Febuxostat is a kind of uric acid lowering drugs, uric acid lowering drugs are divided into drugs to inhibit uric acid production and promote uric acid excretion of drugs, febuxostat belongs to the former category, and it is the same kind of allopurinol.

What are drugs that inhibit uric acid production? In our body there is a substance called purine, purine through a series of metabolic changes, the final product formed in the body is uric acid. When the purine metabolism is disturbed it will cause gout.Febuxostat and allopurinol are drugs that inhibit the metabolism of purines to produce uric acid.

Data statistics, 30% of gout patients belong to the uric acid production of excessive type, that is to say, this part of the patient basically have to use allopurinol or febuxostat to treat; there are also to uric acid excretion drugs such as benzbromarone and so on is ineffective or allergy intolerance gout patients also need to use febuxostat treatment.

So, is it an allergic reaction to febuxostat when you have recurrent gout after taking it? Should we switch to allopurinol or benzbromarone? Today we will talk about it.

Febuxostat is a first-line uric acid-lowering drug in China, but not in Europe and America

We cannot deny the uric acid-lowering effect of Febuxostat. Generally speaking, Febuxostat is mainly cleared through the liver, so people with mild to moderate renal insufficiency can do without dose adjustment; compared with allopurinol, the use of Febuxostat causes less likelihood of rash and other hypersensitivity reactions, and there are few drug interactions. Therefore, febuxostat is more popular among gout patients and is also widely known. But on the other hand, we still need to look at this drug rationally.

Febuxostat is the recommended first-line uric acid-lowering drugs in China, but Europe and the United States will be listed as an alternative to allopurinol, generally used when allopurinol intolerance or poor efficacy; and into the medical insurance drug catalog of febuxostat, but also in the medical insurance to use restricted to allopurinol intolerance range.

Why is this? It's because febuxostat has potential cardiovascular risks. Prior to the approval of the APEX and FACT trials, febuxostat was black boxed and warned in the United States because of the increased incidence of cardiovascular adverse events in the febuxostat 80mg/120mg group; however, recent studies have shown that febuxostat does not increase cardiovascular all-cause mortality.

In China, with the entry of febuxostat into the medical insurance catalog, its price has been reduced.However, what some gout patients have reflected to Dr. Liu is that the uric acid lowering effect of the new version of Febuxostat has been reduced. Dr. Liu feels that firstly, we need to know whether its dosage has been changed, and secondly, we need to make sure that it is the result of the findings through multiple uric acid tests.

In contrast to allopurinol, febuxostat does not need to be tested for the HLA-B*5801 gene, which is a high-risk gene for allopurinol-induced hypersensitivity reactions. What is allopurinol hypersensitivity reaction? It just includes severe erythema multiforme, herpetic epidermal necrolysis and laxity, exfoliative dermatitis, etc. Its incidence in Han gout patients is 6/1000.

Precisely because of febuxostat's current stronger uric acid-lowering effect, less chance of causing hypersensitivity reactions, and the drug's lower risk of increasing sudden cardiac death in Asian populations, then we still recommend febuxostat as a first-line uric acid-lowering drug for long-term use in gout patients.

Generally speaking, more than 90% of gout patients are able to maintain their blood uric acid level up to the standard through febuxostat, but patients with co-morbid cardiovascular diseases still need to use it with caution and should seek medical help when they experience panic and palpitations.

Febuxostat tends to cause gouty flare-ups at the beginning of the medication, but this problem can be solved

In general, febuxostat can be taken independent of food and gastric acid, and can be administered once a day, with no need to change the dose in patients with mild-to-moderate renal insufficiency (Ccr 30-89 ml/min) and in patients with mild-to-moderate hepatic insufficiency (Child-Pugh classes A and B).

If using febuxostat for the first time, it is recommended that the starting dose start at 20mg and monitor the blood uric acid level after 2 weeks; if the blood uric acid level is substandard, then increase the dosage to 40mg, and it is generally not recommended to exceed 80mg.Some patients will be very eager to use a large amount of febuxostat after two weeks of non-compliance, which Dr. Liu believes is not desirable, after all, self-addition can really lead to a variety of problems, such as elevated liver enzymes.

Well, the initial period of febuxostat administration can easily lead to gouty attacks. In a nutshell, a change in blood uric acid levels leads to the mobilization of urate crystals deposited in the tissues. Doctors often refer to this as "crystallizing pain" or "secondary gout" caused by a significant drop in blood uric acid levels. Generally, this symptom is less painful than acute gouty arthritis, and in some cases there may be no swelling at the site of the pain.

What is the cause of this? We still want to say our "uric acid pool". "Uric acid pool" refers to the total amount of uric acid in our body, the normal pool of uric acid in the body of blood uric acid amount of 1200mg, gout and hyperuricemia patients because of excess uric acid production and can not be excreted in a timely manner, then the total amount of uric acid pool will rise.

Our uric acid pool consists of free blood uric acid in the blood and tissue fluids and urate crystals deposited in the joints, cartilage, synovium and surrounding tissues. Whether you have gout or hyperuricemia, the uric acid in the uric acid pool is normally in a dynamic balancing process, which means that as long as the uric acid is not suddenly elevated or suddenly lowered, it will actually still be fine with each other.

However, after the application of febuxostat, of course, including the application of benzbromarone or allopurinol and other uric acid-lowering drugs, there is often a sudden drop in blood uric acid levels at the beginning of the uric acid-lowering process, and then the blood uric acid in the tissue fluid and the bursa fluid will also be reduced, and then the urate crystals that are attached to the synovial membrane, cartilage, or soft tissues of the joints will disintegrate, and the dislodged urate crystals, once phagocytosis, will be swallowed by phagocytic cells, and then there will be recurrent gout attacks. recurrent attacks of gout will occur.

There are also unique clinical features that occur with this condition, including:Gout attacks increase in number or even will not be relieved, but the degree of pain will be relatively mild; with the adherence of uric acid-lowering drugs continue to use, the frequency of its attacks will gradually reduce; generally, if the beginning of the use of high-dose febuxostat, it is easy to this acute gouty situation; with the reduction of the number of attacks, the volume of urate crystals in the joint cavity can be found through the examination will also be reduced.

That said, the occurrence of crystal lysis pain after taking febuxostat is common and demonstrates the uric acid-lowering effect of febuxostat. Common means that 70% of gout patients will experience crystal lysis pain, which is a common concomitant finding during uric acid-lowering therapy. In fact, patients don't care exactly what the incidence is, they care about the solution:

• Solution one, use febuxostat in small doses:Although a number of guidelines call for initial use of febuxostat to start at 40 mg, Dr. Liu's recommendation is to start febuxostat at 20 mg/day, compared with 100 mg/day for allopurinol and 25 mg/day for benzbromarone.
• Solution two, add doses for longer periods of time:Usually after two weeks of 20mg uric acid lowering, if the degree of decline in blood uric acid is not obvious or does not meet the standard, then it is necessary to increase the dosage; in order to avoid the situation of lysis of crystalline pain, can be used in febuxostat in small doses has the effect of lowering uric acid, but did not meet the standard, then increase the dosage after four weeks.
• Solution three, preventive medication:Uric acid lowering is accompanied by the administration of small doses of colchicine (0.5 mg to 1 mg) or nonsteroidal drugs, the duration of which is usually 3 to 6 months; for those without gout stones, prophylaxis requires 3 months after the blood uric acid reaches the standard; for patients with gout stones, treatment is also required for 6 months after the blood uric acid reaches the standard.

All three solutions can be acute at the same time and the benefit of this preventive treatment can last up to 6 months. Then some patients will say, what should they do if they still have a gouty attack during prophylactic treatment? Dr. Liu's advice is that febuxostat should not be terminated because once it is terminated blood uric acid will rise abruptly, leading to a true acute gouty arthritis attack.

Taking febuxostat not only to prevent crystallization pain, but also to monitor liver and kidney function for a long time

Febuxostat is absorbed in the intestinal tract, bound to plasma proteins in the blood, and metabolized and broken down mainly in the liver, where the products of metabolism are inactive substances, 49% excreted through the kidneys, and 45% excreted through the feces. Therefore, patients should pay attention to monitoring liver and kidney functions during the administration of febuxostat.

Monitoring liver and kidney function is important in choosing a treatment plan for gout patients. Because allopurinol, febuxostat or benzbromarone and other drugs used to treat gout and lower uric acid may cause liver injury or kidney injury. Then, if possible liver or kidney toxicity is detected in time during the medication process, the dose of the drug can be reduced or discontinued in time, and hepatoprotective or nephroprotective treatment can be given as early as possible.

What are the main liver and kidney function indicators included? Let's find out today:

• Alanine aminotransferase, an index of liver function:Elevation is common in acute and chronic hepatitis, pharmacologic liver damage, fatty liver, cirrhosis, myocardial infarction, myocarditis, and biliary tract disease.
• Aspartate aminotransferase, an index of liver function:Elevation is common in the onset of myocardial infarction, acute and chronic hepatitis, toxic hepatitis, and cardiac insufficiency.
• Gamma-glutamyl transpeptidase, an index of liver function:Elevation is common in primary or metastatic hepatocellular carcinoma, acute hepatitis, active chronic hepatitis, cirrhosis, acute pancreatitis and heart failure.
• Total bilirubin as an indicator of liver function:Elevation is common in primary biliary cirrhosis, hemolytic jaundice, acute jaundice hepatitis, neonatal jaundice, viral hepatitis, cholelithiasis, cirrhosis, and blood transfusion errors.
• Direct bilirubin as an indicator of liver function:Elevation is common in obstructive jaundice, hepatocellular carcinoma, and cholelithiasis.
• Renal function indicators of urea:It is common in high protein diets, diabetes, severe liver disease, mild renal hypoplasia, hypertension, gout, pre-uremia, cirrhosis, bladder tumors, and severe renal failure.
• Creatinine, an indicator of renal function:Elevation is common in acute or chronic glomerulonephritis, acute or chronic renal failure, severe congestive heart failure, myocarditis, and muscle injury.

In short, febuxostat and allopurinol, benzbromarone move is a uric acid-lowering drugs, can not because febuxostat after taking the situation of lysis of crystal pain, think it is not good, to solve the problem reasonably, or need an initial small dose of preventive treatment. In addition.Febuxostat, febuxostat, fobuxostat, fobuxan, etc., are Febuxostat, only the translation of the name or the region of production is different, Dr. Liu does not recommend to buy their own medicine to take, because the drug is difficult to distinguish between the real and the fake, in addition to the possibility of an unknown adverse reaction.

Hello, I am a nephrologist, today we will open the door, straight to the point, gout patients taking febuxostat, but recurrent gout attacks, this is how it happened? And what should we do about it? I will talk about my opinion.

A brief introduction to febuxostat

When it comes to the drug "Febuxostat", I think patients suffering from hyperuricemia and gout should be more familiar with it. Because it is more expensive, the one used in the market is more than 100 dollars for 12 pills. In terms of pharmacological mechanism, it mainly "inhibits the production of uric acid" and exerts its effect of lowering uric acid.From clinical experience, this drug is really effective in lowering uric acid. So quite a few patients are advised by me to switch to taking it every other day or every two days after their uric acid has remained stable.

What is a gout attack after taking febuxostat?

● After presenting my opinion about this drug, now let me talk about why gout patients who take Febuxostat have recurrent gout attacks instead. As I mentioned earlier, this drug is very effective in lowering uric acid, but uric acid doesn't fall as fast as it should, and this goes to the pathogenesis of gout. In the past and even now there are still many peopleIt is not true that "high uric acid will definitely cause gout", in fact, the root cause of an acute attack of gout is due to "fluctuations in the body's uric acid level induced".

● We have encountered in the clinic, the patient's uric acid is at the normal level or a little higher gout attack. The reason is that the uric acid level in their body is affected by (food, drugs, etc.) and fluctuates (uric acid value rises or falls).Once this balance is upset, the soft tissues or urate crystals in the joints are affected and gout attacks are naturally expected and justified.

The same is true for the question of the subject, because of the significant effect of febuxostat in lowering uric acid, may take just two days of uric acid value dropped a lot, the level of uric acid fluctuations, so the gout attack. In response to the latter part of the question, "Instead of repeated attacks of gout", I think there aresubjective componentOn the inside, in fact, as long as the follow-up does regular medication and follows the various rules and regulations of gout treatment, theThat's not likely to recur, and if it does, you must have missed that part in the middle yourself.

What is the best way to use febuxostat for gout patients?

● Since it is a uric acid lowering medication, my experience has been thatIf an acute attack of gout has been preceded by takingIf you are not taking uric acid lowering medication before gout, then you should still continue to take it during that attack. Otherwise, as soon as you stop the uric acid value suddenly spiked again, gout instead of aggravated; if the gout did not take uric acid-lowering medication before, then do not take uric acid-lowering medication during the acute stage of gout, theOtherwise, the sudden drop in uric acid value is too fast gout will also be exacerbated, you need to wait until the acute phase is over and enter the stabilization phase before starting uric acid lowering treatment.

There are actually quite a few complications in the advanced stages of gout, like gout stones are one of the common complications. So for the course of taking Febuxostat, I suggest that if you don't have gout stones, then continue taking it for 3 months after controlling uric acid below 300; if you have gout stones, then continue taking it for 6 months after the uric acid value is less than 300.Note that whichever one you are on, you must also follow a strict low purine diet, stop smoking, stop drinking, and make lifestyle changes while taking the medication, which is the right way to go.

Author's Message:This article does not constitute medical treatment advice, nor does it constitute medical guidance.For health science purposes only.. It took a lot of time to summarize it without adding a column. Gratuitous and free for all to read, I hope this is helpful. Don't be mean if you learned.Click a retweet to help more people, thanks for the support.

If you are a friend with gout and high uric acid, the drug Febuxostat is generally not unfamiliar. Febuxostat is the most common medication for gout patients to control uric acid levels, but some friends are taking Febuxostat to control uric acid during the uric acid, uric acid is obviously decreasing, but also still still gout, is not gout is caused by high uric acid? How to take the medicine, uric acid are down, but also gout? Today we will introduce the relevant knowledge in this regard.

In order to make sense of this issue, we have to start with the principle of gout attacks. The pathological basis of gout attack is indeed high uric acid, the level of urate in the blood exceeds the standard, urate in the blood precipitation of crystals, and along with the blood circulation, in the joint parts gradually formed deposits, shut down the parts of the deposited urate, if in the influence of certain triggers, further triggered by the joints of the inflammatory reaction, the emergence of severe pain, redness and swelling, and other symptoms, we will be called the gout of the acute attack.

Gout acute attack, generally through active analgesic anti-inflammatory treatment, coupled with moderate rest and life conditioning, acute gout pain symptoms are gradually relieved, slowly disappear, but the gout does not hurt, does not mean that our gout is cured, if the problem of high uric acid is not resolved, in some cases, the gout will come back, repeated attacks.

Therefore, in the gout painless interval, if you want to control the risk of recurrent gout attacks, you must control the body's uric acid level, in general, if it is the first gout attack, in the absence of gout stones, the requirement of uric acid level is usually to control to 360 μmol / L or less, and for multiple attacks of gout, as well as combined with the problem of gout stones, it is usually down to 300 or less to meet the standard.

Usually have an attack of gout friends, uric acid levels are relatively high, and simply through the life of the conditioning intervention, it is difficult to bring down the uric acid, most cases need to be supplemented with drugs to strengthen the control of high uric acid. Febuxostat is one of the commonly used uric acid drugs, in several common uric acid drugs, febuxostat belongs to the inhibition of uric acid production type of drugs, mainly through the inhibition of the synthesis of uric acid related to the activity of purine oxidase, and achieve to reduce the production of uric acid, reduce the role of uric acid level, usually said, febuxostat for a variety of types of high uric acid gout patients, have a very good effect of uric acid.

Some friends take febuxostat to lower uric acid in the gout interval, but in the period of taking medication and again gout, and go to check the uric acid value, but indeed has been lowered, this is how it is? Simply put the principle: Febuxostat does have the effect of controlling the production of uric acid and lowering the uric acid, but as we mentioned earlier, in the high uric acid stage, the urate crystals will form crystals and form deposits in the joints, and if the urate in our blood is lowered, the urate deposited in the joints may reverse dissolve and return to the blood again, and this process, if carried out slowly, will usually not cause gout. This process, if carried out slowly, usually does not cause gout problems. If the rate of uric acid is lowered too quickly, resulting in a violent disturbance in the level of urates deposited in the joints, the process of urate re-dissolution may further induce an inflammatory reaction in the body, leading to the gouty symptom of joint pain. Therefore, taking Febuxostat to lower uric acid in the process of gout symptoms, many times because of the faster the rate of uric acid lowering, resulting in "crystal lysis pain".

How should we respond and solve this problem? To give you the following 3 suggestions -

1. Don't be in a hurry with your medication, be sure to start at a low dose, and take your time in lowering uric acid, don't expect to take your medication once and have your uric acid levels come down quickly, doing so will have a greater risk of causing gout during uric acid lowering. It is safer and less likely to cause gout by starting at a low dose and working with the regulation of uric acid to determine if a higher dose is needed.
2. Life conditioning to keep up, do not think that you have already taken the drug, life is taboo. Want not to appear in the medication during the problem of dissolving crystal pain, life on the conditioning intervention should not relax, drink more water, milk also drink every day, pay attention to the low purine diet, do not excessive fatigue, do not joints cold, all these aspects will help to reduce the gout of further attacks.
3. While taking uric acid-lowering medications, in order to avoid the occurrence of gouty attacks due to urate dissolution during uric acid lowering, you can choose small doses of anti-inflammatory and analgesic medications for gouty attack prevention, such as small doses of colchicine, and small doses of non-steroidal anti-inflammatory drugs, are available.

An increase in the frequency of gouty attacks often occurs during the initial period of taking febuxostat. This is due to a decrease in blood uric acid concentration, which leads to the mobilization of urates deposited in the tissues. To prevent gouty attacks in the early stages of treatment, it is recommended to take NSAIDs or colchicine at the same time. There is no need to discontinue febuxostat therapy in the event of a gout attack during febuxostat treatment. Gout should be treated accordingly to the patient's specific condition.

Hello, I'm Pharmacist Xiong, a licensed pharmacist, and I'm happy to answer your questions.

What is gout?

gout, a crystal-associated arthropathy due to monosodium urate deposition directly related to hyperuricemia (HUA).

According to the natural course of the disease, gout can be categorized into acute attacks, intermittent attacks, and chronic gouty stone lesions.

Untreated or improperly treated gout can lead to chronic symptoms of the disease, including persistent inflammation, an increase in the number of acute attacks, development of gout stones and structural damage to the joints.

Recurrent attacks after taking febuxostat for gout, what is this?

There are 2 ways to consider the reasons here:

1. Start taking febuxostat to lower uric acid

Increased frequency of gouty attacks is often seen at the beginning of the drug administrationThe main reason for this is thatUric acid drops too fast, gout stones dissolvecause secondary gouty attacks, which is quite normal and should have occurred in many patients.What should we do then?

• Adjust the dose of the medication:If one tablet a day read half a tablet a day, two tablets a day read one tablet a day
• Along with some painkillers:Pain affecting daily life can choose non-steroidal anti-inflammatory drugs, such as celecoxib capsules, etoricoxib tablets

2. Intermittent use of medication and dietary disorders

Theoretically, because the current treatment of gout does not eliminate the cause of the disease, the cause of the disease has not been removed is not supposed to stop the drug, so it should be long-term or even lifelong use. If the diet is not controlled and the medication is used intermittently, then it is very unfavorable for the control of uric acid.

What is febuxostat?

Febuxostat is a drug belonging to the inhibition of uric acid production, with a high degree of selective inhibition of xanthine oxidase (XO) activity, able to reduce the production of uric acid; at the same time, inhibit the reduced and oxidized xanthine oxidase, the therapeutic effect of gout is more targeted.

What are the characteristics of febuxostat?

1. The drug of choice for lowering uric acid, with a high degree of safety.
2. The first non-purine oxidase inhibitor , with highly selective not more potent activity, substantially reduces uric acid levels .
3. It is indicated for the long-term treatment of hyperuricemia in patients with gout, but is not recommended for hyperuricemia without clinical symptoms.
4. Normally, a decrease in uric acid levels can be measured within one week of taking febuxostat, and serum uric acid levels are usually reduced to below the norm (6.0 mg/dL) within three months.

Normal reference values for uric acid: 210-420 μmol/L (3.5-7.0 mg/dl) for men, 150-360 μmol/L (2.5-6.0 mg/dl) for women

What are the precautions for taking Febuxostat?

1. This product is contraindicated in patients taking azathioprine and mercaptopurine.
2. Common adverse drug reactions: abnormal liver function, nausea, arthralgia, rash.
3. At the beginning of the medication, there is often an increase in the frequency of gouty attacks, theIt can be taken in combination with NSAIDs; there is no need to stop the medication if you have a gouty attack while taking it.

How often is blood uric acid monitored?

Uric acid should be measured every 2-4 weeks during the adjustment of uric acid-lowering drugs. After reaching the standard (uric acid 6 mg/dl), it should be measured every 6 months.

What should I do if I want to stop taking my medication?

For those who need to discontinue febuxostat for a variety of reasons, after a period of low-dose maintenance therapy, discontinuation may be attempted if blood uric acid is well controlled with paired lifestyle changes, but emphasis should be placed on follow-up and regular monitoring of blood uric acid to assess whether medication maintenance is still needed.

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Why do gout patients who take western medication for gout have recurrent gout attacks instead?

Gout is now also a common and frequent disease, and it is becoming more and more prevalent.

People also know that gout is caused by high purine and uric acid levels.

And what causes high purines and high uric acid?

Assuming that from birth to death, a person lives only 80 years, and that we breathe 18 times a minute, we breathe about 700 million or so in an 80-year life span.

Our breath counts, so what about what we eat? What do we drink? Doesn't it count?

I think there must be a number. But that number is unknown to anyone but yourself, because it also has to do with your own constitution.

Assuming that we are from birth to death, this 80 years to eat crabs, drink beer number is 50,000 bottles, now living conditions are good, how do you want to eat how to eat, how do you want to drink how to drink, yesterday on each eat crabs and drink beer to 49,999, and today each ate two. After getting up in the morning and found that the foot pain can not touch the ground, to the hospital to check the purine high, high uric acid, diagnosed as gout.

Have you ever thought about it? No gout disease before, why eat crabs, drink beer nothing, is that time purine, uric acid is not high? Why after suffering from gout, after eating crabs and drinking beer, purine, uric acid will be high?

Why is the same food so different before and after the onset of the disease.

Why do some people get gout even if they don't eat crabs or drink beer?

In fact, any food contains purine, only the content is high and low, with the age of growth, organs will be worn, the function of the organs will decline, thus causing purine, uric acid can not be completely decomposed and metabolized, and stored in the body, when the accumulation to a certain extent and outbreaks, and ultimately the formation of gout. In fact, this cumulative process is the accumulation process of the number of dietary substances I mentioned above.

The internal organs function is strong, can completely decompose and metabolize purine and uric acid, so that will not suffer from gout, on the contrary, the internal organs function is weak, can not completely decompose and metabolize purine and uric acid, so that the purine and uric acid in the body build up, and finally the formation of gout, what makes the internal organs function decline?

Think about whether it's hot that breaks down metabolized food faster, or cold that breaks down metabolized food faster.

You need to think about it, of course, is hot to break down the metabolism of food fast, that is to say, cold to break down the metabolism of slow chanting.

Then now it is because the internal organs cold, decomposition and metabolism slow, so that the purine, uric acid storage in the body, and finally cause gout.

What chills the internal organs?

Of course is the diet, diet also has its own characteristics, such as chili pepper its nature is hot, watermelon its nature is cool, people often eat, crab ah, beer ah, sex are cold, drinks, fresh milk, sex is also cold.

Are foods hot or cold?

Of course, if you do not believe that you eat chili, ginger, and eat watermelon, cold beer, and see that cold, that hot.

It is because of a large number of cold food, damage to the internal organs, so that its function declines, can not completely decompose and metabolize purine and uric acid, so that it is stored in the body, when the amount of storage to a certain extent, thus causing gout.

Gout disease with Western medicine is not very effective, Western medicine for gout, or to pain relief, and then in conjunction with other forms of treatment, but no matter what medicine, when you stop the medicine, the condition will immediately repeat again, why?

It is because Western medicine is the treatment of superficial phenomena, such as pain relief, such as uric acid and purines, but what causes the increase in purines, uric acid increase in the cause of Western medicine does not treat the cause of this initiation.

Not only does not cure the cause of this start, because it is a chemical drug, the damage to the internal organs is more serious, on the surface is to stop the pain, but secretly more damage to the internal organs, we all know that the medicine is three times poisonous, that is said to be herbal medicine, is not to say that the chemical synthesis of the drug.

Originally, gout is caused by a decline in the functioning of the internal organs, and now it damages the internal organs even more, so when the medication is stopped, the condition will be even worse instead.

We already know that it is the coldness of the internal organs caused by the decline in the function of the internal organs, and finally caused by gout, then how should it be treated?

Improving the function of your organs is the key to treating gout.

One, is to heat up the internal organs, we can use more ginger, moxa, Sichuan pepper, cinnamon sticks, dulcimer, Chuan Jian, and bone marrow.

Secondly, it is to accelerate the elimination of waste from the body, we can use Job's tears, prevented, castor seed, and sole.

Third, it is to activate blood circulation and relieve pain, we can use hyssop, red herbs, yuanhu, angelica, danshen.

The above drugs into the white wine decoction, decoction can not drink ah, with its foot soak, preferably in the morning soak, but if high blood pressure, heart disease can not be used, avoid, avoid.

Prevention of Gout

In fact, there is nothing to say, is to prevent cold, prevent external cold, add more clothes, prevent internal cold, do not be eating cold food.

When you have to think about your own clothing, food, housing, transportation, sleep, that one of the bias, to correct it, have a few months, the physical up, can be restored.

Okay, no more vernacular, like and follow if you like.

Gout patient taking febuxostat instead of recurring gout attacks, what is this and what should I do?

Doctors often tell gout patients to "control your mouth, open your legs, and drink more water", which requires patients to control themselves and be self-disciplined. For people who do not have gout or other diseases, if they can be self-disciplined from the beginning, the probability of getting the disease will be reduced, at least it will be many years later, but for those who already have gout, or even more serious, this self-discipline alone is far from enough.

More severe gout, with frequent attacks, indicates that there are a lot of crystals in the joints, and it is these crystals that rub against the joints to produce pain. In addition, due to the constant production of purines in the body, is to avoid food, but also can not, because although you avoid food, but the liver's ability to metabolize purines did not change, and may even decline.

If you always focus on lowering uric acid, basically passive, can keep the original level is good, many people do not solve the problem, but also may be more and more heavy, so the key to gout is to regulate the liver, inhibit the production of purines.

Western medicine is effective in controlling indicators and symptoms. It is recommended to cooperate with traditional Chinese medicine treatment to identify and treat the symptoms, and not to use heat-clearing drugs easily.

If it's not that the drug has a phase-exclusive reaction with it, then it's that the patient takes the drug and then eats a lot of extra food with medium or medium-high or high purine content. Thinking that the drug has a huge effect, so he can eat and drink a lot. The first time he has a seizure after taking the medicine, he doesn't know what caused it. Then the next time he took the drug again and gorged himself on excess food later.

Let me start by stating that I am not a doctor, but I have a history of gout that is now normal. The lesson learned is that the simpler and lighter your life is, the further away from gout you will be. There is no specific medicine for gout, only diet control and drinking lots of water. According to your situation, eat more vegetables for a period of time, rest early at night, never stay up late, after a period of time to see, I believe it will come down.