Medicines are often kept in the homes of common people as a precautionary measure. Among them, the ones for treating gastrointestinal related diseases such as excessive production of stomach acid"Antacids."e.g.Proton pump inhibitors (PPIs), is is a class of "home remedies" that are very commonly used by the general public.

提"Proton pump inhibitors."This is a name that you may not be familiar with, but the mention of the many medicines represented under it will not be unfamiliar to the little ones:Omeprazole, esomeprazole, pantoprazole, lansoprazole, rabeprazole .....

In recent years.Research on kidney damage from this type of drug continues to escalate.

Just recently, a study published in the prestigious nephrology medical journal Kidney International added another heavy weight of evidence.

Abuse of razole, feel your kidneys first!

The researchers analyzed more than 140,000 people who used acid-suppressing treatments and were followed for five years.

Of those 140,000 people, more than 120,000 used theproton pump inhibitors.Another 10,000 or so were on another acid-suppressing drug, theH2 receptor blocker(Representative drugs include: famotidine, cimetidine, ranitidine, etc.)

In the following, proton pump inhibitors are uniformly referred to as proton pump inhibitors for ease of differentiation."Radicals."; H2 receptor blockers are called"Tildine-type".

Findings:

In both groups, the group using arazoles had a higher risk of chronic kidney disease, decreased renal function, doubled blood creatinine, and uremia, and a higher risk of diabetes mellitus, chronic obstructive pulmonary disease, hyperlipidemia, and cardiovascular disease.

In the past, many have considered that it is due to the increased risk of each of the chronic kidney diseases due to the acute renal failure mediated by the azoles.

However, this study tells us that even though acute renal failure was not observed in people taking arazoles, the risk of developing chronic kidney disease later in life, and the risk of disease progression, decline in renal function, and even uremia in patients with pre-existing renal disease, is significantly increased.

What this study warns the average person

Given the analysis in previous studies, theThe longer the azoles are used, the greater the likelihood of injury to the kidneys.This is another wake-up call to the public for the chronic abuse and over-indication use of these drugs.

In the treatment of peptic ulcers, peptic bleeding and other gastroenterological emergencies, the current status of arazoles is unassailable and very important. However, it is not to be taken as a generic, take-it-or-leave-it medication for an upset stomach.

According to a U.S. population-wide survey, 7.8% of Americans have used a PPI in the last 30 days, apparently many of them, in a supra-indication, supra-therapeutic regimen, due to the fact that arazoles are readily available for purchase in pharmacies.

Think again about China's chaotic drug management ...... Think about it ..... Before you eat it, feel your "silent protest" kidneys!

Implications for people with kidney disease

People with kidney disease need to be more vigilant than the general population, not to be abused, much less for long periods of time.

For example, many people habitually take arazoles when using hormones, but this is clearly inappropriate based on current evidence, and we cannot ignore the damage it can do to the kidneys.

If no other ulcer-causing risk factors exist, tiotropium can be used as a substitute for those who take hormones that cause mild stomach upset, and while no medication is absolutely safe, try to use it on balance.

here areIt's Kidney Online, a patient education platform that is serious about kidney disease science! If you want to know more reliable knowledge about kidney disease! Just pay attention to the kidney on the line!

References:

1、Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury.Kidney International.

2、Proton pump inhibitors and risk of incident CKD and progression to ESRD.JASN

Life will inevitably have some minor illnesses and pains, some people are quite a bit to pass, while some people will take medication as soon as they are uncomfortable, it is easy to cause harm to the body of the drug. So which commonly used drugs are easy to hurt the kidneys?

1. Antipyretic and analgesic drugs. This is a common class of medications used to treat everyday headaches and fever, including Anacin, Acetaminophen, Phenylephrine tablets, and Pseudoephedrine hydrochloride extended-release capsules. Painkillers such as ibuprofen, indomethacin, naproxen, acetaminophen tablets, and celecoxib can cause liver damage.

2. Herbal medicine. Some people like nothing to eat some Chinese medicine, health care body. In fact, some Chinese herbs have particularly serious kidney damage. For example, Fangji, Aristolochia, Houpu, Tianxian vine, bitter tea, Zebu, fish gall bladder, seahorses, centipedes, poisonous snakes, Cinnabar, Xionghuang and so on. It is best not to take these herbs on your own, but to go through a doctor's animal diagnosis and clear precautions.

3. Antibacterial drugs. Gentamicin and neomycin in the aminoglycoside class have great nephrotoxicity and are the most common causes of drug-induced renal damage. Clinical manifestations of renal injury include proteinuria, oliguria, anuria and other symptoms. In addition, penicillin, vancomycin, norfloxacin, lincomycin, lamivudine, etc. also have a certain degree of renal damage.

4. Antihypertensive drugs. Many elderly people take antihypertensive drugs for a long time because they have high blood pressure. Diuretics, angiotensin-converting enzyme inhibitors, and angiotensin receptor antagonists in antihypertensive drugs can cause kidney damage, and the latter two may cause worsening of the condition of patients with moderate or severe impairment of renal function, and this risk is even higher if diuretics, painkillers, and cold medicines are taken at the same time.

Aggravating your regular medications, it's best to ask your pharmacist before taking them to avoid a lot of unnecessary harm, or if that's inconvenient, at least look at the instructions.

The authoritative interpretation of Pharmaceutical Affairs, unauthorized reproduction, plagiarism will be punished.

Messing around with home remedies can also hurt your kidneys!

Mr. Wang is 40 years old this year, it is said that the man forty a flower, it is a good time to be rich and strong, but Mr. Wang always feel that the body is not strong.

Recently, this situation is getting more and more serious, until not long ago, Wang suddenly swollen all over the body, urinary difficulties, to the hospital, but found a chronic renal failure.

A good middle-aged man, how suddenly kidney failure? In the course of the doctor's consultation with Mr. Wang, he discovered that he had a particularly bad lifestyle habit:

Mr. Wang usually seldom go to the hospital to see a doctor, have a headache and fever, are at home to take their own medicine; sometimes in order to get well quickly, Mr. Wang will also take a little more than the prescribed dosage.

Doctors frankly: some of the family's regular medicines are also drug toxicity, often overdose, very hurt the kidneys! Especially the following three:

I. Antibiotics

Antibiotics can be simply understood as anti-inflammatory medications, and most anti-inflammatory medications are antibiotics.

Antibiotics are commonly used in the treatment of diseases, mainly for antibacterial, anti-inflammatory and pain relief effects. Because of the obvious therapeutic effect, they are doubly sought after by some patients.

However, the end result of misusing antibiotics is to hurt your body and kidneys, and you may even run out of medicine.

II. Antipyretics and analgesics

Cold remedies containing acetaminophen as an ingredient, analgin, aspirin, diclofenac, and acetaminophen are somewhat nephrotoxic.

It is best to consult your doctor for everyday colds and fevers, and not to take medicines on your own, especially not several kinds of cold medicines together.

III. Some gastrointestinal drugs

Gastrointestinal disorders are also common, and some families also keep some gastrointestinal medications on hand, such as lansoprazole, esomeprazole, rabeprazole, omeprazole, pantoprazole ..... These medications are generally known generically as proton pump inhibitors (PPIs), and their main effect is to inhibit the secretion of gastric acid in the body, which in turn aids in the treatment of gastrointestinal disorders.

Patients who regularly take arazoles have a higher risk of elevated blood creatinine, chronic kidney disease, decreased renal function, and renal failure uremia; the longer the use of arazoles, the greater the renal damage, with data showing that arazole users have more than a 20% higher risk of developing chronic kidney disease than non-users.

Urine in the two "abnormal", beware of the kidney is bad:

1、Urine odor

Normal fresh urine has a special faint aromatic odor, while it will present an ammonia odor when it is contaminated by bacteria after being placed for too long. The following two kinds of odor, it is kidney disease coming:

Foul odor: Commonly associated with bacterial infections of the urinary tract, cystitis and purulent pyelitis.

Irritating ammonia odor: usually only smells like stale urine (the kind that comes from unkept urinals).

2, urine color abnormal

Normally, urine is clear or light yellow, but if other abnormal colors appear, it is likely that there is a problem with the kidneys.

When there is hematuria visible to the naked eye, it is kidney function damage leakage of more red blood cells, also indicates that kidney function has been damaged to a very serious point;

When there is a soy sauce color, it may be exercise rhabdomyolysis, acute renal failure.

How to take care of your kidney health on a daily basis?

I. Drink more kidney-supporting tea

Water is a diuretic and a detoxifier, drinking more tea and water helps detoxify the kidneys, increase the metabolism and discharge of urine, and reduce the incidence of pyelonephritis, nephritis, and kidney stones.

People with bad kidneys can usually drink more kidney-supporting teas and waters to benefit the kidneys and detoxify the body.

Self-restraint 番麦须须茶

Recipe: A four-part blend of fenugreek, dandelion, yucca and rose in hot water to help care for the liver and kidneys and reduce inflammation and detoxification.

Fenugreek, also known as cornhusk, has a long history of medicinal value. Fenugreek has an inhibitory effect on calcium oxalate crystals in the urine, which can help treat kidney stones. At the same time, it also has the effect of diuretic swelling, reduce the content of urine protein, to a certain extent, improve kidney function, and is very effective for patients with chronic nephritis.

Dandelion, a great herb for promoting liver and kidney activity, tonifies the liver and kidneys and promotes detoxification. Modern research has also found that dandelion contains vitamin C, vitamin B and dandelionin, which promote liver and kidney activity.

It can improve the edema caused by the kidneys, but also promote the harmful substances through the elimination of the body, also has a good effect on the improvement of nephritis.

While yuzhu nourishes yin and promotes fluid, the fluid has kidney-strengthening properties. Rose plays a harmonizing role and relieves the coolness.

II. Improving the renal diet

1, Chestnut

Chestnut temperature, taste sweet, in addition to the role of spleen and stomach, but also has the effect of tonifying the kidney and waist, kidney deficiency waist pain is the most suitable for consumption.

2, black beans

Black beans are known to the ancients as the valley of the kidney, sweet taste and flatness, not only shaped like a kidney, but also tonifying the kidney and strong body, blood and water, detoxification, moisturizing effect, especially suitable for patients with kidney deficiency.

3, nuclear peach

Walnuts, on the other hand, have the role of tonifying the kidney and essence, diuretic stone, laxative, warm lungs and wheezing, often used in kidney deficiency and back pain, urinary tract stones and other conditions.

III. Optimism

A person, who is consistently optimistic, is not in too bad a shape.

Bad emotions such as sadness, depression, and pain can damage a person's kidney health.

This is because a person with a lot of fire will be irritable; and a long period of time with a lot of fire will eventually damage the kidney health.

Fourth, massage the waist

Methods: two palms rubbed against each other, respectively, put to the waist; palms to the skin, up and down the waist massage, until there is a sense of heat.

Effects: Regular massage of the waist can tonify the kidneys and nourish the qi.

Frequency: Once in the morning and once in the evening, 100 strokes each time.

Note: All images are from the Internet, if any infringement can be contacted for deletion.

1. Cold and pain medication

Some of these drugs contain acetaminophen (paracetamol) ingredients, long time indiscriminate use will cause damage to the human kidney function, liver function, so you can not think that the cold and headache is a small matter, just go to the pharmacy to prescribe medication, be careful with drugs such as aspirin, painkillers and so on.

2. Antibiotics

In the old days antibiotics were used clinically whether they were symptomatic or not, and the situation has improved over the years as national controls have been tightened! For example, streptomycin, gentamicin, kanamycin, amikacin, tobramycin, etc. all have some nephrotoxicity.

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There are some Chinese regular medicines will indeed have certain side effects on the kidney, as the saying goes, it is a medicine that is three times poisonous, so in general it is best not to use the medicine indiscriminately. The following is a brief introduction to some of the drugs that can have side effects on the kidneys.

Various cold and flu remedies such as Anacin, Neptune, and diclofenac sodium preparations. There are also antihypertensive drugs that can cause kidney damage, such as: angiotensin-converting enzyme preparations, angiotensin receptor antagonists, diuretics and so on.

In the Chinese medicine category, Aristolochia, Tian Xian Teng, Bitter Tea, Fish Gallbladder, Seahorse, Centipede and Snake Venom have some side effects.

(Contributed by: Gao Lili, Clinical Pharmacy Department, Plain Hospital, Qianfoshan Hospital, Shandong Province)

After absorption, distribution, and metabolism of a drug in the body, the drug or its metabolites are eventually eliminated from the body through the excretory route. The kidneys and bile are the main excretory organs, while others include feces, saliva, and lungs. The kidneys can be both the primary organ for the excretion of most drugs or their metabolites, but they can also be the primary target organ for certain drug injuries. So, there are some home remedies that can injure the kidneys, which ones are they?

The mechanism of drug-induced renal injury mainly includes tubular injury mechanism, glomerular injury mechanism and vascular injury mechanism, etc., which can ultimately lead to tubular epithelial injury, interstitial nephritis, glomerular disease, obstructive nephropathy, nephrotic syndrome, acute renal failure and so on.

When using the above drugs, attention should be paid to the dosage and course of treatment, and the patients with primary or secondary renal disease should pay attention to the adjustment of the dosage when using these drugs that are harmful to the kidneys, and should not be used in combination with two or more drugs that are harmful to the kidneys. In addition some drugs that are damaging to the kidneys can take preventive measures, such as fluoroquinolones, sulfonamides, cyclophosphamide, allopurinol, etc., and can be used during the use of more water. For long-term use, renal function should be monitored regularly if available.

References:

1Anticancer Drug-Induced Acute Kidney Injury[J]. Kidney International Reports,2017,2(4):504-514

2 2016 Japanese clinical practice guidelines on drug-related kidney injury: digest version

3 He Qiang et al. Drug-related acute kidney injury and its clinical diagnosis and treatment[J]. Chinese Journal of Practical Internal Medicine,2016,36(6):445-448

4 Meng Fanying. Mechanisms of drug-induced renal injury and principles of prevention and treatment[J]. China Community Physician, 2009.

every medicine has its side effect

There are several categories of commonly used drugs that can cause kidney damage:

1. Antipyretic and analgesic

Includes ibuprofen, aspirin, acetaminophen, indomethacin, diclofenac, naproxen, aminopyrine, etc.

The scientific name for antipyretic and analgesic drugs is nonsteroidal anti-inflammatory drugs (NSAIDs), which are often used as the main ingredient in cold and flu remedies and painkillers. NSAIDs should not be taken for long periods of time, and cumulative doses should not exceed 2kg if possible.

2. Radicals:

These include omeprazole, pantoprazole, lansoprazole, rabeprazole, and more.

Users of azoles have a 20% to 50% higher risk of developing chronic kidney disease than non-users.

3. Nephrotoxic drugs in traditional Chinese medicine: aristolochic acid

Aristolochic acid is a constituent of Aristolochia sinensis, which is contained in Aristolochia guanmutong, Guangpengzhi, Tianxianteng, Qingmuxiang, and Xinxin, among other Aristolochia species. Therefore, do not take Gentian Diarrhea Pill etc. for a long time.

4. Nephrotoxic antibiotics

Friends with kidney disease can avoid the more nephrotoxic antibiotics, which include two categories:

First, aminoglycoside antibiotics are the most common class of antibiotics that trigger renal impairment, including, for example, gentamicin, streptomycin, kanamycin, tobramycin, neomycin, macromycin, cisomicin, minocycline, amikacin, nertilmicin, and so on.

Secondly, the first generation of cephalosporin antibiotics also have greater nephrotoxicity, the first generation of cephalosporins include cefthiophene (Pioneer I), ceftazidime (Pioneer II), cefadroxil, cefazolin, cephradine and so on.

Friends with kidney disease need to be careful with the above categories

Drugs, but do not choke on them, it is not advisable to refuse to use drugs to avoid the risk of kidney damage. What we need to do is to remain cautious, follow the advice of a professional nephrologist, and not abuse the medication.

In addition, some common substances in life are also nephrotoxic: for example, decoration materials, paints, whitening cosmetics, hair dyes, etc.; as well as some foods, such as animal liver and gall bladder, poplar peaches, crayfish, etc. Kidney patients should try to minimize the exposure of these substances.

This is a true story. Because of a most common cold, it turned a fairy tale into a human tragedy. In just 2 days, proteinuria suddenly increased to 4+.

Xiao Zhu, just yesterday accomplished a major event in his life, finishing his wedding with his longtime girlfriend. But before he could have his honeymoon, he was hospitalized today.

Xiao Zhu told us that the day before the wedding, just got a cold, in order not to delay the wedding, "crazy" to take all kinds of cold medicine. As a result, it is difficult to maintain a year of negative proteinuria, just two days soared to 4 +, urine a "white" (foamy urine)!

I've got a cold.

What are some of the cold remedies you can think of

It's all about "Shaw".

Tylenol, White Plus, Sensodyne, CombiMed, Crypto, Contac ......

The most important ingredient in these medicines for colds is - acetaminophen (paracetamol). Acetaminophen acts as a fever reducer and pain reliever.

The failure is also due to "Xiao He".

Cold remedies containing acetaminophen are contraindicated in cases of severe hepatic or renal insufficiency.

This is because acetaminophen is a nephrotoxic drug that has a damaging effect on the kidneys. This means that too much cold medicine can cause kidney failure, and it is especially important to note that taking it when you have a high fever, are sweating, your body is dehydrated, and your kidneys are deprived of blood may cause acute kidney failure.

Got a cold.The right way to handle it

-01. "Don't care."

Normally, colds heal themselves in about 1 week. There is no need for excessive worry or treatment!

Look for the cause of the cold, rest, drink water and wear cotton clothing. 2-3 days the symptoms of the cold will be significantly reduced, but if there is a fever or the condition is getting worse, you should consult a doctor, do not hold out.

-02. All-purpose hot water

Winter weather is dry, colds and fever body fluids will be lost in large quantities, pay attention to warmth, drink more hot water, replenish the lost water.

-03. The right medicine, less is better.

It is still quite painful to have a runny nose and sneeze all the time, and from the point of view of relieving the symptoms it is still necessary to take cold medicine. So, what is the best cold medicine for kidney patients?

Less is better!

Any of the common common cold medicines we mentioned above are fine. But you can only take 1 kind, and follow the instructions. In addition, pay attention to the appropriate adjustment of the dose according to renal function, the instructions will generally have a very detailed explanation, if this part of the content is omitted, then it may not be a regular manufacturer, can not be eaten.

If you don't take it blindly or increase the dosage arbitrarily, it will not cause kidney damage easily.

Kidney disease focuses on prevention, and once you accidentally get kidney disease, treat it properly according to your doctor's prescription.

If you have questions about kidney disease or want to know more about kidney disease health knowledge, pay attention to the WX public number: Love Kidney now!

In traditional Chinese medicine, the kidney is the foundation of the body's innate nature, determining the entire process of human growth and development and aging and death.

In Western medicine, the kidney is an important organ in the body to maintain metabolism, acid-base balance, and regulate blood pressure.

The kidney is vital to the human body at any level, but there are always some bad dietary and lifestyle habits that are damaging our kidneys, the most serious of which is the use of medication.

Which common medicines at home hurt the kidneys?

1. Aspirin--Unreasonable use of medication can lead to problems such as interstitial nephritis, renal papillary necrosis, renal failure, and elevated uric acid.

2. Amoxicillin--Unreasonable medication use can lead to chronic kidney injury, acute tubular necrosis, and intrarenal obstruction reins problems.

3. Vitamins--Irrational use of the drug can lead to nephrotoxicity, hypercalcemia, acute renal failure, kidney stones, and renal insufficiency.

4. Diuretic drugs--Unreasonable use of medication can lead to problems such as acute interstitial nephritis, acute renal failure, and hyperuricemia.

5. Pain medication--Unreasonable use of medication can lead to problems such as chronic interstitial nephritis, renal insufficiency, and glomerulosclerosis.

Note: The irrational use of the above categories of drugs is very likely to induce kidney injury, so it is recommended that the drugs must be used reasonably under the guidance of a doctor.

The above answer belongs to personal opinion, welcome to leave comments and share opinions. Favorite forwarding, share to the friends around.

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