

Of course, people won't just let these businesses off the hook.The State will conduct regular spot checks, and once falsification of records and vaccine failure are detected, it will definitely conduct rigorous investigations to the end to restore public confidence.

If you don't want people to know, you can't do it.

- 3 -

As an ordinary person, there is always a sense of powerlessness when watching such events happen.

It's really so hard for a person, to live well by the rules. Consuming and using normal medications, but in return, this is how it ends.

In Shanxi, there is a family whose eldest son suffered from encephalitis in 2006 due to the injection of a certain batch of B-brain vaccine, and his intelligence was seriously damaged; the youngest son was exactly one year old in 2008, and during this period, he drank Sanlu milk powder.

A woman in Xi'an, who was bitten by a dog in 2017, was given four rabies shots on time. 28 days later, she died from resuscitation.

And we, really, just want to be ordinary.

Get all the vaccinations you need as required by the Department of Health to protect yourself and others, and I didn't know that there were people who dared to falsify their records;

Drinking milk powder sold in the supermarket, just want to let the child grow up healthily, do not know that there is melamine inside; eating health products just want to strengthen the body, do not know that the original medicine and wine can also be pursued across the province;

After this incident, there is no one in the circle of friends who has become a mother who is not pained, they hate more is that they are not rich enough to go to Hong Kong and Macao for vaccination for every shot.

But who is at fault now? It's the one who ignores production safety and the health of the population.

If a thorough investigation is not conducted to give a reliable result, more people will make and sell counterfeits because it is profitable to do so, and more ordinary people, who are poor, will be pushed to the wall.

I do not know whether it is the temptation of hundreds of millions of dollars, or the lack of awareness of responsibility that led to a batch of substandard vaccines can pass the layers of testing successfully marketed, and injected into tens of thousands of newborns, but the only thing that can be sure is that this matter must be thoroughly investigated to the end.

- 4 -

Sure.Never expect someone to wipe everyone's ass with everything.

We have a lot of other things to do in the face of this than panic.

First, after vaccination, the source of the vaccine will be recorded in the vaccine book, and only the rabies and DPT vaccines of Changsheng and Kangtai are at fault this time, while other vaccines are not affected for the time being.

Second, don't generalize and start being paranoid. The vaccine that went wrong this time failed the potency test, which means that the shot may not work, and according to the medical specialized media, there will be no other side effects on the human body for the time being.

Thirdly, remember what vaccine you are getting, which drug dealer it is attributed to, know the source of each vaccine, and don't trust any organization other than an authoritative hospital with any vaccine you don't know the source of.

It is a good thing that such incidents occur and draw the attention of the whole community.

Without a thorough investigation by the relevant departments to the end, without the public reflecting and reporting, and without the media following up and investigating, a matter will not be put on the table, and when people do not know the seriousness of the matter, they will naturally be unafraid. But this kind of psychological security means nothing.

Vaccine counterfeiting is tantamount to licensed murder, and every painless punishment is an encouragement to violate the law.As the People's Daily said, a thorough investigation of the incident to the end, from the root to eliminate vaccine anxiety, in order to make people stop panicking.

By exposing all those crooked businessmen who are laughing in the dark about making fake drugs and black money to the sunlight, we are not going to let everyone be silently disappointed and wait.

On July 21, an article titled "The King of Vaccines" quickly detonated in WeChat's circle of friends, with more than a million followers, and this article brought the issue of vaccine safety to the forefront.

The incident started last week, initially because of a problem with a batch of rabies vaccine from Changchun Changsheng, followed by a public outcry when it was revealed that two batches of DPT vaccine from Changchun Changsheng and Wuhan Biological were also in trouble.

Comparatively speaking, although the lethality of rabies is extremely high, the incidence can be low, and the problematic rabies vaccine has not been circulated and marketed; however, when the DPT vaccine was in trouble, parents all over the country were thrown into a panic:

• DPT is a class 1 (free) vaccine used to prevent three more critical diseases, pertussis, diphtheria, and tetanus, and is mandatory;

• As many as 650,000 batches were found to be defective, an alarmingly large number.

After the incident many parents have been in various groups, and even in the back office of Dr. Ting's, asking for confirmation and advice.

Dr. Clove has compiled the most concerned questions and strives to answer them one by one from a scientific and objective point of view.

1

Q: What exactly are all the DPT vaccines associated with the incident?

A: The outbreak of the DPT vaccine incident, which was actually a problem at the end of last year, specifically included two manufacturers, theChangchun Changsheng Biotechnology Co. and Wuhan Institute of Biological Products Co.

Official data show that the "problem vaccines", produced in Changchun, were mainly circulated to Shandong, while those produced in Wuhan were mainly sold to Chongqing and Hebei provinces.

Photo credit: Xinhua News Agency

2

Q: What went wrong with the DPT vaccine related to the incident?

A: The main problem with the DPT vaccine is that the potency index is substandard.

The consequence is that the immunoprotective effect may be compromised, but it is not harmful.

According to the announcement of the State Drug Administration, the main problem with the DPT vaccine was that the "potency determination" item was found to be non-compliant during the test.

The National Health and Family Planning Commission (NHFPC) and the health and family planning authorities of Hebei, Shandong and Chongqing provinces (municipalities) had already organized experts to assess the situation in November last year and undertook to take appropriate measures to deal with the situation properly according to the assessment results.

3

Q: What are the consequences of getting a 'problem vaccine'? Are there any possible sequelae?

答：This batch of vaccines, which have no impact on human safety, the biggest risk is the possibility of failure, resulting in the inability to prevent the corresponding disease.

Many parents are concerned about other after-effects of their child's vaccination with the problematic vaccine.

In fact, common adverse reactions to vaccines include localized redness, swelling, heat and pain, fever and allergy, which are generally mild. The incidence of more serious conditions, such as allergies, is very low, and the vaccine is safe for most people.

Adverse reactions to vaccines most often occur within 24 to 48 hours after vaccination, and there is little likelihood of recurrence or sequelae at a later time.

4

Q: How can I determine if I have received a substandard vaccine? What if I received the DPT vaccine involved in the incident?

A: Parents can check the vaccination record of DPT vaccine on the children's preventive vaccination certificate, compare the vaccine manufacturer and batch number, and also consult the vaccination unit at that time.

Vaccination records labeled with vaccine lot and company

▼

One dose of DPT vaccine should be given at 3, 4, 5 months of age and 18 months of age, for a total of 4 vaccinations.

Normally, children who have completed 4 vaccinations are well protected:

• Effectiveness against typical pertussis is about 85%;

• The protective efficacy of tetanus is 80-100%;

• Protection against diphtheria is about 95% effective with more than 3 vaccinations.

The two batches of DPT vaccine that were exposed failed in the potency index, which may affect the effect of immune protection.

Parents who are certain that their children were vaccinated with the DPT vaccine involved in the incident can consult with the local CDC department or vaccination unit to see if they should continue to be re-inoculated, taking into account the number of times their children were vaccinated and the batch of the vaccine.

The first page of the child's vaccination certificate

The telephone number of the vaccination unit to which the child's household belongs is labeled.

▼

5

Q: My child has not yet received the DPT vaccine, can he or she get it?

A: It can be beaten.

The DPT vaccine is effective in preventing three types of critical diseases, and only these two batches are currently in trouble, while other batches have no problems for the time being.

Moreover, the DPT vaccine involved in the previous incident has been discontinued, so parents do not need to worry too much as they will not encounter the vaccine if they go to get it again.

Never withhold vaccines from your child just because you are worried that there is something wrong with them.

If parents really have doubts, they can prioritize the combined vaccine or choose another vaccine made by a more trusted company.

6

Q: The other types of vaccines my child received are also from the company involved in the incident, does he need to be vaccinated as well?

A: For the time being, there are no problems with any of the other batches of other vaccines, so it is advisable to stay calm and stay focused.

Vaccine catch-up is risky, so don't do it blindly.

Dr. Clove will be the first to follow the development of the incident and give you a broadcast.

7

Q: Can I not have my child vaccinated to prevent getting a problem vaccine?

A: You can't choke on it, and it's the children who are at the highest risk if you give up vaccinations out of fear.

The country's current ability to keep diphtheria, pertussis and neonatal tetanus at low levels is based on extremely high vaccination rates.

If all vaccinations are denied because of the vaccine scare caused by these events, then everyone is bound to be hurt.

Monitoring data from the State Drug Administration shows that since 2008, the national drug sampling program has sampled a total of 944 batches of vaccine products, with a pass rate of 99.6%, that is to say.The vast majority of vaccines are very safe.

Hepatitis B, measles, and whooping cough, which are prevented by the Class I vaccine, and chickenpox, which is prevented by the Class II vaccine, are all diseases that pose a huge threat to a child's health.

So, vaccinations are still the best means of protecting our health and we should still insist on them.

Vaccines are mankind's most powerful weapon against infectious diseases, and enough people are vaccinated to create a broad, robust defense.

The fact that things have gone on so far does not mean that the matter has drawn to a close, and everyone should be on their guard.

We are more concerned:

• What is the safety of other batches of vaccines produced by Changchun Changsheng and other manufacturers involved?

• What are the specific aftercare measures? Were they implemented? What can be done to prevent the next occurrence?

• What severe penalties will non-compliant companies end up receiving?

These questions remain unanswered for the time being, and we will continue to keep an eye on them.

And those violators who take the health of the population for granted must pay the price.

Following the revelation that "Changchun Changsheng Biotechnology Company's production of freeze-dried human rabies vaccine involves falsification of records", the company "DPT vaccine failure", another serious incident was exposed, last time, the State Drug Administration of Changchun Changsheng company's punishment, because the discovery of rabies vaccine is not on the market, only ordered "the enterprise to stop the production of rabies vaccine", and this time, the Shenzhen Stock Exchange on the company's punishment is The company was fined a total of 3.44 million yuan.

I said in Changsheng rabies vaccine counterfeiting after the exposure of this kind of even dare to fake vaccine unscrupulous enterprises, first, suspected of violating the law of the enterprise responsible for criminal responsibility, including legal responsibility; second, this kind of rotten heart of the enterprise to be punished to lose all their money.

Rabies vaccination is the only effective way to prevent rabies, and how dare you fake such a life-threatening matter, but what about Paraquat?

Pertussis vaccine is a mixture of pertussis vaccine, diphtheria toxoid and tetanus toxoid that protects against pertussis, diphtheria and tetanus at the same time.

If your child has been vaccinated with the vaccine produced by this company, according to the experts of the State Food and Drug Administration (SFDA), it is a "potency failure", what does it mean? What does it mean? It means that it has no effect.

(b) Taking vaccinations that are ineffective! According to the official explanation, the vaccine found to be problematic has no problem in terms of "safety", only that its "effectiveness" may be affected. I wonder, vaccines are supposed to be used to prevent diseases, how can a vaccine that has no effect be "safe"? Your child was bitten by a rabid dog, your baby was born to be vaccinated with Paraquine, and then you were given a vaccination equivalent to plain water, and then you were told: "It's okay, it's not effective, but it's safe".

What is the safety of a vaccination that has no effect?

What's even scarier is thatChangchun Changsheng Biotechnology Co.Changsheng Biological is not a small enterprise, its 2017 rabies vaccine market share reached 19.70%, ranking second in the country, and even got the top spot in Henan, Sichuan, Guangdong and other places. A giant enterprise with such a high market ranking was actually exposed to problems, and it is hard not to raise concerns about the relevance of the standardization of the entire rabies vaccine production and sales chain.And this time the problem of the DPT vaccine, 250,000 vaccines have been sold almost all the way to Shandong, only 186 left in stock, the people of Shandong suffered.

It's not just this one company that falsifies vaccines

In 2005, the lives of 200 elementary school students in Siachen County, Anhui Province, were put in danger when they received the faulty hepatitis A vaccine.

In 2008, the quality of seven batches of human rabies vaccine from Hebei Fuer Bio-Pharmaceutical Co., Ltd. and Jiangsu Yanshen Biotechnology Co., Ltd. had potency problems.

In 2009, illegally added nucleic acid substances were detected in the human rabies vaccine of Dalian Jingang Andi Biological Products Co.

In 2009, a rabies vaccine incident occurred in Laibin, Guangxi, in which a child was inoculated with a rabies vaccine made "by mixing boiling water with medicine" and died 21 days later.

In 2010, nearly 100 children in Shanxi died or were maimed after receiving vaccines, suspected to have been vaccinated with the "B-brain vaccine".

......

Vaccination can avoid the death of 2-3 million children worldwide every year due to diphtheria, tetanus, whooping cough and measles, children are the flowers of the motherland, people say that when the youth is strong, China is strong, if the flowers of the motherland all use this ineffective prophylactic injections, sickly teenagers, how to take up the responsibility of a strong China?

The ultimate effect of vaccines is herd immunity, and the absence of large-scale plague outbreaks in industrially developed and densely populated countries and regions of the planet today is attributable to public systems of defense, including vaccines. China used this type of herd immunity to eradicate smallpox and polio, and a failed vaccine would be devastating to a population that relies on herd immunity for protection. Doesn't the constant outbreaks of vaccine counterfeiting and failure in recent years warrant deep reflection? Wouldn't these just the exposed vaccine counterfeits be just the tip of the iceberg? Those that have not been exposed? The ones that have not been found out? How many more are there?

But.As always.Changchun Changsheng Biotechnology Company was only penalized by a forfeiture of 3.44 million yuan, which is equivalent to pulling out a hair on this company. According to public information, in 2017, Changsheng's net profit was 586 million yuan, 90% of which came from vaccines, and the company's investment in scientific research expenses in 2017 only accounted for 7.8% of revenue income, and, the company had 2 billion yuan for financial products.

We would rather use it for financial management than take it for research and development. We not only have to ask: Changchun Changsheng Biotechnology Company, why do you still want to harm people when you have earned so much money?

Has anyone used fake vaccines from this heartless corporation? Please speak up and tell us how you feel! If you agree with this article, please like it.

To promote medical science, dissect the doctor-patient relationship, and tell doctor-patient stories, please click on the upper right corner and follow my headline number: Anesthesia Superman Man of Steel.

What is the DPT vaccine?

Pertussis, Diphtheria and Tetanus Vaccine (PDTV) is referred to as the Pertussis vaccine, which is formulated with pertussis vaccine, refined diphtheria and tetanus toxoid in the appropriate proportions for the prevention of the three diseases of pertussis, diphtheria and tetanus.

DPT vaccine has been proved to have good preventive effect against whooping cough, diphtheria and tetanus by years of practice at home and abroad.

Tetanus: After basic immunization with DPT vaccine or immunization with 2 doses of tetanus vaccine, the antitoxin in the serum of all vaccinated individuals can reach a level of protection above the level of protection, and the antibody can be maintained for a period of 10-15 years, with a protection rate of more than 95%. Diphtheria: About 90% of people can reach the protective level of diphtheria antitoxin in serum. If the immunization is reinforced by 1 injection at 1.5-2 weeks of age, the antibody can be maintained for more than 5 years. Pertussis: 1 month after completing the basic immunization of DPT vaccine, the lectin antibody in serum can increase more than 20 times compared with that before immunization, and its protection rate can reach about 80%. 1.5-2 weeks of age and then booster immunization 1 shot, the antibody can be maintained at least for 2-3 years.

Prerequisite: 1, the vaccine is qualified! 2, the transportation is qualified! (The optimal temperature for transportation and storage of DPT vaccine is 2~8℃, and freezing is strictly prevented. Some studies have shown that freezing of DPT vaccine can dissociate the aluminum hydroxide adsorbed on the protein molecular surface and form aluminum salt crystals, which will reduce the immunity effect and increase the vaccination reaction. Therefore, vaccines that have been frozen should not be reused. In order to prevent freezing, the DPT vaccine should not come into direct contact with the inner wall of the refrigerator or the ice raft during storage and transportation.)

Effectiveness of vaccination:

Example: Before immunization was introduced in China, the annual reported incidence of pertussis ranged from 100/100,000 to 200/100,000, with epidemics occurring every 3-5 years. since the 1990s, it has been stabilized at a fairly low level, with annual reported incidence rates of less than 1/100,000 in recent years. However, there are still outbreaks or epidemics rebounding in some localized areas in China.

How many children were victimized this time?

According to public information, 250,000 substandard vaccines, were injected into children or infants. It is that child you regard as a treasure in the palm of your hand, every smile will make you happy for half a day, every crying face will make you upset for half a day, your angel, the future of the great motherland.

You carried him/her to a place where you felt authoritative, trusted, a place where there was no doubt about its reliability, and injected this substandard vaccine.

How did the amount of the penalty come out?

According to the report, this is how it came out: the Jilin Provincial Bureau of Pharmaceutical Supervision imposed administrative penalties on Changchun Changsheng: confiscation of the remaining 186 adsorbed cell-free DPT vaccines in stock and confiscation of the illegal income of 858,800 RMB. At the same time, it imposed a fine of 2.584 million yuan, which is three times the value of the illegally produced drugs, and the total amount of confiscated money was 3.4429 million yuan.

Let's take a look at the penalties for a few small things that happen in the US related to medicine.

In the end, this incident is far from an isolated case, and the reasons behind it are far from clear. If this continues, the consequences will be unimaginable.

First of all, the country was shaken and the people were outraged. The use of unconscionable to describe this let substandard vaccines flow to the market, and is aimed at children's behavior, seem to be insufficient, even the State Council Premier Li Keqiang are late-night instructions "violated the bottom line of morality", visible in the nature of the incident of the bad.

With the unremitting efforts of several generations of public health and medical workers in new China, there is no doubt that world-leading achievements have been made in controlling epidemic infectious diseases through vaccination, but some people's desire for profit has undoubtedly greatly undermined such efforts. The fine of 3.44 million yuan, for a listed company with hundreds of millions of dollars in annual profits, again seems painless.

Let us take a look at how similar medical problems are penalized and compensated in the U.S. In 2001, a patient in Texas, U.S.A., died suddenly of a heart attack, and his widow sued the U.S. pharmaceutical giant Merck Pharmaceuticals Inc. to the court, arguing that the cause of the sudden heart attack was the "Wanluo" analgesic produced by Merck that the deceased had taken during his lifetime. The widow of the deceased sued Merck Pharmaceutical, the US pharmaceutical giant, arguing that the cause of the heart attack was the "Wanluo" analgesic produced by Merck. Although Merck believed that the cause of the disease was the blockage of arterial blood vessels, but because there are long-term scientific studies show that patients who have taken "Wanluo" for more than 18 months will significantly increase the probability of sudden heart attack or stroke, and the drug has been withdrawn from the market in 2004, so the court still ruled in 2005 that Merck lost the lawsuit, and the amount of compensation to the widow of the deceased. The court ruled against Merck in 2005, and the amount of compensation to the widow of the deceased amounted to 250 million dollars.

Although the U.S. judicial system, there are many lawyers and organizations will focus specifically on large pharmaceutical companies to litigation, has reached the goal of fame and fortune, not entirely for the sake of the patients, this harsh scale of punishment will also affect the enthusiasm of drug companies, but for the chaotic Chinese pharmaceutical industry, the current strict enforcement measures, is undoubtedly a reference.