Rosuvastatin is the most mainstream statin drug in the world at this stage, which is famous for its powerful lipid-lowering effect and experimental data that it can effectively reverse plaque. At this stage, the main Rosuvastatin used in China is the imported original research and development of Cordin, which belongs to AstraZeneca Pharmaceuticals in the United Kingdom. The main effects about Rosuvastatin include the following four points:

1、Lower LDL

Rosuvastatin can effectively lower LDL, which is the signature of people Rosuvastatin. Because of the excellent effect of lowering LDL, Rosuvastatin has been the most dominant lipid-lowering drug worldwide at this stage.

2、Lower triglycerides

It can be said that lowering triglycerides is not the main business of Rosuvastatin, so why take statin for those patients with mild to moderate hypertriglyceridemia? On the one hand, statin has a mild triglyceride-lowering effect, and on the other hand, it is mainly for the purpose of reducing the incidence of cardiovascular and cerebrovascular diseases by lowering the LDL in hypertriglyceridemia patients.

3、Treatment of cardiovascular and cerebrovascular diseases

For patients with a clear diagnosis of cardiovascular disease, the vast majority of patients, as long as there are no obvious contraindications, should be treated with an oral statin, especially a potent statin such as Rosuvastatin.

4、Prevent cardiovascular and cerebrovascular diseases

For those at high risk of developing cardiovascular disease, oral statins can be effective in preventing the onset and progression of cardiovascular disease and belong to the recommendations written in the major guidelines.

These four points are the four main effects about Rosuvastatin at this stage, I hope my introduction can do help you.

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Whether it is Rosuvastatin or other statins, statins are the cornerstone drug and drug of choice for clinical use in hyperlipidemia regulation and cardiovascular disease. Some friends with cardiovascular disease, blood fat is not high, but the doctor will also prescribe statins, in the end should be taken? Today we will discuss with you the clinical application of statins.

In fact, as the evidence from clinical trials continues to fill out, statins are no longer just a drug that is being used to lower blood lipids, but they have been shown to have some benefit in secondary prevention of cardiovascular disease, and even in primary prevention, in terms of patients' cardiovascular risk.

Clinical application of statins--regulation of blood lipids

The primary role of statins is, of course, for the regulation of blood lipids, as the first choice of lipid-lowering drugs, statins can accelerate the breakdown of plasma LDL metabolism, but also inhibit the generation of ultra-low-density lipoproteins, is currently the only clear clinical evidence of lipid regulation drugs.

Take Rosuvastatin, its common dosage is 5mg to 20mg, the general recommended starting dose is 5mg once a day at any time, and depending on the regulation of blood lipids, a 10mg dose can be considered, with a maximum of no more than 20mg.

For the lipid-regulating effect of statins, there is a 6% effect, that is, doubling the dose, the lipid-regulating effect of statin can be enhanced by about 6%, therefore, for those who take statins, it is important to synthesize the body's tolerance for side effects and the effect of lipid-regulating effect, do not just increase the dose.

Clinical application of statins--secondary prevention of cardiovascular disease

Secondary prevention of cardiovascular disease is the treatment of patients with existing cardiovascular problems who take medications to prevent the development of cardiovascular disease recurrence.

In addition to the ability to regulate blood lipids, statins also have anti-inflammatory, protect the vascular endothelium and other functions, during the use of statin, will not increase the heart rate, does not produce upright low blood pressure, but also can effectively improve cardiac function and renal blood flow, but also can be reversed cardiac hypertrophy and other effects.

Studies have shown that statin use reduces the risk of cardiovascular disease even for people at high risk of cardiovascular disease who do not have high baseline cholesterol levels.

Clinical use of statins--primary prevention of cardiovascular disease

Several studies have shown that statins have the effect of reversing and stabilizing atherosclerotic plaque in coronary arteries, and as a result, statins are now widely recognized for primary prevention in patients at risk for cardiovascular disease, who have not yet had an episode of cardiovascular disease.

Therefore, if your clinician has assessed that you should be taking Rosuvastatin, then even if your blood lipids are not high, you should still take the medication as long as your body tolerates it, which is beneficial in reducing the risk of cardiovascular disease.

Knowing which diseases Rosuvastatin can treat requires us to dissect statins more deeply, to know the in vivo mechanism of action of statins, and then to understand why it can treat those diseases.
Since the first statin was introduced in 1987, it has been found to be very effective in regulating blood lipids. Subsequently, pharmaceutical manufacturers around the world began to develop various statins with different structures but the same mechanism of action. Simvastatin, pravastatin, fluvastatin, atorvastatin, pitavastatin and AstraZeneca's Rosuvastatin have emerged.

The most important action of statins is to inhibit hydroxymethylglutarate monoacyl coenzyme A (HMG-CoA) reductase, which lowers blood lipids by reducing endogenous cholesterol synthesis. This enzyme is a key enzyme in cholesterol synthesis, and inhibition of this enzyme blocks cholesterol synthesis. Nowadays, statins are mainly used for hypercholesterolemia, and are also effective in diabetic and renal hyperlipidemia.

With the ongoing research on statins, it has been found that they have many other targets for in vivo action in addition to their lipid-modulating effects.

Additionally statins reduce angiotensin II system by acting on theAngiotensin IIOxidative stress on vascular smooth muscle reduces remodeling of the heart by angiotensin; inatherosclerosisMedium Rosuvastatin also has a very good resistance to improve the cardiovascular action function by inhibiting the triggering factors of atherosclerosis, so that the plaque of the blood vessels tends to be stabilized and vascular inflammation is reduced.

In addition, studies have also found that statins can inhibit the release of various inflammatory factors in the body and play an anti-inflammatory role in the body; they also have a certain effect on the disease of polycystic ovary syndrome. It can be said that statins have a wide range of clinical applications, inseparable from its effective mechanism of action in the body.

Rosuvastatin is a type of statin lipid-lowering drug that is primarily used to lower blood lipids. This means that patients with elevated blood lipids need to take statin lipid-lowering drugs. For patients with ischemic cardiovascular and cerebrovascular system diseases (coronary artery disease and cerebral infarction, etc.), lipid-lowering treatment is one of the most central aspects, so most patients need to take it as well.

Statin lipid-lowering drugs mainly lower LDL cholesterol, but can also play a role in lowering triglycerides, but in clinical application, statins are mainly through the lowering of LDL cholesterol to play a significant clinical effectiveness. Commonly used statins on the market are atorvastatin, Rosuvastatin, simvastatin and so on.

In the case of simple hyperlipidemia, the first step is to analyze which of the lipid markers is predominantly elevated. As mentioned above, if elevated LDL cholesterol is found, the patient needs to be evaluated for the need for lipid-lowering medications; if so, statin lipid-lowering medications are generally the mainstay, and if triglyceride levels are markedly elevated, other triglyceride-lowering lipid-lowering medications such as fibrates may need to be added.

Perhaps, some people have some questions: the blood lipid is not high, but why also need to take these kinds of drugs. This condition usually occurs in some patients with ischemic cardiovascular system diseases, such as coronary heart disease. Once diagnosed with coronary heart disease, that is, most patients need to take statin lipid-lowering drugs, even if the blood lipid level is within the normal range. This is because statins, while lowering lipids, may also provide other effects beyond lipid-lowering, such as antioxidant and plaque-stabilizing effects. Of course, the main focus is still lipid lowering.

Regardless of the population, taking statin needs to be monitored for some possible adverse effects, and it is recommended to monitor liver function and creatine kinase after another month of taking the drug, and to observe whether the lipid-lowering efforts have reached the target goal.

Rosuvastatin is currently the best overall evaluation of all statins, due to its water-soluble characteristics, it has a high liver selectivity, so the adverse effects are relatively few, and the drug half-life of up to 13-20 hours, meals do not affect its bioavailability, and most importantly, relative to other statins, Rosuvastatin can be in a very small number of doses to play a very strong lipid-lowering effect!

As a statin, Rosuvastatin has both lipid-modulating and non-lipid-modulating effects:

Lipid regulating effect

Rosuvastatin inhibits the synthesis of endogenous cholesterol by the liver, and it also reduces the levels of low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL), limiting their ability to transport cholesterol and triglycerides to extra-hepatic tissues, which, in turn, reduces the levels of lipids in the blood;

Non-lipid-modulating effects

Rosuvastatin has antioxidant properties that preserve vascular endothelial function, and it alsoinhibitoryPlatelet aggregation, thrombus formation and proliferation and migration of vascular smooth muscle cells, which have a positive effect on the prevention and treatment of atherosclerotic lesions and plaque reversal!

The above is purely personal and for reference only!

Rosuvastatin is a statin lipid-lowering drug, which is mainly used to regulate blood lipids in clinical practice. Rosuvastatin belongs to the younger generation in the statin family and inhibits cholesterol synthesis more than other statins due to stronger inhibition of HMG-CoA reductase in the liver than other commonly used statins. It treats heterozygous familial and nonfamilial hyperlipoproteinemia types IIa, IIb, and III, as well as hypercholesterolemia due to type 2 diabetes and nephrotic syndrome. It is particularly effective in primary hypercholesterolemia with dyslipidemia not adequately controlled by dietary control and other non-pharmacological treatments.

Rosuvastatin can significantly reduce low-density lipoprotein cholesterol LDL-C, increase high-density lipoprotein cholesterol HDL-C, also can reduce the total cholesterol TC and triglyceride TG to a greater extent. lowering range of lipids is broader, the clinic is mainly used for the treatment of hyperlipidemia and high cholesterol lipids.

In addition to regulating blood lipids, statins have other effects.

Because there is a close relationship between high blood lipids and the development of coronary heart disease, in recent years, large-scale clinical trials have proved that statins lipid-lowering drugs are effective in the primary and secondary prevention of coronary heart disease, which can lead to a significant reduction in the morbidity and mortality of coronary heart disease. Statins can also stabilize atherosclerotic plaques and reduce the occurrence of ischemic stroke, angina pectoris and myocardial infarction. Therefore, if you are examined for coronary heart disease or angina, and even if your blood lipids are normal, your doctor may prescribe statins, such as simvastatin, atorvastatin, resuvastatin, etc., to complement the treatment for the prevention of acute cardiovascular and cerebrovascular events.

In addition, statins have a protective and ameliorative effect on the kidneys, which can correct chronic kidney damage caused by abnormal lipid metabolism, and can counteract or inhibit the proliferation of glomerular cells to reduce renal damage, so they can be used as adjunctive therapy for nephrotic syndrome.

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It is one of the most commonly used potent cholesterol-lowering drugs in the clinic and also lowers triglycerides. Clinical indications for use are mainly for lowering blood lipids, especially for lowering LDL cholesterol and total cholesterol, raising HDL cholesterol, lowering triglycerides in mixed hypercholesterolemia and for combining with fibrates to further lower triglycerides, but it is not a preferred agent for lowering triglycerides.

One of the major functions of Rosuvastatin is the prevention and treatment of atherosclerotic cardiovascular disease, and its purpose is to prevent or minimize the occurrence of atherosclerotic cardiovascular disease, and at the same time, in the case of the atherosclerotic vascular disease that has already occurred, Rosuvastatin is able to make soft plaques turn into hard plaques, and the plaques will be reduced in size, and then the stenosis of the blood vessels caused by the atherosclerosis will lessen, and the plaque will also become more stable without acute events, so its two main functions, the first is to prevent the occurrence of atherosclerotic disease, the second is the treatment of atherosclerotic cardiovascular disease, when the patient's stenosis becomes lighter and less prone to acute vascular events caused by atherosclerosis, thus reducing some of the high risk of self-inflicted fatal complications caused by acute myocardial infarction, cerebral infarction and so on.

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