Statins are the cornerstone of treatment in terms of cholesterol lowering, anti-atherosclerosis, and plaque stabilization, and Rosuvastatin, a third-generation statin, is widely used in the clinic due to its lipid-lowering ability and safety profile.

Regarding the side effects of Rosuvastatin, there are commonalities with other statins, except that there are some differences in side effects due to their drug structure as well as pharmacokinetic differences.

1. Rosuvastatin may cause liver function abnormalities and even liver damage. However, it is generally believed that while taking a statin, when the transaminase is not elevated more than three times the normal value, it can be continued with close observation. If the transaminase is more than three times the normal value, the drug can be discontinued, and when it recovers, it can be continued to try to use it or switched to another statin. If the aminotransferase elevation is too high and the patient exhibits hepatic impairment, then the drug may need to be discontinued.

2. Anyone who takes a statin knows that statins are bad for your muscles and can cause myalgia. But there are individual differences in statin-induced myalgia; some people are prone to it and some are not.

Although Rosuvastatin is hydrophilic, studies have shown that Rosuvastatin has a higher risk of muscle damage among several statin drugs. So if you have muscle pain and feel weak while taking Rosuvastatin, you should stop taking it, see your doctor promptly, and try switching to another class of statin if you can't tolerate it; pravastatin and lovastatin have a relatively low risk of muscle damage.

3. The incidence of nephrotoxicity of Rosuvastatin is higher than other statin drugs. This is related to the drug structure of Rosuvastatin, but also related to individual differences, China's Drug Administration approved the maximum daily dose of Rosuvastatin 20mg, the higher the dose, the greater the nephrotoxicity.

4. Statins carry a risk of causing abnormal blood sugar. This may be related to the fact that statins lower cholesterol, and lower intracellular cholesterol levels impair insulin secretion.

However, the guidelines are all suggesting that if there is a clear indication for statin use, it is worthwhile to use it even if there is a risk of causing abnormal blood glucose, except that people at high risk of diabetes need to monitor their blood glucose more intensively.

5. Long-term use of statins may have an effect on cognitive function, although reserpine is water-soluble, so its central nervous system effects will be less severe.

In conclusion Rosuvastatin is a better drug, if intolerable side effects occur, first reduce the dosage, if it does not work then the drug to try other statins or use other lipid-lowering drugs such as fibrates, ezetimibe, etc..

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Rosuvastatin has earned a reputation among the general population of hyperlipidemia and cardiovascular diseases for its superior efficacy. At this stage, more and more people are using it because of hyperlipidemia and cardiovascular diseases rather. So, is there any side effect of taking Rosuvastatin orally for a long time? The answer is yes, but this side effect does not occur in all people, and the occurrence of side effects is still a minority.

1、Impaired liver function

There are not many cases of liver function impairment due to statin consumption in the European and American populations, and comparatively speaking, we do have more cases of liver function impairment in the Asian population. However, it is important to note that impaired liver function does not mean that statins should be discontinued as soon as aminotransferases are elevated; only when aminotransferases are elevated by a factor of 3 or more should discontinuation of the drug or adjustment of the drug be considered.

2. Muscle damage

Another particularly common side effect of taking statin, besides impaired liver function, is muscle damage. This muscle damage can manifest itself in many forms, for example, some people just have tiredness, weakness, some have muscle pain, but very few can manifest as rhabdomyolysis, kidney failure. People taking oral statin at the same time if there is discomfort as described above, it is recommended to check the creatine kinase in time, of course, creatine kinase should be reviewed in the usual review process.

3、Increase the risk of diabetes

There are reports that oral statins can add to the risk of developing diabetes, can elevate fasting blood glucose, impair glucose tolerance, and other adverse effects. In view of this, people taking oral statins must be careful to monitor their blood glucose.

4、Gastrointestinal discomfort

Some patients may experience gastrointestinal discomfort such as loss of appetite and bloating after taking oral statin. If you have any of these symptoms, you can follow up with your outpatient doctor to add medications for gastrointestinal disorders or adjust the statin.

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Of course, whether or not to use a drug depends on its benefit-risk ratio, statin for patients with cardiovascular disease and hyperlipidemia, the benefits far outweigh the risks, we do not have to worry about the sky. Oral statin, in fact, do a good job of the usual monitoring follow-up.

This question is very accurate, different people for the incidence of adverse reactions to drugs and body tolerance is different, therefore, long-term use of statins, indeed, "may" bring some side effects, not necessarily occur in the statin friends, the reason for taking statins is to reduce the risk of cardiovascular disease brought about by hyperlipidemia, so it is necessary and important to understand the possible adverse effects of statins, learn the precautions for taking statins, today talk about Rosuvastatin. The reason for taking statins is to reduce the risk of cardiovascular disease associated with high blood cholesterol, therefore, it is necessary and important to understand the possible adverse effects of statins and learn the precautions for taking statins, today we will talk about Rosuvastatin.

An introduction to the possible side effects of long term use of Rosuvastatin

1. Elevated aminotransferases: Whether it is Rosuvastatin or other statins, it is important to monitor aminotransferases while taking the drug, especially at the beginning of the medication. Compared to lipophilic atorvastatin, simvastatin and other medications, hydrophilic Rosuvastatin has a lower chance of having elevated aminotransferases, but it should be checked regularly and should be discontinued if aminotransferases are elevated by a factor of three or more.

2. Muscle pain: This is one of the possible adverse effects of statins, and is closely related to the intensity of statin use. Rosuvastatin, as one of the most intense lipid-lowering statins, has a higher risk of muscle pain. Therefore, it is generally recommended to check a baseline creatine kinase value before taking Rosuvastatin, and if muscle pain occurs while taking the medication, be sure to check the creatine kinase again, and if this value exceeds the baseline value by more than 10 times, the medication should be discontinued in order to avoid more serious rhabdomyolysis, kidney failure, and other major problems.

3. Abnormalities in blood glucose metabolism: Clinical data have shown that abnormalities in blood glucose metabolism and even new-onset diabetes may occur with long-term use of statins, and that regular checking of blood glucose metabolism (e.g., once every 6 months) is necessary during the medication period, but abnormalities in blood glucose metabolism should not be used as an indication for discontinuing the use of statin medication.

4. Regular check of renal function: More than other statins, Rosuvastatin contains sulfonamide groups similar to sulfonamides, which may affect kidney health when taken for a long period of time. Therefore, it is also necessary to check the urine routine regularly to confirm that the renal function is normal.

5. Other adverse reactions: long-term use of Rosuvastatin, may also occur gastrointestinal discomfort, such as nausea, vomiting, abdominal pain diarrhea and other symptoms, dizziness and headache and other aspects of adverse reactions.

How to minimize the incidence of adverse effects with long-term use of Rosuvastatin

Rosuvastatin is a new generation of statin drugs, strong lipid-lowering effect, long acting time in the body, there is no requirement on the time of taking, just choose a fixed time to take it every day, it is a very good lipid-lowering drug, but due to its high-intensity lipid-lowering effect. Statins, the chance of side effects, usually closely related to the dose of the drug and the intensity of lipid-lowering, therefore, theIn the case of Rosuvastatin, in addition to the occurrence of intolerance, the best way to reduce the incidence of adverse effects is to choose a low dose as much as possible in order to achieve the goal of lowering lipids.。

As an example, a friend with coronary heart disease combined with high blood lipids, taking Rosuvastatin 10mg dose per day, review of blood lipids LDL cholesterol has been reduced to 1.7mmol / L, non-HDL cholesterol also meets the standard, then you can consider reducing the dose of 5mg per day, regular monitoring of blood lipids, its LDL cholesterol can be controlled within 1.8, non-HDL cholesterol control within 2.6, there is no need to increase the dose of non-HDL cholesterol control within 1.8, non-HDL cholesterol control within 2.6, there is no need to increase the dose of 10mg per day. HDL cholesterol is controlled within 2.6, there is no need to increase the dose and have to take 10mg per day.

There is also a point to note is that, with strict self-discipline in life, through life control regulation and medication control regulation of two-pronged approach is to reduce the amount of medication, control of blood lipids must be done, relying on the lipid-lowering effect of drugs, often with limited effect, coupled with a low-fat diet, smoking and alcohol, weight control, moderate exercise and other aspects of the life of the conditioning, and often with half the result with half the effort.

As the saying goes, all medicines are poisonous, and the therapeutic effects of any medicine are accompanied by certain side effects, especially in patients who have been taking the medication for a long period of time, where the chances of side effects increase.

Rosuvastatin belongs to the statin lipid-lowering drugs, side effects are relatively few and mild, most of them are transient, the common ones are: endocrine disorders, headache, dizziness, constipation, nausea, abdominal pain, myalgia, and generalized weakness, etc.; Occasionally, itching of the skin, skin rashes and urticaria and other skin reactions occur. Most of the adverse reactions can be tolerated by patients, and the incidence is also different from person to person, the incidence rate is 1/100 or 1/1000, some rare adverse reactions occurring at a very low rate of less than 1/10,000.

Since Rosuvastatin is mainly metabolized in the liver, long-term use of a small number of patients will be elevated transaminases, and the incidence of increased with the dose, although mild, but still recommended for long-term use of the drug in patients with regular checks of liver function. This product can also have some effects on the kidneys and skeletal muscle, especially in patients with doses greater than 20mg or 40mg, proteinuria and myalgia, myopathy, and even the rare rhabdomyolysis increased chance. If myalgia occurs, prompt testing for creatine phosphokinase (CPK) should be performed and the drug should be discontinued if necessary.

It can be seen that the occurrence of adverse reactions of Rosuvastatin is dose-related, with the increase in the incidence of adverse reactions with the increase in dose. Therefore, do not increase the dose of Rosuvastatin at will when taking it, and if the lipid control is not satisfactory, go to the hospital in time to find a doctor or pharmacist to consult, and give the correct dose adjustment or change the treatment plan.

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Dr. Wang said statin has side effects, what exactly are the side effects of the Rosuvastatin you prescribed me?

Dr. Wang said:In fact, doctors are more afraid of side effects, but for the sake of everyone's health, we have to take this risk together. Precisely because Rosuvastatin can bring you more benefits, which makes us dare and willing to use Rosuvastatin, of course, provided that there must be a guideline recommendation, the guideline is the doctor's treatment of medicine action guidelines, from the summary of large-scale clinical trials.

Let's briefly talk about the positive effects of Rosuvastatin ah!

1, lipid regulation: lowering cholesterol, lowering low-density lipoprotein, elevating high-density lipoprotein, lowering triglycerides. Mainly used for hyperlipidemia.

2, anti-inflammatory stabilization of plaque, prevention of atherosclerosis aggravation, prevention of cardiovascular and cerebrovascular diseases. Mainly used for three high risk groups.

3, anti-inflammatory, stabilize plaque, prevent plaque rupture, protect vascular endothelium, used in coronary heart disease, angina pectoris, myocardial infarction, post-stenting, post-bypass surgery, cerebral infarction, peripheral vascular plaque disease.

Having said that about the positive effects, let's focus on the side effects of Rosuvastatin:.

First, impaired liver function

Different populations are affected differently, Europeans and Americans are relatively low, not excluding Europeans and Americans brother head is big, on the other hand, Oriental people are more cautious about the side effects of drugs, found earlier. It should be emphasized that impaired liver function is not a transaminase elevation as soon as the statin is discontinued, only when the transaminase is elevated by more than 3 times, then consider stopping or adjusting the drug. And for liver function impairment due to Rosuvastatin, early detection thatThe vast majority of them return to normal after stopping the drug, so we don't have to worry so much about liver function impairment caused by Rosuvastatin.

Second, muscle damage

Muscle injury is more troublesome in Dr. Wang's opinion, so we must pay attention to monitoring, this muscle injury can be manifested in various forms, some people just have tiredness, weakness, some have muscle soreness, the most worrying is that a very small number of them can be manifested as rhabdomyolysis, renal failure, and if rhabdomyolysis occurs that would be very troublesome.On the one hand it is essential to review the muscle enzymes regularly, and on the other hand if you have any of the above mentioned discomforts, promptly check the creatine kinase. Just in case this small probability event falls on your head, it is a 100% event when it falls on anyone's head.

Third, blood sugar abnormalities

Taking all statins carries a risk of potential new diabetes, but upon investigation, most new diabetes is in patients with underlying abnormalities of glucose tolerance remains; statistically, theFor every new case of diabetes that occurs, there is a reduction of 9 cases of cardiovascular disease. So it's worth using even if diabetes will occur。

Fourth, other side effects or adverse reactions

Some patients after oral statin will have loss of appetite, bloating and other digestive discomfort, or headache, dizziness; constipation, nausea, abdominal pain, weakness; itching, rash and hives and so on. If it is clear that there is a direct relationship with Rosuvastatin, it can be replaced with another statin, or with another lipid-lowering drug, but other lipid-lowering drugs, which do not have anti-inflammatory plaque stabilizing and vascular protective effects. So, we have to use statin even if we know that it may have potential side effects, because statin can arrive more benefits to the vast majority of patients who have to!

(Doctor Shakeology, describing ten things to do when taking statin. Shakeology #362185328)

Rosuvastatin as the third generation of statin drugs, relative side effects are small, strong lipid-lowering effect, stabilization of plaque effect is sure, is more and more friends are familiar with, but taking statin must understand the side effects of statin!

Dr. Duan Q&A Online 🔑 Side Effects of Rosuvastatin Calcium 🔑

Rosuvastatin belongs to the statin class of drugs with strong lipid-lowering effect, similar to other statins, long-term use can also cause side effects, related to its own statin content. It is important to correctly recognize and prevent statin-related side effects and help patients to take them correctly.

Lipid-lowering effect of Rosuvastatin

(1) Small long-term doses of Rosuvastatin (5-10 mg) can achieve a moderate-intensity lipid-lowering effect, reducing LDL by 30% to 50%. A large daily dose of 20 mg has a high-intensity lipid-lowering effect, lowering LDL by >50%, but will be accompanied by an increase in side effects.

(2) Rosuvastatin maintains its effects in the body for a long period of time, offering the possibility of intermittent dosing when side effects do exist.

Side effects of long-term use of Rosuvastatin

(1) Liver damage

Most commonly, it manifests as elevated aminotransferases, most often within the first 3 months of administration, with the incidence increasing with higher doses.

Correct prevention and treatment methods are: ① check liver function before taking, for transaminases elevated more than 3 times the upper limit of normal, do not take (except fatty liver), wait until the transaminases are normalized before taking. Patients with liver failure or decompensated cirrhosis are prohibited. Check liver function regularly after taking the drug. Once exceeding 3 times of the upper limit of normal, stop the drug and observe; if not, continue to observe.

(2) Muscle damage

Manifestation of muscle pain, fatigue, with or without increased creatine kinase, severe cases can be rhabdomyolysis, not only muscle pain and fatigue, creatine kinase increased more than 10 times the upper limit of normal, blood creatinine increased, often with dark urine and myoglobinuria, can cause acute renal failure.

Therefore, check creatine kinase regularly while taking it; if myalgia occurs, check creatine kinase to rule out drug damage; if creatine kinase is elevated (3 to 10 times the upper limit of normal), observe closely or change drug or reduce dosage; if it exceeds more than 10 times the upper limit, or if there is a gradual increase, or if rhabdomyolysis occurs, discontinue the medication immediately and treat the problem.

(3) Elevated blood sugar

Long-term use of statins increases the risk of diabetes by raising blood glucose. However, the cardiovascular protection provided by statins outweighs the risk of diabetes. Therefore, it is important to check your blood glucose regularly while taking them, and if your blood glucose rises, to treat it in the correct way for diabetes.

(4) Impairment of neurological and cognitive functions

Long-term use may cause neurological reactions such as abnormal sensations, vertigo, insomnia, peripheral neuropathy, impaired memory function, cognitive dysfunction and depression. But statin has cardiovascular health benefits that far outweigh cognitive dysfunction. So if such a condition occurs while taking it, other causes should be ruled out first, such as alcoholism and thyroid problems.

(5) Statin damage to the kidneys is closely associated with rhabdomyolysis.

Dr. Duan specifically warned:

(1) To prevent side effects, check your blood sugar, liver function and creatine kinase regularly while taking Rosuvastatin.

(2) People should not only see the side effects of Rosuvastatin and ignore its cardiovascular protection, but should make the right choice under weighing the pros and cons.

(3) There is considerable individual variation in the side effects of Rosuvastatin.

(4) Correct understanding of the side effects, in order to correctly prevent and treat, and can enhance the patient's confidence in long-term adherence to take.

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Netizen: Isn't it said that Rosuvastatin has no side effects on the liver? How come my liver function transaminases are still elevated after taking it?

The above statement is a patient's misunderstanding of the drug or the meaning of the word. The incidence of visceral damage may be less with Rosuvastatin versus other fat-soluble statins (e.g., atorvastatin) because of the water solubility, which is partially excreted through the kidneys; however, there is an increased likelihood of nephrotoxicity.

With any medication, the effects and side effects are probabilistic situations, and a lesser incidence is not the same as no incidence.

"It's a medicine that's poisonous." Who is a fool to still take it for a long time? Especially when you hearRosuvastatin and other statin lipid-regulating drugs, can lower blood lipids, anti-vascular inflammation, stabilize atherosclerotic plaque, prevent plaque rupture and shedding, etc., prevention of cardiovascular disease, improve the prognosis of heard that it is a "miracle drug" in general, but also applies to a very wide range of people! Is currently atherosclerotic cardiovascular disease primary and secondary prevention of the only first-line drugs.

In fact, the "three poisons of medicine" is for each drug can occur (only the incidence can be different), but for individuals taking the long-term use of the drug is to do basically no side effects! Let the drug play a better effect.

1, overall liver safety is good (don't worry)

Liver damage occurs mainly at high doses, and our new guidelines suggest that a medium-strength starting dose (lower doses are appropriate for special populations) is safe. Even if the incidence of side effects is small, it is still important to follow up with your doctor regularly.

(1) Before taking the drug, liver function and enzyme profile should be routinely tested. For the first dose, blood lipids and liver function and creatine kinase should be rechecked within 6 weeks of administration.

(2) If the blood lipids can be reduced to normal and there is no adverse reaction, the above blood tests are gradually changed to be reviewed every 6~12 months.

(3) Whenever the type or dose of medication is adjusted, it should be reviewed within 6 weeks of treatment.

(4) If the blood lipids have not been reduced to the predetermined target (the doctor will determine the target according to the condition) and there is no adverse reaction, blood tests will be monitored more than once every 3 months. If the blood lipids still do not reach the target after 3 to 6 months of treatment, it is necessary to adjust the dosage or type of drugs, or to combine drugs with different mechanisms of action for treatment.

If you notice any discomfort such as jaundice, fatigue, or drowsiness, promptly follow up with your doctor to rule out or relieve the side effects of the medication.

A large body of evidence-based data confirms that there is no increased risk of either.

Side effects on a person's cognition and kidney function are still said to be uncertain. Lipid regulating drugs to lower LDL to 1.0 mmol/L may still be safe. However, further observation is still needed.

Statins such as Rosuvastatin may increase the risk of new-onset diabetes, but are associated with high doses, advanced age, and diabetes risk factors. Pay attention to individualized treatment with regular medical checkups to monitor people at risk for diabetes, and your doctor will adjust the type or dose of medication in time for better prevention.

Pay attention to drug and food applications that cause increased side effects of hair statins and even life-threatening events. Patients should inform the doctor about all the drugs being taken.

The overall incidence of adverse muscle reactions is 5% to 15%, and patients should seek prompt medical attention in the event of muscle pain. Can occur with all statins, varies by statin, dose related, not related to lipid-lowering efficacy. The most serious myopathy is rhabdomyolysis, which occurs in 1~3 cases per 100,000 people per year, and recovers rapidly after discontinuation of the drug; rhabdomyolysis has a good prognosis if hydrated promptly.

Gastrointestinal reactions such as nausea, diarrhea, bloating, constipation and drowsiness. Promptly follow up with your doctor for medication adjustments.

Rosuvastatin is a third-generation statin drug, belonging to the high-intensity lipid-regulating drugs, the drug has significant efficacy, high safety, the price is also relatively affordable, very suitable for patients with cardiovascular and cerebral vascular disease long-term use, but "three poisons are drugs", Rosuvastatin also has most of the side effects of other statin drugs, common such as headache, Dizziness and other neurological abnormalities, as well as nausea, abdominal pain, constipation and other digestive system abnormalities; however, the above adverse reactions are not serious, the vast majority of people can tolerate, while some symptoms are more serious, special attention should be paid to, and even need to be given in the process of taking close monitoring, as follows:

1, elevated blood sugar: is also one of the more common side effects of statin drugs, there are reports confirming that the drugs have increased the risk of diabetes, of course, we can not be choked, after all, the benefits of taking the drug is far greater than the harm, however, in the process of long-term use or should be given close monitoring;

2, liver function abnormalities: a small number of patients may experience elevated transaminases while taking the drug, but most cases are mild, asymptomatic and transient, however, when the transaminases are elevated more than three times, measures need to be taken, such as reducing the dosage or discontinuing the use of the drug;

3, muscle damage: this is a relatively rare side effect of statin drugs, but also a fairly serious one, in a small number of patients treated with the drug may appear myalgia, myopathy (including myositis), as well as rare rhabdomyolysis, so, the process of taking the drug if there is muscle pain or abnormal fatigue, you should be timely detection of creatine kinase content, and even if the patient does not have these symptoms, usually should be creatine kinase as a routine medical examination! And, even if the patient does not have these symptoms, creatine kinase should be included as a routine part of the physical examination!

But with all medications, there are more or less side effects, however, as long as the benefits of statin for the prevention and treatment of cardiovascular disease outweigh its risks, it is worth taking!

The above is for reference only!

Read the instructions.

I took Rosuvastatin for a while more than 10 years ago and it worked well, then I was not reimbursed for this drug and switched to a different one, and now I am taking this drug again because I am not able to lower my lipids to the desired level, but the problem is not only severe muscle pain, but also an intestinal obstruction. I think this probably has something to do with being too old. I am in my eighties.