The answer is probably, that's too a bit scary isn't it, diabetes is much harder to treat than hyperlipidemia for example and is much more dangerous to your health!

Various clinical patient meta-analyses with statin lipid-lowering agents, suffering from new-onset diabetes mellitus, to each of the statin lipid-lowering agents reported to occur.Associated with high doses of statins, advanced age, and risk factors for diabetes.

The risk factors associated with diabetes are: Metabolic syndrome(obesity or overweight, hyperlipidemia, hypertension, hyperglycemia, hyperuricemia, etc.).Body mass index (BMI) > 30 kg/m^2which is the number of kilograms of height divided by the number of square meters of height.Impaired fasting glucose and glycated hemoglobin >6%.

For the above elderly, diabetes risk factor people to monitor blood glucose, individualized treatment plan: dose selection control, etc. according to the situation. So, as a patient, don't buy your own medications such as lipid-lowering drugs, not to mention not following up with your doctor for a long time!

The most important purpose of taking statin lipid-lowering drugs is to prevent ischemic cardiovascular disease (stroke, coronary heart disease myocardial infarction, etc.).

1, Cardiovascular riskhigh risk(hypertension, advanced age, smoking, impaired fasting glucose, dyslipidemia, family history of early onset cardiovascular disease, abdominal obesity, elevated blood homocysteine, etc.), diabetes risklow riskThe population: In comparison, the cardiovascular benefits outweigh the risk of developing diabetes, i.e., the risk of developing diabetes is small, and thus statins are taken at normal effective and safe doses.

2, cardiovascular risk, diabetes riskall at high riskof the population: regular monitoring of blood glucose, for the elderly is not suitable for high doses of statin lipid-lowering drugs.

3, Cardiovascular risklow riskDiabetes riskhigh riskof the population: Doctors assess the condition, whether statin lipid-lowering drugs are needed, and do not over-treat if they are not necessary. If needed, choose statin lipid-lowering drugs that can be achieved with regular dosage and monitor blood glucose regularly.

4, statins lipid-lowering drugs, long-term observation (more than 4 years) in patients taking them, benefit in prevention of cardiovascular events: statin increased risk of new-onset diabetes = 9:1

This friend's question is very representative: after taking atorvastatin for 5 years, I found that my blood sugar is high, so can I still take statin? Statins taken over a long period of time do have the risk of causing elevated blood glucose and new-onset diabetes, but it should be made clear at the outset that not all friends who take statins over a long period of time will develop diabetic problems, and that the cardiovascular health benefits of taking statins are still far outweighed by the risk of side effects under the premise of rational application.

Do statins really cause abnormal blood sugar?

The answer is yes, to share a set of clinical data, according to a 2009, including more than 57,000 subjects, medical clinical meta-study data show that long-term use of statins experimental group triggered diabetes than the placebo group about 6% to 13% higher rate. In fact, data from other clinical trials have also shown that long-term use of statins does carry the risk of abnormal blood sugar and even new-onset diabetes.

As to why statins may cause abnormalities in glucose metabolism, there is no clear conclusion yet, and research on the mechanism of action of statins in causing elevated blood glucose is also underway. The common inference is that statins can increase the level of insulin in the body, but they can also reduce the sensitivity of insulin, which can lead to abnormal glucose metabolism. In addition, statins can affect the mitochondria of the cells, leading to abnormal glucose uptake and utilization in the cells, thus affecting the normal metabolism of blood glucose, resulting in abnormal glucose tolerance, elevated blood glucose, and even new-onset diabetes.

Do the various statins, have the same effect on blood glucose metabolism?

A large clinical study of nearly 100,000 people showed no significant difference in the effects of hydrophilic statins (e.g., fluvastatin, resuvastatin, pravastatin) versus lipophilic statins (atorvastatin, simvastatin, lovastatin, etc.) on blood glucose metabolism. However, different statin drugs were shown to have different effects on blood glucose metabolism. The results of this clinical study showed that long-term use of Rosuvastatin showed the greatest increase in abnormalities of glucose metabolism, followed by Atorvastatin and Simvastatin, while for Pfafferastatin and Lovastatin, there was no significant difference in the incidence of diabetes between the experimental group that took the drug and the placebo group that took the drug. The results of these clinical data are also useful for everyone in drug selection.

Overall, the magnitude of the risk of statins causing abnormal glucose metabolism is closely related to the intensity of the medication. The greater the intensity of lipid lowering, the higher the risk of producing abnormal glucose metabolism or even new-onset diabetes. For example, with atorvastatin, there is a significant increase in the incidence of diabetes in patients taking a 10mg daily dose versus those taking an 80mg daily intensive dose, taking the intensive dose.

How to avoid the risk of new-onset diabetes with long-term statin use?

Statins are effective in lowering blood lipids and reducing the risk of cardiovascular disease. For those who are at high and very high risk of cardiovascular disease and at the same time have substandard blood lipids, taking statins is still the clinically preferred choice. Want to reduce the risk of diabetes caused by taking statin, the most important thing to do is to do this, on the basis of maintaining blood lipids up to standard, try to choose a low to medium dose of statins to take, try not to take a long-term high-intensity statin, so that you can greatly reduce the risk of new-onset diabetes because of long-term use of statin. In many cases, if low- and medium-intensity statin is not able to make the blood lipid completely reach the standard, adding other mechanism of action of lipid-lowering drugs, such as ezetimibe, is also a good choice.

Another point to note is that there are many risk factors that cause abnormalities in blood glucose metabolism, not just the medication aspect. There are many other risk factors that cause new-onset diabetes, and poor lifestyle habits, such as long-term high-sugar diets, smoking, and other problems such as obesity, high triglycerides, high blood pressure, and high uric acid, will increase the risk of new-onset diabetes, and so on, and therefore, you want to reduce the chances of new-onset diabetes. Therefore, in order to reduce the chance of new onset diabetes, in addition to paying attention to the intensity of statin medication, it is also necessary to maintain good lifestyle habits, control weight and related risky chronic diseases to reduce the risk of diabetes onset.

Long-term use of statins, the occurrence of elevated blood glucose, statin still eat or not?

Many friends who notice elevated blood glucose while taking statins struggle with the question of whether to take the medication or not. To date, there are no guidelines or drug regulatory agency statements that use abnormal glucose metabolism as an indicator for discontinuing statins.

In fact, if your blood lipids must be controlled by taking a statin, and you are at high risk for cardiovascular disease, statins should still be taken, after all, if cardiovascular disease problems occur, the damage caused to health will be greater. At this time, we can pay attention to our blood lipid monitoring, as far as possible in the control of blood lipids under the premise of reducing the dose of statins. On the other hand, it is also important to pay more attention to our life to reduce the influence of other risk factors that trigger abnormal glucose metabolism.

The issue of statin increasing the incidence of new-onset diabetes is a problem that has indeed gripped the hearts of all those who take statin. Because many people who have diabetes need to take statin, what follows? Continue to take it or not? And patients who do not have diabetes, even more worried, taking statin caused diabetes how to do? Statin still eat or not?

1. Patients with diagnosed diabetes

For many patients who have been diagnosed with diabetes, many of whom are at high risk for cardiovascular disease, the benefits of statin consumption for these individuals far outweigh the possible risks. Therefore, it is an unshakeable fact that for most diabetics who have no contraindications and also have indications, it is essential to take statin for a long period of time.

2. Patients without a diagnosis of diabetes

For those who do not have diabetes, many people take statins to lower blood lipids and prevent cardiovascular disease. While taking statin, they can pay attention to monitoring their blood glucose, improving their lifestyle, and using pitavastatin or pravastatin, which have less impact on blood glucose, if necessary. Overall, the benefits outweigh the risks for these people taking statin for sure.

In conclusion, although statin has the potential to increase the incidence of diabetes, but because of its role in reducing the incidence of cardiovascular disease is obvious, so it should be taken or eat. Only, the process of eating can pay attention to monitoring blood glucose, improve lifestyle, if necessary, can be combined with ezetimibe, or the use of less impact on blood glucose statin. There are many solutions to this problem, so don't give up on it.

I'm Dr. Small Eyes.

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A cardiologist with a passion for fitness, like my answers and click on the top left corner to see more about cardiovascular disease!

When I saw your question, Dr. Small Eyes was initially taken aback for a moment, because Small Eyes, who often recommends the use of statin lipid-lowering medications, only knows thatStatin lipid-lowering drugs for liver damage, did not know that statins for blood glucose also have damage, so small eyes of the doctor in detail to check the past information, and now put their own experience for you to recount.

Regardless of the types of statin side effects, statin lipid-lowering drugs are still the basic medication for secondary or primary prevention in patients with coronary artery disease, and remain the first-line medication.

Even if statins have an effect on blood sugar control, theStatins are any good at preventing coronary plate rupture and lowering blood lipids.

Based on the current clinical studies reported, Rosuvastatin, Atorvastatin Calcium Tablets, Simvastatin Tablets, and Lovastatin Tablets were found to have definite glycemic side effects.

But pravastatin tablets remain controversial The effect of pitavastatin on blood sugar is neutral, and there is no clear evidence of blood sugar damage, at least until now.

Based on current clinical experience, statins have a much smaller hypoglycemic effect compared to other drugs, and statins lead to more than 8 times more prevention of cardiovascular disease than they affect blood glucose, so the risk-benefit ratio is very clear.

For patients who are already comorbid with hyperglycemia, Dr. Small Eyes suggests that you stick to the standard by lowering your LDL by more than half, and you will also be able to pass theLifestyle interventions, exercise interventions to counteract the side effects of blood glucose due to statins.

If you simply have impaired glucose tolerance, you can slow the progression of diabetes to some extent by taking oral metformin, alpha glucosidase inhibitors and other medications.

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Statins are widely used oral lipid-lowering drugs that can lower cholesterol levels to prevent and treat coronary heart disease and atherosclerosis, and are the mainstay of treatment for high blood cholesterol. However, as the number of cases of their use increases, the possible side effects of statins that may lead to the development of new-onset diabetes mellitus have also come to light. According to the Australian Longitudinal Study of Women's Health, the dose of statins is positively associated with the risk of inducing diabetes. Some studies have shown that statins contribute to diabetes risk because they reduce insulin sensitivity and the process by which pancreatic cells acquire blood sugar.

In addition to this, it interferes with the normal secretion of insulin by the beta cells, leading to mutations in the genes, which can cause an increase in blood glucose levels. The use of statin elevates glycated hemoglobin and fasting blood sugar levels, leading to abnormal glucose tolerance. Both of these are important measures of diabetes.

Although the side effects of statins are very serious, there is no more mature lipid-lowering drug that can replace it, so how to avoid its side effects has become a great concern for patients.

1... People at high risk for diabetes, such as middle-aged and older adults need to be evaluated and guided by a physician for medication.

2. When using statin, you should clearly follow the dosage and requirements.

3, the process of taking statin to continue to detect changes in blood glucose, and strive for early detection and early defense.

4、During the medication period, you can regulate your blood glucose through diet control and exercise, eat less high-sugar, high-fat, high-calorie food, and maintain a light diet to prevent overburdening of the pancreatic islets.

The use of statins carries certain risks, and patients should choose them carefully and choose other alternatives with fewer side effects when not necessary.

Instructor: Hui Lichao, Deputy Chief Physician, Department of Endocrinology, Jinzhou Central Hospital.

She has been engaged in endocrine clinical work for 15 years and specializes in the diagnosis of diabetes and other common endocrine diseases.

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Dr. Duan Q&A Online 🍀 Talking Statin Drugs 🍀

Statins have a significant role in the treatment of dyslipidemia and the prevention of thrombosis-related cardiovascular disease, but at the same time they have an increased risk of new-onset diabetes!

Who is at risk for new-onset diabetes after statin application?

(1) Age and gender factors: more common in the elderly and women;

(2) Presence of diabetes risk factors: e.g., obesity, hypertension, hyperlipidemia, gout, etc;

(3) Those who have been using statins for a long time;

(4) Those with a family history of diabetes.

Different dosage forms and doses with different risks of triggers

(1) Risks vary by intensity: e.g., high-intensity atorvastatin, resuvastatin, etc., have a high degree of risk; medium-intensity pravastatin, lovastatin, etc., have a low degree of risk of glycemic effects;

(2) The higher the dose, the greater the magnitude of the effect: e.g., according to the study, the risk of new-onset diabetes was 17% for low-dose statins, and increased to 51% for high-dose statin use.

How to reduce the risk of new-onset diabetes with statin use?

(1) Intensive and effective lifestyle interventions: such as scientific and regular dietary structure, moderate and sustained physical activity, which can not only lower lipids and reduce the dosage of statins, but also lower blood glucose and reduce the probability of diabetes mellitus;

(2) Intensive antihypertensive treatment and selection of appropriate antihypertensive drugs: angiotensin-converting enzyme inhibitors such as captopril and enalapril, and angiotensin II receptor antagonists such as valsartan and timosartan, which have insulin sensitizing effects and can well reduce the risk of new-onset diabetes;

(3) Selection of appropriate statin dose and dosage form: If possible, try to apply low-intensity, low-dose statin therapy and actively cooperate with lifestyle interventions to achieve the blood lipid standard.

So can diabetics be treated with statins?

Diabetes mellitus is a risk factor for atherosclerotic heart disease, and should be taken as prescribed by a physician when there is an indication for the use of statins, especially when the following risk factors are present:

(1) Diabetic patients with concurrent coronary heart disease, myocardial infarction, cerebral infarction, or arterial stenosis >50%;

(2) Those who have LDL of 1.8 mmol/L or more or total cholesterol of 3.1 mmol/L or more and are over 40 years of age should initiate statin therapy.

special attention

(1) The benefits of statin therapy far outweigh the risk of new onset diabetes, so it's "hooliganism" to talk about side effects in isolation from efficacy;

(2) Lipid-lowering therapy is a comprehensive treatment, and lifestyle interventions should be implemented throughout;

(3) For those who take statins in high doses or for long periods of time also be aware of liver damage and rhabdomyolysis.

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Statins do have the potential to cause blood glucose abnormalities, particularly elevated fasting blood glucose, elevated glycosylated hemoglobin, and abnormal glucose tolerance, and the FDA and the Food and Drug Administration have issued warnings about adverse reactions.

The mechanism by which statins cause blood glucose abnormalities is unclear, and it is considered that it may be related to the following factors.

1. statin may trigger mitochondrial dysfunction in pancreatic beta-cells and decreased insulin secretion.2. statin causes muscle damage and muscle fatigue, which indirectly leads to less exercise and less energy expenditure. The risk is higher for obese patients.3. Skeletal muscle cells as well as adipocytes increase insulin resistance.

How can I reduce the risk of abnormal blood sugar from statin use?

1. First of all, the use of statin should have a clear indication, do not take it arbitrarily.

2. People who are suitable for statin use should be monitored for changes in blood glucose, especially the elderly, who are at higher risk of abnormal blood glucose with statin use.

3. For people at high risk of diabetes, risk factors should be assessed before statin use. For example, screening fasting blood glucose, glucose tolerance.

4. Attention should be paid to lifestyle regulation to maintain a normal weight. For example, exercise and diet control, which can lower blood lipids and also help control blood sugar.

5. If diabetes develops during statin use, early intervention should be given to lower blood sugar. If you feel that the use of one statin has a greater effect on your blood sugar, you can switch to another one or adjust the dose under the guidance of your doctor.

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Dr. Wang encountered many such patients, always asked Dr. Wang statin triggers diabetes, I stop statin!

Dr. Wang said:What if I stop having high blood lipids and have a recurrence of heart attack?

Which! Which! Which! How's it going!

There is no need to avoid the fact that statins have the potential to cause elevated blood sugar and even diabetes, we need to face it properly.

Any medicine comes with potential risks, perhaps causing adverse reactions or even toxic side effects.

Let's ask ourselves why we are taking this medicine in the first place. What will happen if we don't take it?

We take statins to lower blood lipids, fight inflammation, stabilize plaque, and prevent cardiovascular disease. If we don't take them, we can have myocardial infarction, cerebral infarction, etc.

Discontinuation of statin in patients with myocardial infarction significantly increases the risk of another myocardial infarction.

Let's take a look at the side effects that cause elevated blood sugar in just a portion of the population, a small percentage of the population, and see what the experts recommend.

It was able to provide benefits to nine people, triggered one case of elevated blood glucose, and the elevated blood glucose was controllable and provided benefits that far outweighed the elevated blood glucose.

So, it's time to choose statin or not, as for how to prevent it, so far, there is no way to prevent it, it's just regular review and early detection and treatment!

But! It must be clear that statin can bring benefits to most people, and even if it causes diabetes, it is manageable, and the harm of new onset diabetes is minimal compared to the benefits of statin!

Hello, everyone! I'm Blessed Dad, a licensed physician. Specializing in weight management and nutritional treatment of disease for twenty years. I hope my answer is useful to you.

Statins were initially used as lipid-lowering drugs to reduce cholesterol and LDL. However, in the course of use, it was found that in addition to their precise lipid-lowering effect, statins also have anti-inflammatory and atherosclerotic plaque stabilizing effects, which can substantially reduce the risk of serious cardiovascular and cerebrovascular events. Therefore, statins have a landmark significance in the prevention of cardiovascular and cerebrovascular diseases. There are no other drugs that can replace statins.

However it's all about the medicine and statins have side effects. Taking statins for a long time has the potential to raise blood sugar and even increase the risk of type 2 diabetes. Let's talk about how to prevent and reduce statin-induced diabetes.

Who is susceptible to diabetes with statin

Statin-induced elevated blood glucose or diabetes is generally seen in people who are already at high risk for diabetes, such as those who are obese, have metabolic syndrome, pre-diabetes, and abnormal glucose tolerance. These people are themselves at high risk for diabetes and have an increased risk of developing diabetes after using statins.

Normal people taking statins for long periods of time also have elevated blood sugar, but the risk is much smaller.

Close monitoring of blood glucose

All people who take statins on a long-term basis should have their blood sugar checked regularly. For people who are themselves at high risk for diabetes, more intensive blood glucose testing is needed to detect abnormal changes in blood glucose.

Positive diabetes education and dietary lifestyle interventions

Among the five carriages of diabetes treatment, diabetes education, exercise therapy and diet therapy are very important and can be said to be the foundation of diabetes treatment. For people who are at high risk of diabetes and need to take statins for a long period of time, it is important to popularize general knowledge of diabetes, encourage regular aerobic exercise and establish healthy eating habits. These measures can substantially reduce statin-induced blood glucose elevation and diabetes.

Use of statins that have less impact on blood sugar

There are more types of statins, with pitavastatin and pravastatin having a much lower risk of getting diabetes. For people who are at risk of diabetes, these two statins can be used long-term if they can achieve their treatment goals.

Don't give up statin just because it increases diabetes risk

Treatment with medication has both side effects and efficacy, and we need to fully assess the side effects and efficacy and weigh the pros and cons. Statins causing diabetes is, after all, a low probability event, whereas the prevention of cardiovascular disease is very obvious.According to statistics, long-term use of statin drugs, for every case of diabetes caused, at the same time can prevent 9 cases of cardiovascular and cerebrovascular events. What's more, diabetes can be controlled for a long time, while cardiovascular events are either death or disability, such as myocardial infarction and cerebral infarction.The lesser of the two is clear.

So don't give up on statins just because you notice an elevation in your blood glucose; instead, be aggressive in controlling your blood glucose and adjusting your statin varieties.

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Some studies have linked statin lipid-lowering drugs to new-onset diabetes with the following factors:

1. Increased risk of diabetes with high-dose statins compared to moderate-dose statins;

2. New-onset diabetes is strongly associated with age, gender, elevated fasting blood glucose, elevated triglycerides, obesity, and comorbid hypertension in patients taking statins.

To prevent the risk of new-onset diabetes with statin lipid-lowering drugs, it is recommended that the initiation of statin therapy in patients with undiagnosed diabetes be under the supervision of a medical professional:

1. Assess diabetes risk factors and the degree of cardiovascular disease risk, and screen fasting blood glucose or glycosylated hemoglobin before statin initiation in those at high risk for diabetes;

2. To reduce the risk of diabetes and cardiovascular disease before and during statin use, understand the importance of diet and physical activity in maintaining body mass and measure waist circumference regularly;

3. Unless there are contraindications, standardized amounts of statin should generally be used to reduce the risk of cardiovascular disease according to medical advice;

4. If diabetes is diagnosed during statin therapy, lose weight and take glucose-lowering medications as prescribed by your doctor.

and make appropriate dietary and behavioral activity modifications.