At present, among the various types of lipid-lowering drugs, the "big brother" status of statins is still unshakeable. Statin drugs as the first choice for regulating blood lipids and basic drugs, can effectively improve the situation of high LDL cholesterol, and at the same time for high triglycerides and low HDL cholesterol, but also has a certain role in regulating and improving the effect of the current clinical effect of one of the most clear lipid regulating drugs.

As a widely used clinical lipid regulation drugs, statins are also very important to take the timing of mastery, so in the end what time to take statin is the most appropriate it, some doctors say that before bedtime, some doctors say that dinner time to take, and some doctors say that any time to take, the patient is easy to confuse, and today on the various types of statin time mastery to give a brief introduction to you! --

1. Simvastatin, lovastatin

These statins are older statins with a shorter duration of action in the body, and there are statins that are lipophilic in nature, so it is recommended that they be taken at dinner. There are 2 reasons, the first is that the night is the human liver cholesterol synthesis is the most active time, therefore, for short-acting statins, after taking in the evening, the night rest just to reach the peak of blood concentration, to play the best effect of lipid regulation; second, lipophilic statins, take at mealtime, you can increase the absorption of the drug in the body, the drug absorption degree is high, lowering the effect of lipids is better.

2. Pravastatin, fluvastatin

Both drugs are also short-acting, but less lipophilic, and therefore, drug absorption in the body is less affected by whether or not a meal is eaten; therefore, it is generally recommended that they be taken at bedtime, again to ensure that the drug works during the most active time of night when cholesterol synthesis is occurring.

3. Atorvastatin, Rosuvastatin, Pitavastatin

These three drugs are new long-acting statins, taken once a day, can continue to exert the effect of inhibiting cholesterol synthesis within a day, therefore, for these three drugs, there is no great care in the dosing time, choose a fixed time to take every day can be.

As an additional hint, for coadministration with fibrates, in order to minimize the risk of side effects of myalgia caused by the drug combination, it may be advisable to opt for a dosing regimen of an early dose of fibrate and a late dose of statin, even if it is a long-acting statin.

Finally, the ultimate purpose of taking statins, whether it is taking drugs or life low-fat diet, strengthen exercise, weight control and other aspects of control, the ultimate goal, or in order to control the blood lipids, so that the blood lipids up to the standard, to reduce the risk of cardiovascular disease, therefore, in the control of blood lipids up to the standard under the premise of the selection of the appropriate intensity of statins to take (as far as possible to choose the effective low-dose), the use of the correct way of taking medication to Try to improve the bioavailability and drug efficacy, while not relaxing the life intervention to regulate blood lipids, this is the best way to comprehensively regulate blood lipids and reduce the risk of cardiovascular and cerebrovascular diseases.

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Since the meaning of the word "time" in the question is not particularly clear, I would like to answer this question in two ways. The first is what is wrong with our bodies and when is it time to start taking statin; the second is what is the best time of day for people who need to take statin.

I. Let's start with the first question: when do you need to start taking a statin.

1. Total cholesterol (≥ 7.2 mmol/L) or LDL cholesterol (≥ 4.9 mol/L), which are higher than normal, are the main indications that a statin should be taken, and the goal of statin use is to achieve cholesterol compliance and reduce the risk of atherosclerosis;

2. Mixed hyperlipidemia, not simply elevated LDL, with elevated triglycerides or lowered HDL cholesterol, can also be controlled by statins;

3. Lipids are still in the normal range, there is no current cerebral infarction, coronary heart disease, etc., but at the same time there is diabetes mellitus, age greater than 40 years old, if the LDL cholesterol is not less than 1.8 mmo / L, is also recommended to take statin;

3. Lipids are still in the normal range, there is currently no cerebral infarction, coronary heart disease, etc., but at the same time have high blood pressure, and smoking or obesity, if the LDL cholesterol is not less than 2.6 mmo / L, also recommended to take a statin;

4. Having had cardiovascular and cerebrovascular diseases, such as cerebral infarction, angina pectoris, etc., as long as the LDL cholesterol is not less than 1.8 mmo/L, it is also recommended to take statin.

Above is the timing of initiating statin therapy, those who have these conditions stated above, without the side effects of taking statin, it is recommended to start taking it and stick to it for a long period of time, taking care to monitor the lipid profile to adjust the dosage.

Second, when you start taking statin, what point in the day is the best time to take statin?

Statin can be taken once a day at any time of the day.

However, for some statins with shorter half-lives, such as theSimvastatin, fluvastatin, taken after 8 p.m., the lipid-lowering effect is better than in the morning;

lovastatinIt is recommended to take it with dinner.

Some other statins with long half-lives such asAtorvastatin, Rosuvastatin, you can take it in the morning or at night, just take it at a fixed time every day.

Why is it that statins, which have a short half-life, work better when taken at night? This is because the enzymes that synthesize cholesterol are most active at night, and it is on them that statins work. The reason that the effect of a statin with a long half-life is less affected by the time of day it is taken is because it still maintains a high concentration of the drug into the evening.

Hello!

Statin is a class of lipid-lowering drugs that is currently quite widely used. It not only lowers cholesterol and LDL, but also stabilizes atherosclerotic plaques. It is mainly used in patients with hyperlipidemia and atherosclerosis with plaque formation, and almost every patient with cardiovascular and cerebral vascular diseases is using statin.
Patients who have taken statins know that they are taken at bedtime. The reason why it is taken before bedtime is because it is related to the body's metabolism. About 80% of the body's daily cholesterol is synthesized by itself, and the peak of cholesterol synthesis is at night. The main effect of statin is to inhibit cholesterol synthesis, and studies have found that taking statin before bedtime can better limit cholesterol synthesis, lower cholesterol, and reduce its damage to blood vessels. Therefore, statins benefit the most when taken at bedtime. However, newer generation statins, such as atorvastatin and resuvastatin, can also be taken in the morning due to their longer duration of action.

At the same time of using statin treatment, if supplemented with dietary control, it will make the patients taking statin benefit more, such as reducing the intake of cholesterol-rich foods, like animal offal, animal brain tissue, shellfish, etc., which we often eat, as well as animal fat tissue, which are rich in cholesterol, although the intake of cholesterol through the food is not much, but the control of the diet at the same time, it will make the effect of lowering blood lipids more obvious .

In addition, hyperlipidemia is mainly divided into hypercholesterolemia, hypertriglyceridemia and mixed hyperlipidemia, statin mainly reduces cholesterol and LDL, triglyceride lowering effect is weaker, if it is mainly triglyceride elevation, it is not recommended to use statin, you can choose Betel drugs, triglyceride lowering effect is better. And statin drugs in the use of the period, there are a number of adverse reactions, need to be in the guidance of the specialist physician reasonable use of drugs, close monitoring of relevant indicators, such as transaminases, creatine kinase, etc..

Thanks for reading and good luck with your health!

Are you taking your statins at the right time? Does every statin need to be taken at night?

The overall prevalence of dyslipidemia among Chinese adults is as high as 40.4%, a substantial increase from 2002. Elevated serum cholesterol levels in the population will lead to an increase of approximately 9.2 million cardiovascular disease events between 2010 and 2030 in China. Statins, also known as hydroxymethylglutaryl formyl-coenzyme A (HMG-CoA) reductase inhibitors, have been repeatedly proven to have good lipid-lowering efficacy and clear cardiovascular benefits. Commonly used statins include simvastatin, atorvastatin, lovastatin, fluvastatin, pravastatin, and resuvastatin.

Knowing the importance of statins, when do you benefit most from taking them?

Because the rate-limiting enzyme in the early stages of cholesterol synthesis in human hepatocytes, hepatic methylglutaryl coenzyme A (HMG-CoA) reductase, is most active at night, statins are likely to have the greatest cholesterol-lowering effect when taken at night. According to the above statement, are all statins only suitable to be taken at night? Are there other factors that influence this? Of course there are, and it has a lot to do with half-life.

Simvastatin, lovastatin, fluvastatin and pravastatin have short half-lives and are more effective when taken at night.

Atorvastatin and Rosuvastatin can be taken at any time due to their long half-life.

Medication is one aspect, diet and lifestyle is another. Dietary treatment and lifestyle improvement are the basic measures for treating dyslipidemia. Regardless of whether or not medication is administered to regulate lipids, dietary control and lifestyle improvement must be adhered to. A good lifestyle includes adherence to a heart-healthy diet, regular exercise, staying away from tobacco and maintaining an ideal weight.

The authoritative interpretation of Pharmaceutical Affairs, unauthorized reproduction, plagiarism will be punished.

The best time to take statins

statin (loanword)which has a wide range of applications.Neurology and cardiovascular medicineAll can be used.

It can regulate blood lipids and reduce the incidence of cardiovascular diseases.

Regular statins are taken just before bedtime

Because the body's peak cholesterol synthesis occurs at night, taking statins at night produces the greatest blood cholesterol-lowering effect, theOne study demonstrated a 5% increase in efficacy.

short half-life statin.e.g. simvastatin, fluvastatin, lovastatinIt is true that the medication is more effective when taken at night.

However, due to the continuous research discoveries and updates of statins, theA new generation of statin, more active and longer acting, such as atorvastatin. Instead of taking it at night, patients can take it in the morning and can take it with other medications to reduce the number of doses.

Optimal dosing schedule for statins:

Data from UpToDate Clinical Decision Making Database

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Statins are widely used clinically, mainly in patients with cardiovascular and cerebrovascular diseases because they not only lower blood lipids and stabilize plaque, but also improve vascular endothelial cell function and reduce arterial inflammatory response.

Statins have been developed to the point where they are now in the third generation of statins. The new generation of statins are mainly atorvastatin, resuvastatin, pitavastatin, that is, the third generation of statins. As the new generation of statin has a long half-life and strong potency, the effect of the time of taking the medication is less, the effect of taking the medication in the morning or before going to bed is not significant, and the effect of the medication lasts for 24 hours, so you can benefit from taking the medication according to the doctor's prescription.

The first two generations of statin mainly include lovastatin, fluvastatin, simvastatin and so on. As the principle of statin to lower cholesterol and LDL is to inhibit its synthesis, and the human body cholesterol at night for the peak of its synthesis, due to the two generations of statin half-life is short, most of them only 1-2 hours. Therefore, these two generations of statin drugs are best taken before bedtime, better lipid-lowering effect.

Nowadays, most patients take the third generation statin: atorvastatin, resuvastatin or pitavastatin. The half-life of the new generation of statin ranges from more than ten hours to twenty hours, which basically maintains a continuous lipid-lowering and plaque stabilization throughout the day. Therefore, the majority of patients and friends do not have to worry too much about the time of taking the drug will reduce its efficacy, you can take it before going to bed, you can also take it in the morning.

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I don't know anything about western medicine or western medicine. Thank you!

When statins are taken is closely related to their half-life.Simvastatin, lovastatin, fluvastatin, and pravastatin, which have short half-lives, are recommended to be taken in the evening or at bedtime. Atorvastatin and Rosuvastatin, which have longer half-lives, can be given at any time of the day.

Statins work to lower low-density lipoprotein (LDL) by inhibiting hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, which blocks cholesterol synthesis in the liver. Since cholesterol synthase has a circadian rhythm and the liver is most capable of synthesizing cholesterol at night, with synthesis peaking around 12 p.m., theIt is recommended that statins be taken in the evening or just before bedtime for most statins, after taking the drug, it is absorbed and metabolized, and the best efficacy can be achieved exactly at around 12:00 pm, thus maximizing the inhibition of cholesterol synthesis. Rosuvastatin and Atorvastatin have a half-life of 19 hours and 14 hours respectively and can be taken at any time of the day.

In addition, it is reminded that it must be taken on time to improve medication compliance in order to achieve good therapeutic results.

I am Clinical Pharmacist Wan Wan Yau Yee, I hope my answer is helpful to you!