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Will those who demand that TCM must be double-blind clinical talk about the purpose and significance of double-blind trials?

Will those who demand that TCM must be double-blind clinical talk about the purpose and significance of double-blind trials?

Is the Chinese people know, tiger penis wine is an aphrodisiac, but few people on the mainland know, in the 1980s Taiwan had a double-blind test on the tiger penis wine, the practice is to use a batch of real tiger penis wine, at the same time with the same number of plastic imitation of the fake tiger penis wine. Specific operation is to tell the people who drink the real tiger penis wine, they drink the fake tiger penis wine, and tell the people who drink the fake tiger penis wine, they drink the real tiger penis wine. The marvelous thing is that, after a general time, drink the real tiger penis wine of the batch of people said no effect, drink the fake tiger penis wine of the batch of people but most say that the aphrodisiac effect is obvious.

Without getting into the complexity, make it simple. One medication, how effective it really is, no comparison. A group of patients (for example, all diagnosed with diabetes), half of the medicine, half of the similar non-drug (harmless but similar shape and texture of the drug), the patient blind (each patient does not know that they are eating real drugs or non-drugs); doctor blind, the doctor to give the patient what to eat themselves are not clear is a drug or non-drugs, and anyway, the bag of the same medicine, programmed with a number. Finally, each patient's adverse reactions, therapeutic effects, various indicators ah symptoms ah and so on all the content. Finally, the blind, according to the number to open the envelope to know whether the number is a drug or non-drug, and then take the drug patients and patients taking non-drugs to compare all the information. Through this comparison, you can objectively understand whether the drug is effective or not, there are no adverse reactions. It will not be influenced by the doctor's own view (for example, the doctor thinks that this drug is good beforehand), and it is not influenced by the patient's own view (for example, the patient thinks that this drug does not work beforehand).

Whether this method is scientific and applicable to Chinese medicine, practice is the only criterion for testing the truth!

First of all, I would like to correct the questioner's misconception that he has been indoctrinated by Chinese medicine hacks: double-blinding has never been just one kind of medicinal experiment, i.e., not all of them, and not necessary! Note: there is no distinction between Chinese and Western medicine here, but rather a true scientific theory that must be followed in all fields of medicine!
First, let's talk about double-blind. The full name is called a large sample randomized double-blind controlled trial. This Chinese medicine black people "popularized". However, Chinese medicine black people tirelessly "popularize" to you in the end what is double-blind and double-blind science, never tell you double-blind experimental subjects, experimental purpose and why the drug must be double-blind rather than like other areas of the experimental verification of a larger sample and a longer period of time as more.
A. The object and purpose of double-blind experiment: double-blind experiment is a kind of drug validation experiment for the limited strength of the drug and the possible side effects before clinical application on the basis of only theoretical research of a drug. Note the key words: new drug, before actual clinical application! People who willfully ignore these keywords basically have ulterior motives!
B. Why experimentation and why double-blind: Human beings have actually taken many detours on the road to fighting diseases, especially in the history of what drugs are used to treat which diseases, and at the same time have paid a very high price. With the advancement of science and technology, mankind has actually been able to verify the effectiveness and possible side effects of a new drug to the greatest extent possible without paying too much - this is called pharmacovigilance experiments.
However, all experiments necessarily have natural limitations - i.e., they cannot be excluded from the complex, unpredictable and unestimated confounding factors that may be encountered in practical clinical applications. Therefore, the so-called scientific design of experiments is particularly important: in the field of medicine, for example, it is impossible to recruit a sufficient number of volunteers for any experiment within a short period of time. In fact, the so-called "large sample" principle cannot be realized at all!
Take the so-called "people's hope" Ridecivir in the current outbreak as an example: from the perspective of experimental data, there is a big difference between the experiments in China and the United States! Chinese medicine black people say that China's sample size is small, so the U.S. conclusion is more reliable [face] [face] [face] [face] In fact, this interpretation itself is an ulterior motive, one, China's double-blind experiments with raltegravir fully in line with the experimental requirements, on what grounds it is considered "unreliable"? Secondly, Chinese medicine black people think that the United States of America's experimental conclusions are more reliable itself does not mean that they have recognized the same as the experimental principle of verification experiments, large samples to be more important than double-blind?
So ask the TCM hacks: which drug from Western medicine has an experimental sample size comparable to traditional Chinese medicine? [aura] [aura] [aura] [aura].
Finally, the so-called Chinese medicine fans are reminded that the metaphysicalization of Chinese medicine is a trap for Chinese medicine hacks, and that they should not fall into such a public opinion trap!
Please recall the consultation and treatment process of a Chinese medicine practitioner and note two details: one, compared with Western medicine, any prescription made by a Chinese medicine practitioner is heavenly to a layman, not to say double-blind, but at least single-blind in many cases. Two, what is the last medical advice given by a Chinese medicine practitioner after the first prescription? Isn't it often, "Prescribe a course of treatment first and try it at home. We will make adjustments next time". May I ask what is meant by "try"? Of course, it is the doctor's experimentation of the medicinal properties of the medicine on the basis of the classical prescription according to the actual condition of the patient!
That's what I've been saying all along: compared to Western medicine, which can only be used as a basis for marketing registration, the validation of medicinal properties has been done for thousands of years and is much more convincing! In fact, Chinese medicine has been doing validation experiments for thousands of years and they are more convincing - simply because: compared to Western medicine, which treats patients as cold numbers and replaces the patient's own experience with a third-party perspective, Chinese medicine focuses more on the patients themselves, one after another!
May I ask all Chinese medicine black, you as a patient unfortunately become 90% cure rate of the remaining 10% how to feel? It will not be like that Heshan Shuo like in the "preparatory morgue" still for this "scientific" system singing, right? [face][face][face][face][face][face][face][face][face][face][face][face][face][face][face][face][face].

Is double blinding a western method of evaluating TCM?

Many people regard double-blindness as a Western medical thing, saying that double-blindness in Chinese medicine is to evaluate Chinese medicine with Western medical methods, saying that Chinese medicine is not suitable for double-blindness because of one-person-one-side dialectic treatment, and double-blindness is a way for Western medicine to suppress Chinese medicine. Some people even ask whether double-blindness can be effective, can cure the disease?

Double blindness is neither a medicine nor a cure, so what makes it effective? How can it be a cure?

Double-blind is neither Western medicine nor Chinese medicine. It is just a method of comparative validation practice, a more objective and scientific method of comparative experimentation that effectively evaluates a certain aspect and can exclude the influence of subjective assumptions. In scientific research, often used, only in the clinical validation of Western medicine is more famous and well known. In Chinese medicine to engage in double-blind experiments do not exist in Western medicine evaluation of Chinese medicine.

Doesn't Chinese medicine's one-person, dialectical approach lend itself to double-blind evaluation? Is double blinding testing all subjects with one protocol? This is a cop-out and an excuse. If you are confident, it is perfectly fine to be double-blind. I will design a double-blind experiment in Chinese medicine to ensure that individual differences in patients are not ignored: there is a foot massage parlor next to our residence, and the attendant said that she has cured many elderly people's diabetes by soaking their feet in traditional Chinese medicine, is her statement credible? Double-blind experiments can be very good proof. Choose 100 elderly people, divided into two groups of 50 people (so many samples have statistical significance), let her diagnosis of each old man dialectic, with a good prescription (to ensure that you dialectic treatment, do not say double-blind is not suitable). Then give 50 of them a foot soak with the real prescription; the other group of 50, a placebo foot soak. Of course, the 100 people were grouped by lottery, and the foot soaking executive attendant didn't know who was using the real medicine (where the blindness lies). After two months, the blind was revealed to compare the results. See if the attendant's claim to cure diabetes is true or false.

In this evaluation experiment, double blinding is all-importantly applicable.

Then again, a person a party, dialectical treatment, is not unique to Chinese medicine, Western medicine treatment of the same set of programs for a patient to eat different combinations of medicines, said Western medicine to the patient one-size-fits-all, what is the basis? [微笑][微笑][微笑][微笑][微笑][爱慕][爱慕][爱慕][爱慕][爱慕]

In order to rule out all sorts of artifacts (self-healing, placebo effect, individual differences, etc.) and to find drugs that are truly effective and have acceptable side effects, all drugs need to be clinically tested and proven to have efficacy before they can be approved by the FDA for marketing. What makes Chinese medicine so special that it refuses clinical trials? What are they afraid of? If they are proved to be effective by world-recognized standards, is it not conducive to the development of Chinese medicine in the world?

TCM simply can't do it. The diagnosis and treatment program itself, the prescriptions prescribed to cure the standards are different, there is no such a large sample to do. Unless the diagnosis and test results of Western medicine to verify.

I would like to take this opportunity to talk about a few points of view, first, Chinese medicine for thousands of years for the Chinese people to treat all kinds of diseases, leaving behind countless stories of legendary efficacy of the story of the best stories, emerging generation after generation of legendary doctors, medical saints, medicine saints, medicine saints, praised to this day, since ancient times, and that the people will not recognize it? However, there has never been any proposal to conduct double-blind tests on Chinese medicine. Second, today, if anyone asks Chinese medicine to do double-blind test, first of all, we must have the knowledge and ability to have a close relationship with the human life and physiological changes in the Department of the seven feelings and six emotional problems, as well as natural climatic conditions, factors, are to get out the accurate data parameters factors, in order to determine how you make double-blind test drugs and human changes in line with the body, right? For this reason, so thousands of Western medicine why most of them and one by one were negated ineffective or negative effects and eliminated? Asked first with mice to do experiments in the human body can be applied? This is undoubtedly to take people as mice as the same view. Comparison of Chinese medicine is very different, Chinese medicine inventors are often the first in their own body or loved ones have done experiments, the success of the body will only be used in its people, the effect is very different from the Western medicine, therefore, not only will not be ineffective or negative effects of Chinese medicine out of the large both that is, there are prescriptions containing poisonous ingredients, but also has never been toxic to the human body, and the fact is that thousands of years of prescriptions are still effective, and today! The fact is that thousand-year-old formulas are still effective today, and the ancient anti-epidemic formulas still work wonders. Thirdly, based on the above two points, it is also necessary to understand why Chinese medicine can be inherited for thousands of years and its efficacy will not be eliminated? First of all, we must understand that human beings and any living creature of nature, are nature in the sun, moon, stars, rivers, lakes and seas under the nourishment of the product, Chinese medicine is the same source of food and medicine with people, we eat every day grains, vegetables, fruits and other food, including animal food, are the same medicinal value, and Chinese medicine is the same attribute, if you want to double-blind test, you should also be your daily food also experimented with, before you can eat. To this end, the last word, today's so-called what double-blind test, practice has proved that is not a panacea, not to mention the so-called science that is universally applicable, the fact is that many areas are very different and absurd. Western medicine is also questionable, Chinese medicine is even more outrageous. That's all for today, welcome to the exchange.

Why is it that modern medicine has proved the effectiveness of Chinese medicine, but there are still some small rash head who has learned a little Western medicine and still black Chinese medicine is ineffective all day long? For example, Huanglian, ephedra, rhubarb, Panlangen, Artemisia and even arsenic and so on and so forth. To these rash little Western medicine is really speechless! Another thing to say is that Chinese medicine has been hundreds of flavors of the combination of Chinese medicine used to perfection, more than a single drug effect dozens of times better! However, a dose of Chinese medicine in the boiling process of the combination of changes, figure out the modern technology is not yet, at least a hundred years after the supercomputer to break through. So, before you can't fix the complex chemical structure, can't you save lives? The answer is no. Thousands of years of traditional Chinese medicine to save countless people, like one plus one equals two argument, so far can not be proved clearly, the mathematician Chen Jingrun spent his life can only lift the tip of the iceberg of one plus one equals two. But if it is not clear, can't it be applied? Of course, even an old peasant woman selling vegetables knows how to apply it. Practical and theoretical are two different things, Chinese medicine black simple-minded, mix them together to spray to get pleasure is extremely stupid!

As a side note, prehistoric civilizations were far ahead of modern ones, for example <上池之水><麻沸汤>, and these two things alone were enough to eliminate all the complexity and weight of C, MR|, etc. In the years to come, when it is discovered that doctors can see what's going on outside the walls of the house by drinking a safe chemical, then tests, ultrasounds, C, etc. will be obsolete! In the years to come, when it is discovered that doctors can see the hairs on the walls, the internal organs, and the diseases of the body after taking a safe chemical drink, then tests, ultrasound, consumer goods, etc. will be obsolete! 麻沸散的麻醉抗菌让那些现代抗生素統统淘汰! Of course, the prehistoric legacy of Ana-Bo-San and the water of the upper pool was destroyed by Cao Cao (who killed Hua Tuo), leaving medicine lagging behind by more than a thousand years!

The purpose of a double-blind trial is to eliminate all kinds of (environmental, psychological, physical, etc.) interference, to see what the effectiveness and reliability of the drug or treatment method. Traditional Chinese medicine is fundamentally unable to exclude subjective influence, psychological implication, etc., and even if it is effective, its reliability is not high. Participation in double-blind trials is tantamount to self-defeat, so they try to avoid double-blind trials.

Without a double-blind trial, how can you tell if this medicine works for this disease? If you take a dose of a drug and this disease clears up after a few days, how can you tell if it's the drug that cured it? Or is it a placebo effect or the disease itself is self-limiting? Because the disease itself has a certain self-healing rate and how to remove the proportion of placebo effect?

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