Before talking about the side effects of clarithromycin, first introduce this drug, clarithromycin belongs to the class of macrolide antibacterial drugs, it belongs to the same class of antibiotics with erythromycin, azithromycin, roxithromycin and so on, so the clinical application is similar, it is mainly used for the treatment of respiratory tract infections caused by sensitive bacteria, skin and soft tissue infections, at the same time, it can be used for the treatment of all kinds of Mycobacterium (in addition to Mycobacterium tuberculosis) caused by infections. At present, the more commonly used clinical combination of other drugs for the eradication of Helicobacter pylori infection treatment, and thus reduce the recurrence of gastrointestinal ulcers.

The drug will have what side effects in the process of daily use, we all know that drugs have a therapeutic effect, but also produce some effects that have nothing to do with the therapeutic purpose, that is, side effects, for adults the most common adverse reactions are gastrointestinal reactions, such as dyspepsia, abdominal pain, nausea, vomiting diarrhea, etc., but also by the headache, taste abnormalities, etc., this kind of adverse reactions can generally be tolerated, no need to stop the drug. Of course, it can also cause some relatively serious adverse reactions, such as liver function abnormalities, cholestatic hepatitis, generally can be recovered after stopping the drug; in addition, it can also cause hepatic necrosis, pancreatitis, convulsions, serum creatinine elevation, etc., but this kind of adverse reactions rarely occur, many of them are related to its serious underlying diseases or taking other drugs at the same time; some patients taking clarithromycin orally develop allergic reactions such as urticaria and skin rashes Clarithromycin has been shown to cause tachycardia and cardiac arrest in patients with a family history of sudden cardiac death, electrolyte disorders, or who are taking antiarrhythmic medications.

Clarithromycin can have some adverse effects in combination with some drugs; its combination with statins (lipid-lowering drugs) can increase the blood concentration of the latter and increase the risk of rhabdomyolysis occurring; with colchicine (gout), it may cause colchicine heaviness, causing renal failure and total blood count reduction; and its combination with calcium-channel blockers may cause renal injury or hypotension.

Whether it is clarithromycin or other drugs, there will be different degrees of side effects, different individuals, the reaction to the side effects are different, can tolerate can not stop the drug, if there is a relatively serious situation should be discontinued in time to seek medical attention.

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Hello, I am a pharmacist who has worked in a public hospital for many years and is a state licensed pharmacist and would be honored to answer your questions.

Since the type of formulation is not involved in your question, we will just go over the basic structural features of clarithromycin, a common macrolide, the characteristics of its clinical application, and the basic aspects of side effects that are of concern to you.

First let's take a brief look at macrolides. From its basic structural features, it is generally composed of a macrolide as the parent, usually 12 to 20-membered ring, and is condensed to a basic glycoside through hydroxyl groups in the form of glycosidic bonds with 1 to 3 deoxyamino sugars on the macrolide ring. The 14-membered and 16-membered rings are more common, with the former being dominated by erythromycin and its derivatives, and the main common drugs of the latter being spiramycin, madecassicin, and other acyl derivatives.

The adverse effects of macrolides are varied, mainly gastrointestinal flora disorders, and damage to the liver, heart, and the most common adverse effects are ototoxicity. At the end of the 20th century, with the deepening of its research, a number of new drugs have been marketed in our clinic, such as azithromycin, erythromycin, dirithromycin, and the protagonist that we are going to deal with today - theclarithromycin (antibiotic). It can be said that since that time, macrolide antibiotics have been playing an increasingly important role in clinical practice, and it can also be said that an era belonging to macrolides has begun! (Of course, in recent years, there are also macrolide antibiotics on the market, such as mikacin and rotenomycin, etc., because of space, we will not introduce them in detail here.)

So let's re-jump our thoughts back to the question you asked, "What exactly are the clinical applications of Clarithromycin and its common adverse effects?" Clarithromycin has a slightly stronger effect on gram-positive bacteria than erythromycin, and is the NO1 among macrolides. at the same time, its antibacterial activity against Legionella pneumophila, Chlamydia pneumoniae, Chlamydia trachomatis, and Mycoplasma pneumoniae is also several times that of erythromycin. Clinical application of clarithromycin is mainly used forRespiratory tract infections, soft tissue skin infections and genitourinary infectionsand other aspects of the treatment. Finally, let's take a look at its adverse effects:Adverse reactions to clarithromycin are generally gastrointestinal; neurologic reactions such as tinnitus, rash, and headache are occasionally seen, as well as a transient increase in serum aminotransferases.

I hope this helps you ^_^

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