People often experience a variety of pain, and many people who experience pain in their bodies go to the drugstore to buy painkillers to eat. As a result, painkillers are almost a must for every family. Pain patients to take more "pain" attitude, so the habit of long-term painkillers, this is feasible?

What the people usually call "painkillers".Commonly used are aspirin, anti-inflammatory pain, propofol and paracetamol.This is the most widely used class of medication for quick relief of pain symptoms. Most of these drugs are OTC, meaning they can be purchased at a pharmacy without a doctor's prescription, which can lead to drug abuse.

Experts suggest that painkillers are double-edged sword, reasonable use can reduce pain; but if long-term use, especially abuse, will cause serious damage to human health.

Adverse effects of long-term application of pain medication

(i) Gastrointestinal damage:Sodium salicylate, indomethacin, aspirin, prednisone, meprobamate, and piroxicam may cause dyspepsia, erosion of the gastric mucosa, bleeding from gastric and duodenal ulcers, and in severe cases, perforation.

(ii) Kidney damage:Ibuprofen and naproxen, which can cause nephrotic syndrome; ketoprofen, which can cause membranous nephropathy; and indomethacin, which can cause renal failure and edema.

(iii) Liver damage:Most painkillers can cause liver damage; long-term high-dose use of acetaminophen can cause severe liver damage, especially liver necrosis; high-dose use of prednisone can cause liver damage, producing jaundice and hepatitis; the use of salicylates in idiopathic patients can cause liver damage.

④ Cardiovascular damage:Recent research data suggests that long-term use of NSAIDs significantly interferes with blood pressure, increasing mean arterial pressure and the prevalence of cardiovascular disease. An increase in the relative risk of cardiovascular events, such as heart attack and stroke, has also been reported in patients taking rofecoxib for 18 months.

⑤ Inducing tumors:Some painkillers have the risk of inducing renal pelvis, bladder, and papillary cancers when taken for long periods of time.

(vi) Adverse neurological reactions:Headache, dizziness, tinnitus, deafness, amblyopia, drowsiness, insomnia, sensory abnormalities, and numbness may occur. Some symptoms are uncommon, such as hyperactivity, excitability, hallucinations, tremor, etc. The incidence is usually <5%.

(vii) Adverse effects in pregnancy:Non-steroidal anti-inflammatory painkillers are considered a potential trigger for acute fatty liver in pregnancy; aspirin, taken during pregnancy, can cause bleeding before, after, and during labor; and indomethacin may cause short limb malformations and penile hypoplasia in the fetus.

(8) Hearing impairment:Long-term use of painkillers can lead to hearing loss.

⑨Allergic reactions:Many painkillers can cause asthma, urticaria, and allergic rhinitis, and atopic reactions such as angioneurotic edema can occur in atopic individuals.

If you blindly take painkillers without knowing the cause of the pain, although the pain symptoms can be temporarily relieved, it hides the cause of the disease, so that the diagnosis loses an important basis, which is not conducive to early diagnosis and treatment. Therefore, the treatment of pain should be based on etiological treatment, supplemented by analgesic treatment.

(Duty Editor: Tomomi)

Pain is an unpleasant sensation and emotional feeling, and painful episodes can make it impossible to eat, sleep, and interfere with daily life. Pain is very common and most diseases have the potential to present with pain symptoms. Many people, due to the lack of medical knowledge, often take painkillers to relieve pain, and the abuse of painkillers is very common. The painkillers mentioned here are non-steroidal antipyretic and analgesic drugs that can be purchased casually at the drugstore, commonly aspirin, acetaminophen, analgin, indomethacin, ibuprofen, diclofenac sodium and other drugs. Other opioid analgesics are commonly used for cancer patients and are not readily available due to strict controls, and are generally not accessible to people with common ailments such as headaches and fever.

What are the dangers of prolonged use of antipyretic and analgesic drugs?

1. Gastrointestinal reaction Painkillers have greater damage to the gastric mucosa, can cause nausea, vomiting, epigastric discomfort, large doses can induce and aggravate ulcer and gastrointestinal bleeding, so patients with ulcer disease should be prohibited. It is generally required to be taken after meals to reduce stimulation of the gastric mucosa. Irritation of the gastrointestinal tract is the most important adverse reaction of antipyretic and analgesic drugs, and the risk of serious gastrointestinal toxicity in patients with long-term application of antipyretic and analgesic drugs is three times higher than that in patients who do not use such drugs.

2. Liver function damage Most antipyretic and analgesic drugs can lead to liver damage, but most of them are temporary, and liver function can be restored to normal after stopping the drug. However, there are some more serious or fatal, especially the elderly and chronic liver disease patients, unreasonable use may occur more serious damage. Large doses of POTASONE can cause liver damage, producing jaundice, hepatitis, etc.; overdose of acetaminophen, and even reports of hepatic necrosis.

3. Renal function damage The long-term use of antipyretic and analgesic drugs may lead to the dirty damage of renal function, manifested as acute renal insufficiency, interstitial nephritis, renal papillary necrosis, glomerular filtration rate decreased, acute renal failure, etc. Ibuprofen, indomethacin, hydroxypolyprednisolone and aspirin, etc. can almost always lead to renal damage. The higher the dosage, the more serious the resulting condition. Acetaminophen can cause renal colic or acute and chronic renal failure if applied in large quantities over a long period of time, especially in people with low renal function.

4. Coagulation disorders Painkillers can prolong bleeding time and can cause bleeding in patients with severe liver damage, low prothrombinogen, vitamin K deficiency and hemophilia, and should also be discontinued in patients one week before surgery to prevent bleeding.

5. Effects on blood cells Analgesic drugs may cause thrombocytopenic purpura, granulocytopenia and aplastic anemia. Among the antipyretic and analgesic drugs, indomethacin, pau tazone, diclofenac, anandamide, aminopyrine and ketoprofen have more serious effects on the blood system.

6. Cardiovascular effects Clinical use of celecoxib has been shown to result in a higher risk of cardiovascular events with prolonged use than without the drug. The FDA has suggested that an increased risk of adverse cardiovascular events may be a response to all antipyretic and analgesic drugs.

As a gastrointestinal surgeon, I am very qualified to answer this question.

I have read the answers of the previous few friends, has listed very clearly, long-term consumption of fenpropidol, fotarabine, aspirin, anti-inflammatory pain, pau tazone, paracetamol and other painkillers, there are many side effects, the emergence of gastrointestinal reactions, liver and kidney function damage and so on, let me give you an example of the dangers of long-term consumption of painkillers.

As a gastrointestinal surgeon, I have treated many patients with gastric perforation, and a large portion of these patients, just took oral painkillers for a long time. There is a 65-year-old patient, because of arthritis, long-term shoulder and knee pain, he did not go to the doctor, he went to the pharmacy to buy their own painkillers to eat, at first a day to eat a piece of effective, and then not, the more you eat more and more, has been required to eat three times a day, each time to eat two tablets to be effective. Finally, one morning, the patient was woken up by joint pain, and immediately took two painkillers orally on an empty stomach. After half an hour, the patient experienced a knife-like pain in the upper abdomen, which then spread to the whole abdomen, along with fever, nausea and vomiting. He realized that it was bad and rushed to our hospital. The emergency doctor knew the problem as soon as he asked him about it and took X-ray, which showed a large amount of free gas in the abdominal cavity and oozing liquid around the stomach, which was a gastric perforation caused by the painkillers. The stomach had broken through a hole, and the strong acidic gastric juice, gas, and food residues inside the stomach leaked into the stomach, causing diffuse peritonitis, which, if not operated on, could lead to infectious shock and the patient's life would be in danger.

This picture above is a standing abdominal film, and you can see that there is free gas in the abdominal cavity, which is direct evidence of a GI perforation, and this patient was later operated on to repair the gastric perforation. Therefore, I would like to caution everyone that painkillers should not be taken casually, and that they must go to the hospital and follow the doctor's advice. Taking painkillers for a long period of time can not only cause gastric perforation, but also gastric hemorrhage, which is equally dangerous, and in the case of hemorrhage, life-threatening.

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As the saying goes, any drug taken for a long period of time will have side effects. When using the drug, you have to fully weigh whether the benefits outweigh the drawbacks or the drawbacks outweigh the benefits; if the benefits outweigh the drawbacks, then it can still be used under the condition of monitoring the side effects, but if the drawbacks outweigh the drawbacks, then you need to consider stopping the drug.

The same is true for painkillers, for a patient with advanced tumor, painkillers are essential, this time can not consider too many side effects, and even the dosage can be increased, but only in the use of drugs based on the combination of other drugs to reduce the side effects, for example, some non-steroidal anti-inflammatory pain relievers stimulate the stomach, need to be combined with acid-suppressing and mucous membrane protective agents, some of them have liver and kidney function damage, then it is necessary to regularly review the liver and renal function indicators and timely correction or adjustment of the variety and dosage of painkillers. Kidney function indicators and timely correction or adjustment of the variety and dosage of painkillers.

For the average person, there is no need to take painkillers for long periods of time, and those that can be taken for long periods of time are more or less addictive.

Here I give you a real clinical case: that is a 49-year-old chronic, because of liver damage admitted to the hospital, laboratory bilirubin is close to 10 times the normal, coagulation is extremely poor, prothrombin time up to 24s, thromboplastin activity up to 39%, reached the standard of liver failure. Follow-up history of the patient from the age of 10 years old began to take long-term paracetamol, usually a headache and fever to eat two tablets, back pain to eat a piece, tired to eat a piece, and finally nothing to chew a piece, and now is not eaten on the hard, painkillers into the box to buy. Finally, after treatment, life is saved, and guaranteed not to eat in the future, but really can not control it is not good.

What I want to tell you here is that pain is the body tells us where the problem is, and finding the cause of the pain is the key, pain relief is only a temporary means of slowing down the discomfort, and I hope that we can do and cherish!

Dr赵

First of all, thank you for your question. The question of what happens when you take painkillers for a long period of time should first clarify the two questions of for what reason you are taking painkillers and what type of painkillers you are taking. Here is a brief description of painkillers.

Painkillers can be broadly categorized into three main groups:

1, non-steroidal anti-inflammatory painkillers. Commonly used aspirin, ibuprofen, paracetamol, celecoxib and so on. Pain relieving effect is relatively weak, no addiction, more widely used, the efficacy of the exact, for general pain.

2. Central painkillers. Tramadol as a representative, is a synthetic central painkiller, belongs to the second floor of the psychotropic substances, non-narcotic painkillers, its pain-relieving effect than the general antipyretic and analgesic drugs to be stronger, but less than the narcotic painkillers, its pain-relieving effect is morphine 1/10. mainly used for moderate degree of all kinds of acute pain and post-surgical pain.

3. Narcotic painkillers. Represented by morphine, pethidine and other opioids. These drugs have a strong pain-relieving effect, but long-term use will be addictive, and these drugs have a strict management system and cannot be used arbitrarily, mainly used for advanced cancer patients and so on.

For the use of painkillers is the need to strictly grasp the common such as neck, shoulder and lumbar pain should be preferred to non-steroidal anti-inflammatory analgesic drugs, such as fen-phen. For patients with fever accompanied by toothache and headache, antipyretic and analgesic drugs such as aspirin and anti-inflammatory pain should be preferred. For patients with advanced cancer should follow the principle of treatment according to the ladder, the last choice of opioids. Therefore, without the guidance of physicians or pharmacists in formal medical institutions, not to judge on their own to choose to take pain medication, especially long-term pain medication, there may also be a delay in the condition, resulting in drug abuse and other adverse effects on the body and mind may bring unnecessary harm.

I hope the above answer will help you.

The authoritative interpretation of Pharmaceutical Affairs, unauthorized reproduction, plagiarism will be punished.

Painkillers can really be described as a miracle drug, in the area of pain relief is really immediate, but things have two sides, painkillers are also not everything, long-term use of the human body will have side effects.

Painkillers can be roughly divided into two categories, one is that we don't need a doctor's prescription, we can buy the drug in the pharmacy, this kind of painkillers composition for non-steroidal anti-inflammatory drugs, such as aspirin, ibuprofen and so on, we know, it can quickly relieve the pain; and there are central analgesics, such as morphine, Dulcolax and so on, this kind of drugs for the restriction of the use of drugs, we can't buy it in the drugstore, even in hospitals, it can only be used under special circumstances because of their addictive properties. Therefore, the painkillers we focus on here are NSAIDs.

Non-steroidal anti-inflammatory drugs are generally applied to joint pain, rheumatism patients with the most, short-term use of non-steroidal anti-inflammatory drugs does not affect the human body, in the symptomatic improvement of the drug can be discontinued, but non-steroidal anti-inflammatory drugs can not be removed from the root cause of the disease, and there is a drug-resistant, many patients in the discontinuation of medication, not only the pain than the previous more serious, and the effect of taking medication is also not obvious.

Long-term use of painkillers may also have the following effects on the body: 1. affect the function of the gastrointestinal tract, gastrointestinal tract irritation, and increase the risk of peptic ulcer; 2. affect the liver and kidney function, long-term use of the liver will make the liver transaminases rise, but also affect the blood flow of the kidneys, so patients taking painkillers for a long time need to be regularly rechecked for 1-2 months of the liver function, kidney function; 3. may increase the risk of cardiovascular and cerebrovascular disease, studies have reported that smoking and obese patients, taking painkillers have a higher risk of heart disease. Risk, some studies have reported that smoking and obese patients, taking painkillers have a higher risk of heart disease. Therefore painkillers should always be used on the advice of a doctor.

Taking painkillers for a long period of time can be very harmful to the body. There are two common types of painkillers on the market today, non-steroidal anti-inflammatory drugs (NSAIDs) and central painkillers. Common painkillers are aspirin, painkillers, paracetamol, pau tazone, rofecoxib, ibuprofen, and intazacin.

The use of pain medication in the population is very common, such as toothache, joint pain, headache, these conditions, menstrual cramps in girls, this is when people think of taking some pain medication first to ease the pain. Over time, especially the elderly. Inevitably, there will be some side effects produced by painkillers. There are many side effects produced by painkillers.

First and foremost the use of painkillers can mask the original condition, making it difficult for doctors to determine exactly what is wrong and causing the pain.

The next thing is that long-term use of pain medications, especially centralized ones, can create a certain level of dependence.

Point 3, long-term use of pain medications, especially NSAIDs, is most commonly associated with gastrointestinal symptoms, causing peptic ulcers, and even peptic bleeding and peptic perforation. It is more common clinically.

The fourth point is also more common in the clinical pain medication-induced renal damage. Generally, the tubular damage has been the main manifestations such as low specific gravity urine, increased nocturia, a small amount of proteinuria, and gradually develop into glomerular injury, resulting in chronic renal failure. This is also a situation often seen in our nephrology department.

Other side effects, including liver damage, thrombocytopenia, bleeding tendencies, and allergies.

Painkillers are best described as a three-pronged poison. Therefore, I suggest that we do not use painkillers easily, and long-term use is even more important.

I would like to say a few more words about menstrual cramps in girls, make sure you go to a gynecologist to get professional advice from a gynecologist!

Good health.

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　　If abnormal pain occurs, it is best not to blindly and indiscriminately take painkillers, but to go to the hospital as soon as possible to ask the doctor to identify the cause of the disease and treat the symptoms. Many pains, especially pains in internal organs, make it difficult for patients to identify what exactly is wrong. If you blindly and prematurely take painkillers, although you can temporarily relieve the pain, but due to the painkillers mask the location and nature of the pain, not conducive to the doctor's observation of the condition and determine the location of the disease, is not conducive to the doctor's correct diagnosis and timely treatment.

　　In addition, after taking painkillers so that patients temporarily feel no pain, but in fact the disease may be in further deterioration, such as ectopic pregnancy hemorrhage, appendicitis secondary necrosis and perforation, this temporary pain will cover up the real condition, will make the development of the disease aggravated, resulting in serious consequences. Abuse of painkillers refers to the arbitrary use of painkillers for a long period of time, in excessive dosage, or without a strict understanding of the indications, not in accordance with the doctor's orders or drug instructions. This may bring all kinds of harm to the body due to some side effects of painkillers themselves.

　　Painkillers are generally divided into three categories: the first category is antipyretic analgesic anti-inflammatory drugs, such as aspirin, ibuprofen, etc., can be used for general common pain, non-addictive, but long-term use of gastrointestinal stimulation, may lead to gastritis and peptic ulcers. The second category is narcotic analgesics, including morphine and cocaine, which are addictive for long-term use and should not be applied casually. The third category is class II psychotropic drugs represented by tramadol, drugs with mental dependence, which are hard to not use and addictive for long-term use.

　　When people are in pain, it is easy for them to take painkillers on their own and medicate the pain away. However, misuse of painkillers can have serious consequences. Some painkillers can cause allergic reactions, many painkillers can cause asthma, urticaria, allergic rhinitis, etc., but also angioneurotic edema and other allergic reactions, such as aspirin, anti-inflammatory pain can cause asthma and so on.

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There are many patients in their own pain when they go to the pharmacy to buy painkillers privately, which if nothing wrong okay, if once any serious side effects or not worth it. So, if the body appears what uncomfortable pain in the doctor's guidance, reasonable medication, can not be clever painkillers a pass buy haphazardly eat.

What are the dangers of taking painkillers for a long time?

Painkillers can reduce the pain associated with tissue damage, but they can also have some adverse effects with long-term use.

1: Long-term use of painkillers can easily lead to abnormal gastrointestinal function, such as gastric mucous membrane erosion, gastric perforation and other serious symptoms.

2: There is also damage to the kidney, such as ibuprofen and other painkillers, long-term use may also lead to nephrotic syndrome. Ketoprofen may also lead to membranous nephropathy when taken for a long time. There are other painkillers that can cause kidney edema and so on.

3: ingested drugs are to be decomposed through the liver, if long-term use of painkillers is likely to lead to liver damage, elevated jaundice, hepatitis, etc., and in severe cases, liver necrosis.

4: Tumors are caused by many factors, of which if you overdose on the same drug it is likely to cause cancer.

Some people, who may have necrosis of the head of the bone and femur, or who may have a herniated disc, often take painkillers, which are three times more poisonous than other medicines, and there is no harm to the body. And people, buy their own painkillers, medicine is no science, may be a piece of painkillers, is a part of the self does not hurt, but at the same time he also masked the symptoms of other diseases, may delay the treatment of other diseases. In medicine, this is called masking the symptoms! There are also painkillers that are addictive, such as opioid painkillers, which can make people addicted and dependent, and there are also allergies, stomach injuries, and liver injuries.
etc.