What are the dangers of taking sleeping pills for a long time?
What are the dangers of taking sleeping pills for a long time?
The problem of insomnia is widespread in countries all over the world, and it is just as serious in our country. For example, the problem of insomnia among all age groups reaches more than 40%, while the number of elderly people who have insomnia problems reaches 50%. Many people are ready to take, have taken or are taking sleeping pills because of the chronic insomnia problem, so what are the adverse effects of taking sleeping pills for a long time?
What are the adverse effects of sleeping pills?
Sleeping pills also include many types such as benzodiazepines, non-benzodiazepines, and barbiturates.
Some of the more common adverse reactions are drowsiness, dizziness, fatigue, depression, etc. Occasionally, ataxia, tremor, urinary retention and jaundice can be seen with high doses. Behavioral disorders, abnormal excitement and even irritability may also occur when taking clonazepam.
Less common adverse reactions include blurred vision, mild headache, cough, weakness in the extremities, numbness, pain or pins and needles in the hands and feet, hallucinations, depression, rash or allergies, nausea, slurred speech, and increased airway secretions.
Long-term use of sleeping pills generally need to regularly check the liver and kidney function, because all drugs are either metabolized by the liver or kidney metabolism, and a long period of time will certainly increase the burden on the liver and kidneys, which may cause liver function or kidney function abnormalities.
Another long term medication that gets the most attention is the addiction to sleeping pills. In fact, addiction is not all sleeping pills, only benzodiazepine drugs may appear drug dependence (also known as addiction) when taken continuously for more than 8 weeks. The current third most popular sleeping pills belong to the non-benzodiazepine class of drugs, because the mechanism of action is different from that of benzodiazepines, so there is no possibility of creating drug dependence.
Tell us about the concern about what happens when you become addicted to sleeping pills.
Personal views are different, I think that if it has been determined that taking benzodiazepines addiction, but the sedative effect is very good, there is no drug resistance, then in fact, you can continue to take medication to improve sleep, and regular review of test indicators can be. Of course, if for some reason you need to stop taking the addictive drug, you can also use scientific methods to reduce or even avoid the withdrawal reaction after addiction.
Generally we avoid withdrawal reactions by slow tapering, which can be done by reducing the therapeutic dose of the medication by 25% every two weeks until it is reduced to a minimum and then maintained for 2 weeks of discontinuation. I have used this method to help many patients successfully discontinue benzodiazepine sleeping medications, so it is perfectly acceptable for clients who need to discontinue their medications to use this method with the advice of your primary care physician.
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I was 19 years old began to take Xulabendazole, when the street drugstores everywhere, 70 cents a sheet, 40, 50 pills, very useful, and then, the control is tight, a lot of small children to take as ecstasy to eat, first of all, you must register ID card, and then it is completely banned from the sale of drugstores, non-formal hospitals can not be a prescription. Until now, the hospital only dares to prescribe at most ten tablets, seven or eight tablets.
I am now 55 years old, there are more than 30 years of history of taking sleeping pills. Personal feeling, really can not sleep, three or four days in a row completely insomnia, has seriously affected learning, work and life, or take sleeping pills, do not have to avoid medicine taboo, many senior leaders, day-to-day management, and a lot of pressure, heavy burden of entrepreneurs, writers, scientific research workers, but also to rely on this to maintain sleep, people do not sleep, mental depression, nervous disorders, is going to be bad.
I, one thing is okay, is that once insomnia, take a few days of medicine, can sleep well, I can quickly put to stop, once the life is regular, can not rely on sleeping pills can also sleep, dependence is not very strong.
Sleeping pills are nerve suppression, side effects, harm is certainly there, sometimes, the drug works, the next day is still drowsy, feel not waking up from sleep; sometimes, very sleepy; sometimes, the heart works, no medicine can not fall asleep. These are not good phenomena. If you take it for a long time, it will definitely damage the nervous system of the brain to a certain extent, but it is definitely not as horrible as the rumors, and you will not become a fool.
Under normal circumstances, it is better to develop good habits, the food, the sleep, the play, don't collapse the nerves too tight, don't let yourself too tired, don't take up too much of a bull's-eye, a lot of things, let go, slow down, stop, no big deal, life in the world, in addition to the life and death, are not a big deal, must be able to afford to take, let go, to relax themselves, happy themselves, don't spin a cocoon, I can't pull myself out of it!
The pace of society is getting faster and faster, the pressure of people's life is getting bigger and bigger, insomnia also occurs in all kinds of people, from teenagers and students to the elderly, insomnia covers a wide range of ages, and it affects the patients' body, study and work to a greater or lesser extent. In 2006, a study conducted in six cities showed that adults in mainland China had insomnia symptoms as high as 57%, and in recent years, the proportion of insomnia patients has been rising year by year, and more and more patients are taking sleeping pills, and for some patients who have been taking sleeping pills for a long period of time, the toxicity and side-effects of sleeping pills have become a matter of great concern.
The main categories of sleeping pills currently approved by the U.S. Food and Drug Administration (FDA) are as follows:
(1) Short- and medium-acting benzodiazepine receptor agonists (BzRAs)
They mainly include diazepam, clonazepam, eszopiclam, triazolam, alprazolam, lorazepam, and other benzodiazepines, and the common adverse effects include dizziness, headache, dry mouth, decreased appetite, constipation, impaired consciousness, inability to concentrate, dyskinesia, residual sedative effects the next day, worsening of symptoms of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome (OSAS), and prolonged use can cause tolerance and Dependence. In addition, there are zopiclone, dexzopiclone, eszopiclone, zolpidem and zaleplon, this kind of drug is highly effective, low toxicity, less addictive, in the clinic is very popular, is a little bit expensive, but its less side effects may also be related to its market time is not very long, and the lack of long-term use of observation data.
(2) Melatonin receptor agonists:
Such as ramelteon, there have been adverse reactions including dizziness, headache, fatigue, drowsiness, arthralgia, muscle pain and other sleeping pills conventional adverse reactions, the incidence of low and mild symptoms, long-term use of drugs do not produce drug dependence, but long-term toxicity to the human body, including reproductive toxicity, carcinogenicity at present the lack of research.
(3) Antidepressants with sedative effects
The main ones include trazodone, mirtazapine, fluvoxamine, and doxepin, with common adverse effects ranging from dry mouth, constipation, residual sedation, postural hypotension, and weight gain.
Long-term insomnia may be far more harmful to the body than the toxic side effects of insomnia drugs, so patients should not worry too much about the toxic side effects of insomnia drugs, such as addiction, dependence, cognitive impairment, etc., the patient as long as they follow the doctor's instructions, do not arbitrarily buy drugs, increase the dose of medication on their own, the use of sleeping pills is still safe.
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Sleeping pills, i.e. sedative-hypnotic drugs, is a class of central inhibiting drugs, small doses can cause quiet or sleepy state, manifested as sedation, and medium doses can cause approximate physiological sleep, the current clinical use of sleeping pills mainly include two major categories, a class of classical benzodiazepine sleeping pills, common drugs are mainly eszopiclone, alprazolam, diazepam, clonazepam, etc., and the other class is a new type of non benzodiazepine sleeping pills, common drugs are mainly zolpidem, zopiclone, zaleplon etc. Compared with these two classes of drugs, they have faster onset of action and shorter half-life. The other type is the new non-benzodiazepine sleeping pills, common drugs mainly include zolpidem, zopiclone, zaleplon, etc. Compared with these two types of drugs, the new non-benzodiazepine sleeping pills have a fast onset of action, a short half-life, and the safety is better than that of the benzodiazepine sleeping pills.
Prolonged use of sleeping pills may cause the phenomenon of "hangover", that is to say, the day after taking the pills, the pills have been completely metabolized and excreted from the body, and the patients still suffer from dizziness, drowsiness, fatigue, tiredness, etc., thus increasing the risk of accidents for drivers and people working at heights, as well as the risk of falls and injuries for the elderly. In addition, long-term use of sleeping pills can cause tolerance and addiction. Tolerance means that patients are tolerant to sleeping pills and need to increase the dosage to achieve the original efficacy of the drug, which also increases the risk of adverse reactions to a certain extent, and addiction means that patients crave for continuous use of the drug, and once it is discontinued withdrawal symptoms such as insomnia, anxiety, tachycardia, tremor, nightmares, etc. can occur. Finally, long-term use of sleeping pills can also cause respiratory depression and liver damage, patients with respiratory diseases such as asthma and chronic obstructive pulmonary disease should be cautious, or even prohibited sleeping pills, and liver function should be checked regularly during the use of the drug.
Therefore, sleeping pills should be taken on the basis of etiological treatment, cognitive-behavioral therapy and sleep health education, as appropriate, on-demand, intermittent, such as the expected difficulty in falling asleep, 5-10 minutes before going to bed to take the drug, waking up during the night can not go back to sleep again and from the expected time to get up for more than 5 hours, you can use zolpidem and other sleeping pills with a shorter half-life, intermittent medication for 3-5 days per week, to avoid taking medication every night, the course of the medication Generally should not exceed 4 weeks, these are effective ways to reduce the harm of sleeping pills.
In conclusion, sleeping pills are a class of drugs that inhibit the central nervous system, and long-term use of the drugs can cause "hangover" phenomenon, tolerance, addiction, respiratory depression and liver damage and other hazards, therefore, sleeping pills should be taken under the guidance of a doctor on demand, intermittently, and the course of the medication should not exceed 4 weeks, and sleeping pills are psychotropic drugs that are under international control, and the use of them should be strictly controlled. Sleeping pills are internationally controlled psychotropic substances and their use should be strictly controlled. Reasonable use of sleeping pills can minimize the harm of the drugs to the body.
References:
Chinese Guidelines for the Diagnosis and Treatment of Insomnia in Adults (2017 Edition)
Although taking sleeping pills can help people with sleep disorders to fall asleep, if taken for a long period of time they may cause side effects such asNeed to take more and more doses, daytime drowsiness, easy to fall, sleepwalking or amnesia, insomnia worsens after stopping the drug。Let me elaborate on each of these side effects and introduce you to a treatment that is recommended by experts - Cognitive Behavioral Therapy.
The following are the 5 main side effects of taking prescription sleeping pills for long periods of time
1. Taking the same dose of sleeping pills with diminishing results
When sleeping pills are taken for a long period of time, the body develops a tolerance, i.e., it graduallyMore and more doses need to be taken to achieve the previous effect.
When the dosage reaches a certain level, theThere may be a risk of respiratory distress or even death. Therefore, if you feel that this medicine is not as effective as before, or you need to increase the dose to be effective, you must inform your doctor so that he or she can help you adjust your medication regimen, and never add more medication without authorization.
If you only have a short-term sleep disorder and need to re-establish a normal sleep pattern, you can take sleeping pills. However, in order to minimize the risk of such side effects, theDon't take sleeping pills for more than 7-10 days。
2. Drug residue causing daytime drowsiness
People who take some forms of sleeping pills, such as zolpidem, may still have drug residue in their bodies by morning, which can interfere with activities such as driving.
Women and people taking extended-release sleeping pills are more likely to experience daytime drowsiness. As a result, the U.S. Food and Drug AdministrationAsk drugmakers to lower the recommended dosage for women and advise doctors to lower the dosage for men.
In general, don't take sleeping pills like zolpidem unlessMake sure you have at least seven hours to sleep.
3. Balance deteriorates and falls easily
Some studies have shown thatPeople taking zolpidem were 4 times more likely to fall than those not taking it。
Because our feet have "sensors" that constantly balance our center of gravity and position, we can balance our entire body on two feet. However, taking medication can dull this system and there is a risk of falling.
Particularly important to note:Older people taking sleeping pills are more likely to have problems with falls.
4. Appearance of some strange behavior
Sleeping pills may causeSleepwalking and Amnesiaetc., especially benzodiazepines (e.g. triazolam), and people who take these sleeping pills may not know where they are when they wake up.
If you notice strange behavior while taking sleeping pills, contact your doctor and explain the situation.
5. It's hard to quit sleeping pills
Once you start taking sleeping pills, it can be hard to stop, especially if you've been taking them for a long time. In some people, insomnia comes back easily after stopping the medication, and sleep problems may worsen.
If you want to stop taking sleeping pills, you need to gradually reduce the dose of the drug under the supervision of your doctor.
Your doctor may cut the dose in half each week: assuming that you were originally taking 10 milligrams of a drug each night, try taking 5 milligrams each night for a week, then halving the dose to 2.5 milligrams the following week, and finally stopping the drug altogether.
Cognitive Behavioral Therapy (CBT) may "work" better than medication
While the use of sleeping pills for insomnia has many side effects and is prone to relapse, CBT may be better than drug therapy for chronic insomnia, with no side effects.
CBT can help insomniacs change their thinking patterns. Often people blame lack of sleep for all the negative energy such as crankiness and irritability, taking sleep too seriously, and insomnia breaks out immediately afterward.CBT can correct this distorted thinking.
When doing cognitive-behavioral therapy, the therapist will help you change your view of sleep and learn techniques to help you sleep (e.g., changing the environment in which you sleep, limiting activities before bedtime, etc.) Depending on the situation, sometimes a combination of medications is needed.
And finally, here are 4 tips that can help with sleep
1. Go to bed and wake up at approximately the same time every day, even on weekends. This will get your brain and body used to this healthy pattern of nighttime sleep and daytime naps. Over time, you'll be able to sleep soundly throughout the night and quickly nod off to sleep during the day.
2. Do something to relax your body and mind about an hour before bedtime, such as reading something calm and deep, listening to quiet music, doing bedtime yoga or taking a hot bath.
3. Putting a pillow between your legs can better align your hips, reduce the pressure on your back, and relieve back pain.
4. Choose a pillow that suits you. The size of the pillow should meet the person: when lying on the back to support the natural curve of the neck, not too high, not too low; when lying on the side should meet the nose and the body's center is in the same straight line, rather than and the stomach in the same straight line.
The above content is compiled by "Ask the Doctor" from the American Family Physician's Think Tank, for more authoritative and interesting health knowledge, welcome to follow us!
For long-term use of sleeping pills, the body is certainly said to be harmful, this is an indisputable fact. First of all, to insomniacs big service caused by dependence, and then a reason we all know; is a drug three poisons, the human body will cause harm to do, one of the most common symptoms is gastrointestinal damage, resulting in gastrointestinal digestive dysfunction, stomach full of flatulence, the ambassador dry and other symptoms. Do not believe that we can check or consult an expert to know, the doctor to prescribe drugs is subject to strict control, can not be prescribed, because the doctor knows how much harm to the human body of this drug. So limited prescription. I'd like to say that these are enough to prove it!
Thank you for inviting Wu Yibo, a member of the Chinese Popular Science Writers Association, to answer your questions.
Simply put, after taking a sedative drug, the next day you may experience symptoms of mental lethargy, drowsiness, fatigue, and depression; another common side effect is that the patient may experience "rebound insomnia" after stopping taking the sedative drug. Addiction and drug dependence are also a major potential threat to the use of sedative drugs.
In the hectic pace of modern society, many people suffer from sleep disorders, usually when the symptoms of difficulty in falling asleep, insomnia and sleeplessness. At this time.Most people choose to use sleeping pills to relieve insomnia symptoms under the supervision of a doctor.
Commonly usedSleeping and sedative drugs are categorized into benzodiazepines and non-benzodiazepines, of which the most representative drug in the benzodiazepine class is theDiazepam (Valium) and Eszopiclone (Soludanum), non-benzodiazepines tozolpidem (loanword)as typical.
Today we will focus on the adverse reactions that some patients may experience after taking some sedative and sleeping medications.
Taking sleeping and sedative drugsThe most common type of side effectIt's just that."Hangover."phenomenon, which is to say that some patients who take a sleeping sedative drug the night before may experience the next day'sSlackness, lethargy, weakness and depressionThe symptoms. Of course.The "hangover" phenomenon can have a significant impact on many people's daily routines and lives.Some people who work with high demands on mental strength and concentration, such as drivers and people who work at high altitudes, are much more likely to be involved in accidents and dangers at work if they have a "hangover" after taking sleeping pills, and if their minds are slack and their alertness is lowered.In addition, for some elderly people who are slow in movement and have difficulty in walking, the phenomenon of "hangover" may also cause them to have an accidental fall, which may lead to serious adverse consequences.
The "hangover" phenomenon occurs mainly because ofTaking too high a dose of sleeping and sedative drugsor the drugLong metabolism time in the body, short elimination half-life of the drugThis is the reason why there is a large accumulation of drugs in the body and the effect of drugs lasts for a long time. If an insomniac suffers from a "hangover".You can consult with your doctor and reduce the dosage appropriately or change the type of medication under the effective guidance of your doctor.
Another common class of side effectsIt is the patient who may be instop taking (medicine)Sedative and sleeping medication followed by"rebound insomnia."The phenomenon, that is, after stopping the medication the patient suffers from insomnia symptoms again, even more severe than the previous insomnia symptoms.
At this time, if the patient finds that he or she has "rebound insomnia" after stopping the medication.Never take sleeping pills without authorization, or even increase the dosage to relieve insomnia symptoms. Abuse of psychotropic drugs such as sedative sleeping pills without medical advice may lead to serious side effects and even drug dependence.
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Addiction and drug dependenceIt is also a major potential threat to the use of sedative sleeping medications, and the main reason for this is also that theIrregularity in the use of sedative sleeping pills for the treatment of insomnia, prolonged use of sleeping pills, or taking two or more sleeping pills at the same time.Reasons such as this can make a patient more dependent on sedative and sleeping medications, which can develop into drug addiction.
And as a result.Hospitals are very strict in controlling the use of psychotropic drugs, and patients should also follow strict medical advice when using sleeping pills and should never abuse them.Doctors should determine the cause of the disease before administering medication to a patient, and if the symptoms of insomnia are due to psychological problems only, the preferred treatment plan should also start with thepsychotherapyStart.Regardless of the medication, there are always side effects, big or small, on the body, and it is important to use as little or as small a dose as possible when treating an illness.
Questions answered by Yumei Liao, Harbin Medical University Reviewed by Yibo Wu
Insomnia is the most common sleep disorder, with a prevalence of 4% to 48% in the general population, depending on the definition of insomnia. Between 31% and 75% of patients who meet the diagnosis of insomnia have chronic insomnia, with more than two-thirds of these patients having a duration of illness greater than one year.The most effective treatment for insomnia is behavioral therapy and medication. And in this fast-paced society, it's really hard to get you to correct behaviors like not playing with your cell phone or drinking stimulant beverages before bedtime, so medication stands out, but the side effects of medication that come along with it are always there to affect our health.
What exactly are the side effects of sleeping pills?
- In the clinic we more commonly usebenzodiazepine, including alprazolam and eszopiclone, which shorten the latency period for falling asleep and improve sleep.Prolonged or high doses can produce adverse effects such as withdrawal phenomena, rebound insomnia, effects on cognitive function the next day, tolerance and dependence.
- Non-benzodiazepines, such as zolpidem and zopiclone. Adverse effects are relatively mild, butdezopicloneWhile improving the subjective and objective insomnia in elderly insomnia patients, it may run the adverse effects of dry mouth, dizziness, and drowsiness; the adverse effects of zaleplon are drowsiness, nausea, dry mouth, dizziness, headache, and dyspepsia.
- Antidepressants with sedative effects in small doses are also commonly used to treat chronic insomnia. Commonly used in the clinic are trazodone, mirtazapine and so on. Many patients feedback the use ofmirtazapine (loanword)Symptoms such as dizziness and weakness occur afterward.
Long-term use of sleeping pills generally requires regular checkupsliver and kidney functionThe reason is that all drugs are either metabolized by the liver or the kidneys, and prolonged medication will definitely increase the burden on the liver and kidneys, possibly causing abnormalities in liver function or kidney function.
We are most worried and concerned about the addictive properties of sleeping pills, and there are some patients who are afraid to use sleeping pills even if they have been ravaged by insomnia for a long time is afraid of his addictive properties. Dr. Li is here to teach you how to fight against sleeping pill addiction and use the drugs rationally.
Teaching you a trick to fight sleeping pill addiction
To prevent sedative-hypnotic addiction, it is important to understand the following basic principles of sedative-hypnotic use: 1.short term
Addiction does not usually occur with short-term use of sedative-hypnotics. However, if taken for a long period of time, addiction increases.By short-term use, I mean try not to use sedative-hypnotics for more than 4 weeks in a row.
2.a small quantity
The higher the dose of sedative-hypnotic drugs used, the higher the risk of addiction. Therefore, the smallest possible dose should be used to improve sleep.Try not to exceed the upper limit of the dose of sedative-hypnotics used。
3. Interruptions
The risk of addiction is significantly higher with continuous use of sedative-hypnotics than with intermittent use. Therefore, it is important not to take them every day.It is recommended to try to fall asleep on your own firstIf you are unable to sleep, consider using sedative hypnotics.Instead of the regular bedtime dose. If you really can't get away from sedative hypnotics it is recommended to use "Weekend withdrawal" approach, i.e., sedative hypnotics are taken on weekdays for sleep duration and quality; sedative hypnotics are not used during weekend breaks because there is no important agenda.
4.according demand
Patients with chronic insomnia have improved sleep if theOccasional reoccurrence of insomnia, such as insomnia due to a major event or jet lag,Sedative hypnotics can be used temporarily to help a person sleepso as not to worsen the condition because of a single bout of insomnia.
Sedative-hypnotic drug addiction can be prevented by mastering the four basic principles mentioned above. @HeadlineHealthAlliance @Headline @TheGreenCloudProgram
Most sleeping pills are sedative-hypnotics, some of which were originally anxiolytics or antidepressants, and the older generation of sleeping pills have the potential to be addictive, with an overdose leading to death. The newer sleeping pills are much less addictive and fall asleep faster after taking them, but long-term use can still be physically dependent.
Since sleeping pills interfere with normal breathing, they are dangerous if you suffer from chronic lung diseases such as asthma, emphysema, or chronic obstructive pulmonary disease, so use them with caution.
Common side effects of sleeping pills include burning or numbness in the hands, arms, feet, or legs, changes in appetite, constipation, diarrhea, inability to maintain balance, dizziness, daytime sleepiness, dry mouth or throat, bloating, headache, heartburn, problems with concentration or memory, uncontrollable shaking of a body part, unusual dreams, and weakness.
Some sleeping pills have potentially more serious side effects that can lead to deep sleep, sleepwalking, eating in your sleep, and talking on the phone in your sleep. Extraordinary situations such as having sexual intercourse in your sleep can also lead to falling asleep while driving. Deep sleep caused by sleeping pills is rare and difficult to detect. There are a few cases in foreign countries where a person was accused of rape by his girlfriend or ex-girlfriend, but he went to his girlfriend's house involuntarily in a state of deep sleep after taking sleeping pills, and then fell asleep after forced sexual intercourse, and didn't wake up until the police came to his door, which is difficult to decide because it is hard to determine whether he is in a state of deep sleep.
Just because sleeping pills have more side effects, some of which are more serious, it is important not to overdose on sleeping pills or take them with alcohol.
Sleeping pills can be helpful in the short term if insomnia is indeed severe, but long-term use of sleeping pills often does more harm than good. The solution to sleep disorders must also start with sleep habits, address the underlying causes of sleep disorders, and avoid sleeping pills as much as possible.
Insomnia is a very terrible thing, at present everyone is in high pressure, fast-paced life, every day facing work, study, buy a house, buy a car and other pressures, resulting in many people have anxiety, insomnia, and even mania and other problems. Long-term insomnia can disrupt the normal biological clock, leading to a number of problems, such as gastrointestinal problems, indigestion, constipation, daytime lethargy, fatigue, fatigue, skin deterioration, causing cardiovascular disease, and even cancer and so on.
Oral sleeping pills are a good way to fall asleep quickly in a short period of time, and the sleeping pills we commonly use are Valium, Alprazolam, Eszopiclum or Lorazepam. When the doctor prescribes sleeping pills to the patient, some patients will refuse to take them, thinking that sleeping pills will have serious side effects, in fact, this is not true, a short period of time to take these drugs orally, will not cause obvious toxic side effects, sleeping pills bring benefits, is obvious, is certainly more good than bad.
The following side effects may occur with long-term use of sleeping pills:
(1) Drowsiness, dizziness, fatigue, etc., which are the most common side effects. Some people are very sensitive to sleeping pills, and after taking them, they are groggy during the day; for these patients, the dosage can be reduced.
(2) A small percentage of patients may develop a rash and leukopenia.
(3) Individuals may experience euphoria, polygraphy, and even hallucinations. They will disappear immediately after stopping the drug.
(4) Long-term continuous use can lead to dependence and addiction, and withdrawal reactions may occur with discontinuation of the drug, manifesting as agitation or depression.
(5) In case of overdose, drug intoxication, coma and even life-threatening conditions can occur.
All in all, it is okay to take sleeping pills for a short period of time with very few side effects. Some patients, because of the needs of their condition, take sleeping pills orally for a long period of time, and there will be no serious side effects.
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