First of all, let's popularize what is Coenzyme Q10? Coenzyme Q10, also known as ubiquinone and vitamin Q10, is a fat-soluble quinone compound that is widely found in microorganisms, plants and animals, and is found in high levels in the human body, especially in the heart, liver, and kidneys, where it promotes the conversion of energy and assists in the action of various enzymes. Coenzyme Q10 levels in the human body may also decline with age and heart disease. Dietary supplements are the most common way to increase coenzyme Q10 levels in the body.

In China, Coenzyme Q10 has been approved as a prescription drug, according to the instruction manual, Coenzyme Q10 is used for the adjuvant treatment of the following diseases: 1. Cardiovascular diseases, such as: viral myocarditis, chronic cardiac insufficiency. 2. 2. Hepatitis, such as: viral hepatitis, subacute hepatic necrosis, chronic active hepatitis. 3. Comprehensive treatment of cancer: it can reduce certain adverse reactions caused by radiotherapy and chemotherapy. In Europe and the United States, coenzyme Q10 is categorized as health products rather than drugs. So essentially they are the same as far as ingredients are concerned. The only difference is that Coenzyme Q10 is defined as a drug in China, which can be said to be a kind of auxiliary medicine. Of course, if you are in good health, it is okay to take foreign-approved and compliant supplements as a nutritional supplement. However, it is not appropriate to use Coenzyme Q10 on one's own if one is suffering from a disease or illness and does not follow the doctor's instructions.

Another point that needs to be emphasized is that if you are taking imported health products or health products brought back by your family members abroad, you should pay attention to the dosage of the products, and be sure to read the instructions for use of the health products carefully. If the foreign language can not read, it is best for children or family members to read on behalf of, in particular, to read the precautions and taking method, to avoid the original health care products for health into the body of the "poison".

(Onjung Lee, Pharmacist)

Coenzyme Q10 has now become a "hot" thing, which is inseparable from the vast number of health product manufacturers to vigorously publicize the coenzyme Q10 is indeed a good nutrient, the human body in the young usually through the daily diet can be supplemented and absorbed, but with the growth of age, middle-aged and elderly people in the body of coenzyme Q10 content will decline, moderate supplementation can assist in the treatment of cardiovascular disease, hepatitis, cancer and other problems, also help the body nutritional supplementation and health maintenance. With age, the coenzyme Q10 content in the body of middle-aged and elderly people will decline, moderate supplementation of coenzyme Q10 can assist in the treatment of cardiovascular disease, hepatitis, cancer and other problems, but also help the body's nutritional supplementation and health maintenance, for migraine, taking coenzyme Q10 also has a certain role in relieving.But at the end of the day, no matter how amazing it is made out to be, Coenzyme Q10 is more of an adjunctive therapy and nutritional supplement, and is not a substitute for the medications associated with treating a disease.

In our country, coenzyme Q10 has two types of medicinal and health products, such as medicinal "Nengqilang" and many brands of health products at home and abroad, so there is no difference between medicinal and healthy name in the end? There is a difference, there is no difference, why do you say so, listen to me to analyze---

There's no difference between a drug name and a health name

To say there is no difference means that if the company making the health product is also a conscientious enterprise, then there is no difference between these two things in terms of the main drug ingredients, their main ingredient is coenzyme Q10, coenzyme Q10 is a fat-soluble quinone compound, and if you see some products written ubiquinone, ubiquinone, or vitamin Q10, etc., all of these substances are in fact aliases for coenzyme Q10, and all of them are said to be One thing.

There's also a difference between a drug name and a health name

Pharmaceuticals usually have formal and strict quality standards, but also strict production management standards, therefore, pharmaceuticals produced out of the product, often the content and purity is also very high, the product of other excipients in the safety of the product is also relatively high.

Here to say a few words, due to the coenzyme Q10 in most cases is a nutritional supplement, and there is no clear role in the treatment of disease, therefore, this "drug" in our country, but in Europe and the United States is not, in Europe and the United States, the coenzyme Q10 is more as a dietary supplement (i.e., we often say that the health care products) to the sale of, no matter it is Regardless of the domestic "health" or Europe and the United States "dietary supplements", the regulation of these products relative to drugs is still a little lax, therefore, the quality of the product in the end, but also to see whether the producers are conscientious.

Another point of difference is that the coenzyme Q10 of drug brands, such as Nengqilang, has a lower content of coenzyme Q10, with each tablet containing 10mg of coenzyme Q10, whereas most of the coenzyme Q10 of health brands or foreign countries have a much higher content of coenzyme Q10 in the range of 100-300mg per tablet.

The existence of this problem, mainly coenzyme Q10 daily supplement how much of the problem, for the taking of coenzyme Q10 and supplementation, how much to eat every day, is a lot of friends confused about the problem, for this daily supplement, advanced European and American countries are not uniform, if the recommended dosage according to the domestic drug name, 30mg per day is enough, but Japan, Europe and the United States for the recommended amount of supplementation of coenzyme Q10 is a variety of, the main recommended daily dose are between 100mg ~ 300mg. The main recommended daily dose is between 100mg~300mg. For the auxiliary treatment of disease or the prevention of side effects of medication, daily supplementation of 30~50mg of coenzyme Q10 can be enough, if the elderly, exogenous supplementation of coenzyme Q10, it is not recommended to take more than 300mg per day.

Coenzyme Q10, also known as ubiquinone, was discovered by American scientist Dr. Kaluforukas in 1957, for which Dr. Kaluforukas was also awarded that year's American Chemical Society's highest medal of honor.

Coenzyme Q10 is a fat-soluble ubiquinone that is structurally very similar to vitamin K. It is a powerful oxidizing agent, as well as an essential substance for life. Coenzyme Q10 is a strong oxidizing agent and at the same time an important substance essential for life. In the medical field, such as cardiology, oncology, endocrinology and other research areas are doing in-depth research on this substance. However, it is the continued rise of Coenzyme Q10 in the field of health products that has brought it to the attention of the general public.

There are two main ways to obtain essential coenzyme Q10, i.e., self-synthesis and dietary supplementation. The process of self-synthesis involves 7 vitamins and various trace elements, and requires 17 steps of biosynthesis and the participation of at least 12 proteins in a complex process, so it is susceptible to the influence of various factors. Exogenous Coenzyme Q10 is found in relatively high levels in foods such as sardines, swordfish, animal offal (heart, liver, kidney), beef, pork, peanuts, etc., but dietary supplementation is not sufficient to fulfill the body's needs.

Over the past few years, the understanding of coenzyme Q10 has increased, especially in the cardiovascular field. A number of studies in Europe and the United States over the past few years have shown that CoQ10 may provide significant benefits to patients in both heart failure and cardiovascular conditions such as hypertension. The findings of these studies are summarized below.

① It has been found to be therapeutic in elderly cardiovascular patients and in their neurological, tumor, and diabetic lesions.

② The addition of Coenzyme Q10 is beneficial when combined with Alzheimer's disease, Parkinson's disease, and many neurodegenerative conditions.

(iii) Recently, there have been more reports that Coenzyme Q10 is also very beneficial in diabetes mellitus.

④Newly advanced studies have shown that coenzyme Q10 can improve the quality of life of patients with heart failure.

⑤ Coenzyme Q10 has recently been reported to be effective in the treatment of viral myocarditis.

Finally, Dr. Zhang especially reminded that the above are some studies, and at this stage coenzyme Q10 has not been written into any guideline recommendations, so please recognize this. Even if you use Coenzyme Q10, you should always use it under the guidance of your doctor.

Thank you for inviting Wu Yibo, a member of the Chinese Popular Science Writers Association, to answer your questions.

Simply put, there is no difference between the medicinal and nutraceutical types in terms of active ingredients, but there is a difference in terms of quality control. Although Coenzyme Q10 has also become a prescription drug in China, it is more likely to be described as an adjunctive therapy rather than that.

What everyone needs to be aware of here is thatAlthough there is no difference in the active ingredients between the pharmaceutical and health care types of Coenzyme Q10, the national quality standards for these two products are different, and there are differences between the two products in terms of ingredient content, adjuvant composition, and drug purity.Overall, pharmaceutical coenzyme Q10 is a bit more demanding and certainly safer.

Now, let's popularize the big name Coenzyme Q10, what kind of substance is it?

Coenzyme Q10, also known as ubiquinone, is a quinone compound with fat solubility, which plays a wide range of roles in both the tissue composition and physiological functions of the human body. Therefore, people also used to call itVitamin Q or Vitamin Coenzyme Q10. If you see these names at the drugstore as well, don't get confused.

Coenzyme Q10 has attracted more and more attention in recent years, to explore its root, mainly because it plays an indispensable physiological function in the human body, then, let's take a look at it, what are its physiological functions?

Readers who have taken middle school biology will know that theThe oxygen and nutrients absorbed by our bodies are converted and utilized in the mitochondria within our cells.而Coenzyme Q10, then binds to the inner mitochondrial membrane, as a hydrogen transporter.Controls intracellular energy conversion and production, and also has antioxidant properties.

These are the mechanisms of action of Coenzyme Q10, so what are the specific manifestations of it in our body?

First, optimal concentrations of coenzyme Q10 can act as a metabolic activator, promoting cellular energy production, in layman's terms.Stimulate cellular activation, which is the basis for its use as a nutraceutical. As research progressed, it was discovered thatCoenzyme Q10 can also enhance the body's immunity and anti-tumor capabilities. This is another big reason why coenzyme Q10 is attracting attention. On the immune side, coenzyme Q10 canIncrease the activity of human immune cells, which promotes the production and activity of antibodies, and overall improves the ability of human non-specific immunity; in terms of anti-tumor, it has been found that theCancer patients who regularly take coenzyme Q10 can exhibit tumor regression, and a subset of patients can be prevented from developing tumor metastasis.

Secondly, the functional characteristics of coenzyme Q10 itself, which determines that it can prevent the oxidation of human body tissues, i.e., to play the function of antioxidant.It is mainly anti-lipid and protein oxidation, blocking oxidative damage to tissues from external stimuli as well as from the body's own metabolic disorders.As it happens, the antioxidant function of Coenzyme Q10 coincides with the antioxidant concept of beauty nowadays, therefore, it is also quite popular in the field of beauty wash and care. Further.As Coenzyme Q10 can promote metabolism and enhance cellular vitality, it also brings benefits to patients with cardiovascular diseases.It improves the heart's beat function and blood vessel elasticity by improving myocardial and vascular metabolism. It also improves atherosclerosis and lowers blood pressure, which largely reduces the risk of cardiovascular disease onset. Finally, many diseases have been shown to be associated with coenzyme Q10 deficiency, so it can be used as an adjunctive drug to target these medications.

With the improvement of people's living standards, more and more people are concerned about health, beauty and wellness.And the fact that Coenzyme Q10 meets these needs with few side effects marks it as having excellent prospects.There are a lot of supplements about it on the market today, but one should not rely on them too much.Even though these supplements are effective for the human body, they cannot replace the help of natural Coenzyme Q10 from food sources for our body.People who want to increase their intake of it canto use fish, fish oil, animal liver, etc.All of these ingredients are rich in high amounts of coenzyme Q10.

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neverthelessAs a prescription drug, coenzyme Q10 is currently prescribed domestically as an adjunct to the comprehensive treatment of cardiovascular disease, hepatitis and cancerThe other symptoms are not provided for. Therefore.People should not overestimate the role of coenzyme Q10 in clinical dosingAfter all, it is only a complementary medicine.

As the market of Coenzyme Q10 is getting bigger and bigger, there are some merchants who over-exaggerate the effect of Coenzyme Q10 to the consumers and ask for exorbitant prices for various reasons. In this regard, we should have a full understanding of Coenzyme Q10, in order to distinguish the real from the fake, to prevent being deceived.

Questions Answered by: Zhang Han, School of Pharmacy, Shandong University Reviewed by: Wu Yibo

First of all, their main ingredients are the same, mainly production specifications and processes are different. The main thing is that the production standards, inspection standards and sales standards are different.

1, Product Concept

(1) Coenzyme Q10 for medicinal purposes:For medicinal use, it is classified as a drug, usually with clinical symptoms or clear prevention of related diseases, usually with a high content, and belongs to the category of pharmaceuticals.

(2) Coenzyme Q10 Health:Health care products belong to the category of food, that is, they can regulate the function of the body, prevent some specific diseases or improve the physique, so they are generally low in active ingredients and belong to the category of food.

2, Production standard

(1) Coenzyme Q10 for medicinal purposes:Pharmaceuticals in strict accordance with the provisions of the pharmaceutical GMP production standards, from raw materials, production, inspection, the entire process has a strict gatekeeper and monitoring, and there is a clear registration system, each with a review.

(2) Coenzyme Q10 Health:Health care is in accordance with the health food production process and quality standard technology production, relatively not as strict as drugs, although also the whole process of monitoring, but not particularly strict, such as the degree of purification of the production plant. Must belong to the food category.

3, Inspection standards

(1) Coenzyme Q10 for medicinal purposes:The inspection of drugs is particularly strict, generally need special pure, will use imported liquid chromatography, gas chromatography and atomic detection equipment. And mainly this component, the other components of the strict control, slightly unqualified can not be sold.

Then there is the main batch of a test, the test batch of drugs more than the skin, such as 100 to be sampled 50。

(2) Coenzyme Q10 Health:Health care products belong to the food, so there will be other substances what, food is more relaxed, may be in addition to the name of the ingredients and Chinese medicine health, vitamins, minerals, mainly health care.

Then there is the batch of inspection relative to the drugs, if the drugs are 50 out of 100 inspection, this is 10 out of 100 sampling.

4, Sales Standards

(1) Coenzyme Q10 for medicinal use: medicinal generally have to be prescribed by a licensed physician, and then a pharmacist to review, in order to purchase.

(2) Coenzyme Q10 health care: this can be purchased, in addition to drugstores, convenience stores, in the online store can buy, must be health food. All can sell all can buy, pay out money can buy.

Comprehensively, the name is the same, but the difference from production, inspection, sales purchase is particularly large. So buy according to the situation.

There is a difference between healthcare and medicinal. Coenzyme Q10 does, and so do other products. For example, when we go to the drugstore to buy calcium tablets, most of the store recommends calcium tablets (health supplements) that are several times more expensive than the hospital's, whereas I would just go with the medicinal calcium tablets.

1, the price is not the same, some health products are several times more expensive than drugs, the role of more or less fortunately, you buy health products did not get cheated and fooled.

2, safety and purity are not the same, health care requirements are not as high as the quality of drug requirements. The health care market is much more confusing, and there are too many fake health care products. If you are not careful, you may eat the fake ones.

Second, what is Coenzyme Q10? Is it right for you?

It is a kind of nutrients that our body needs, but also a kind of adjuvant therapy and nutritional supplements, can not replace the treatment of disease-related drugs, not to mention the role of a clear treatment of disease, as with many other health care, can assist in the treatment of cardiovascular disease, hepatitis, cancer and other problems, and migraines have a certain role in relieving. If the body is relatively healthy, just need health care, do not need medication, it happens to be economically viable, of course, can be supplemented (too many such health care products, blowing their own trumpet, really not better than scientific life, exercise).

If the disease is in the body, the need to take medication, do not give up should treat the disease of the drug and turn to simply supplement such nutritional supportive therapy, do not clamor, and treatment of diseases eat too much medicine, the heart is too annoyed, the confidence of life has been greatly reduced! It is important to enhance the courage to live. If necessary, take health care products to listen to the doctor's schedule.

In the past few days, a man with advanced lung cancer, 51 years old, coughing and wheezing for 2 months was admitted into the ward. He was found to have lung cancer for more than 1 month, and the metastatic lymph nodes on the surface of the chest were surgically removed and grew painfully again, and his condition gradually aggravated, with high fever, chest pain and chest tightness, coughing and wheezing, and he couldn't sleep at night with frequent coughing and had difficulty in breathing.

Admission to the hospital for examination and blood tests suggested a particularly severe infection. He was given anti-inflammatory, asthma-relieving, pain-relieving, cough-suppressing and oxygen-absorbing treatments. The next day, when checking the room, asked about the situation of taking medication, replied that he was taking another "medicine", listening to others say that this "medicine" can not eat other medicines, and can not eat meat (nonsense), so did not eat the cough suppressant prescribed by the doctor, and of course, the night sleep is not good, very painful! I'm not sure if I'm going to be able to do that.

At first glance, it was a wheat-flavored solid drink and wall-broken ganoderma lucidum spore powder capsules! And I suspected it was fake. The patient asked if this can really stop coughing and asthma? I said no, looking at his breathing difficulties, sick and desperate to take useless and expensive health care products.

I answered him that this is a nutritional product to strengthen the resistance, if you can eat an egg a day, you can not eat. Doctors prescribe cough suppressants to take, can relieve the frequency of coughing caused by breathing due to difficult and chest pain (narcotic cough suppressants).

Nowadays, people live in good conditions, know how to enjoy, and pay particular attention to physical health, and know the health care at a young age. But health care, often inappropriate, or even wrong, especially in the use of health care products, some blindness, favoring the efficacy, but do not know the pros and cons.

In many cases, it is difficult to make a clear distinction between health supplements and medicines, but if medicines are confused with health supplements, then there will be adverse consequences. Therefore, the need to make clear the difference between coenzyme Q10 medicinal and health care, coenzyme Q10 has a place in the current health care market, it is a fat-soluble antioxidant, can activate the nutrition of human cells and cellular energy, enhance the antioxidant, delay aging and enhance the vitality of the human body, etc., the medical treatment is widely used in cardiovascular diseases, and widely used at home and abroad for nutritional health products and food additives.

The difference between Coenzyme Q10 for medicinal use and for healthcare is as follows:

First, medicinal coenzyme Q10 is used for the treatment and diagnosis of diseases, the role is to cure the disease to save people. While Coenzyme Q10 health products are used for health care and auxiliary treatment.

Second, the medicine is pure coenzyme Q10, the capsule contains 30 to 50mg ranging from coenzyme Q10, most of the chemical synthetics, if taken for a long time, may have certain side effects. In the field of health care products, generally each capsule contains coenzyme Q10 22.8mg, health care products are generally for human beings to take nutritional care, the side effects are not so great.

Third, the biggest difference between drugs and health care products is that drugs are synthetic, while the real dietary nutritional supplements should be all-natural, raw materials from nature, health care products are easily absorbed by the body, while the drug because it is synthetic, the body can not be recognized, can not be fully absorbed, or will cause the burden of some organs of the human body, which is why they say that "three poisons are medicines! "

Therefore, if consumers are used for health care use, then when choosing a product, in order to ensure safety, it is best to choose health care products with the small blue cap logo, and when taking coenzyme Q10 health care products, take them in accordance with the recommended dosage.

The scope of health care products is very wide, especially in recent years, people for the importance of health care, health care industry is like a hormone, blossoming everywhere, the use of health care products is more than happy!

However, Coenzyme Q10 should not be classified as a nutraceutical, but as a medicine. The simple line between a drug and a nutraceutical is that nutraceuticals do not have therapeutic properties, whereas drugs do have therapeutic properties.

Coenzyme Q10 is not a health supplement, it is a drug.

However, coenzyme Q10 is rarely used in clinical work, especially in cardiovascular clinical treatment of heart disease, except in myocarditis, where the drug may be used, and almost never in other heart diseases.

We have difficulty coenzyme Q10 instructions written for the indication.

It is mainly used as an adjunctive treatment for mild to moderate heart failure, and also for hepatitis and cancer.

Clinical application Oral: 10-20 mg/dose, 3 times/day with meals.

Adverse reactions:Loss of appetite, nausea, stomach upset or diarrhea may occur, but discontinuation of the drug is not necessary.

Please take a close look at the instructions which clearly state that it is an adjunctive treatment for heart failure, hepatitis, and cancer.

What is meant by complementary treatment? In other words, it is optional medication, not that it is necessary to use it, but it is used to be able to play a certain auxiliary role.

Coenzyme Q10 is adapted to be taken by patients with heart failure, hepatitis, and cancer, but one must always consider whether or not the addition of coenzyme Q10 is necessary on top of the most basic of treatments, because after all, it's not the basic treatment.

Take our common heart failure.

Heart failure cannot be treated without the Golden Triangle - betalactam, spironolactone, prilosec or sartan or nortriptyline, and even sometimes diuretics, vasodilators, and antihypertensive drugs. But coenzyme Q10 can be done without, at least no one in our clinic uses coenzyme Q10 for heart failure, and the guidelines don't recommend this drug.

Therefore, although Coenzyme Q10 has many such as heart failure, hepatitis, cancer, etc., and adapted to this type of people, but is not the basic drug, these diseases must be under the guidance of the doctor on the basis of the regular use of medication and then consider the adjunctive use of drugs.

Many friends read this article and find it strange, saying that it does not say that Coenzyme Q10 has many effects? How come there is not much clinical use?

The above just surfaces what Coenzyme Q10 does in the instructions, and they make it very clear that it is a supplement.

Here's Dr. Wang's take, which is basically that it can be used or not used, and we almost never use it for heart failure patients!

I don't know if that makes sense.

Coenzyme Q10 is not a nutraceutical, it is a pharmaceutical product and is a supplement for heart failure, hepatitis, and cancer!

There is no difference between the two in terms of pharmacological effects, but there is a strict difference between the two in terms of production process and legal regulations.

Let's first start by understanding the pharmacological effects of Coenzyme Q10:

Coenzyme Q10, by binding to the inner mitochondrial membrane, controls the conversion and production of energy in the cell, and also has antioxidant properties. In other words, coenzyme Q10 can promote cellular energy generation, that is, to stimulate cellular excitability, so that he can play to the best performance, especially in the cardiac ischemia and hypoxia can improve cardiac tolerance, at the same time, his antioxidant effect can be counteracted by some chemotherapeutic drugs, such as adriamycin cardiotoxicity as well as hepatoprotection, that is to say, coenzyme Q10 plays a role in the fodder, the adriamycin is the first to bind to coenzyme Q10, and avoid binding to cardiomyocytes and hepatocytes. Coenzyme Q10 binds first to Coenzyme Q10 and avoids binding to cardiomyocytes and hepatocytes, thus achieving the effect of organ protection. Whether it's a drug or a healthcare product, the mechanism of action doesn't change.

Next we talk about the difference between drugs and supplements:

1, drugs are prevention and treatment of disease, treatment and rescue for the purpose of the use of the object for the patient, not the healthy population. Drugs need to have clear indications, contraindications, adverse reactions clear dosage, treatment and medication precautions, and need to have the supervision and guidance of professionals to use; and health care 'refers to food with specific health care functions, health care is a special kind of food, can be done to improve the function of the role of the disease, but can not be used to treat the disease, the health of the population can also be used in the health food.

2, in the production process, drugs must be produced in a qualified pharmaceutical plant, quality control requirements are very high, such as air cleanliness, sterility standards, the quality of raw materials and so on, all drugs before leaving the factory to meet the national standards, that is, the quality of pharmaceutical production norms, the English name is GMP. health care products, the production of food factories is also legal, his production standards are much lower than the drugs, basically! Only monitoring bacteria, pollutants, these simple health indicators, qualified to market, in other words, health care products as long as you eat without incident on the line, drugs not only to be safe but also to cure the disease.

3. Pharmaceutical coenzyme Q10 is not allowed to advertise, while health care products can be, which also gives some unscrupulous businessmen some loopholes for them to make a big fuss, while there is no clear standard for medicinal use, so that they exaggerate the pharmacological effects, publicized as a miracle drug, misleading consumers.

Final scratch: how do you tell the difference between drugs and supplements?

Drugs: the approval number says State Drug Permit, it's a drug

And health food: the approval number written on the Wei Food and Health words, the State Food and Health words, is food, qualified health care products on the "blue hat" logo, if even the blue hat are not health care products, that is garbage, must not buy.

The authoritative interpretation of Pharmaceutical Affairs, unauthorized reproduction, plagiarism will be punished.

Coenzyme Q10 is divided into two kinds of medicinal and health care, medicinal coenzyme Q10 is mostly synthesized by chemical synthesis, so the content of by-products is high, long time to take, there will be some side effects, so most people, to health care Q10 is good.

The best coenzyme Q10 is extracted by microbial fermentation, such that it is biologically active, easily absorbed, has no side effects and is suitable for most people.