Yunnan Baiyao has been accused of adding the prescription hemostatic drug tranexamic acid, what are the possible adverse effects of long-term use?
Yunnan Baiyao has been accused of adding the prescription hemostatic drug tranexamic acid, what are the possible adverse effects of long-term use? 
I'm all too familiar with tranexamic acid, commonly used to stop bleeding.
About its role and side effects, there are already a large number of authors in the popularization of science, I do not need to go into detail. If you're still not sure, it's easy to search on Baidu.
I'm going to talk about a point of view here that's not quite the same as everyone else's:
1 This ingredient should be legally added.
Since the manufacturer dares to write the ingredients to the product packaging, the description is that it is its is in line with industry norms and product standards, it is permitted under the law to add.
2 Talking about toxicity in isolation from dose is just plain bad taste.
Manufacturers are supposed to have very low levels of tranexamic acid in toothpaste, it's not a drug after all. (But I think it should still be labeled with the exact amount) Intravenous, oral, and topical, and the percentage of drug absorption varies wildly.
There are not many adverse reactions to the clinical use of tranexamic acid, and its side effects usually occur at regular therapeutic doses. There should be little research data on what adverse effects microdoses may have in the body over time.
Please refer to the instruction manual of saline, it is surprising that it can also be written so long? Isn't it scary too?
3 For special populations such as children and pregnant women. Safety warnings should be given for added pharmaceutical ingredients.
There are no reliable references on the safety of aminoglycolic acid applications with pregnant women and children. (There is neither evidence of safety nor of harm, and the relative harm can be considered insignificant for the time being.) However, for these special populations, special safety warnings should be given on the product and the user should be given full informed choice.
I'm not saying this to wash my hands of the manufacturers, just to help people think more objectively and calmly from multiple perspectives. In fact, I also resent the use of western medicine to solve problems under the banner of Chinese medicine. (Refer to my last Q&A)
Toothpaste is just for cleaning your teeth, don't expect it to cure anything.In fact, I personally choose toothpaste never care about any of its ingredients and healing properties, and only take the most common and cheapest affordable ones from the shelves.
I don't use any kind of toothpaste for a long time, it's best to keep replacing it.
Welcome to follow Dr. Cheng's 100 high and focus on the health issues around you.
In fact, when I first heard about this is a shock, because this brand of toothpaste is our family used to use, my mother especially like to use, is because often bleeding gums; of course, we have also worried about blindly stopping the bleeding may cover up the risk of oral diseases, so went to the dental hospital to do a series of tests, the results proved that it is not a serious oral disease, so also rest assured with the use of the;
Although added tranexamic acid toothpaste does have a good hemostatic effect, but after all, it is a drug, in the case of unknowing use will inevitably have some adverse reactions, more importantly, there are contraindications to the use of the drug, because it has a tendency to stabilize blood clots, so all people suffering from thrombotic disorders or the possibility of thrombosis should be avoided to use tranexamic acid; however, there is also However, there is a question about the effective dose of the drug. Is the dose of toothpaste we usually use for brushing our teeth sufficient to induce adverse reactions? Unfortunately, the relevant data are not available and it is difficult to make a valid assessment!
However, it is worth saying that the substance is also really allowed by the state as a cosmetic additive, you know, tranexamic acid to reduce black spots than vitamin C is nearly 50 times more powerful, so not only toothpaste, some common whitening cosmetics on the market most of the substance is added, but its product ingredients written not tranexamic acid, but Tranexamic Acid, at present, Ming Tranexamic Acid series of cosmetics involving To dozens of varieties of cosmetics, such as facial cleanser, water milk cream, serum, makeup remover, BB cream, body milk, etc., and even the legendary whitening injection also has the existence of the substance;
In summary, on this matter of tranexamic acid in toothpaste, we are advised not to worry too much, and to settle down for the time being and wait, there will be a statement eventually!
The above is for reference only!
First of all it's Yunnan Baiyao toothpaste, not Yunnan Baiyao. Correct the questioner's mistake and omission.
Due to the lack of research one can only reason from the drug mechanism. However, there is reason to suspect an increased risk of stroke and heart disease.
Tranexamic acid is used to help clot blood, and blood is something that can't just clot, it can cause big trouble. That's why it's used as a prescription drug, monitored by a doctor for careful use, and not for long periods of time.
However, now that this drug is added to toothpaste, in order to have an effect, there must be a certain concentration and dosage, otherwise would it not be a waste of money if it is added and does not work? Artificially increase the cost, but also leave a handle.
So here's the problem, it's toothpaste, anyone can just buy it and use it for a long time, not for days and weeks, but for years and years and years, and for brand loyalists, most likely from childhood to old age, for decades.
So with such prolonged use, does it increase the risk of diseases involving excessive blood clotting, such as stroke (strokes) and heart disease? Let's just say we don't know.。
Toothpaste manufacturers do not care about the long-term health of consumers, only the moment tube, and added Western medicine is not clear to tell you, in the publicity only said that the essence of Chinese herbs, safe and non-toxic side effects, which is suspected of fraud in any case!
Among the top ten causes of death in China today, ischemic heart disease and cerebrovascular disease (stroke) rank among the top three, accounting for about 39%, i.e., about four out of ten people die from these two types of diseases, and the occurrence of these diseases has a great deal to do with excessive blood clotting.
And the indiscriminate addition of clotting-promoting drugs to toothpaste, given the sheer number of people using it and over time, would mean that just the slightest elevation of risk would result in the deaths of a large number of consumers for no apparent reason.
I call on the state to put in place regulations banning the use of any drug in toothpaste, whether it be a prescription drug or some herbal remedy, toothpaste is toothpaste, not a drug.
Yunnan Baiyao has been accused of adding the prescription hemostatic drug tranexamic acid, what are the possible adverse effects of long-term use?
To answer this question, you first need to have a brief understanding of tranexamic acid.
Coagulation and fibrinolytic mechanisms of blood
Since our blood is a fluid, once it breaks through the "boundaries" of the blood vessels, it can be lost in large quantities, which can lead to death in severe cases.
Thus, blood has its set of clotting mechanisms, and when bleeding occurs, some of the components can coagulate into clots to stop the bleeding.
The coagulation mechanism consists of two main aspects, that is, many clotting factors in the blood, mainly some proteins, when the coagulation mechanism is triggered, these proteins will coagulate into a fibrous mesh structure used to network the tangible components in the blood helps to form blood clots to plug the holes in the blood vessels.
Another major component of the clotting mechanism is platelets, which stick together when the clotting mechanism is triggered and are caged by a web of clotting proteins.
The clotting proteins form a network like the reinforcing cages and cement in concrete, and the aggregated platelets are like the stones and sand in concrete, working together to form clots that plug the holes in the blood vessels to stop the bleeding.
But then again, our blood needs to remain sufficiently mobile to not allow for random clotting.
Once a blood clot forms and blocks a blood vessel, it can lead to serious and even fatal diseases. For example, heart attacks due to thrombosis of the coronary arteries of the heart, cerebral infarction due to blockage of the cerebral blood vessels, deep vein thrombosis, and other infarctions due to thrombosis of any blood vessel; as well as embolism due to dislodgment of blood clots in other tissues and organs, such as pulmonary embolism due to dislodgment of blood clots in the heart of a patient with atrial fibrillation.
As a result, there is also a set of mechanisms in the blood that are anti-blood coagulation, mainly inhibiting platelet clumping, and coagulation fiber aggregation. The latter are mainly a number of enzymes that can dissolve fibrous clots.
The coagulation and anticoagulation mechanisms are kept in a balanced state so that our blood can flow smoothly; and once bleeding occurs, a blood clot can be formed in time to stop the bleeding.
tranexamic acid
Tranexamic acid works by preventing theEnzymes in the body break down blood clots and thusIt is an anticoagulant fibrinolytic prescription hemostatic drug.
What do you mean by calling it a prescription drug?
It is the medication that requires a doctor's prescription based on the diagnosis and needs of the condition, and the patient can only purchase it with the prescription and follow the usage and dosage in the doctor's prescription. During the purchase, the pharmacist will also check the doctor's prescription and provide more specific instructions to the patient.
For what diseases does a doctor prescribe tranexamic acid?
salientTwo indicationsIs:
Prolonged and severe menorrhagia in women；
and forPreventing bleeding before tooth extraction in hemophiliacs。
In other words, this drug is only needed if the patient is thought to have or may have a coagulation-fibrinolysis defect causing abnormal bleeding.
Of course, it can be used for some other bleeding situations. For example, to prevent bleeding from surgical wounds.
In fact, in normal people, even with surgery or trauma, the use of these drugs is not really useful as the blood clotting mechanism is normal.
However, as with many other drugs, when introduced into the country, the range of indications for the drugs is often expanded without limit.
Therefore, under this question, many professional doctors and pharmacists said, oops, tranexamic acid, ah, I am too familiar with it, clinically used every day.
In fact, a very large portion of the use actually falls into the category of abuse.
General side effects of tranexamic acid
severe allergic reaction
Like all medications, tranexamic acid can trigger allergic reactions, including severe allergic reactions.
We know that allergic reactions are non-dose-dependent, meaning that exposure, even in extremely minute amounts, can trigger an allergy.
General Adverse Reactions
Like all medications, tranexamic acid can have some general adverse reactions, including nausea, vomiting, and diarrhea; dizziness, lightheadedness, and headache (which can be severe); mild itching or rash; or abnormal sensations.
Side effects of tranexamic acid that require special warning
Since, tranexamic acid works by preventing enzymes in the body from breaking down blood clots and anticoagulant fibrinolysis, it is mainly used for coagulation disorders in which there is a defect in the relevant coagulation factors.
This means, then, that the balance of the blood's bleeding and coagulation mechanisms is disturbed. Especially in normal people, where the coagulation mechanism is otherwise balanced, the result of this interference is that it "helps" the formation of blood clots.
As we know, cardiovascular disease is the number one killer of contemporary mankind, in which the main problems are ischemic heart disease and ischemic encephalopathy caused by atherosclerotic thrombosis, as well as ischemic diseases of other parts of the arteries and veins, including deep vein thrombosis and pulmonary embolism.
The use of tranexamic acid, however, can be precisely the mechanism to gather these diseases to get the possibility to show that.
The use of tranexamic acid is associated with visual problems, including impaired color vision (temporary color blindness). This is mainly a problem of arteriovenous thrombosis in the fundus of the eye.
Dizziness, syncope-like sensation. This is mainly a sign of reduced cerebrovascular blood flow.
Signs of a stroke. Sudden numbness or weakness in a limb (especially on one side of the body), sudden severe headache, slurred speech, vision or balance problems.
Seizures (convulsions).
Signs of blood clots in the lungs. Chest pain, sudden coughing, wheezing, shortness of breath, coughing up blood.
Signs of a blood clot in the leg. Pain, swelling, warmth or redness in one or both legs.
Although, the chances of these occurring are low, they are serious problems.
Therefore.However, tranexamic acid must be used with great care in any patient who has problems with thrombophilia. For example:
Fundus Vascular Problems. Includes the use ofTemporary color blindness has occurred with tranexamic acid.
have hadhistory of stroke, either hemorrhagic stroke or ischemic stroke.
coronary heart disease, especially with a history of heart attacks.
kidney disease(affects blood clotting mechanisms).
Women taking birth control pills--Estrogen and progesterone both promote thrombosis.
Pregnant or planningPregnant women, a doctor should be consulted.tranexamic acidWhether it is harmful to the fetus is unknown.
Tranexamic acid passes into breast milk.lactating womanThe use of tranexamic acid also requires consultation with your doctor.
That's tranexamic acid, and you think it should be added indiscriminately to the most commonly used household product like toothpaste?
Problem of chemical additions to proprietary Chinese medicines
It's been a long time coming.
Why add?
Because the manufacturers know full well that what they claim to be their all-natural medicines don't mean shit, and have no choice but to add, either explicitly or covertly, chemicals that actually work. Typically, explicit additions such as thirst pills; covert additions such as fast-acting heart pills (which once stated they contained nitroglycerin, but were later secretly erased).
Yunnan Baiyao issue
Yunnan Baiyao has a similarly long history of controversy.
Yunnan Baiyao is a hundred years ago, Yunnan region of a village doctor's recipe, and then was somehow whole into a national confidential formula, the national protection of traditional Chinese medicine varieties.
In fact, does Yunnan Baiyao work?
It's kinda useful, if it's for external bleeding from trauma.
However, with this use, applying Yunnan Baiyao is no different than applying incense ash or any other ash, or a handful of sterile earth (e.g., stovepipe earth), to stop bleeding.
Because, each of these ash or earth powders, each particle of which is a core that triggers the blood clotting mechanism, will have a significant hemostatic effect.
In modern surgery, on the other hand, the principle of treating traumatic wounds is strict debridement (removal of all contaminated or necrotic tissue) and the prohibition of the use of any topical medications. Because, these can trigger an inflammatory response, affecting wound healing, and especially predisposing to scar formation, as well as increasing the risk of infection.
But even so, for patients with coagulation disorders like hemophilia and advanced liver disease, Yunnan Baiyao is as useless as incense ash.
As for taking it internally, again, two words: bullshit.
I will never use toothpaste to brush my teeth again ......
No no ...... I'm never brushing my teeth again ......
This is a targeted use of bad media and netizens to domestic enterprises to combat, touch black, its nature and techniques with the same for Hongmao medicinal wine event, the doctor came out to question the back of a large state of the unscrupulous media out to build momentum, like Hongmao medicinal wine event to the final results of the questioner also can not get any evidence and examples of toxic accidents, but they conspire to achieve the purpose of the Hongmao medicinal wine enterprises are now faced with the workers layoffs, Enterprises do not spend, I hope that the relevant state departments to intervene as soon as possible, can not let Yunnan Baiyao become the second Hongmao medicinal wine event, the skeptics (such as can not get the real evidence) to bring to justice, digging deep after the twilight to promote the black hand.
In the past two days about a well-known toothpaste added tranexamic acid thing is very eye-catching, today Dr. Zhang as far as he knows to talk about this tranexamic acid.
When it comes to tranexamic acid, cardiac surgery has a say because it may be used in cardiac surgery procedures. All of the following knowledge comes from the 2016 guideline Perioperative Blood Management for Cardiovascular Surgery - Antifibrinolytic Therapy.
The reason why tranexamic acid is needed in cardiac surgery is because one of the most important aspects of protection in cardiovascular surgery is how to achieve a reduction in intraoperative bleeding. Tranexamic acid is used in cardiac surgery to stop bleeding.
A large amount of research data and clinical practice have confirmed that lysine analogs (tranexamic acid) can effectively reduce perioperative bleeding and transfusion of allogeneic blood products in cardiovascular surgery and have a high degree of safety, making them the predominant antifibrinolytic therapy in cardiovascular surgery today.
Tranexamic acid is a lysine analog, and tranexamic acid has a long history of use for perioperative hemoprotection in cardiovascular surgery. It competitively occupies the lysine binding site on fibrinogen, blocks the binding of fibrinogen to lysine on fibrin, reduces the production of fibrin degradation products, and ultimately reduces bleeding. Regarding the dose of tranexamic acid, most centers use a higher administration dose, i.e., loading dose of 30 mg/kg + preloading dose of 2 mg/kg + maintenance dose of 16 mg-kg-1-h-1. (Dosage may vary from center to center.)
The side effects of tranexamic acid, which is the main concern of everyone, are also mentioned below, and this is going to be from this guide above as well.
1, Blood clot incident
It is now well documented that intraoperative tranexamic acid is effective in reducing perioperative blood loss and lowering transfusion rates in cardiac surgery, and does not increase the incidence of perioperative thrombotic events in cardiovascular surgery (including myocardial infarction, stroke, deep vein thrombosis, and pulmonary embolism).
2. Liver and kidney function
The intraoperative use of tranexamic acid did not show any significant effect on the function of the kidneys, liver and other important organs.
3. Perioperative epilepsy
Studies have noted that the use of high doses of tranexamic acid can increase the incidence of postoperative epilepsy, but there are no long-term sequelae and it does not lead to structural brain changes.
4. Other side effects
Other adverse reactions to tranexamic acid include gastrointestinal reactions, skin irritation, and visual changes, which have been reported in clinical cases.
The above is Dr. Zhang's personal talk about tranexamic acid that I know from the cardiac professional guide, and I hope to be able to throw a brick to help you.
Happy to answer your questions.
First of all, thanks for the invitation.
Tranexamic acid, a type of prescription drug. It is a very common and frequently used medication to stop bleeding.
So what are its side effects. It is also called coagulant acid, slightly bitter flavor, long-term use, may trigger lesions of the retina, in addition, for their own blood clots in patients, pregnant women, lactating women, etc., are not supposed to use the drug.
So the question is, is Yunnan Baiyao toothpaste problematic when it has this hemostatic agent in it?
Chemistry, talking about toxicity without metrology is all hooliganism.
Yunnan Baiyao, such a big brand, clearly puts tranexamic acid in the list of ingredients, and in a more backward position, stating just that:
1. Pass the state's audit and see the light, can be public.
2. Positioned at the back, it is not the main component and contains less.
Well, a little toothpaste, put some bleeding medication in it, no problem.
What should I do with my toothpaste?
You should not be biased. Toothpaste, shower gel and shampoo, please change them regularly and do not use the same brand and model continuously~
If you find it useful, just give it a like and a pink friend.
It cost about 0.3KB of traffic hahahahahaha.
After all, I'm so cute.
Strange, many toothpastes have this ingredient, why are they saying it's a problem with Yunnan Baiyao toothpaste, it feels like someone behind the scenes is operating this thing, don't be used as a gun by others
As a doctor, I'll answer this because we use tranexamic acid on a regular basis. Tranexamic acid is a hemostatic, antifibrinolytic drug, his mechanism of action is still relatively clear. In order to clarify the mechanism of action of tranexamic acid, we first need to popularize the coagulation mechanism of normal people.
Mechanisms of blood clotting
If you are cooking, accidentally cut their hands, blood vessels bleeding damage, the first thing is that the blood platelets in the blood immediately contract, if the break is not large, platelets can make the blood vessel closed. If the damage is large, the intima of the blood vessel is damaged, the activated platelets adhere to the subintima tissue and gather into a mass, becoming a loose hemostatic plug to fill the wound. Then, the soluble fibrinogen in the plasma is transformed into insoluble multimers of fibrin molecules, and the platelets and fibrin form a firm hemostatic plug, or clot, which stops the bleeding.
Role of tranexamic acid
At the same time of hemostasis, the fibrinolytic activity in the blood is activated, and the fibrinogen is activated to become fibrinolytic enzyme, which can dissolve fibrin, preventing the blood clot from increasing and the coagulation process from spreading to other places where there is no bleeding. Tranexamic acid can competitively inhibit the adsorption of fibrinogen on fibrin, thus preventing its activation, protecting fibrin from being degraded and dissolved by fibrinolytic enzymes, and ultimately achieving the effect of hemostasis. Therefore, tranexamic acid is mainly used for all kinds of bleeding caused by primary hyperfibrinolysis, preoperative or intraoperative bleeding prevention.
Side effects of tranexamic acid
Tranexamic acid has few side effects, but can occasionally cause thrombosis and is used with caution in people with a tendency to thrombosis (e.g., acute myocardial infarction). Tranexamic acid can enter the cerebrospinal fluid and can cause central nervous system symptoms such as blurred vision, headache, and dizziness. It can also cause menstrual discomfort in women because of menstrual blood clotting. Combining tranexamic acid with oral contraceptives, estrogen, can increase the risk of blood clots. Also, tranexamic acid can cross the placenta and is secreted in breast milk, so it should be used with caution in pregnant and breastfeeding women.
Why is tranexamic acid added to toothpaste?
Tranexamic acid is a prescription medication to stop bleeding, what is the dosage of tranexamic acid added to toothpaste and is it added to stop bleeding? For some herbal toothpastes, claiming that they have the effect of preventing gum bleeding, is it because of the addition of tranexamic acid, is it suspected of false advertising? These need to be identified by the relevant national authorities. As ordinary people, we would like to know whether the addition of tranexamic acid to toothpaste is legal, whether clinical trials have been conducted before the toothpaste is put on the market, whether there are any side effects, and how potentially harmful it is. As an ordinary consumer, we should enjoy the right to know, and I think the side effects and precautions of Tranexamic Acid should be written in the instruction manual of the toothpaste, so that we, ordinary consumers, can decide whether to buy or not to buy.
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