Thank you, I am an attending physician at SCMS.

Cephalosporin is often called "anti-inflammatory drugs", it is an antibiotic, that is, antibacterial drugs, mainly used for anti-infection treatment.

There are many people who will have questions: since oral or intravenous administration may be allergic or even bad for liver and kidney function, why can't we use antibiotics topically for localized bacterial infections?

The main reason lies in drug resistance.

Simply put, if topical antibiotics are used we do kill some of the bacteria, however there is another part of the bacteria that can't be killed and escapes, but they are honed in such an environment that the next time the same antibiotics are used they won't necessarily be effective, the bacteria are very proliferative, and then the condition will only get worse.

From an individual, antibiotics cannot be used topically. But what about from a whole country? Each individual is equivalent to a localized one, so we must strictly prohibit the abuse of antibiotics by each individual! Otherwise, bacteria gradually evolve, and when superbugs, which we know are hard to kill with antibiotics, appear and spread, it will be a disaster for mankind!

Cephalosporin dressings are not allowed! In the case of traumatic wounds, you can not use cephalosporin to pour directly on the wound dressing. Often encountered this situation, there are wounds, directly to the oral antibacterial drugs will be broken open the capsule powder on the wound, this is very dangerous, easy to cause bacterial resistance and allergic reactions, serious can lead to anaphylactic shock.

When there is trauma is appropriate to use saline to clean the wound for debridement treatment, the wound has dirt contaminated wounds must also use hydrogen peroxide (3% hydrogen peroxide solution) disinfection treatment, and then with Levano solution also called yellow medicine (lactic acid isacridine solution) gauze block wet compresses, and finally gauze cover bandage, do not pour cephalosporins in the wound on the bandage.

Cephalosporin is also commonly known as anti-inflammatory drugs, cephalosporins are divided into 4 generations. The 1st generation of cephalosporins (cefazolin, cefadroxil), used for enzyme-producing Staphylococcus aureus and other sensitive G+ coccus infections, with nephrotoxicity; the 2nd generation of cephalosporins (cefaclor, cefuroxime), the role of G+ coccus with the 1st generation of the role of the first generation of the first generation of G+ coccus similar to the part of the Gram-negative bacilli also have antibacterial activity, nephrotoxicity is less severe, the β-lactamase is more stable; 3rd generation of cephalosporins (ceftriaxone, The 3rd generation cephalosporins (ceftriaxone, ceftazidime), enterobacteriaceae and other gram-negative bacilli have powerful antibacterial effect, of which ceftazidime, cefoperazone also has strong antibacterial activity against Pseudomonas aeruginosa, low nephrotoxicity. The 4th generation of cephalosporins (cefepime), antibacterial spectrum than the 3rd generation of cephalosporins, antibacterial activity, the activity of streptococci and penicillin-resistant Streptococcus pneumoniae increased, the role of Pseudomonas aeruginosa is similar to ceftazidime, used for Ampcase-producing strains of bacteria caused by serious infections. Cephalosporins adverse reactions are mainly prone to allergies.

The 2015 version of the Guiding Principles for the Clinical Application of Antimicrobial Drugs suggests that topical application of antimicrobial drugs should be avoided as much as possible. Because the local application of antibacterial drugs absorbed by the skin and mucous membrane is less, in the infected area can not reach the effective therapeutic concentration, but easy to induce bacteria to produce drug resistance. Topical application of antibiotics for skin wounds is recommended to use antibiotics that are less irritating, less easily absorbed, less likely to be resistant, and less likely to cause allergies. The common bacteria of skin infections are mostly gram-positive cocci, which can be applied externally with mupirocin cream or povidone-iodine, or with a wet compress of Rivanol. Penicillins and cephalosporins are prone to allergic reactions and even anaphylactic shock, so cephalosporins are forbidden to be used directly on wounds, and topical antimicrobial preparations that are not easily allergic and less irritating (tincture, application, lotion, ointment, etc.) should be used.

Antibacterial drugs should not be abused, but improper wound treatment or untimely treatment, often secondary wound infection, such as fever, elevated white blood cells, elevated c-reactive protein and other evidence of systemic infection, in addition to local enhancement of disinfection and disinfection, change of treatment, but also systemic antimicrobial drugs (oral, intramuscular or intravenous) to control the infection. Note that penicillins and cephalosporins are prone to allergic reactions and should not be applied locally, and aminoglycosides (gentamicin, kanamycin, streptomycin) are ototoxic and should not be used locally in the ear as ear drops, and should not be used intraocularly or subconjunctivally because of possible macular necrosis.

The authoritative interpretation of Pharmaceutical Affairs, unauthorized reproduction, plagiarism will be punished.

Antibiotics (cephalosporins) can be used topically. However, it is easier to develop resistance to topical use. So they are not usually used that way. But there is such a use, but it is rarely used clinically.

If you have a wound, don't repeat different ways of treating it. Otherwise it will affect the wound healing as well.

First after the peroxide rinse, keep the wound clean and you can cover it with a dressing. Erythromycin is also a good medicine. It can be evenly applied to the wound to play a preventive and antiseptic role. In the future, change the dressing regularly, or if the wound is not too big, direct exposure is also possible. Regularly flush with a little saline. But don't always use irritants, such as hydrogen peroxide. That's not good for wound healing.

In the past, topical application of antibiotics was more recommended, but nowadays it is highly discouraged. The main reason for this is that topical antibiotics are not much more effective than systemic antibiotics, and resistance to antibiotics can develop. Besides, there are enough topical disinfectants nowadays, excluding the commonly used ones such as povidone-iodine, some physical antiseptics are also effective when applied topically.

Wounds are classified into three levels, removing the need for thorough debridement and drainage of contaminated wounds, much less the need for topical application of antibiotics in clean wounds.

It is very not recommended to use cephalosporin in this way, mainly for two reasons:1. Most cephalosporin antimicrobials are very unstable when exposed to the air, because they are unstable to heat, easy to hydrolyze, and do not tolerate acid and alkali properties, cephalosporins are usually made into sterile powder, and then configured for clinical use. Topical cephalosporin will be decomposed into ineffective components, not to mention the effect, cephalosporin hydrolysis, oxidation products will greatly increase the risk of allergy; 2. Cephalosporin class of antimicrobials mechanism is to inhibit the synthesis of the bacterial cell wall, which belongs to the bacteriostatic agent, the effect of direct external far from iodine povine, alcohol, benzalkonium chloride and other topical bactericides to direct, the external preparation of the drug is simple and cost-effective than injections and oral cephalosporins cheaper. The cost is also cheaper than injections and oral cephalosporins.

Topical cephalosporin is highly discouraged based on the two points above.