What is the limit of human lifespan?

The human limit life span this definition is more difficult, but theoretically there is a general range of life span, generally based on the human cell division cycle (2.4 years) and the number of divisions (generally 50 times), this range is about 120 years old, can live to this age should be a phoenix, right .....

Since the human body's own laws give us this life expectancy range, it is logical that there should be a lot of people who exceed this limit, but the actual situation is that it is extremely difficult to approach this age, let alone exceed it! The fact is that there are many factors throughout the course of our lives that contribute to our inability to reach our physiological lifespan, the main ones being the following:

First, our genes are defective. If it is the hands or the feet that do not affect the life expectancy, it may not have much effect, but what if it is the key organs that support life? Life is like a wooden barrel, the amount of water it can hold depends on the length of the shortest piece!

Secondly, our body cells have more serious problems due to various external factors, such as radiation or other factors that lead to the accumulation of splitting errors!

Third, the late diet and various living habits lead to or work too hard to accumulate diseases, etc.

IV. Disease infection and medical failure to relieve the disease ultimately leads to death

V. Deaths due to various accidents, etc.

All of these factors lead to the possibility of early signs of disease, and although modern medicine has a very high cure rate for diseases detected early, it is often not the case that they are detected at an advanced stage, and medical intervention can only reduce suffering but not save lives!

So who has approached or exceeded this limit so far? The current world record for longevity is a French woman named Jeanne Louise Calment who lived to be 122 years old (1875-1997)!

How can we achieve such an enviable life expectancy? Until now through gene editing to eliminate defects in the technology is not so mature, then only from the acquired diet and lifestyle habits and work and other aspects to pay attention to consider, of course, accidents can not be avoided, here will not be long-winded, I think you should be more than anyone know what their own habits are not good!

Also, what are some of the techniques that future medical technology can use to extend a person's lifespan?

One, gene editing eliminates the threat of most congenital diseases at their source.

Second, you can clone or 3D print your own organs in order to replace them during extraordinary times, theoretically eliminating rejection and extending your lifespan.

Third, it might be possible to achieve life extension by modifying the number of cell divisions, but this might be a bit longer in time.

Fourth, the future development of technology, perhaps the human consciousness can be taken out and then downloaded on the cloned blank body .....

Of course these are still on paper, not even a shadow, relying on these means is not reliable, the only thing you can do now is simply the attention and maintenance of the latter, because we do not like the car has so many parts can be replaced ......!!!!

There are so many unanswered questions about the human body, such as how diseases come about, how personalities are created, and most importantly how long we humans actually live.

Human longevity, in particular, has been the most important topic for mankind since the beginning of time, and every biologist has tried to figure out why humans age and why they die.

So far, there have been more than 300 theories to explain aging and death, but none have yet been officially certified by the mainstream.

Since they are all hypotheses, let's pick a few solid ones today to explain the theoretical value of human lifespan and why humans age.

telomere

We know that the human body has a large number of cells to maintain the normal functioning of the human body, and the cells are through the division of the way to replicate itself, in short, "one point two, two points four, four points eight", a cell can finally split and replicate into many cells.

However, these cells do not divide and replicate themselves without limit, but have their own end of life.

It actually has to do with telomeres.

A telomere is a small segment of the DNA-protein complex at the end of a DNA strand that exists for no other purpose than to act as a cap at the end of the DNA strand.

But telomeres reduce their length with division, which simply means that the telomeres on each chromosome get progressively shorter with each cell division.

Let's take an example, if the first telomere is 100 RMB, at the beginning, a DNA chain contains 100 RMB, but the cell divides once to become two cells, and each cell can only have 50 RMB, and then along with the cell division, the RMB is divided again. Until the RMB is no longer divisible, the cell will activate the apoptosis mechanism. Therefore, telomeres are also known as the "clock of life" by scientists.

In 2009, the discovery of how telomeres and telomerase protect chromosomes was an achievement that earned three scientists the Nobel Prize in Physiology (Medicine) that year.

In 1961, the American scholar Heilfli observed, based on experiments, that the number of embryonic cell divisions is regular, while human cells are divided to 50 generations when all will die, and the cycle of division is about 2.4 years.

Thus from the factor of telomeres, the theoretical life expectancy of humans should be 120 years.

However, there are many factors that affect telomere length, as mentioned in a 2005 article in the prestigious medical journal magazine The Lancet:Drinking and smoking shortens telomere length, so you'll live less timeIn addition to this, scientists have found that telomeres are not as long as they should be. In addition to this, scientists have found that telomeres are not as long as they should be, for example: cancer has been linked to telomeres that are too long, or no longer shortened.

Of course, you may have heard of people living longer than 120 years in reality, in fact, scientific research does not rule out a routine behavior, because genes are subject to minor variations.

But if the longevity villages in a certain place all have a collective life expectancy of more than 120 years, then it is not necessarily because the village has any secret of longevity, it is more likely that it is the result of the confusion of the local household registration system.

Brain Survival Limits

While we cheer the fact that modern medicine is able to cure more and more illnesses, scientists are pessimistically realizing that the lifespan of the brain is failing to keep up with the body's development.

For example, there is an increase in brain disorders in the elderly, most typically Alzheimer's disease, which is a neurodegenerative disorder. Simply put, there is an increase in the accumulation of harmful proteins in the brain.

If a patient with Alzheimer's disease is in perfect health, he could theoretically live to be 120 years old, but due to the brain disease Alzheimer's disease causes deterioration in the brain function and therefore body temperature, memory, heart rate, etc. are also destroyed. This also means that human beings will die due to the degeneration of brain function.

And the brain on the disease, and not only Alzheimer's disease, there are gradual freezing, Parkinson's, etc., and these diseases within the brain the older the age, the higher the incidence, so the brain's actual survival life, than the human body life expectancy to be slightly shorter, but how much shorter, there is no accurate figure.

Factors affecting human longevity

Did you realize that from the telomere point of view alone, even if human beings do not reach the theoretical upper limit of life expectancy, there should not be too much difference, so why is the average life expectancy of the Chinese people is only 68.7 years old?

In fact, this is because not all of the cells in our body want to "make us live longer", such as testosterone, for example, for young men, too much testosterone can help to enhance masculinity, make men stronger, more agile, and more conducive to win in the competition between the sexes.

But when it comes to old age, too much testosterone can in turn cause male reproductive health and increase the incidence of reproductive cancers. It has now been shown that the higher the testosterone levels, the shorter the life expectancy of men.

On the contrary, scientists have found that although dwarfism is caused by the body's low production of growth hormone, this gene is not prone to cancer, so people with dwarfism live longer compared to the general population.

But instead of selecting the gene that makes us live longer, natural selection selects the gene that makes us more competitive when we are young, even if we will die quickly after reproduction because of that gene.

In addition to self-factors, an individual's lifestyle, mental health, friendships, and living environment can all have an impact on an individual's life. In short, there are many factors that affect life expectancy, which is why human life expectancy rarely reaches the theoretical value of telomeres.

The longest living person in human history lived to be 146 years old!

Well, it's the old Indonesian man below, who lost 10 siblings, 4 wives, and all his children one after another, yet he's still alive, and has outlived the second-place Frenchman by a full 24 years!

This should be, as before, the limit of human lifespan.

What's the secret of longevity for old people, you ask?

The answer is laughable, the old man is an old smoker, smoked all his life, to say the secret, he once replied with a look of indifference, "what else can be done, keep patience."

But it is painful to live to such a great age as a man forgotten by death. He has said many times that he doesn't want to live anymore, not at all, and he says to people, "It's so nice to be dead ......"

He did not die of a disease, but rather a "suicide". Before his death, he was still in good health and able to walk on the ground, but he died because he had become so misanthropic that he went on a hunger strike, which ultimately led to his death.

To live to this age is a feeling of loneliness that runs deep in your bones. There's no one to talk to, and the grandchildren don't want to hear him talk about things that happened more than 100 years ago.

His grandchildren are already half a hundred years old, except for feeding time with him in a piece, he can only silently swallow the torment of ten thousand loneliness. In fact, when he was 122 years old, he had already prepared a tombstone for himself, looking forward to an early with his wife and children in the heavenly countryside, but death just forgot him.

After reading this, I just want to ask the question back to the Lord: do you really want to live until you're 200 years old, watch your wife, children, and even grandchildren die, and then live on in endless loneliness yourself?

I don't want to anyway. And it's obviously silly to expect those scientists to live a hundred or eighty more years and bring about more discoveries when, scientifically speaking, one's brain is already as rusty as it is long after 90 years of age.

Simply extending the human lifespan is meaningless, cracking the genes that control human aging is the ultimate way, right!

Let the difficult science, become simple, become interesting, welcome to pay attention to "science heavy"!

According to available information, human life expectancy is 120 years at most!

Although life expectancy of 130 or even 140 years is often reported in Japan and other countries! However, in the end, it turns out that many of these are the result of their children, grandchildren and other descendants not reporting the death of the elderly long after they have passed away in order to receive the high Japanese old age allowance! This creates a false impression that Japanese elderly people can live up to 140 or even 150 years old. In reality, it is all a lie!

So why is it that the limit of human lifespan is 120 years at most? Because the organs of the human body age over time, no matter how well they are maintained. And after 120 years of metabolism, the vast majority of older people are long dead. The very few surviving older people will also have deactivation of their organs, which will eventually cause them to pass away!

Of course with the development of gene technology, cloning technology and so on. In the future, human organs will definitely be replaceable like car parts. And if, like cars, some people can have regular medical checkups and pay attention to maintenance, it is estimated that living to 200 years old will not be a problem!

Everyone wants to live forever, but longevity is still a long way off, and even though technology is now very advanced, the number of people who live long lives is still small. The Guinness Book of Records recognizes the world's longest-living person, a South African village woman named Molokotai, who lived to be about 134 years old.

So where is the limit of human lifespan? According to modern science, especially the discovery of telomeres, scientists have estimated that the limit of human lifespan is about 120 years. Of course, this is only an estimate, because the length of telomeres may not be the same for everyone, and the speed of cell division may not be the same, and the speed of telomere shortening may not be the same, so it is not possible to completely determine a very accurate value. However, according to the average, 120 years old is almost the highest life expectancy of human beings. And the records of the world's longest-living people do show that many long-lived people do not live beyond 120 years old.

However, as the saying goes, "My destiny is mine but not God's", and the whole history of human development can also be said to be the history of development against nature. Therefore, through relevant basic research on life expectancy, modern people have begun to improve their life expectancy through scientific means. At present, the average life expectancy of our country can reach 77 years, which is already far greater than that in ancient times. Therefore, the life expectancy of modern people is gradually increasing.

Now some scientists, based on the discovery of telomeres/telomerase, are hoping to work out the structure of telomerase. By synthesizing telomerase to repair our damaged telomeres, we can achieve the goal of "longevity". However, the analysis of the structure of telomerase is a very difficult work, scientists are currently able to analyze the structure of the map resolution is not enough, I hope that in the future, such as Shi Yigong protein structure scientists can perfectly analyze the structure of the telomerase, so that perhaps human beings are really by the day of immortality.

In China's seventieth birthday ceremony, I heard the host said a set of data, seventy years ago, that is, in 1949, the average life expectancy of the Chinese people is 35 years old, and seventy years past the average life expectancy of our country has become 75 years old, which is sufficient to show that our country's seventy years of rapid development, the seventy years of China's sons and daughters of the wind and rain.

Any living creature has a life span limit Some are living and dying, there are cycles of "eternal life", such as the lighthouse jellyfish, and the human life span in the animal kingdom also belongs to a longer one, the modern society generally can live a seventy, eighty, eighty-nine years old. But where is the limit of human lifespan?

In Chinese history, there is a strange man, he almost lived through a dynasty, in the Qing Dynasty 41 years after the establishment of Li Qingyuan was born, 21 years after the fall of the Qing Dynasty, the strange man died, lived 256 years. However, due to the lack of information, whether Li Qingyuan really lived 256 years, is now more controversial. According to the chromosome telomere, the limit of human life is about 120 years old, and there are facts that the world's longest-lived people can reach about 130-140 years old, seems to have exceeded this limit.

We want to maintain vitality, then the cells should have vitality, the cells also have a life expectancy, the cells in our body will continue to divide, but the number of divisions is limited. In the chromosomes on the existence of telomeres, and with the cell division, telomeres are constantly decreasing, and eventually reach a state where cells can no longer continue to divide and eventually die, then with the cells can not divide gradually die, the body's functions will naturally be affected, and ultimately the death of the individual, which is the principle of the limit of life.

There is also the maturation theory, which states that the age of sexual maturity is about 15 years old, and that life expectancy tops out at 8-10 times the age of sexual maturity, so that the limit of human life expectancy is between 120 and 150 years old. Human evolution is the process of harmonizing the environment, and as technology advances and medical care improves, the average life expectancy of human beings will become greater and greater, but there is a limit to life expectancy under the influence of the telomere limitation theory.

compareaverage lifespan, the maximum lifespan is usually considered a stabilizing characteristic of a species.The highest reported age of death for humans is set at 122 years old for Jeanne Calment, the longest-lived human being ever recorded。On the human life expectancy in the end there is no limit, scientists are still debating without reaching a unanimous conclusion, even in the last three years published in the top journals "Nature" and "science" research, but also come up with opposite results。

Driven by technological advances, human life expectancy has increased significantly since the nineteenth century. Demographic evidence shows that mortality rates in old age have continued to decline and the maximum age of death has risen. Coupled with the observation that lifespans in different animal species are flexible and can be extended by genetic or pharmacological interventions, these results have led to the idea that lifespans may not be subject to strict species-specific genetic limitations. However.Most studies show that there is a limit to the maximum human lifespan, and no one has lived beyond 120 years since Jeanne Calment held the record for longevity at 122.4 years in 1997, as follows。

In a 2016 study published in the journal Nature, researchers at Albert Einstein College of Medicine analyzed data from the Human Mortality Database, which includes data on people and deaths from more than 40 countries. The researchers found that since 1900, the survival rate of people aged 70 and older has steadily increased with the number of years they were born.

However, survival rates for people over 100 have not risen, and the age at death of the world's longest-living people has not increased since the 1990s, implying that there is a genetic limit to human longevity. ResearchersA survey of people over the age of 110 in four developed countries (the United States, Japan, France, and the United Kingdom) found that the maximum age of death for this age group increased between the 1970s and the early 1990s, but leveled off in the mid-1990s. As a result, researchers have estimated that 115 years may be the average limit of human longevity。

But a study published last year in Science suggests otherwise.. In the Science study, a team of researchers analyzedItalians aged 105 and over3,836 personsThe data, which tracked theSeven years, from 2009January 1through Dec. 31, 2015, during which time 2,880 people died. The researchers found thatAlthough the risk of death increases with age, with human mortality increasing exponentially after age 80, in the study population this risk appears to level off after age 105 at a rate of 50% per year. In other words, a person 107 or 108 years of age or olderrisk of deathThere are no people significantly older than 105, and the human limit of life will be progressively refreshed as soon as enough people reach the age of 105.

The environment, conditions, and determinants of life expectancy for men and women are currently very low: very few men are 90 years old, and very few women are 100 years old. Extreme life expectancy is guaranteed by the conditions and at any price.

But have we thought about it? We can't just pursue longevity, the elderly can't take care of themselves, they are dragging their families down. Taking care of an elderly person who can't take care of himself is more laborious than raising two baby dolls. Moreover, there is no hope.

Nowadays, people's lives are so stressful that the only thing they can do is fall asleep and enjoy themselves, and all they can think about when they open their eyes is making money. Tired ah!

The pursuit of longevity is natural, but you can't base your longevity on your children's undivided attention, and your heart won't bear it! Children are too tired! I know this personally!

In my opinion, it is reasonable to live a long life, and it is reasonable not to get by with it, and try to trouble your children as little as possible, and try to take care of yourself as much as you can. If you can't take care of yourself, you have to wait for death.

People will think that I am unethical, but I said the big truth, and, ritual piety has the opposite, but the facts speak louder than words. Being there is the true feeling, you can not simply pursue longevity, it is better to think of longevity in a comprehensive manner!

A: The extreme life expectancy of humans, is around 120 years; the longest living human for which there is currently good evidence is a French woman, Jana Calment, who lived 122 years and 164 days (February 21, 1875-August 4, 1997).

Tens of thousands of years ago, human ancestors were still living by hunting, when the average life expectancy was only in the teens, and very few could live up to 20 years old; in the Song Dynasty, the average life expectancy of the ancients was around 30 years old, which had doubled a few times in comparison with the average life expectancy of modern people, which was close to 80 years old.

On the one hand, it is the improvement of the nutrition level of food, and on the other hand, it is also the great progress of modern medicine, but after all, human beings also age, and when the cells proliferate to a certain number of times, it will cause the decline of the stem cells, the DNA damage, etc., so that there is a limit to the life span of human beings.

Scientists have studied the division of human cells, speculated that the limit of human life in about 120 years, which is very consistent with the actual situation; exclude the folk of the various legends, said that certain living a few hundred years of high, these are not conclusive evidence, not enough to believe.

In the Guinness Book of Records, a French woman named Yana Calment became the longest living person (122 years and 164 days) with good evidence.

As medical technology advances, the average human lifespan is increasing, but researchers have also found that of those over 105, the maximum lifespan of these long-lived individuals is beginning to stabilize, signaling that this is approaching the limit of human life, which current medical technology is struggling to break through.

If human beings want to continue to increase the limit of life expectancy, we have to start from the genetic aspect. Only by solving the ultimate mystery of human aging, can we find the right medicine and the key to continue human life.

That's all from me, for those readers who like our articles, remember to click to follow us - Abel Smith!

After going all the way through the history of mankind, civilization, feudalism, modernity and contemporary history, the statistics of the extreme life span of human beings under normal conditions are as follows:

(1), the emperor, all were hailed "long live", by the emperor's edict of "nine thousand years old", "a dry age", but one did not as desired.

(2), the truly highest longevity in our country, is that of the common people, who are recorded as living beyond one hundred and thirty years.

(3) Bill Gates, once the richest man in the world, has donated all his wealth to reach the limit of his life in order not to let his life span be taken up by his wealth.

(4), according to the evidence, the length of human life is completely controlled by the desire of the most important key factors, where the stronger the desire, the more chaotic Hu as, the more annoying brain, the more narrow the heart, the more narrow the heart, qi and blood obstruction, squeezing all kinds of organs in the body can not survive normally, resulting in a normal life expectancy of even half are very difficult to maintain.

The person who has no worries, no desires, and does not even expect to live tomorrow as comfortably as he does today, that is the person who can truly live to the limit of his life.