What is the difference between insulin and glucagon?
What is the difference between insulin and glucagon?
Both insulin and oral hypoglycemic drugs are common hypoglycemic drugs for diabetics. People with type 1 diabetes must rely on insulin to lower their blood glucose. some people with type 2 diabetes can control their blood glucose by choosing oral hypoglycemic agents, and some people with type 2 diabetes also need insulin to control their blood glucose.
Insulin is a hormone secreted by the body to directly lower blood glucose. When the body's pancreatic islets function abnormally, resulting in insufficient insulin secretion, hyperglycemia will occur. Since patients with type 1 diabetes mellitus have total or partial failure of their own pancreatic function, they must control their blood glucose with the help of exogenous insulin injections. For patients with type 2 diabetes mellitus, due to a certain amount of pancreatic islet function remaining in the body, blood glucose can be controlled through oral hypoglycemic drugs, because oral hypoglycemic drugs to play a role in lowering blood glucose must rely on a certain amount of pancreatic islet residual function.
Type 2 diabetes patients must resort to external assistance new insulin injections are: 1, with the progress of the disease, pancreatic islet function gradually decline, it is necessary and type 1 diabetes patients, with the help of insulin to control blood glucose. type 2 diabetes patients in some special circumstances, such as ketoacidosis, surgery and other cases, also need to use insulin as soon as possible to control blood glucose well.
Simply put, insulin is a blood glucose-lowering hormone secreted by the body itself, and diabetic patients can inject exogenous insulin to control their blood glucose due to their own insulin secretion disorder.
Oral hypoglycemic drugs are divided into several types, one for drugs that stimulate insulin secretion, such as sulfonylureas, one for drugs that increase the sensitivity of body tissues to insulin, such as metformin, which improves insulin resistance and exerts hypoglycemic effects by increasing the sensitivity of muscle, fat, and other tissues to insulin, and a-glucosidase inhibitors, which competitively inhibit the absorption of carbohydrates in the small intestine and thus lower the Postprandial blood glucose.
This is a seemingly simple but highly specialized question.
Let's start by answering what insulin isIt is a peptide hormone secreted by β-cells in the pancreas, which, by binding to its receptor, induces continuous phosphorylation of intracellular proteins and produces biological effects, promotes the synthesis of fats, glycogen, nucleic acids, and proteins, facilitates glycogen storage and amino acid transport, inhibits proteolysis, and accelerates the heart rate, enhances the contractility of the heart muscle, and reduces the flow of blood to the kidneys, among other things.
Having just sold my expertise, to put it simply, the main function of insulin is to promote the synthesis and conversion of glucose into something else in the bloodstream, thus lowering the level of glucose in the bloodstream. Insulin preparations can only be injected, not taken orally.
Re-answering the question of what is a hypoglycemic drug: Generally refers to oral hypoglycemic drugs, which are more generally known as drugs that can be taken orally and then lower the level of glucose in the blood. There are many classifications, including metformin, which promotes the action of insulin in muscle and fat; glibenclamide, gliquidone, etc., which stimulates insulin secretion; repaglinide, nateglinide, etc., which stimulates insulin production only during meals; acarbose, voglibose, etc., which inhibits glucose absorption; rosiglitazone, pioglitazone, etc., which increases insulin sensitivity.
To summarize briefly, oral hypoglycemic drugs are medications that lower the level of glucose in the bloodstream by using various means to either stimulate the body's secretion of insulin, reduce the absorption of glucose, or increase the body's sensitivity to insulin.
Difference between insulin and hypoglycemic drugs: Insulin lowers blood glucose directly, while most oral hypoglycemic drugs lower blood glucose indirectly through their action on insulin.
The biggest difference between insulin and glucose-lowering drugs is that one requires injections and the other is taken orally, and they share the common characteristic of smooth blood sugar control.
What is insulin? First I introduce insulin, insulin is the body's hormone, we normal people also need insulin to regulate blood sugar, the use of insulin relative to oral medication than the side effects of smaller, because he does not need the liver and kidneys metabolism. The effect of insulin is good, but this has a disadvantage, the disadvantage is that this is mainly through the injection of drugs, flesh will be more painful, the body will be covered with a lot of needle holes is also much more expensive than oral medication, easy to produce lazy. However, it is important to pay attention to the timing of the insulin injection diet to prevent hypoglycemia.
The advantage of hypoglycemic drugs is that it is easy to take, less painful, the disadvantage is that the side effects are relatively large, mainly because the drug needs to be metabolized by the liver and kidneys, long-term use of the drug can have a certain degree of damage to the liver and kidneys, but also do not have to hit the effect of insulin fast. If you take hypoglycemic drugs for a long time, you need to check your liver and kidney functions regularly.
You're asking this question, so I'm guessing you have unstable blood sugar, to give you some dietary advice:
1. Prohibit foods that are high in cholesterol, high in fat and high in sugar;
2, pay attention to usually drink more water, eat more high-fiber coarse food, the major stores are selling coarse grain buns.
3, diet should pay attention to three meals a day seventy percent full, to eat more meals, smoking, drinking and other bad habits are strictly prohibited.
4、Positively increase some sports and exercise, maintain a good state of mind.
Let's start with a direct answer to your query, there are two main differences between insulin and hypoglycemic drugs:
Insulin is a kind of hypoglycemic hormone secreted by our body, which promotes the synthesis of glucose in the blood to be converted into other substances so as to realize the lowering of blood glucose, which belongs to direct hypoglycemia; whereas oral hypoglycemic drugs adopt various ways to lower blood glucose, such as stimulating insulin secretion, increasing the body's sensitivity to insulin and so on, which can be interpreted as indirect hypoglycemia.
②The other thing is that, for all kinds of insulin preparations, our route of administration can only be injection and not oral; this is the most direct difference with hypoglycemic drugs.
Whether we choose insulin or hypoglycemic drugs, the purpose is the same, i.e., to reduce the glucose content in our blood, but the mechanism of action and application of the two are different, and they can be used alone or in combination. Here we first need to know the two main types of diabetes: type 1 and type 2. type 1 diabetes is dominated by pancreatic β-cell destruction, which is characterized by a significant reduction in the number of pancreatic β-cells and the disappearance of insulin secretion caused by the absolute decline or lack of insulin, once the diagnosis is made it is necessary to treat it with insulin. type 2 diabetes is dominated by insulin resistance, the relative insufficiency of insulin secretion, which belongs to the relative lack of insulin, it can be taken to oral hypoglycemic drugs to reduce glucose. It can be treated with oral hypoglycemic drugs. When we use insulin alone, adverse reactions such as hypoglycemia and weight gain are likely to occur. If we can use insulin and oral medication together scientifically, it can increase the effect of lowering glucose while reducing the occurrence of adverse effects caused by insulin. For example, for patients with type 1 diabetes, insulin must be used for life to maintain life. If we apply insulin in combination with metformin or acarbose, we can improve glycemic control and reduce the amount of insulin. For patients with type 2 diabetes mellitus, we can consider starting insulin therapy if we have already used effective lifestyle interventions and 2 or more oral hypoglycemic agents to control blood glucose and still do not meet the target. For example, basal insulin injections combined with oral insulinotropic agents.
Ke Jing, Pharmacist-in-Charge, Shiyan People's Hospital
The authoritative interpretation of Pharmaceutical Affairs, unauthorized reproduction, plagiarism will be punished.
I'm happy to answer this question, both insulin and hypoglycemic pills help sugar users control their blood sugar, they are both medications.
Insulin is a protein hormone, it is a protein hormone secreted by pancreatic islet β-cells stimulated by endogenous or exogenous substances, such as glucose, lactose, glucagon and so on, and it is the only class of hormone in the body that can directly reduce the concentration of blood glucose. Insulin is a hormone that exists in the human body itself, there is no dependence or addiction, so don't be compelled by rumors.
Insulin acts mainly in the liver, muscle and adipose tissue, controlling the metabolism and storage of the three major nutrients: sugar, protein and fat. Insulin lowers blood glucose by increasing the utilization of glucose and inhibiting glucose production, thereby increasing the amount of glucose going out and decreasing the amount of glucose coming in. Insulin also promotes the synthesis and storage of fats and proteins and inhibits their breakdown.
Hypoglycemic drugs, also divided into Chinese medicine hypoglycemic drugs and western medicine hypoglycemic drugs, each hypoglycemic drugs have different mechanisms of action. Whether it is Chinese medicine hypoglycemic drugs or western medicine hypoglycemic drugs, they should be rationally selected according to the patient's condition and pay attention to the indications and contraindications of each type of drugs.
It is important to note that hypoglycemic drugs are not like cold medicines, what others eat they also eat, diabetes is a very complex disease, each person's condition is different, the appropriate drugs are also different. The dosage and taking time of glucose-lowering drugs are very delicate, if you don't follow the doctor's instructions, you may not be able to play out the effect of the drug. In addition, medication should be accompanied by dietary control and exercise control, so do not rely on medication without dietary control.
For type 1 glucose patients, they need to rely on insulin treatment for life, taking glucose-lowering drugs is ineffective, and there is no insulin that can be taken orally. In contrast, type 2 glucose patients are treated with glucose-lowering drugs or glucose-lowering drugs with insulin therapy, etc., depending on the damage of the pancreas.
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Insulin is a type of hypoglycemic drug, belonging to the injectable hypoglycemic drugs, while what people usually call hypoglycemic drugs generally refers to oral hypoglycemic drugs.
The only glucose-lowering substance in the human body is insulin, and the etiology of diabetes is caused by insufficient insulin secretion by the patient's pancreatic islet cells, so the application of insulin therapy is designed to replenish exogenous insulin to the patient in order to make up for the body's deficiency to lower glucose.

Oral hypoglycemic drugs are commonly used in the following categories: 1. Sulfonylurea hypoglycemic drugs, representative drugs are glibenclamide (euglycemic), glipizide (mepivoxil), gliclazide (Damecam), gliquinolone (Glucophage), glimepiride (Amoride) glipizide (Ketoglycolide), 2. Non-sulfonylurea insulin secretagogues such as Repaglinide (Novaluron), Nateglinide, which are designed to promote the secretion of insulin by pancreatic cells to lower glucose. Most of these hypoglycemic drugs are prone to cause hypoglycemic reaction and need attention.

3. Metformin, there are metformin, phenyl ethyl metformin, they are through the inhibition of intestinal wall absorption of glucose to achieve the purpose of lowering sugar, long-term use will suppress appetite, stimulate gastrointestinal, make people lose weight.

4. α-glucosidase inhibitors, commonly used are Bayerisin, which also has the end result of reducing glucose absorption by the intestinal wall and lowering glucose.

5. Insulin sensitizers, such as rosiglitazone and pioglitazone, can lower glucose by reducing insulin resistance and increasing insulin sensitivity. The above hypoglycemic drugs are commonly used in clinic, for different diabetic population, must be applied according to the person, according to the time, must not abuse on their own, must follow the doctor's instructions for the use of medication.

Increased daily blood glucose testing and other aspects of diabetes management will prolong your life. Other classes of less commonly used medications will not be repeated.
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