Osteoporosis friends know that calcium supplements must be combined with vitamin D or osteopontanol or osteotriol, but do you understand the relationship and difference between the three drugs, vitamin D, osteopontanol and osteotriol?

For calcium in food or calcium tablets to be absorbed in the human gut, there must beA helper ------ Osteotriol.The scientific name is 1,25 dihydroxyvitamin D3 (referred to as active vitamin D3), which is made from vitamin D in the body after theLiver and kidneysFormed after two activations, calcium absorption in the small intestine is a process that requires calcium-binding proteins and consumes ATP.

Osteotriol, the active vitamin D3.It promotes the massive synthesis of 'calcium carriers' ------ calcium binding proteins in the intestines. Calcium binding proteins promote calcium absorption and transport by intestinal cells!

Vitamin D, alias osteopontanol, is absorbed by the body and then transported to the liver where it is converted into 25-hydroxyvitamin D3. 25-hydroxyvitamin D3 is then converted again in the kidneys into 1,25-dihydroxyvitamin D3.It is the active vitamin D3 - osteotriol, which plays a role in promoting the absorption of calcium in the intestinal tract! Therefore, patients with liver failure (liver cancer, cirrhosis) or kidney failure (hemodialysis patients), or patients with poor liver and kidney function, the body can not normally synthesize active vitamin D3, and thus can not effectively promote the absorption of calcium in the intestinal tract and transport!

Alfacalcitol is a product of the renal conversion of vitamin D to 1-hydroxyvitamin D3, which, after oral absorption, requires only 25-position hydroxylation in the liver to form 1,25- and hydroxyvitamin D3, theThere is active vitamin D3 Osteocalciferol, which plays a role in promoting intestinal absorption of calcium!Therefore, in patients with poor liver function, taking alfacalcitol is ineffective and does not work to promote calcium absorption!

Thus, osteotriol, alfacalcitol, vitamin DBoth can promote the absorption and transit of calcium in the small intestine, but remember that the applicable population is different, vitamin D is used for people with good liver and kidney function, such as children, adolescents, etc.; Osteopontanol is used for patients with poor liver and kidney function, such as hepatocellular carcinoma, renal failure in elderly patients; Alfacal Osteopontanol is used for patients with poor renal function but good liver function!

Osteotriol, alfacalcitol and vitamin D are all classes of bone mineralization promoting drugs that work the same way in the body, except that they have to be converted differently. In fact, of these three drugs, it is osteotriol that is truly active in the body.

1, vitamin D, is a fat-soluble open-ring sterols, including animal sources of vitamin D3 and plant sources of vitamin D2. they are inactive in the body, need to be catalyzed by hepatocyte microsomal hydroxylase into the osseous diols, and then the osseous diols are transported to the kidneys through the bloodstream, and then converted into osseous trisol by the action of the 1 α-hydroxylase.

2. Alfacalcitol, an analog of osteotriol, can be converted to osteotriol in the liver after only one step. It does not need to pass through the renal tubules. So patients with poor liver function, taking alfacalcitol is ineffective, can not promote the role of calcium absorption; and for those patients with kidney disease, you can choose to take alfacalcitol for the treatment of osteoporosis.

3, Osteotriol, is vitamin D has been through the liver and kidney hydroxylase after 1, 25-dihydroxy compounds, has been activated vitamin D, is the body's active substances. It can be used to prevent osteoporosis, relieve pain in osteoporosis patients and reduce the incidence of fractures. In addition, it is commonly used clinically in chronic renal failure, renal osteodystrophy especially in hemodialysis patients, postoperative and idiopathic hypoparathyroidism, and vitamin D-dependent rickets. This drug is often used in nephrology; in addition, patients with hepatic and renal insufficiency are preferred to osteotriol, which is prone to hypercalcemia in the process of using the drug, therefore, attention should be paid to monitoring the blood calcium level in the process of application.

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First, let's start by talking to you about Osteotriol and Alfacalcitol. Both drugs are derivatives of vitamin D3, but with different advantages and disadvantages.

1, Osteotriol: is vitamin D has been through the liver and kidney hydroxylase after 1, 25 double hydroxyl compounds, has been activated vitamin D. Mainly used for postmenopausal osteoporosis, chronic renal failure renal osteodystrophy, especially hemodialysis patients with renal osteodystrophy, postoperative and idiopathic hypoparathyroidism, pseudo-hypoparathyroidism, vitamin D-dependence rickets and so on. Osteotriol is preferred in patients with hepatic and renal insufficiency. The disadvantage is that it is easy to cause hypercalcemia, and blood calcium concentration should be monitored during application.

2, Alfa Osteocortisol: is vitamin D in the kidney after hydroxylation of the product 1 hydroxyl compounds, after ingestion in the liver after re-hydroxylation to become a double hydroxyl of osteotriol. MainIt is used for postmenopausal osteoporosis, postoperative and idiopathic hypoparathyroidism, pseudohypoparathyroidism, and vitamin D-dependent rickets.Blood calcium concentrations are more stable relative to osteotriol.

3, vitamin D, including vitamin D2 and vitamin D3. ordinary vitamin D3 must be hydroxylated to 25 hydroxyl compounds through the liver at its 25 position, and activated by renal hydroxylase at its 1 position to become 1.25 bis-hydroxylated activated vitamin D3. therefore, it requires normal hydroxylation of the liver and kidneys, and additionally does not easily cause hypercalcemia.

It is important to note that serum25 The minimum target for vitamin D supplementation is met when hydroxy D reaches 30ug/L.According to the 2010 International Osteoporosis Foundation guidelines, the recommended supplemental doses of vitamin D are as follows: 400-800 U of regular vitamin D per day for normal adults under 50 years of age, 800-1,000 U per day for those over 50 years of age, and 2,000 U for those who are obese, have osteoporosis, have not seen sunlight for a long period of time, or who have malabsorption; and it is also recommended that these individuals should be It is also recommended that these individuals should be monitored every 3 months, and the medication can be adjusted individually after the maintenance amount has reached the standard.

Additionally, in reducing non-vertebral fractures and falls, some studies now suggest that vitamin D derivatives have a slight advantage over regular vitamin D. However, due to the lack of randomized controlled trials, their effectiveness needs to be further confirmed.

I hope it helps someone in need, thanks for your interest and likes.

Osteotriol, alfacalcitol, and vitamin D are a class of bone mineralization-promoting drugs, and it is osteotriol that is active in the body.
vitamin DVitamin D includes vitamin D2 and vitamin D3, which are inactive in the body and need to be catalyzed by the microsomal hydroxylase of hepatocytes to become osseous diols, and then by enzymes in the mitochondria of renal tubular epithelial cells to ultimately generate physiologically active osseous triols. Here in the difference between vitamin D2 and vitamin D3.Vitamin D3 is mainly extracted from animal tissues, while vitamin D2 is mainly extracted from plants.. Vitamin D3 is generally considered to be more easily absorbed.

alfacalcitol, an analog of osteotriol.As soon as it is catalyzed by the hydroxylase enzyme in the liver it can produce active osteotriol without passing through the renal tubules.For those who suffer from kidney disease, they can choose to take Alfacalcitol for the treatment of osteoporosis.

calcitriol, is an active substance in the body. It can effectively prevent osteoporosis, relieve pain in osteoporosis patients and reduce the incidence of fractures.However, clinically, it is mainly used for renal bone disease caused by chronic renal insufficiency (especially for those patients with uremia, who need hemodialysis for a long time), there are both injectable and oral dosage forms used longer in nephrology.

Vitamin D may be used clinically more often mainly in gynecology pediatrics.Like the prevention of osteoporosis in postmenopausal women, the use of vitamin D in combination with calcium is a commonly prescribed. And children with malnutrition can take some vitamin D drops for nutritional supplementation. And Osteotriol is mainly used for bone disease in patients with renal insufficiency or hemodialysis, or for the treatment of decreased parathyroid function.