Thanks for the invitation!

What do you think of "paracetamol from $400 to $23,300 a month"?

First of all, the price increase is not just paracetamol, but involves a number of APIs, the form of price increases are completely out of the value of the pivot of the continuous surge.

Why is there a spike in API prices?

Finished drug marketing approach extends to APIs

According to public information, the reason for the surge in the price of these APIs is not in the pharmaceutical companies, but in the circulation area.

Some people with high prices, plus high rebates to obtain one or several kinds of API "national general distribution" "national general agent" status, in essence, is to obtain the corresponding drug national monopoly.

Since, there are relatively few API producers, obtaining this monopoly is relatively simple, as long as there is enough financial and resource support. Like paracetamol, there are only six API producers in the country.

Having gained a monopoly position, one can raise prices as much as one likes and reap monopoly excess profits.

This is essentially an extension of the marketing of finished drugs, which has been characterized by "high rebates" over the years, to APIs. Although all levels of government, institutions, pharmaceutical companies and hospitals and doctors do not recognize that there is such a thing as drug rebates.

Even if there is an occasional exposure, it is blamed on the "misbehavior" of an individual.

In fact, we all know very well that "unspoken rules" or "rules of the road" or "rules of the road", since it is a "rule", it is definitely not just an individual's business, but an industry-wide one.

For example, this time the price of APIs skyrocketed, a practitioner confided:

Three years ago, a pharmaceutical buyer received an unfamiliar phone call, said that after the supply of inosine (a drug) APIs with his contact, they are the "national general distributor".

"General Distributor" is just a name, "but in reality it's a monopoly,There are only two or three manufacturers of inosine raw materials in the country, and all the supplies are in their hands.."

The first thing that happened after inosine was "master distributed" was a price increase:

In July 2015, the price of inosine rose from 92~95 yuan/kg to 200 yuan/kg all of a sudden, an increase of more than 100%; in July this year, it rose to 600 yuan/kg. three years rose five times.]

3 years up 5 times, is already ultra-profiteering - the API as stocks, futures to speculate ah, and is only profit, 0 risk of speculation, as long as there is no administrative or legal intervention then.

Why would an API manufacturer sell its distribution and pricing rights so easily?

The same industry insider spilled the beans:

Model Contracts for Master Distributors:Underwriting for two to three years, supply price increases by 30% to 50%And there is [supply price to me (pharmaceutical company marketing staff to raise 30%] secret deductions. And there is also [supply price to me (pharmaceutical company marketing staff) to mention 30%] of the hidden deductions.

Paracetamol soared 58 times in 1 month, this manipulator is probably crazy - tired of living!

Paracetamol, chemically known as chlorpheniramine maleate, is one of the "oldest" and most commonly used medications and is very inexpensive.

Previously, paracetamol tablets were available as a medicine in 4 mg 100 tablet bottles, and 1 bottle was only 1 or 2 dollars.

Paracetamol is more commonly used as a compounding ingredient in cold and flu remedies (almost all cold and flu remedies contain it), and rhinitis remedies.

Therefore, it is the most commonly used and cheapest drug.

APIs are of course very cheap, 400 per kilogram before the price increase, although on the low side, but also considered reasonable, after all, in addition to administrative licenses, there is no barrier to a commodity.

It is reasonable to increase prices appropriately for super-cheap drugs like these. However, like this, a 1-month surge of 58 times, the manipulator is probably crazy, but also tired of living.

This is because it violates at least the Anti-Monopoly Law, the Pharmaceutical Affairs Law, and even the criminal law crime of "disrupting the market order".

For example, Chapter VII of the Drug Administration Law, Article 55 of the Administration of Drug Prices and Advertisements: ...... Drug manufacturers, operators and medical institutions shall comply with the provisions of the competent price department of the State Council on the administration of drug prices, set and indicate the retail prices of drugs, and prohibit profiteering and price frauds that are detrimental to the interests of the users of the drugs.

　　Article 58: It is prohibited for pharmaceutical manufacturers, business enterprises and medical institutions to secretly give or receive kickbacks or other benefits in the purchase and sale of pharmaceuticals off the books.

It is prohibited for a pharmaceutical manufacturer, business enterprise or its agent to give property or other benefits in any name to a person in charge of a medical institution, a drug purchaser, a physician or any other relevant person who uses its pharmaceutical products. It is prohibited for persons in charge of medical institutions, drug purchasers, physicians and other relevant personnel to accept property or other benefits in any name from drug manufacturers, business enterprises or their agents.

That is to say, paracetamol and other raw material drug price surge, not normal market behavior, but someone suspected of monopoly means maliciously disrupt the market order of illegal or even criminal behavior.

I believe that the law will "strike when it is time to strike".

Although paracetamol is a cheap drug, but within a month rose 58 times, this speed even the rocket can not catch up, and then cheap drugs can not withstand this speed of rise. And according to media disclosure, the price of paracetamol is not a pharmaceutical company price, but in the circulation process caused by the monopoly of dealers, as if the pig farmers did not raise the price of pigs, but the price of pork trafficking, such price increases are really puzzling.

Paracetamol is the first generation of antihistamines, clinical application is very wide, mainly used for allergic diseases and relief of tears, sneezing, sniffling and other cold symptoms, is one of the ingredients of many compound cold medicines, is a raw material medicine, like rice, oil and such commodities, once the price increase will cause a chain reaction, the other downstream products will also be price increases, and ultimately out of the pocket of the people still. For such an important basic medicine, the state should strengthen the supervision and management of prices, especially in the circulation of large price increases.

According to reports, including paracetamol, five kinds of APIs were speculated soaring, including phenol even rose 99 times, flour prices, bread can not rise? Paracetamol is already one of the few cheap, after this price increase, I'm afraid there is no cheap medicine. Prior to this, there are often media reports to prescribe a few dollars or even a few cents of low-cost drugs of good doctors, later, medical ethics and good doctors, I am afraid to want to prescribe can not open such a prescription.

I'm not the God of Medicine" reflects the miserable fate of ordinary people in front of the high price of drugs, while the substantial increase in the price of paracetamol is the capitalist's harvest of all people. I hope that the relevant departments can strongly intervene to standardize the price adjustment of APIs, leaving a piece of cheap medicine for the people.

(Image from the web)

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This is a matter in which I hope the state will intervene.

This kind of behavior is already monopolization and it is disregarding the lives and health safety of the people.

Marx really was so right, capital drips blood and filth from every pore.

This price hike in pharmaceutical raw materials is the result of several large capitalists in the upper reaches joining forces to monopolize the supply of raw materials and maliciously raise prices.

What is paracetamol is a common term for a medicine that is closely related to the common man. Who does not have an allergy? And this medicine was not expensive, if the raw material rises dozens of times at once, the price of this medicine does not follow. And this raw material is also an ingredient in our cold medicine, so most cold medicines will follow the rise.

This is a livelihood issue.

I Am Not the God of Medicine, which is still in theaters, reflects how patients are struggling to survive and fight against high drug prices. If the drugs used to treat leukemia are new high-tech drugs and tens of billions of dollars have been invested in research and development, and it is reasonable to sell them at such a high price, then it can still be justified. But this time is completely different, this time the rise in drug raw materials is completely a few big capitalists use the resources in their hands, blackmail, blackmail downstream drug manufacturers.

It's fine if you don't agree to increase the price, then I won't sell it to you, let's see what you do.

In the end, it's we the people who get hurt!

I'm really angry to see this.

The capitalist's abomination is evident in this incident.

1, the public first do not need to panic, raw material drugs rose 58 times, this does not mean that the finished drug, such as chlorpheniramine maleate tablets, will be synchronized with the price increase of 58 times. Although the price of drugs has been canceled ZF pricing (maximum retail price), for ordinary drugs, now have been handed over to the laws of the market to adjust, which does not mean that the price of drugs can be left to the sale of enterprises to do whatever they want, because the final finished product of the retail price of pharmaceutical preparations, the relevant state departments will still be regulated.

2, if you are interested, you can telephone or network query their own location, province or municipality directly under the Centralized Purchasing Platform for pharmaceuticals, you can find the retail price of paracetamol preparations, some provinces and cities in the platform official website can be found, and some identity may need to call the query to be able to. For example, the centralized purchasing platform of medicine in Beijing can find out by itself that the current price of chlorpheniramine maleate (paracetamol) tablets or injections, for different manufacturers, 1 bottle of 100 tablets packaged, its price is within 10 yuan.

3, the retail price of drugs did not increase, the price of raw materials of drugs, may lead to the production of drugs will stop or will not be a large number of production of the drug, because the more production, the loss may be more. The drug itself, paracetamol, belongs to the cheap class of drugs, for example, the price division of the NDRC did a research 10 years ago, and paracetamol is in the catalog of the reality of this cheap shortage of drugs. If this speculation really happens, it will directly lead to the medical institutions or social pharmacies can not purchase this drug, therefore, for the public, it may lead to go to the hospital or big pharmacy can no longer buy this drug.

4. Personal speculation and opinion. Relevant generic drugs with paracetamol as the main potent ingredient may be in short supply in the market for a period of time, possibly in medical institutions in certain areas. If there is a phenomenon of drug production stoppage, the relevant departments should interview the manufacturers of these drugs to study the production plan or subsidy program, or interview the suppliers or manufacturers of APIs to verify the cost and meet the public demand for drugs to the maximum extent possible. In addition, after the re-introduction of these drugs to the market, the retail price may rise slightly, because compared with similar anti-allergy drugs, such as loratadine or cetirizine preparations, the retail price of paracetamol is indeed much too cheap. But don't worry, it won't be an exaggeration like a 58-fold jump.

Welcome to read Wukong Q&A, I am a pediatric pharmacist Mei II Kang, focusing on children's drug safety science for many years, I have my own unique point of view on the interpretation of drugs and parenting, looking forward to your likes, attention, sharing and comments.

"Raw material drugs skyrocketed 99 times": anti-monopoly investigation should be taken against the distributor

Jiang Delbin (1932-), PRC human rights activist

Soaring 99 times the API: pharmaceutical enterprises afraid of cut-off dared to speak out, only the people to pay the bill. Recently, the centralized purchasing network of drugs and medical consumables in Liaoning Province issued a warning notice involving 81 kinds of drugs that cannot be normally supplied and distributed. Due to the monopoly of APIs by dealers, paracetamol rose to 58 times a month, from 400 yuan/kg to 23,300 yuan/kg. phenol rose from 230 yuan/kg to 23,000 yuan/kg, up 99 times.

In a market economy, price increase is not a problem, the key is to see how it goes up. If the market supply and demand imbalance, resulting in substantial price fluctuations, then it is a normal phenomenon, relying on the market's independent regulatory mechanism, you can gradually restore the balance of supply and demand, and then iron out the price fluctuations. But if the businessmen monopolize the market, exclude market competition, relying on arbitrary price increases to obtain huge profits, then it is suspected of monopoly, illegal market manipulation, etc., belongs to be severely cracked down on, punished behavior.

According to the media investigation, "paracetamol rose to 58 times a month, from 400 yuan / kg rose to 23,300 yuan / kg, phenol from 230 yuan / kg rose to 23,000 yuan / kg, up 99 times," behind the market is not due to market factors, it is the distributor and the manufacturer signed a contract to increase the price of the country's exclusive general distribution! Thus monopolizing the supply of APIs, the price also skyrocketed. It can be seen, this is a typical monopoly business behavior, dealers control the supply of APIs, has achieved a negotiation advantage, if the pharmaceutical companies do not accept the price increase, will face the crisis of supply cuts, can only bow down.

APIs are intermediates of medicines, which are indispensable materials, and once the supply is cut off, pharmaceutical companies will not be able to continue production. Therefore, in order to maintain normal production, pharmaceutical companies need to buy APIs at high prices, which directly pushes up the cost of drug production, and these increased costs will also be transmitted to the ex-factory price of drugs, retail prices, and finally by the people to pay the bill. It can be seen that the end of the monopoly of raw materials by dealers, is a small number of dealers to obtain excessive profits, but to the pharmaceutical companies, patients to bear the consequences of illegal price increases, in fact, is not fair.

As the API is completely monopolized by the dealer, price increases do not inspire API manufacturers to expand production, increase market supply, stimulate market competition, but also did not play the price lever of the market adjustment effect. It can be seen that the monopoly operation led to price increases is not a reasonable behavior, is a deformed market control, dealers rely on the monopoly advantage, the upstream and downstream control in their own hands, the supply of raw materials, prices are at the mercy of.

The supply of drugs is a social and livelihood issue, which is related to the immediate interests of the majority of patients and should not be underestimated. Therefore, the regulatory authorities can not sit idly by, to realize the social harm of the dealer monopoly of raw materials, according to the law on its anti-monopoly investigation, if the evidence is conclusive, the dealer to take punitive fines, and forced to terminate the illegal contract, break the monopoly trading chain, the supply and demand of raw materials back to the market competition.

At the same time, the competent authorities of the pharmaceutical industry should also modify the standards in due course, to liberalize the production and supply of APIs, and no longer issue separate approvals, as long as the manufacturers comply with the pharmaceutical production standards and environmental protection standards, they can independently decide on the production of APIs. Thus realizing the market-oriented supply of APIs and competition, in order to eliminate the monopoly caused by the inflated price space, to ensure the unimpeded supply of APIs, reduce the burden of pharmaceutical companies and patients.

There are policies above and strategies below, drug reform has been imperative, this has been the mainstream direction to do things, but also the people's heart, the important issue of the immediate interests of patients and their families, after all, in the treatment of illnesses and medication expenses is indeed the main source of a family's burden, crushing many families, and in these things also concerns another group of interests, this group is the production, supply and sales of drugs, and the people. This group is the people who produce, supply and sell medicines.

The high profits of drugs has long been no secret, part of the doctors and manufacturers linked to take kickbacks has also been exposed many times, all of this is linked to the interests of money, every industry will have competition, there will be a variety of competition will have a variety of schemes, open and shut and behind the back of the play Yin's existence, and the interests of the existence of a separate link is not just a chain of things, touch a link will involve all the links above the entire chain of interests! It is a chain-like thing, touching a link will involve the interests of all the links above the entire chain.

Like this health care reform to allocate some of the drugs into the scope of health insurance, most of the anti-cancer drugs collective price cuts, all because of a movie, before this movie came out, many important generic prices are strangely high, some are not even cheaper than still in the patent protection period of the original drug to where, the original drug is expensive mainly due to the previous R & D investment is huge, and what is the rationale for the generics are expensive, why a movie came out to cause great resonated when these generics were drastically reduced in price, whereas before that drug prices were frighteningly high.

Said that these price cuts are voluntary that is absolutely impossible, said the manufacturer's conscience that is also a lie, it can be said that these are the external pressure to force these manufacturers to reduce prices, of course, these behaviors will certainly make the price cuts after the profits than before the price cuts a lot less, these will affect the entire chain above the interests of each link, in the face of these interests can take up and put down accepted by few people, but in this link there is no way to change anything, only from other aspects to make up for the losses in this, the problem is. But in this link there is no way to change anything, only from other aspects to make up for the loss in this, the problem comes.

In fact, the relationship between raw material suppliers and drug manufacturers is not just buying and selling relationship, there is a deeper kind of relationship, this kind of partnership is not too much to say that the family is also a loss, the exchange of equal benefits is not as simple as on the surface, the high and low prices of drugs sold directly affect the interests behind the top of the hope that the price of drugs a little bit lower, so that the interests of the people in line with the interests of the stability of the manufacturer, and the manufacturer of course, want to drug Prices higher, so that you can get more benefits, but can not defy the will of the above, how to do? Only from the source to think of ways, the price of raw materials is high, that is equal to the cost is high, of course, the price of drugs can not be lowered so that the reason is sufficient, anyway, the user has no way to resist.

General some things high prices are basically related to some monopoly, only monopoly can free pricing, like this paracetamol a month skyrocketed more than fifty times, which inside a monopoly of the problem is very obvious, this is not caused by the scarcity of raw materials, these are man-made, some people want to raise the price of the virtual means of coaxing the way to some people to pressure to get more benefits, can be said to be bold and daring, and can also be said that this Is playing with fire, can even say that this is a demonstration, can imagine that dare to do so must be strong enough, the general public who dare, their own to make up for the complexity of the relationship between the inside of the brain.

The price increase of paracetamol raw materials is not an isolated phenomenon, in addition to paracetamol accident, many other drugs have followed the rise of raw materials. What causes the raw materials of drugs to rise so rapidly?

First of all, the improvement of living standards, prices rise, pharmaceutical raw materials as a commodity its price increase is also inexcusable.

Secondly, prices have risen, then people's wages are naturally rising, which has led to a lot of human resources costs of APIs have also risen, these rising capital naturally have to be counted in the cost of APIs.

Again due to environmental restrictions, the production of API by-products can not be comprehensively utilized up, which leads to the situation of the supply of APIs in short supply, in the case of short supply, prices will naturally rise.

Finally, the high demand for APIs, a variety of flight inspections are a number of small enterprises, unregulated enterprises may have closed down, leaving only some large enterprises to produce, which is likely to cause a monopoly situation.

Then the raw materials rose, the people will face what? Like paracetamol so commonly used basic drugs are up so quickly, the cost of expensive, no doubt, made of preparations will naturally become higher costs, as for the magnitude of the rise will not want to dozens of times as raw materials, this is not easy to say, but the price will certainly rise.

But we all know that drugs are not like other commodities, drugs are necessary to cure the sick and save lives, is indispensable to everyone, so the price of drugs naturally can not want to house prices above the bottomless rise, so this requires the state to intervene, through a variety of means to stabilize the price of medicines to meet the needs of the masses of the people, for the artificial monopoly of medicines or raw materials for the act of cracking down on the commercial bribery will never be condoned and condoned. Commercial bribery will never be condoned.

The above is only a personal opinion, not as a basis for the use of medication, please use the medication under the guidance of a physician, any questions or views are welcome to leave a comment at the bottom of the article.

The authoritative interpretation of Pharmaceutical Affairs, unauthorized reproduction, plagiarism will be punished.

The reasons for the rise in raw materials are manifold. Some resources have actually been on a rising trend for a long time, but need a driving force. Paracetamol is a good example.

And what is this prompting force? That would be state policy. It's not that the state wants drug prices to go up. So what are the policies here? Such as the provisions of drug consistency evaluation, strict quality supervision, camp reform and increase, and more and more strict environmental protection policies and environmental protection inspections.

All these policies can make raw materials rise. But it is not possible to make raw materials rise substantially. The real reason is monopoly and speculation. There are two aspects here.

[1] raw material manufacturers have long wanted to increase prices, but there has not been a very reasonable "reason". The state of these policies, just so that manufacturers have found an excuse, and then the surge.

[2] Some people take advantage of this opportunity to hoard large quantities of raw materials. As a result, the market demand exceeds supply, the price is bound to rise, and then wait for the right time to sell the goods in hand.

After prices have risen, it is generally very difficult to bring them down again, especially for these essential items. The rise in raw materials will definitely lead to a rise in drugs, which will then be paid for by the people.

First of all thanks for the invitation! Paracetamol, a constituent of commonly used medicines! The market capacity is particularly large! Prices may have skyrocketed for the following reasons, first, China has always been a big country of APIs, but in recent years the environmental protection check is particularly strict, may be related to the impact of environmental protection restrictions on the production of production shutdowns, so that the cost of production to increase! Second, from the competition in the market, so that the supply of APIs less pharmaceutical companies are suppressed!

The state must regulate the price of APIs to prevent monopoly formation!

As a 10,000 production enterprises have to say, certain people's greed, take the national livelihood of the drugs to earn black money, the cost of unnatural rise, monopolize the market supply, the pharmaceutical company how to do? What about the patients? Have been waiting for half a year, looking forward to the country directly intervene to crack down on similar behavior, chlorpheniramine maleate is just one of them, there are more raw materials in the operation, the market has been messed up, waiting for the country to take action, for the people to get rid of the harm!