Can myasthenia gravis be cured?
Can myasthenia gravis be cured?
Myasthenia gravis is an autoimmune disease caused by dysfunction of transmission at the neuromuscular junction, with clinical manifestations such as drooping eyelids, blurred vision, diplopia, strabismus, and bitter smiles, etc. The prevalence of this disease ranges from 77 to 1.5/1,000,000, with more females than males, and is often due to too much change in psychological and emotional conditions, mental stimulation, overfatigue, various kinds of infections, endocrine imbalance, female abortion, women's menstruation, taking medication improperly, etc., which leads to recurrence or aggravation of myasthenia gravis and affects the prognosis.
So, can myasthenia gravis be cured? This is a question that many patients are concerned about. In fact, myasthenia gravis can not be cured, need to take long-term medication to control the condition. In the acute attack period, by taking drugs to make the attack end as soon as possible. During the remission period, medication is taken to avoid the recurrence of myasthenia gravis. Myasthenia gravis, like hypertension and diabetes, is controlled by medication. Without medication, patients are more susceptible to autoimmune-related antibody attacks, which can aggravate their condition.
In addition to medication, there are two other treatments for myasthenia gravis that you can take depending on your health condition and whether or not you need to take them.
First, biological treatment, biological nerve repair cell therapy can effectively solve the problem of myasthenia gravis, good therapeutic effect, high safety, is so far the better treatment of myasthenia gravis therapy
Second, plasma exchange method, this treatment method is relatively special, because it is not all patients can use, this treatment method is used in a narrower scope, usually only used for severe myasthenia gravis patients, and the cost of the therapy is very expensive, the treatment effect is maintained for a relatively short period of time, usually can be maintained in 7 to 15 days or so, to take this method of treatment, but also a helpless choice! It is only to reduce the patient's pain.
Through the above understanding, we know that myasthenia gravis is indeed very difficult to be completely cured, but as long as the treatment is proper and timely, it will still not affect the normal life.
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I would like to say a few words about the treatment of myasthenia gravis, Western medicine is symptomatic to alleviate the symptoms quickly and obviously, but does not get rid of the root cause. And Chinese medicine through dialectical treatment, treatment of disease seeking the root of a fundamental in the spleen, kidneys, liver three organs, the core of the disease mechanism for the spleen qi weakness, liver depression and kidney deficiency, the treatment should strengthen the spleen and qi, tonifying the kidneys and soothe the liver, the square with self-proposed formula to benefit the kidneys and strengthen the spleen decoction plus subtraction treatment, can completely stop the basic cure of Western medicine, only so that is said to be basically cured and did not say that is a complete cure is because I've only been treated in three cases, a case has been 5 years without recurrence, one has been three years without relapse, one has been a year without recurrence, just the course of treatment is longer need the patient's confidence to cooperate with the treatment. One case has been five years without recurrence, one case has been three years without recurrence, one case has been one year without recurrence, only the course of treatment is longer need to have confidence in the patient to cooperate with the treatment, the longest one with three and a half years, the shortest one with two and a half years, traditional Chinese medicine is relatively slow, as long as adhere to the sufficient course of treatment I want to believe that myasthenia gravis are basically can be cured, the Chinese medicine is a profound and profound is the treasure of the medical science.
Myasthenia gravis is an autoimmune disease that involves the neuromuscular junction and is often characterized by drooping eyelids, weakness in swallowing and chewing, dysarthria, and in some cases, limb weakness, inability to walk up stairs, and difficulty in lifting arms. These symptoms often worsen with activity and lessen with rest or medication. Some patients experience weakness of the respiratory muscles, leading to respiratory distress, which can be life-threatening.
Myasthenia gravis is a recurring and fluctuating disease, and the course of the disease and the response to medication varies greatly from patient to patient, so the prognosis is not the same. In clinical practice, brompheniramine tablets are commonly used to inhibit cholinesterase and thus improve the symptoms of myasthenia gravis, and some patients can get a better effect by taking brompheniramine tablets alone. However, more patients will take immunosuppressants to inhibit autoantibodies from attacking cholinesterase receptors and related receptors. Immunosuppressants are often taken for a long period of time, ranging from a few months to several years, and then the dosage will be gradually reduced according to the patient's symptoms and the results of the examination. Thymectomy may be considered in patients with associated thymic lesions (e.g., thymoma), or when tests suggest high myasthenia gravis antibody potency in the blood, or poor response to cholinesterase inhibitors and immunosuppressive drugs. Thymectomy may reduce future recurrences of myasthenia gravis or decrease the dose of medications taken, but some patients do not improve significantly after thymectomy. If a patient is in myasthenia gravis crisis, high-dose immunoglobulin or hormone shock therapy is often preferred to help relieve respiratory distress and save the patient's life.
Myasthenia gravis is a heavy burden for patients and their families. The prognosis for patients with myasthenia gravis varies greatly. Some patients can go for many years without experiencing any worsening of symptoms, while others, even after regular medication or thymectomy, still experience unsatisfactory symptomatic relief, and may even suffer more damage from the side effects of the medication. At present, there is no definite answer to the question of whether myasthenia gravis can be completely cured, but it is extremely important to stabilize the condition by taking regular treatment and avoiding the triggers that lead to fluctuations in the symptoms of myasthenia gravis. We look forward to medical advances that will benefit more patients.
[2017-12-28 Chinese Medical Science Answer]As the title suggests, and thanks for the invitation, to answer this question, one needs to know how patients with myasthenia gravis are generally treated clinically; oral medications are sufficient for mild cases, and ventilator-assisted ventilation is often required for severe cases.
Once the diagnosis of myasthenia gravis is clear in the clinic, anticholinesterase drug treatment should be given. If the efficacy of single anticholinesterase drug is not obvious, adrenocorticotropic hormone or immunosuppressant, thymectomy, plasma replacement therapy can be applied together for comprehensive treatment. In addition to the etiology and symptomatic treatment, various triggering factors of the disease should be avoided as much as possible, various infections should be prevented and drugs that can lead to aggravation of the disease should be prohibited or used with caution.
1. Anticholinesterase drugs should start from a small dose, gradually increase the amount to maintain daily living as appropriate. Commonly used drugs are: pyridostigmine orally, the duration of action of 6 ~ 8 hours; new stigmine orally, the effect of 3 ~ 4 hours; mesostigmine orally, the effect of 4 ~ 6 hours. Pyridostigmine is most commonly used. Potassium chloride and ephedrine can enhance the effect of anticholinesterase and can be used as adjunctive drugs.
2. Adrenocorticotropic hormone can inhibit autoimmune reaction, reduce the generation of AChR antibody, increase the release of ACh in presynaptic membrane and promote the regeneration and repair of motor endplate, and improve the transmission function of nerve-muscle junction. It is suitable for various types of myasthenia gravis.
3. Immunosuppressants For those who are not effective or cannot tolerate adrenocorticotropic hormone, or who cannot use adrenocorticotropic hormone because of hypertension, diabetes mellitus, or ulcer disease.
4. Thymus treatment Thymectomy: for patients with thymic hypertrophy and high AChR antibody potency; patients with thymoma with all types of myasthenia gravis; young women with generalized myasthenia gravis; patients who do not respond satisfactorily to ChEI treatment. About 70% of patients are relieved or cured after surgery. Thymus radiotherapy: For the old and weak, patients with serious complications who are not suitable for thymectomy or those who have recurrence after surgery, deep thymus radiotherapy is feasible.
5. Plasma replacement therapy mainly removes disease-causing factors such as AChR-Ab and other immune complexes in plasma, so as to relieve symptoms rapidly. It is characterized by rapid onset of action and significant effect, but the maintenance time is short and expensive, and it is only applicable to critical and refractory myasthenia gravis.
6. Intravenous immunoglobulin (IVIG) Exogenous IgG can interfere with the binding of AChR antibody to AChR and thus protect AChR from being blocked by antibody. It is especially suitable for the treatment of myasthenia gravis exacerbation, refractory myasthenia gravis and myasthenia gravis crisis.
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Myasthenia gravis (MG) is an acquired autoimmune disease mediated by acetylcholine receptor antibodies, cellular immunity-dependent, and complement-involved, which involves the postsynaptic membrane of the neuromuscular junction, causing impaired transmission at the neuromuscular junction and contractile weakness of skeletal muscle. In a very small number of patients, the disease is mediated by antibodies to muscle-specific tyrosine kinase and low-density lipoprotein receptor-associated protein 4. Its main clinical manifestations are skeletal muscle weakness, easy fatigability, aggravated by activity, and significant relief and reduction of symptoms with rest and application of cholinesterase inhibitors. The average annual incidence rate is (8.0-20.0)/100,000 people.MG can develop at all ages. Before the age of 40, the incidence of MG is higher in women than in men; between the ages of 40 and 50, the incidence of MG is equal in both sexes; after the age of 50, the incidence of MG is slightly higher in men than in women.
Myasthenia gravis subtypes are categorized as:
1. Type I: oculomotor type, the lesion is limited to the extraocular muscles only, and other muscle groups are not involved within 2 years.
2. Type II: generalized, with more than one group of muscles involved. Including: Type IIA: mild generalized type, with mild involvement of limb muscle groups, with or without extraocular muscle involvement, usually without mastication, swallowing and dysarthria, and self-care; Type IIB: moderate generalized type, with moderate involvement of limb muscle groups, with or without extraocular muscle involvement, usually with mastication, swallowing and dysarthria, and difficulty in self-care.
3. Type III: severe radical type, with acute onset and rapid progression, involving the pharyngeal muscles within weeks or months of onset; respiratory muscles within half a year, with or without extraocular muscle involvement, and inability to take care of oneself.
4. Type IV: late-onset severe type with insidious onset and slow progression. gradual progression over 2 years from types I, IIA and IIB, involving respiratory muscles.
5. Type V: myasthenia gravis, skeletal muscle atrophy and weakness may appear within six months of the onset of the disease.
Prognosis of myasthenia gravis:
In patients with oculomotor MG, 10% to 20% recover spontaneously, 20% to 30% are always confined to the extraocular muscles, and the majority of the remaining 50% to 70% may develop generalized MG within 3 years of onset of the disease with progressive involvement of the medulla oblongata and the limb muscles. 2/3 of the patients have a peak in disease severity within 1 year of onset of the disease, and 20% develop MG crisis within 1 year of onset of the disease. Signs and symptoms of myasthenia gravis are exacerbated by certain conditions, such as upper respiratory tract infections, diarrhea, thyroid disease, pregnancy, elevated body temperature, trauma, and use of medications that affect transmission at the neuromuscular junction. Before the widespread use of immunosuppressive drug therapy, the case-fatality rate of MG was as high as 30%, but with the widespread use of mechanical ventilation, intensive care techniques, and immunosuppressive drugs in the treatment of MG, the case-fatality rate (the proportion of deaths directly attributable to MG and its complications) has now been reduced to less than 5%.
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There is basically no cure for this disease, and theoretically there will be a way regardless of Chinese or Western medicine. In reality there is no way. My family once suffered from myasthenia gravis with thymoma, at first the doctor said cutting off the tumor would be good, and there was relief after the surgery. But long term on hormones and strychnine tablets, can maintain a normal life, can not work. Three years after the operation, the condition worsened, the life appeared critical, must be on the medical rescue, the hospital is the ventilator and a large number of hormones to maintain life. Later turned to Chinese medicine hormone care slightly improved, often repeated, and finally the Chinese medicine is ineffective, hormone gat a lot. At this time, life is also coming to an end, to the onset of the death of a total of eight years. This disease is a disaster, but also a great misfortune for the family. In short, this disease is difficult to cure the onset of dyspnea, swallowing weakness, think about it is difficult.
Myasthenia gravis is an autoimmune disease caused by dysfunction of transmission at the nerve-muscle junction. It is mainly characterized by symptoms such as ptosis, blurred vision, diplopia and strabismus. This disease is treatable, and can be treated with immunosuppressants and other medications as well as thymectomy, in which cholinesterase inhibitors, immunosuppressants, plasma exchange, immunoglobulin, and traditional Chinese medicine are mainly used. From the therapeutic effect, a small number of patients can be completely relieved through standardized treatment, but most of the patients can be maintained by drugs to improve the symptoms.
Needless to say, TCM treatment for myasthenia gravis is not only curable, but also free of any negative effects.
Loneliness is called the muscle weakness among psychological injuries, that is, a lonely person will slowly become unable to feel the presence of people around him, he himself does not have the ability to love others, and he does not feel it when others love him, this is loneliness. If you go and suddenly praise a lonely person in an exaggerated way, saying you're great, you're so nice, pay attention, this is the time when it brings not good but harm to him. A severe loner will feel, you are supposed to be making fun of me by saying these things to me. So this is the feeling of muscle weakness, he has no power to recover. The most common symptoms triggered by loneliness are depression, suicide, insomnia, hostility to society, and so on. And to top it all off, the rate of cardiovascular disease goes up steeply in people with loneliness. Doctors say that a person who lives alone for a long period of time causes no less damage to himself than smoking for a long period of time, and the same damage as smoking, it will cause a lot of cardiovascular diseases.
The solution is as follows:
The first is to take off the colored glasses.
When you feel lonely, you have to first take off your colored glasses. What do I mean by taking off the colored glasses? Loners usually have a negative opinion of the world at large.
Tip #2 Identify self-defeating behaviors.
The third trick is to learn to think differently.
In terms of mainstream medicine can not be cured, but the masters in the folk, you can try to appropriate Chinese medicine rehabilitation techniques to adjust!
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