Helicobacter pylori is gram-negative, the bacterial body is curved, spiral, U-shaped, S-shaped and W-shaped, with different lengths, after many evolutions, the bacterial body becomes spherical. Single-ended 2~6 flagella, can be colonized in the epithelial layer of the gastric mucosa, micro aerobic bacteria, optimal growth temperature of 37 ° C, pH 6.8, because the bacterium is not sensitive to a variety of antibiotics, and easy to develop drug resistance. It is the main pathogenic factor causing chronic gastritis, gastric ulcer, duodenum, and inducing gastric cancer.

Antimicrobial drugs that are sensitive to H. pylori include amoxicillin, metronidazole, tinidazole, clarithromycin, tetracycline, doxycycline, and furazolidone.

Drug therapy is usually a triple combination of a colloidal bismuth preparation plus two antibiotics or a proton pump inhibitor, omeprazole, plus two antibiotics for a two-week course. There is also a quadruple therapy of proton pump inhibitors (omeprazole class) plus two antibiotics plus a gastric mucosal protector (such as bismuth pectin, magnesium aluminum carbonate granules, bismuth subcarbonate, bismuth potassium citrate, etc.). It is only then that the clearance rate of H. pylori reaches more than 80%.

Do not take a combination of proton pump inhibitors in the treatment of chronic atrophic gastritis to kill Helicobacter pylori, and try to use drugs that have not been taken before, to avoid the occurrence of drug resistance and the failure to achieve therapeutic effects.

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Helicobacter pylori is the most important risk factor for chronic gastritis, peptic ulcers and even stomach cancer. Some people infected with H. pylori have symptoms, while others are asymptomatic. After detecting H. pylori, if you have stomach disease yourself or have a family genetic factor for stomach cancer, H. pylori eradication treatment is usually recommended. The current treatment is a quadruple therapy of 2 antibiotics + bismuth + proton pump inhibitor for 2 weeks.

Proton pump inhibitors such as omeprazole, pantoprazole, and lansoprazole. Omeprazole is taken 20mg twice a day, half an hour before meals. Proton pump inhibitors can be chosen with fewer interactions with other drugs such as lansoprazole, rabeprazole.

There are 7 combination regimens of 2 antibiotics: amoxicillin with clarithromycin or metronidazole, or tetracycline, or levofloxacin or furazolidone, as well as tetracycline with metronidazole, and tetracycline with furazolidone, with amoxicillin at 1 g,twice daily, metronidazole as 0.4 g 3 or 4 times daily, and tetracycline at 0.5 g 3 times daily.

Levofloxacin and clarithromycin, as well as metronidazole, have different rates of resistance in different regions, so a drug sensitivity test can be done if necessary to choose a more appropriate drug. Levofloxacin is not recommended as a first eradication treatment, but can be used as a drug of choice after treatment failure. Antibiotics are usually best taken with a meal.

The bismuth agent of choice is usually bismuth potassium citrate, usually in a dose of 220 mg twice daily, taken before meals.

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In fact, Helicobacter pylori is also a carcinogen, which does not mean that infection with Helicobacter pylori will definitely lead to stomach cancer, but if Helicobacter pylori can be eradicated in time, it can effectively reduce the risk of stomach cancer, so it can be said that eradication of Helicobacter pylori is an extremely important preventive measure against stomach cancer at present. If you are detected with H. pylori, and you have stomach diseases or have family genetic factors of stomach cancer, it is generally recommended to undergo H. pylori eradication treatment. The current treatment is quadruple therapy, i.e., 2 antibiotics + 1 bismuth + 1 proton pump inhibitor for 7-14 days.

Two antibiotics, mainly: clarithromycin, ampicillin, metronidazole, tinidazole, quinolone antibiotics, dysentery and tetracycline. Among them, the more common is the combination of amoxicillin plus clarithromycin, the reason why the choice of two antibiotics, mainly to reduce the incidence of bacterial resistance to increase the success rate of eradication, patients who are allergic to amoxicillin, at the same time, you can also consider the combination of clarithromycin + metronidazole, clarithromycin + levofloxacin, clarithromycin + tetracycline, and so on, the specific how to combine and the dosage of the use of the specialists, you need to The specific combination and dosage need to be developed by a specialist according to your individual situation. This class of drugs is generally recommended to be taken after meals.

1 kind of bismuth agent common bismuth potassium citrate, bismuth pectin, bismuth subcarbonate, etc. Bismuth agent can effectively protect the gastric mucosa, and at the same time, it has a certain inhibition effect on Helicobacter pylori, and the combined use of bismuth agent can improve the eradication rate of Helicobacter pylori. In the process of use, it should be noted that milk and antacids can interfere with the action of the drug, can not be taken at the same time, and need to be spaced out for a period of time before use. This type of drug is recommended to be taken half an hour before the last meal.

1 Proton pump inhibitors commonly include esomeprazole, omeprazole, lansoprazole, pantoprazole, rabeprazole and so on. This type of drug can activate Helicobacter pylori on the one hand, so that it is in an active state, easy to be killed by antibiotics, on the other hand, regulating the acid-base pH value of the stomach, improve the antibiotic antibacterial activity. Specifically how to choose these kinds of drugs, it is recommended that you can choose with less interaction with other drugs such as lansoprazole or rabeprazole. This type of drug is taken half an hour before the last meal.

The combination of these four drugs mentioned above is the most common combination for H. pylori eradication treatment. After the treatment is completed, it is recommended to have a regular review to confirm the success of H. pylori eradication. In addition, it is important to pay attention to personal hygiene and dietary hygiene in daily life, use chopsticks in public, use your own toothbrush, wash your hands, and remember to clean ingredients, dishes, etc. Even if H. pylori has been successfully eradicated, it does not mean that it will not be re-infected, so it is important to pay attention to personal hygiene at all times to minimize the chances of being infected by H. pylori.

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Helicobacter pylori is so far, the stomach is the only pathogenic microorganisms found in the stomach, because the stomach can secrete strong acidity of gastric acid, general bacteria microorganisms can not survive, but Helicobacter pylori due to its unique structure, able to resist the erosion of gastric acid, so it has been accompanied by human beings for 50 million years, until the 90s of the last century, Helicobacter pylori's pathogenicity was confirmed, Helicobacter pylori infection is an important factor leading to gastric ulcers, duodenal ulcers, chronic gastritis and other diseases. Helicobacter pylori infection is an important factor leading to gastric ulcers, duodenal ulcers, chronic gastritis and other diseases, therefore, the eradication of Helicobacter pylori treatment has also been a lot of friends concerned about the issue of today to give you a brief introduction.

The eradication regimen of H. pylori is constantly progressing with the continuous advancement of drug development, from the initial triple therapy to the quadruple therapy recommended by the mainstream guidelines, from the original use of tildine-based H2 receptor antagonists as antacids to the current use of azoles as antacids, although the drug regimen is constantly being updated, the eradication rate is fundamentally not very high, the current quadruple therapy The eradication rate of H. pylori is only about 70% in general, and in some regions where antibiotics are widely abused, this rate is even lower. Therefore, it is generally recommended that patients with clear H. pylori infection and relevant indications, such as gastric ulcer, chronic gastritis, MALT lymphoma, and a family history of gastric cancer, etc., should undergo eradication therapy if they need to undergo treatment, and for those who have only positive H. pylori infection without any family history of gastric cancer, the eradication therapy should be carried out. For those who are only positive for H. pylori infection without any related symptoms, it is not recommended to rush for eradication treatment.

A brief introduction to the H. pylori eradication treatment program-

Quadruple therapy usually contains two antibiotics, such as the combination of amoxicillin plus clarithromycin, the reason why the choice of two antibiotics, mainly to reduce the incidence of bacterial resistance to increase the success rate of eradication, for amoxicillin allergy friends, you can can consider clarithromycin + metronidazole or clarithromycin + levofloxacin and other combinations, the specific antibiotics that can be used generally amoxicillin, clarithromycin, furazolidone, metronidazole, levofloxacin, tetracycline, etc. Furazolidone, Metronidazole, Levofloxacin, Tetracycline, etc. Please also follow your doctor's advice on how to combine them.

In addition to the two antibiotics, the quadruple therapy also contains an antacid. Nowadays, the proton pump inhibitors of the azole class are usually recommended, such as rabeprazole, esomeprazole, etc. The antacid on the one hand can activate the Helicobacter pylori bacteria, so that they are in an active state and easy to be killed by antibiotics, and on the other hand, it is very important to regulate the acidic and alkaline pH value of the stomach and increase the antibiotic's antimicrobial activity.

In addition to the above three drugs, the dosing regimen of quadruple dosing also includes bismuth, such as colloidal bismuth pectin, bismuth potassium citrate and so on are common choices, bismuth can effectively protect gastric mucosa, and at the same time has a certain degree of inhibition of Helicobacter pylori, and combining bismuth can improve the eradication rate of Helicobacter pylori.

The combination of the above four drugs is the usual combination of drugs used in the treatment of H. pylori eradication, the specific medication program will not say more, the doctor will generally be based on the patient's physical condition, the corresponding combination of prescriptions to carry out the eradication of H. pylori, usually two antibiotics to take after meals, while the two gastric mucous membrane protection drugs to take before meals, the course of treatment for 10-14 days, the end of the course of treatment, after stopping to take the drug, you can go back to the examination to confirm whether the removal of H. pylori successfully. More than a month, you can go back to the examination, to confirm whether the Helicobacter pylori bacteria removal success, there is also a reminder that if the successful eradication of Helicobacter pylori bacteria, does not mean that it will not be re-infected in daily life must pay attention to dietary hygiene, personal hygiene, and to reduce the Helicobacter pylori bacteria secondary infection chances.

H. pylori is closely related to the development of chronic gastritis, peptic ulcer and gastric cancer. Currently, there is no preventive vaccine available, and the treatment of H. pylori is one of the measures for the treatment of chronic gastritis, peptic ulcers and other digestive diseases and for the prevention of gastric cancer.

In the case of peptic ulcers, usually referred to as gastric ulcers and duodenal ulcers, long term untreated gastric ulcers have the potential for the following complications.

1, pyloric obstruction, long-term chronic gastric ulcer resulting in extensive scar formation.

2, Perforation, which is one of the common complications of peptic ulcers.

3, gastrointestinal bleeding, if the bottom of the ulcer capillary cracking can be a small amount of bleeding, if the bottom of the ulcer large blood vessels are corroded can cause hemorrhage, and even hemorrhagic shock life-threatening.

4, Cancer, often seen in patients with long-term gastric ulcers.

It can be seen that gastric ulcers are potentially very harmful to the human body, and Helicobacter pylori is an important factor in the formation of gastric ulcers, so the treatment of Helicobacter pylori should also be actively pay attention to.

However, it is not necessary to treat H. pylori infection as soon as it appears. Treatment for H. pylori is often appropriate for the following chronic gastritis patients.

1, There are abnormal chronic gastritis such as erosions, heterotrophic hyperplasia, and so on.

2, a family history of stomach cancer.

3, with celiac duodenitis.

4, Ineffective conventional treatment for GI symptoms.

Treatment for H. pylori often involves the use of proton pump inhibitors such as omeprazole, rabeprazole, or colloidal bismuth such as bismuth potassium citrate, plus two antimicrobial drugs such as amoxicillin, clarithromycin, and metronidazole for one to two weeks.

I am a Sichuan sister brave fight Helicobacter pylori, finally clear clean, can be a square company dinner, my method are below!

I'm a spicy family, no chili really feel like eating any meal is not good, I feel like I'm not the wrong fetus, is not I'm a Sichuan girl, on the high school to eat chili is especially much, relatively speaking, the stomach is not good, the stomach is occasionally uncomfortable, my suitcase is always always ready to eat a packet of stomach uncomfortable ......

Graduated from high school in college, because in the weight loss, often do not eat at night, one evening study directly eat a banana, suddenly stomach pain can not straighten the waist, when the classroom from the dormitory on the distance up and down the stairs, but is not able to stand up to the counselor leave did not go to class, their own dormitory a variety of looking for stomach pills to eat, too unbearable, the next day is really can not stand it on the examination, celiac gastritis ~

At that time took some medicine to eat, but occasionally still have discomfort, after all, every day to eat the cafeteria to eat takeout is also more, but there is no way, after all, school is this condition ......

Later, after graduation to go to the company to physical examination, one of the must check the Helicobacter pylori, go to the hospital to see the test fee surprisingly 140, in order to work on the check, with the c14 test, blowing blow how long to forget, and then to the nurse lady, in fact, the same day on the results (I waited for a week to have the results), showing a positive 500!

I: have celiac gastritis, usually do not eat will be hungry stomach pain, has not been taken seriously, the doctor said that is the Helicobacter pylori, and asked the breath is not big, I think it is quite big, because the former boyfriend is because of my breath break up, the doctor said that exceeds the standard by five times, there is no discomfort without the use of medication, but you need to take to will be less than 2-3 months of the fight against the Helicobacter pylori bacteria of the probiotic gold free pylori. If you use drugs to treat it is also simple, is to take the medicine on the line! I'm thinking of going without medication! I don't feel anything, just take the gold.

Then go to the office and report to the HR lady!

The personnel lady said that I should bring my own food bowl from home as soon as she saw the positive, and said that I should not use the company's one!

I thought this is not discrimination. I asked her why she didn't use the company's, and she said that Helicobacter pylori is contagious, and that eating together would spread it to coworkers ~ that self-esteem is hurt to the core ~ and I don't know how everyone knows I have Helicobacter pylori! Everyone knows about my H. pylori, and they point at me when I eat! No one wants to share a meal together, they have checked the H. pylori, are negative, I am positive, dinner are deliberately said that now H. pylori will be contagious, and H. pylori over the standard to pay attention to, in fact, I am also very conscientious of each meal will be using two pairs of chopsticks, one as a pair of chopsticks, but I feel a little embarrassed!

How can a newbie like me afford this! I asked my friend who is a medical student! She recommended probiotics, a set of hundreds of dollars, too expensive for new graduates can not afford ah!

Then he also understands, it said let me take a side effect small triple drug went to the pharmacy to buy fourteen days, can be expensive, this point also spent more than 700, because the two people together to share a meal kissing, to my boyfriend also infected my boyfriend is also over the limit! My amount of medicine I think is still relatively small, insisted on eating a few days! I went ~ diarrhea! Diarrhea headaches every day! Especially a headache when I took Claritin and Lan**zole! Taking two pills a day doesn't help either!

I went to my friend ~ my friend said it was because of the side effects of the antibiotics, holy crap that's horrible! Then there is no way to insist on taking it, after taking it for a week truly can not eat! Every time I take it, I get a headache in the afternoon! I asked her if it was okay to take it for a week.

She then recommended that probiotic again! I thought I'd give it a try! I had an upset stomach and took the probiotic and it worked really well! It really works!

Now because of graduation, it is often their own cooking, seldom go out to eat, occasionally they will stew a soup to drink, soup also stomach, now also eat probiotics gold free pylorus, probiotics this thing in the end is not the concept of the product, in general I ate the effect is not bad, at least I turned the negative, the key I think and the mood has a great deal to do with, there are times when the pressure is great, but also will be an uncomfortable stomach.

I don't know if you've read the book "The Secret", but I feel like I'm still self-healing, and I keep telling myself that my stomach doesn't feel sick, and that my stomach might want to believe it, so I won't feel sick.

This is what the doctor gave me for H. pylori. Take it for 10 to 14 days.

I. What is Helicobacter pylori

Many people are not familiar with Helicobacter pylori, but the infection rate of this bacterium in adults can reach 60%, Huazi's unit physical examination, many of his colleagues were infected with this bacterium. This is a kind of bacteria living in the human digestive tract, do not look at it insignificant, but the harm can be not small. According to statistics, 90% of duodenal ulcers and 80% of gastric ulcers are related to Helicobacter pylori, and it is also the number one risk factor for stomach cancer.

Helicobacter pylori is spread through oral transmission, such as parents feeding their children mouth-to-mouth, couples kissing each other, or even people using their own chopsticks to give food to others at the dinner table, which can cause infection.

II. Symptoms of infection

70% of people infected with Helicobacter pylori do not reveal obvious symptoms and do not necessarily develop peptic ulcers, and the infection is only detected during a physical examination. Whereas 10% of people suffer from indigestion, around 20% may develop peptic ulcers, which manifest as symptoms such as acid reflux, heartburn, epigastric pain, bad breath, bloating, epigastric discomfort and loss of appetite.

In addition to peptic ulcers, H. pylori can cause atrophic or non-atrophic gastritis, lymphatic gastritis, gastric polyps, gastric mucosa-related tumors, and can lead to anemia, thrombocytopenia, and vitamin B12 deficiency due to decreased absorption of iron ions.

Third, how to treat Helicobacter pylori infection

Although asymptomatic H. pylori infection can be left untreated, being asymptomatic does not mean that it is harmless. The gastric mucosa of the infected person has already undergone inflammatory changes, and it is also easy to infect one's family and friends. The high infection rate of H. pylori is also the main reason for the high incidence of stomach cancer in China. Therefore, after detecting H. pylori infection, eradication treatment is recommended.

Nowadays, the main methods of eradicating Helicobacter pylori are triple therapy and quadruple therapy, but triple therapy has high bacterial resistance, and quadruple therapy is mainly used at present. The method is a combination of 1 proton pump inhibitor + 1 bismuth + 2 antibiotics, which lasts for two weeks. Hua Zi has organized the common medications for the eradication of H. pylori and the method of taking them into the following table.

The 2 antibiotics that are often used in the hospital where Huazi works are Amoxicillin and Clarithromycin. It should be noted that people with penicillin allergy should avoid taking amoxicillin. However, the resistance of H. pylori is getting higher and higher nowadays, and the eradication rate can only reach about 60%. If the chosen antibiotic treatment is not effective, you can try to change to other varieties.

For children infected with H. pylori, eradication therapy is not recommended under the age of 5 years. If needed or if older children are treated, the medication regimen should not be copied from adults. The medication should be individualized under the guidance of a pediatrician. It is important to avoid possible side effects and minimize drug resistance.

IV. Preventive methods of Helicobacter pylori

Regardless of whether or not we have contact with a carrier, we should wash our hands with soap before and after meals; avoid mouth-feeding children; share meals and use separate utensils; use communal chopsticks when eating out; and avoid intimate contact between couples when one of the partners is infected during the treatment period.

Huazi tips, the medication listed in the article, is for reference only, and can not be the basis for the use of medication. Medicines should be used under the guidance of a doctor, and if you find any problems in the process of using medicines, please contact your doctor or pharmacist in time. I am pharmacist Huazi, welcome to follow me, let me become your side of the pharmacist.

At present, the infection rate of Helicobacter pylori in China is about 59%, and some infected people may have dyspepsia, peptic ulcer, and gastric cancer and other concomitant diseases, so patients with H. pylori eradication pointers should use anti-H. pylori medications reasonably in order to strengthen the protection of the gastric mucosa. What kind of drugs should be taken for H. pylori eradication? Next, Medical Senlution will analyze it for you.

There are more drugs with the ability to kill H. pylori, including antibiotics and bismuth that are sensitive to H. pylori, and there are more programs commonly used to eradicate H. pylori, ranging from the previous triple therapy to the recent quadruple therapy. However, the success rate of H. pylori eradication is not the same with different drugs and different combination programs: take antibiotics as an example, drugs such as clarithromycin, metronidazole, levofloxacin and so on have a high resistance rate to H. pylori and are on the rise, and drugs such as amoxicillin, tetracycline, furazolidone and so on have a relatively low rate of H. pylori resistance, and the high and low rate of resistance determines to a large extent the success rate of eradication, therefore different Different combinations of antibiotics can show different eradication efficacy; take quadruple therapy as an example, although the previous triple therapy can also eradicate H. pylori, but the overall success rate shows a decreasing trend, while quadruple therapy including bismuth (one kind of proton pump inhibitor+bismuth+two kinds of antibiotics), the success rate of eradication of H. pylori is as high as 90%, so currently the eradication of H. pylori with quadruple therapy as the first choice.

In quadruple therapy, proton pump inhibitors have the effect of inhibiting gastric acid secretion, which can increase the chemical stability of antibiotics, increase the concentration of antibiotics in gastric juice, etc., increase the effect of antibiotics, thus increasing the success rate of eradicating H. pylori, commonly used proton pump inhibitors are lansoprazole, pantoprazole, rabeprazole, esomeprazole, omeprazole, etc., but it is necessary to use a standard dosage, for example, omeprazole is 20mg each time, each time to take two times, are taken half an hour before meals; bismuth not only has the role of killing Helicobacter pylori, but also can form a protective film on the gastric mucosa, which can promote the healing of ulcers, bismuth maybe twice a day, need to be taken before meals. Antibiotics, as mentioned earlier, are divided into two main regimens based on amoxicillin or tetracycline, with a total of seven combinations, all of which are preferred, except for the levofloxacin-containing regimen, which is not used as a first eradication regimen. The course of treatment is usually 2 weeks, and the 13C or 14C urea breath test should be repeated at the end of eradication, but no proton pump inhibitors should be taken two weeks before the review, and no drugs such as bismuth or antibiotics should be taken for the first four weeks.

In summary, at present, quadruple therapy including bismuth is preferred for the eradication of H. pylori, which consists of a proton pump inhibitor + bismuth + two antibiotics, and the success rate of eradication is more than 90%, and the 13C or 14C urea breath test should be rechecked at the end of the eradication treatment in order to find out the success of eradicating H. pylori or not, but proton pump inhibitors can not be taken in the two weeks prior to the rechecking, and bismuth or antibiotics etc. cannot be taken in the four weeks before the rechecking. Medications.

Thank you all for reading!

Please correct me if I am wrong!

Feel free to ask for advice and exchange ideas in the comments section! Note: The content of this article is intended as health science only, and is not intended as medical advice or opinion, and does not qualify as medical guidance.

Whether or not to eradicate H. pylori bacteria detected in a physical examination needs to be determined based on the disease that is infected and the impact of the infection on the ultimate prognosis of the disease. The only two that are strongly recommended for eradication are peptic ulcer and gastric mucosa-associated lymphohistioma. Drug treatment program, due to the high incidence of antibiotic resistance in China, basically recommended acid inhibitors combined with bismuth and then combined with two antibiotic quadruple program, acid inhibitors are proton pump inhibitors, that is, a variety of azoles such as Esomeprazole magnesium and lansoprazole, omeprazole, etc., the principle of action of this type of drug is to inhibit the secretion of gastric acid to increase the chemical stability of antibiotics. This enhances the bactericidal effect. Antibiotics, levofloxacin, clarithromycin and metronidazole resistance rate are greater than 20%, amoxicillin, tetracycline and furazolidone on the sensitivity of H. pylori is better, are less than 5%, it is recommended to prioritize the use of our country due to the large number of use of quinolone drugs, H. pylori resistance to this type of drug is very high, so do not recommend levofloxacin for H. pylori infection in the initial treatment. In addition, older adults older than 70 years of age have reduced tolerance and adherence to eradication regimens and should be treated individually with a comprehensive benefit-risk assessment. In children, there is a low risk of infection with serious diseases including peptic ulcer, atrophic gastritis, and gastric cancer, a small variety of medications to choose from (salvars are not suitable for children under 18 years of age, and tetracyclines are not suitable for children under 8 years of age), poor tolerance of adverse drug reactions, and some spontaneous clearance of infections in children, and the rate of re-infection after eradication may be higher than that of adults; therefore, routine Detection of Helicobacter pylori