感谢悟空的邀请，痛痛痛，痛的无法生活自理，痛不欲生，痛风发作真的要人命啊！ This time to reduce uric acid has become our main means of eradicating gout pain, so what are the side effects of using drugs to reduce uric acid at the same time? Dr. Tian Tian and you together to understand:

I. Promote uric acid excretion class:

1. Benzbromarone: Gastrointestinal reactions such as nausea and vomiting, bloating and diarrhea are sometimes observed. Rash and conjunctivitis are rare, and there have been reports of redness of the face as well as itching sensation and other discomforts after taking benzbromarone, and finally the presence of kidney stones requires caution in the use of benzbromarone.

2. Propecia: Gastrointestinal symptoms are most common, such as nausea and vomiting, and occasionally peptic ulcers. Occasionally, leukopenia and bone marrow suppression may occur. Most notably, this product should be used during the chronic phase of gout, and care should be taken to ensure that the urine pH is ≥6.5 during administration, otherwise there is a risk of kidney stone formation.

Second, inhibit uric acid formation class:

1. Allopurinol: The most common adverse reaction to this product is rash, and it should be observed for the occurrence of severe drug rash during use. There are also gastrointestinal reactions (abdominal pain and diarrhea and nausea and vomiting), leukopenia, thrombocytopenia, lymph node enlargement, and interstitial nephritis.

2. Febuxostat: This product has the fewest side effects of the uric acid-lowering drugs currently in use, with a few cases of water, fatigue, mood abnormalities, pain, and thirst. There is also a relatively high risk of elevated liver enzymes that need to be watched out for.

Finally, no matter how big the side effects of uric acid-lowering drugs, are not as serious as the consequences of an acute attack of gout due to high uric acid, so gout patients with acute attacks, we must go to a regular hospital clinic, and as soon as possible under the guidance of a physician to lower uric acid treatment.

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With the social and economic development, people's lifestyle and dietary structure changes, the prevalence of hyperuricemia in China is increasing year by year, and the trend of rejuvenation, has become the second largest metabolic disease after diabetes mellitus. In addition to causing gout, elevated blood uric acid is also related to the occurrence and development of kidney, endocrine metabolism, cardiovascular and cerebrovascular diseases.

Commonly used uric acid-lowering drugs and their side effects.

Uric acid-lowering drugs commonly used in clinical practice include two categories: inhibiting uric acid synthesis, promoting uric acid excretion, and novel uric acid-lowering drugs.

1. Drugs to inhibit uric acid production: commonly used drugs include allopurinol and febuxostat. These drugs reduce uric acid synthesis by inhibiting xanthine oxidase activity.

Allopurinol: It can cause skin allergic reaction and liver and kidney function damage, and in severe cases, hypersensitivity reaction syndrome such as lethal exfoliative dermatitis can occur. The application of thiazide diuretics such as hydrochlorothiazide and renal insufficiency are risk factors for the occurrence of adverse reactions to allopurinol.

Febuxostat: a new anti-uric acid drug, common adverse reactions include liver function abnormalities, nausea, diarrhea, headache and rash.

2. Drugs promoting uric acid excretion: commonly used drugs include benzbromarone. This kind of drugs through the inhibition of renal tubular uric acid transporter protein-1, inhibit renal tubular uric acid reabsorption and promote uric acid excretion, reduce blood uric acid level.

Benzbromarone: common side effects include diarrhea, gastrointestinal upset, rash, hives, and itching.

3. Novel uric acid-lowering drugs: including uricase and selective uric acid reabsorption inhibitors.

Labrylase: a recombinant protein that is commonly used as a uricase, an oxidase that catalyzes the inactivation of uric acid, causing it to dissolve as its metabolite and be excreted from the body. Side effects include nausea and vomiting, fever, headache, abdominal pain, constipation, and diarrhea. Serious allergic reactions are rare.

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Patients with high uric acid can take some sodium bicarbonate tablets, baking soda, benzbromarone, allopurinol and other drugs, which are beneficial to reduce uric acid. All of these drugs have a characteristic that is easy to cause intestinal reactions: for example: nausea, abdominal pain and diarrhea.

Patients with high uric acid should pay attention to the diet: prohibit eating some spicy and stimulating food, prohibit eating seafood and drinking beer, prohibit eating some high purine-containing food and animal offal, you can eat some fruits or vegetables with high vitamin content: such as: apples, tomatoes, cucumbers, winter melon, watermelon and so on, and drink a lot of water, and drink 2,000-3,000 milliliters of water per day. It is conducive to the discharge of uric acid. Relieve the attack of gout.