Middle-aged and elderly people, due to hardening of the arterial wallsDecreased vasodilatationThe result is a high systolic blood pressure and a low diastolic blood pressure, so antihypertensive drugsVasodilators may be usedFor example, calcium channel blockers lower blood pressure by dilating small peripheral arteries, for which both nifedipine and amlodipine are available, as they are both calcium channel blockers.

Middle-aged and elderly people have large fluctuations in blood pressure and are prone to upright hypotension and postprandial hypotension, which requires the selected antihypertensive drug to have two points:

First, the duration of lowering blood pressure is long, and full coverage of lowering blood pressure for 24 hours as much as possible to reduce the fluctuation of blood pressure in order to reduce the risk of cardiovascular events. For this point, nifedipine extended-release tablets (III) and control tablets meet the requirements, can last for 24 hours, only need to take the drug once a day, almost constant rate of lowering blood pressure; Lovoxil and Shihuida also meet the requirements, their duration of lowering blood pressure can be as long as 48 hours, better than nifedipine extended-release tablets (III) and control tablets, and in time, if you forget to take the drug on a certain day, you don't need to replenish the drug, and continue to take it the next day, and patients' compliance is also higher. Patient compliance is also higher.

Second, do not lower blood pressure too much, try to lower blood pressure as gently as possible to reduce the occurrence of hypotension. To address this point, it seems that amlodipine is a little more gentle, but because nifedipine controlled-release tablets release the drug at a constant rate for 24 hours, adverse effects such as hypotension are significantly reduced compared to nifedipine tablets and extended-release tablets. It only takes longer for amlodipine to reach steady state than nifedipine.

Middle-aged and elderly people using drugs, should try to choose drugs with fewer adverse effects

Both nifedipine tablets and amlodipine are associated with adverse reactions such as ankle edema, headache, flushing, and palpitations during use. The incidence of edema in nifedipine controlled-release tablets (e.g., baisinomide) is about 9.9%, headache is about 3.9%, and the rest of the adverse reactions are less than 3%; the incidence of adverse reactions of amlodipine is related to the dosage, e.g., the incidence of edema in 10 mg of loxinomide is about 10.8%, the incidence of palpitations is about 4.5%, the incidence of flushing is about 2.6%, and the incidence of headache is not clear in relation to the dosage, which is about 7.3%.

In summary, both extended-release (III) or controlled-release tablets of nifedipine and amlodipine can be used in the treatment of hypertension in middle-aged and elderly people, both are long-acting antihypertensive, but amlodipine is more gentle in lowering the blood pressure, and it takes longer to reach the steady state, and they are comparable in terms of the incidence of adverse effects.

Thanks for reading!

Differences between nifedipine and amlodipine vs.

1. Price Comparison

Nifedipine, tradename Baycyntom, comes in a box of 7 tablets of 30mg each, with a reference price of $26 a box, costing $111 a month.

Amlodipine, trade name Lovoxil, comes in a box of 7 tablets of 5mg each, with a reference price of $29 a box, costing $124 a month.

So from the price point of view Lovoxil is a little bit more expensive than Byxinomics, we can choose Byxinomics.

2. Different metabolism of drugs in the body

Bysyntropin (nifedipine) is made into a controlled-release tablet by a process modified to release slowly in the body, with a prolonged half-life in the body, so it is sufficient to take one tablet a day. Therefore, Bayxin Tong tablets should not be broken and the non-absorbable shell can be found in the feces.

Lovoxil (amlodipine) is a third-generation calcium-blocking drug with a relatively long half-life in vivo, specifically: slow absorption, slow onset of action, and long duration of action.

3. Comparison of side effects

The most common adverse reactions to Lovoxil were dizziness 3.4% vs. edema 3%. dizziness occurred in 11% at the 10 mg dose.

The most common adverse reactions to Bayzentra were dizziness 3.9% and edema 10%.

Therefore, from the above three points, it can be seen that nifedipine controlled-release tablets and amlodipine have similar side effects, similar half-life and similar effect, so which one is cheaper, choose to take which one.

Hypertension is a common disease that seriously jeopardizes the health of middle-aged and elderly people, and requires long-term treatment with antihypertensive drugs. Nifedipine and amlodipine are both commonly used drugs for the treatment of hypertension, for the elderly to lower blood pressure, the use of nifedipine is good or amlodipine is good for this problem, personal opinion:

If you compare nifedipine ordinary tablets with amlodipine tablets, it is definitely better to use amlodipine tablets. Because of the short half-life of nifedipine tablets (usually only 4-5 hours), need to be taken several times a day, the antihypertensive effect is not stable, and side effects such as facial flushing and rapid heart rate can occur. The effect of amlodipine tablets is similar to that of nifedipine, but the antihypertensive effect is slower than that of nifedipine, the duration is longer than that of nifedipine (up to 35-50 hours), and it can be taken once a day, and the antihypertensive effect is smooth.

However, nifedipine extended-release or controlled-release formulations are now mainly used clinically as long-term treatment for patients with hypertension. The difference between nifedipine extended-release and controlled-release preparations and amlodipine is not significant.

First of all, nifedipine extended release preparation overcomes the shortcomings of ordinary tablets, the drug can be released slowly and persistently, and the number of times a day is reduced, the extended release tablets can be taken twice a day (every 12 hours), and the controlled release tablets can be taken once a day to achieve a smooth lowering of blood pressure. Like amlodipine, it can improve patients' compliance, effectively delay patients' target organ damage, and reduce sudden death, stroke and heart attack.

Again, in terms of efficacy, there are studies that prove it:

The efficacy of amlodipine and nifedipine extended-release tablets in the treatment of geriatric systolic hypertension is comparable, and the antihypertensive effect is exact, safe and reliable. For the treatment of non-systolic hypertension in the elderly, patients taking nifedipine extended-release tablets and amlodipine benzenesulfonate in the evening can effectively reduce blood pressure, but for the improvement of circadian rhythm abnormality, nifedipine extended-release tablets are more effective than amlodipine benzenesulfonate, and are safe and effective. For the treatment of essential hypertension in the elderly, amlodipine significantly improves the efficacy and reduces the incidence of adverse effects compared with nifedipine. For the treatment of diabetic hypertension in the elderly, the efficacy of nifedipine extended-release tablets and amlodipine benzenesulfonate is comparable, with no significant difference, but amlodipine benzenesulfonate has milder adverse effects.

In addition, nifedipine is less expensive, the antihypertensive effect is real, the most commonly used; amlodipine is expensive, is a long-acting preparation, if there is a leakage in the middle of the dose, it does not have much effect on the blood pressure, and the current clinical application is increasing.

In short, what antihypertensive drugs to take to lower blood pressure in the elderly, whether to choose nifedipine or amlodipine, need to be based on the patient's specific causes of the disease, combined with the type of hypertension, economic conditions, the patient's adherence to medication and other aspects of the consideration, can not be generalized.

References:

1, Dingliang Wang, Guangyun Qin, Comparison of the efficacy of nifedipine controlled-release tablets and amlodipine benzenesulfonate in the treatment of elderly nonpareil hypertension Journal of Practical Heart, Cerebral, Pulmonary and Vascular Diseases, No. 4, 2014

2. Liu Zhigao, Wan Ruilan, Comparison of amlodipine and nifedipine in the treatment of simple systolic hypertension in the elderly Chinese Journal of New Drugs and Clinics, No. 2, 1999

3, Wu Zhigang, Comparison of the efficacy of amlodipine and nifedipine in the treatment of essential hypertension Chinese and Foreign Medical Research, No. 32, 2011

4, Li Mingchu, Observations on the efficacy of nifedipine extended-release tablets and amlodipine benzenesulfonate in the treatment of hypertension in elderly diabetes mellitus Journal of Clinical Rational Use of Drugs, No. 3, 2014

5. Zhao Xuerong, Comparison of the efficacy of amlodipine and nifedipine in the treatment of essential hypertension in the elderly Hebei Medicine, 2000, No. 11.

6, Jin Guoyu, Yang Yanping, Luo Huanwen, Observations on the clinical efficacy of amlodipine benzenesulfonate in the treatment of systolic hypertension in the elderly Chinese Community Physician, Issue 9, 2016

The authoritative interpretation of Pharmaceutical Affairs, unauthorized reproduction, plagiarism will be punished.

First of all I have to give you credit, I think that's a very good question because these two drugs are very commonly used in the clinic. But there are actually huge differences.

Commonality.

1. First of all, it must be clear that both drugs belong to calcium channel blockers. Class Ia dihydropyridines: representative drugs are nifedipine, nicardipine, nifedipine, amlodipine, nimodipine and so on. The vascular smooth muscle has a better improvement effect, can obviously diastolic blood vessels, mainly diastolic arteries, especially the coronary blood vessels are more sensitive, so to a certain extent, it can effectively improve the blood supply of the heart base, and have a significant effect on angina pectoris. The second is better to improve vascular atherosclerosis. It is a better drug in the clinic.

Differences.

There are many different kinds of nifedipine tablets, and I'm not sure what kind you're talking about here, (the three specific kinds of nifedipine tablets, nifedipine extended-release tablets, and nifedipine controlled-release tablets), so I'll just assume that you're talking about nifedipine tablets here, and start to expand on the instructions.

1. The most realistic price.

Nifedipine tablets: the usual size is 10mg in a box of 100 tablets, but the actual price is only a few dollars, and the usual starting dose is 10mg 3 times daily.

Amlodipine: Amlodipine is divided into (Amlodipine Benzenesulfonate and Amlodipine Benzenesulfonate) the former specification 5mg, the latter 2.5mg, in fact, the effect of the same difference is the dose. A box of 7 pills, about 29 dollars a box.

Summary:Amlodipine tablets are much more expensive than nifedipine tablets.

2. Characterization of the role:

To look at the two put, first of all, antihypertensive drugs after decades of development has been derived from a number of generations, nifedipine tablets belong to the first generation, amlodipine tablets belong to the third generation, from the common sense can be seen that the latter high-level, high-level where. The first generation of nifedipine antihypertensive effect is obvious, fast, but there is a fatal drawback is the short effect of the drug, the effect time of 1 to 3 hours or so, so you have to eat several times a day. Secondly, the side effects are obvious, facial flushing, lower limb edema, liver and kidney function damage are more obvious. So now the clinic rarely recommend patients to eat this drug for a long time, are blood pressure rise, temporary use, but then the scientific development of nifedipine extended-release tablets and controlled-release tablets of two types is also very good to, not much to say here today.

Look at amlodipine, although only 5mg, but due to the smooth release of the drug, the action time can be up to 30 hours or more, you say this effect is how long-lasting. So in general, mild, moderate hypertension a day to eat a very OK.

And the aforementioned facial redness, edema, and liver and kidney function damage were all minimized as much as possible.

In conclusion:From the point of view of side effects on drug action, amlodipine tablets are completely superior to nifedipine tablets.

3. Characteristics of blood pressure in the population: we must know that with age, the vascular microenvironment is getting worse and worse, atherosclerosis, arterial vascular peripheral help increase and other factors are required, the patient's needs are smooth and long-lasting, low side effects. Without considering the economic conditions, it is recommended to take oral amlodipine tablets.

4. Expansion:

① In fact, the actual clinical experience shows that patients with hypertension often oral administration of an antihypertensive drug can not achieve the desired antihypertensive effect, this time we have to consider the combined effect of antihypertensive drugs. Here is an analogy. Everyone can refer to it. You can also suggest with your own doctor. For example:Many patients suffering from hypertension often start with calcium channel blockers is amlodipine tablets. In accordance with medical advice in the development of blood pressure is reduced you come, but did not fall to 140/90mmhg a little. At this time we can consider the combination of drugs, in the absence of bronchial asthma, the first acei class of drugs to pressure, representative drugs: fosinopril tablets or perindopril tablets. The combination of the two drugs 90% of the blood pressure can be reduced, if this does not come down to contact a multi-specialty hospital to check and then adjust.

②. The second thing to explain is the real life to buy drugs to eat. We will come across hundreds of trade names of blood pressure medications, we have a concept of course, provided that the medication is under the doctor's orders, I'm just talking about common sense. xx controlled-release tablets are better than xx extended-release tablets are better than xx tablets. That is to say, medications ending in controlled release tablets are generally the best and most expensive. (Not an absolute but most of it makes sense)

I hope my answer can be read by all readers. For more health science, please follow Xiao Li, or search for the headline: "Health Observer Xiao Li"

First of all, let's talk about the general characteristics of elderly hypertensive patients: vascular fragility increases, compliance decreases, peripheral vascular resistance increases, so the pressure difference generally increases, renal function gradually decreases, sodium excretion capacity decreases, and salt sensitivity increases. For most elderly hypertensive patients, the systolic blood pressure increases significantly, the blood pressure fluctuates greatly, the morning peak phenomenon is more obvious, may be combined with cardiac insufficiency, and is prone to postural hypotension.

Therefore, elderly patients with hypertension, the choice of antihypertensive drugs should be selected to lower blood pressure more gently, less fluctuations in blood concentration troughs and peaks, and maintenance time is long.

Nifedipine and amlodipine are both calcium channel blockers. Nifedipine is the first generation, while amlodipine is the third generation. The first generation of nifedipine ordinary tablets due to the rapid antihypertensive effect, short half-life, easy to cause blood pressure drop too fast, short maintenance time, resulting in blood pressure fluctuation is more obvious, so it is not recommended that patients with hypertension long-term use of nifedipine ordinary tablets.

The half-life of amlodipine itself is as long as 35-50h, so it can be used once a day to control blood pressure effectively. Compared with nifedipine ordinary tablets, it has obvious advantages, such as less fluctuation of blood pressure, gentle lowering of blood pressure, low incidence of adverse reactions such as facial flushing, peripheral edema, palpitation, postural hypotension, etc., and it is a hypertension drug that can be used for a long period of time.

As nifedipine ordinary tablets are not suitable for long-term blood pressure control, pharmaceutical companies have made nifedipine controlled-release tablets and extended-release tablets after process modification. It can achieve the effect of lowering blood pressure smoothly and maintaining the effect of the medicine for a long time, and the controlled-release tablets can lower blood pressure more smoothly compared with the extended-release tablets.

Amlodipine and nifedipine extended release preparations compared to each other, each has its own advantages and disadvantages, which is more suitable for patients with hypertension, there are individual differences, so there is no absolute who is better, the patient in the choice of the need to be based on the response to the drug, the tolerance of adverse reactions and other circumstances of the choice of comprehensive consideration.

I'm Pharmacist Anonymous, click to follow and I'll share more of my drug knowledge with you.

Elderly people with high blood pressure can choose either nifedipine or amlodipine, but if you choose nifedipine, it is recommended that you choose the long-acting nifedipine controlled-release tablets (Baxin Tong). Both nifedipine controlled-release tablets and amlodipine belong to long-acting antihypertensive drugs, which need to be taken only once a day, with strong antihypertensive effect and fast onset of action. This can greatly improve the medication compliance of hypertensive patients.

Whether it is nifedipine or amlodipine, both belong to the dihydropyridine class of calcium antagonists class of antihypertensive drugs, is the same class of drugs, but also are elderly hypertension can choose to take the commonly used antihypertensive drugs, then choose nifedipine or amlodipine? Today we will discuss this issue with you.

Diphenhydramine drugs are a good choice for older patients with high blood pressure

Diphenhydramine antihypertensive drugs through the inhibition of vascular smooth muscle calcium channels, so as to achieve the role of inhibiting vascular smooth muscle tension, can make the arterial vasodilatation, to achieve the role of lowering blood pressure. These drugs have a strong antihypertensive effect, the intensity of blood pressure reduction is dose-dependent, there is no absolute contraindication, is a very commonly used clinical antihypertensive drugs.

Dipyridamole, which is particularly suitable for elderly hypertensive patients without tachyarrhythmias, may be considered as an option for blood pressure control in either of the following two conditions -

1. Elderly hypertensive patients with a high-salt diet: A high-salt diet can cause volume-type hypertension. Numerous clinical research data show that the antihypertensive effect of diphenhydramine-type drugs is not affected by a high-salt diet, and this is especially true for salt-sensitive elderly hypertensive patients with a high-salt diet.

2. Elderly hypertensive patients with atherosclerotic problemsThe effect of diphenhydramine on several aspects of atherosclerosis by affecting the physiological activity of calcium ions and its high lipophilicity has shown that diphenhydramine has the effect of delaying the progression of atherosclerosis. Therefore, it is suitable for the elderly who have high blood pressure accompanied by stable angina pectoris, hypertension accompanied by carotid arteriosclerosis, hypertension accompanied by coronary arteriosclerosis, and hypertension accompanied by peripheral vascular disease. choose diphenhydramine to control blood pressure.

Which one to choose between nifedipine and amlodipine?

When it comes to diphenhydramine drugs, nifedipine and amlodipine are arguably the two most common. So how to choose? Give a few tips:

1. If it is the ordinary tablets at the same time, of course, preferred amlodipine, compared with amlodipine, nifedipine is the first generation of short-acting drugs, short antihypertensive effect time, high clearance, bioavailability is also low, nifedipine ordinary tablets, even if you take 3 times a day, may not be able to achieve the effect of 24 hours of smooth control of blood pressure, the drug compliance is not good, and the short-acting drugs are more likely to affect the sympathetic nerves cause heartbeat The short-acting drug is more likely to affect the sympathetic nerve causing heartbeat, headache, palpitations and other adverse reactions. Amlodipine has a half-life of 35 hours, and levamlodipine has a half-life of 50 hours, making it a long-acting, third-generation drug that can be taken once a day for smooth blood pressure control, so when comparing the two, amlodipine is of course the preferred choice. These long-acting drugs are also available as long-lasting CCB drugs, such as Lercanidipine and Lacidipine, which have longer tissue half-life.

2. In the case of nifedipine extended-release tablets 1 or 2, compared with amlodipine, it is still recommended to choose amlodipine. These two dosage forms of the drug, which adopt the extended-release technology, making nifedipine able to have a blood pressure-lowering effect within 12 hours, and are taken 1 to 2 times a day, are still slightly inferior to amlodipine in terms of medication adherence and smoothness in the control of blood pressure.

3. If it is nifedipine extended-release tablets 3 or controlled-release tablets, and amlodipine choose which, depends on individual differences, nifedipine extended-release tablets 3 and controlled-release tablets, can also be done to take once a day, to maintain the slow release of drugs to play a role in lowering blood pressure for 24 hours, and amlodipine's role in the effect of the effect of comparable, which to choose, it depends on the effect of lowering blood pressure, the body tolerance and so on the situation.

4. Whether it is nifedipine or amlodipine, may cause rapid heartbeat, palpitations, headache, ankle edema, gingival hyperplasia, constipation and other aspects of the adverse reactions, long-term use of the drug during the period, but also should pay attention to these adverse reactions of the body's tolerance, a reasonable choice of drug dosage, or the joint application of other drugs, synergistic lowering of blood pressure at the same time, reduce the incidence of adverse reactions.

Dr. Duan Q&A Online 🔑Which is better for lowering blood pressure, nifedipine or amlodipine 🔑

First of all, note that nifedipine is available in three dosage forms: tablets, extended-release tablets and controlled-release tablets. To compare the antihypertensive effect with amlodipine, it is best to choose nifedipine controlled-release tablets, which belong to the same class of antihypertensive drugs, and need to be taken only once a day to reduce blood pressure slowly, smoothly and with fewer side effects.

Blood pressure characteristics of middle-aged and older adults, especially those over 60 years of age:

①Systolic blood pressure (high pressure) increases and pulse pressure difference increases. ② Large fluctuation of blood pressure in 24 hours a day: it is easy to have early morning hypertension, postural hypotension, and postprandial hypotension. ④ Increased white coat hypertension.

Therefore, antihypertensive drugs for middle-aged and elderly people should be in line with: smooth and effective antihypertensive; fewer side effects; and easy to take.

Comparison of amlodipine and nifedipine for blood pressure reduction:

(1) Both have the same antihypertensive mechanism: they are calcium channel antagonists - dihydropyridines, through blocking calcium channels in vascular smooth muscle, dilating arterial vasculature, lowering peripheral vascular resistance, so as to achieve the purpose of lowering blood pressure.

(2) Side effects are similar: headache, facial flushing, and ankle edema are common.

(3) Nifedipine is divided into nifedipine tablets, nifedipine extended-release tablets, and nifedipine controlled-release tablets. Nifedipine tablets have a rapid onset of action, short maintenance time, need to be taken 3 times a day, and large fluctuations in blood pressure. Nifedipine controlled-release tablets must be swallowed, not chewed, slow onset of action, maintenance time of up to 24 hours, taken once a day, blood pressure control is smooth. Nifedipine extended-release tablets are in the center and need to be taken 2 times a day.

Therefore, nifedipine controlled-release tablets, which lower blood pressure smoothly and slowly, are easy to take and not easy to forget, are used as the first choice for lowering blood pressure.

(4) Amlodipine is only available as a tablet, but has a slow onset of action and a maintenance time of up to 50 hours with smooth blood pressure control when taken once a day.

Dr. Duan specifically warned:

(1) From the above, we know that both nifedipine controlled-release tablets and amlodipine tablets are the first choice of antihypertensive drugs, and there is no need to be too insistent on one or the other.

(2) The two medicines are in the same class and should not be taken at the same time. When one medicine fails to control blood pressure, it is necessary to combine other kinds of antihypertensive medicines.

(3) Blood pressure should be measured regularly while on the drug, especially in the elderly.

👇 Follow Dr. Duan for health and wellness! 👇

Nifedipine and amlodipine belong to the calcium antagonist, diphenhydramine class of drugs, which is suitable for the treatment of hypertension in the elderly, as well as for simple systolic hypertension in the elderly.

Elderly high blood pressure is characterized by large fluctuations, need to choose some long-acting antihypertensive drugs to make blood pressure stable, nifedipine's controlled-release tablets and amlodipine, the former is through the production process, the latter itself has a long half-life, can achieve a long-lasting therapeutic effect.

In addition, the elderly have more comorbid diseases, if it is a combination of renal insufficiency, then calcium antagonists can be safely used, nifedipine and amlodipine can be chosen.

Other than that, there are some differences between the two in terms of selection.

1. The antihypertensive efficacy varies.

From Dr. Xu's personal clinical experience, nifedipine is more effective than amlodipine in lowering blood pressure. Therefore, for elderly patients with persistent hypertension, nifedipine can be tried.

The antihypertensive characteristics of amlodipine are more gentle, so patients who are sensitive to antihypertensive drugs can choose amlodipine, and amlodipine can be broken to take, easy to adjust the dose.

2. Different onset times for lowering blood pressure.

Nifedipine is fast acting and can be taken temporarily to lower blood pressure quickly in elderly hypertensive patients whose blood pressure has risen suddenly.

Amlodipine works a little slower, so that the blood pressure falls slowly, usually 2-4 weeks to reach a stable blood concentration. For poor tolerance, blood pressure fluctuation sensitive elderly hypertension patients, you can choose this drug, so that the blood pressure slowly decline, the patient has a process of adaptation.

3. Different choices in hypertension with heart failure.

Note that nifedipine is not a suitable choice for patients with hypertension with heart failure, as it has a negative inotropic effect, which is detrimental to heart failure. Amlodipine should be chosen in this case.

4. The incidence of side effects varies.

Nifedipine has a somewhat higher incidence of side effects such as panic, flushing of the face, and swelling of the ankles.

Amlodipine is a third-generation calcium antagonist with a somewhat lower incidence of side effects.

These are just a few suggestions from Dr. Xu on the selection of nifedipine and amlodipine for elderly hypertensive patients.

Focus on your health, focus on "Dr. Xu".

For hypertensive patients, the older the blood pressure fluctuations will be more significant, which makes middle-aged and elderly patients in the application of antihypertensive drugs in the process of blood pressure is more likely to fall too much, too fast, in addition, some of the older patients may also often forget to take the medication, so the selection of antihypertensive drugs should have the best of these characteristics: gentle lowering of blood pressure, stable effect, and a long period of action.

The half-life of amlodipine is as long as 30 to 50 hours, and its effect is smooth and stable, only once a day can maintain a good effect of lowering blood pressure, even if the dose is missed once, the effect of lowering blood pressure is enough to be maintained until the next dose, which is very suitable for middle-aged and old-aged patients to take; and among the several dosage forms of nifedipine, only the nifedipine sustained-release tablets Ⅲ and the controlled-release tablets of nifedipine have such a long-lasting effect, but the effect of the two steady lowering of blood pressure can only be maintained for 24 hours, once missed, blood pressure will rise rapidly; therefore, amlodipine is better in comparison. The effect can only be maintained for 24 hours, and once the dose is missed, the blood pressure will rise rapidly; therefore, in comparison, amlodipine is better;

However, for amlodipine to achieve a stable therapeutic effect, at least after 3 to 4 weeks of administration, during which time the dosage should not be adjusted, the initial antihypertensive effect of amlodipine is rather inferior to that of nifedipine extended-release tablets III or nifedipine controlled-release tablets when first administered.

Nifedipine and amlodipine belong to the same class of dihydropyridine calcium antagonists, and their mechanism of action and adverse effects are not very different, but due to the existence of individual differences, there may be a considerable difference between the two in terms of therapeutic efficacy and adverse effects, so the choice of drugs should still be based on the patient's specific situation.