Hyperuricemia population is increasing year by year, and tends to be younger, is one of the diseases that seriously affect our health, but also the second largest metabolic disease after diabetes, so some people will be hyperuricemia and diabetes, hypertension, hyperlipidemia and known as the "four high". Long-term elevated blood uric acid is not only directly related to gout, but also closely related to the occurrence and development of endocrine diseases (such as diabetes, hyperlipidemia, etc.), cardiovascular and cerebrovascular diseases (hypertension, coronary heart disease, stroke), renal diseases (gouty nephropathy, etc.) and other systemic pathologies.Hyperuricemia focuses on prevention, early detection and early management. We suggest hyperuricemia patients to start from their daily life in order to better control the condition. Specific suggestions are as follows:

1, reasonable diet: patients with hyperuricemia should: ① try to avoid or eat less high-purine food (such as avoid eating animal offal, shelled seafood and broth, less animal meat and fish); ② try to avoid drinking fructose-rich beverages (such as fruit juices, cola, etc.); ③ eat fresh vegetables and low-fructose fruits, the appropriate use of beans; ④ to encourage the drinking of low-fat or skimmed milk and its products, 300 ml a day is appropriate.

2, strict smoking cessation, restriction of alcohol: smokers gout probability than non-smokers increased significantly, so need to quit smoking; at the same time do not recommend drinking alcohol, such as the condition is stable, can be appropriate to drink red wine.3, drink more water: it is recommended to drink more than 2000ml of water per day to help dilute and discharge uric acid, it is recommended to drink white water, but also can drink soda, light tea and coffee.

4, appropriate exercise, pay attention to warmth: patients with hyperuricemia should adhere to appropriate regular exercise, which helps to control the condition, but should avoid strenuous exercise; at the same time, you also need to pay attention to warmth in daily life, avoid sudden cold.5, maintain a good state of mind and regular work and rest: daily life should pay attention to the regulation of emotions, avoid anger, anxiety, depression, etc.; at the same time, we should rest on time, avoid staying up late, tired.

6, weight control: research shows that nearly half of the patients with hyperuricemia for overweight or obese people, so it is recommended that we must control their weight, obese people (including abdominal obesity) should be active weight loss.7, rational use of drugs: most patients with hyperuricemia can rely on lifestyle interventions to control blood uric acid in the normal range, but for the following groups, it is recommended to actively use uric acid-lowering drugs: ① simple asymptomatic hyperuricemia, when the blood uric acid level of more than 540umol / L; ② combined with diabetes mellitus, hypertension, hypertension, coronary artery disease, stroke, etc.: it is recommended that the blood uric acid level of more than 480umol/L; ③ Combined with gout and related complications (e.g. gout stone, gouty nephropathy, etc.): when the blood uric acid level exceeds 420umol/L, then start uric acid lowering treatment.

8, regular review: hyperuricemia should pay attention to review, especially the use of drugs in the process of treatment, need to monitor the occurrence of adverse reactions, but also to understand the control of the condition, in order to better develop targeted programs to control the condition.

Thanks for reading, this article was originally written by General Practice Sweeper on Today's Headlines & Wukong Q&A.

Society is developing, the standard of living is improving, people's awareness of health is also progressing, more and more people, in the physical examination, found that the blood biochemical examination index items, found an excessive index, that is, the value of blood uric acid, men's blood uric acid more than 420 μmol/L, women's blood uric acid more than 360 μmol/L, belongs to the value of uric acid exceeds the standard problem, we are usually called "high uric acid".

Many times found that the value of uric acid is high, but the body does not have any uncomfortable feeling, in the end, high uric acid is how, high uric acid and what effect on health? Today to give you a brief introduction.

Although called "high uric acid", but here we refer to the high, but refers to the value of uric acid in the blood, the human blood uric acid, under normal circumstances, will maintain a "production" and "output" balance, so as to maintain a stable concentration of uric acid in the blood within a healthy range. Under normal circumstances, uric acid in the human blood will maintain a balance between "production" and "output" to keep the concentration of uric acid in the blood stable within a healthy range. When this balance is disrupted and too much is produced, or too little is produced, or both, an imbalance in uric acid metabolism will occur, leading to an increase in the concentration of uric acid in the blood, which gradually accumulates and leads to the problem of hyperuricemia.

Therefore, in the final analysis, the production of high uric acid, or the body for the metabolic balance of uric acid problems. Most of the production of uric acid in the human body originates from the internal cell metabolism, apoptotic cell nucleic acids, after multiple steps of enzyme catalysis, oxidation and other steps, and ultimately converted to uric acid, there is a small portion of uric acid originating from the external intake of food purines, in the body to be absorbed into the transformation, but also into uric acid; and uric acid excretion, mainly through the renal filtration and reabsorption of excess uric acid into the urine, with urine excretion, there is a small portion of uric acid, in the intestine, by intestinal flora to be excreted. Urine, with the urine out of the body, there is a small part of uric acid, in the intestine, by the intestinal flora decomposition, with the feces out of the body. Therefore, these two processes, no matter which one has problems, may lead to the elevation of uric acid value in the blood and produce the problem of high uric acid.

High uric acid belongs to the chronic metabolic diseases, should be given enough attention, although often high uric acid initial body without any uncomfortable symptoms, but if long-term high uric acid is not controlled, may cause the following aspects of health problems -

1. Gout, which is a well-known problem. The reason why gout is induced is because when the concentration of uric acid in the blood is too high, the micro-soluble urate will precipitate crystals in the blood, the urate crystals are deposited in the joints, triggering the body's immune system's immune response, appearing in the joints of the redness, swelling, burning, severe pain and other phenomena, is the principle of high uric acid triggering gout attacks, due to the differences in physical condition, not all patients with high uric acid will suffer from attacks of gout, but the high uric acid If you don't control it for a long time, the risk of having a gout attack will become greater and greater.

2. Uric acid kidney stones: there are many kinds of kidney stones, a small number of kidney stones are caused by high uric acid, high concentration of urate, in the renal excretion, urate concentration is too high, precipitation of crystals, and ultimately deposited into kidney stones.

3. Gouty nephropathy: high uric acid will not only cause gout and kidney stones, but also stimulate and affect the cortical cells of the kidneys, affecting the health of the kidneys. Long-term uncontrolled high uric acid will also affect the health of the small renal arteries, accelerating the sclerosis of the small renal arteries, and ultimately, gouty nephropathy will be formed.

4. Cardiovascular system impact: high uric acid in addition to affecting kidney health, but also on the cardiovascular system to cause certain effects, with high blood cholesterol, high blood pressure, high uric acid is also affected by arterial vascular sclerosis risk factors, high uric acid patients with poor control of blood uric acid, but also increase the risk of cardiovascular disease incidence.

5. Diabetes: People with high uric acid problems are six times more likely to develop new diabetes than those without high uric acid problems, so keeping uric acid under control can also reduce the chances of diabetes.

Therefore, if you find that there is a high uric acid problem, regardless of whether there are no related health problems, you should pay attention to timely, if it is mildly high, no other related diseases or symptoms, you can pay attention to life regulation, weight control, drink more water, stop smoking and limit alcohol, strengthen the movement, a low purine diet, maintain a good work and rest, which will help to regulate the blood uric acid, if there is a gout or other health problems, and uric acid value exceeds 540, you can consider seeking medical advice to confirm the need to take medication to control the value of uric acid. If you have gout or other health problems, and your uric acid level exceeds 540, you can consider seeking medical advice to confirm whether you need to take medication to control your uric acid level.

Most of the uric acid in our body comes from normal cellular metabolism, and the rest comes from dietary intake.Uric acid is produced when purines contained in food are digested and metabolized. Whether synthesized on its own or ingested in the diet, uric acid is excreted from the body in the urine via the kidneys. As a result, uric acid is maintained within a fixed range (80-360 μmol/L for women and 150-420 μmol/L for men).

However, ifExcessive production of uric acidorPoor access to uric acidThis leads to the accumulation of uric acid in the body, which is often referred to as elevated uric acid.

Below, "ask the doctor" will tell you about the causes of elevated uric acid and what effects high uric acid may have on the body.

What are the causes of elevated uric acid?

So, what are those behaviors that can lead to elevated uric acid? Generally speaking, there are several main ones:

(1) Eating foods high in purines:For example, seafood and animal offal.

(2) Love of alcohol:Alcohol competitively inhibits uric acid excretion in the renal tubules.

(3) Slow self-metabolism:The concentration of uric acid has something to do with the rate of metabolism. Some people metabolize more slowly and the uric acid is not excreted in a timely manner.

(4) Taking certain medications:Things like diuretics, some chemotherapeutic drugs, and immunologic agents may inhibit uric acid excretion, all of which can lead to elevated uric acid.

In addition, some severe trauma can lead to excessive cell destruction in the body and elevated uric acid.

What are the effects of high uric acid on the body?

Uric acid is a slightly water-soluble acid, and when the concentration of uric acid in the blood is within the normal range, it will be honest. But once the concentration is over the limit. Uric acid will precipitate out of the blood and become crystalline. These crystals travel all over the body with the blood and deposit in the joints, tendon sheaths, kidneys and other parts of the body, bringing about no small amount of trouble.

(1) Gout

When uric acid crystals gather in the joints, it will lead to deformation, swelling and pain in the joints, which is what we often call gout.

(2) Renal failure or kidney stones

Kidney is an organ that deals with blood all the time, any blood changes, like high blood sugar, high blood pressure, high blood lipids, high uric acid may lead to kidney damage. When the uric acid in the blood becomes crystallized and deposited in the kidney tissues, it leads to chronic inflammation of the kidneys. It usually appears asFrequent nocturia, foamy urine, swelling of lower limbsand other symptoms. Failure to lower uric acid in time may also lead to chronic renal failure.

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In recent years, the number of people with high uric acid has been increasing and getting younger and younger. Long-term studies have found that if hyperuricemia is not actively dealt with, it will indeed lead to a lot of problems in the long run. Currently, the diagnostic criteria for hyperuricemia in China are:Fasting venous blood uric acid levels greater than 420 umol/L on two non-same-day occasions on a normal purine diet.

Problems due to high uric acid:

1. Gouty joints Manifesting as red, swollen and hot pain in the joints It is the most common condition in patients with high uric acid, but also only about 10% of hyperuricemia will eventually develop into gout.
   
   

2. Other complications Long-term hyperuricemia can cause or exacerbate organ dysfunction, such as uric acid nephropathy of the kidneys hyperglycemia hypertension hyperlipidemia coronary heart disease strokes, etc.

It is true that there is some sensationalism in the above, but if it doesn't happen to you, you won't feel anything, if it happens to you, then you won't think so, for example, a person who has had gouty arthritis, he can't forget that feeling for the rest of his life, and if it recurs for a long period of time, it will greatly affect his life and work.

For people with hyperuricemia.Live by drinking plenty of water, making sure you have enough to get more than 2,000ml of small variables, eating a low purine diet, being appropriately active, and controlling your weight. Keep the uric acid level at 360umol/L or less, or 300umol/L or less if there are serious complications, but it is not recommended to reduce the uric acid level to 180umol/L or less.For those with hyperuricemia, it is important to see a doctor to evaluate the need to initiate uric acid-lowering medication, as well as to choose the right medication to control uric acid.

Recently a friend, the civil service examination, written interview first place, but the physical examination, kidney function problems, let me help read the report, found that its uric acid as high as 566umol / L, if because of this reason the job is gone, is not it too much of a pity, so I recommend that you pay attention to their own bodies, regular physical examination, found that the problem is dealt with as early as possible.

When it comes to high uric acid, gout comes to mind. Yes, gout can be triggered by high blood uric acid, and the causes of elevated uric acid in the blood are either less excretion (the main factor) or more production.

Since the questioner is asking about harm to the body, let's focus on the dangers here, without going into much detail about why.

Hyperuricemia is often referred to as the "silent killer" because it causes the following harm:

injure a joint

The brunt, of course, is the joints.

Urate crystals, the main culprit of joint pain in gout patients. In the joints and tendons of patients with chronic asymptomatic hyperuricemia, ultrasonography reveals urate deposits in 30% to 50% of patients, which can cause severe joint pain.

injure the kidneys

If too much uric acid in the body, the formation of crystalline salts, the kidneys are in a long time in a kind of chronic inflammation of this kind of machine, weakened function.

Once kidney function is impaired, the ability to excrete waste products (including uric acid) is reduced, which in turn can further elevate uric acid levels, leading to further impairment of kidney function, which can be described as a vicious cycle.

The deposited uric acid will also form stones, causing kidney diseases such as renal colic, hematuria, and pyelonephritis.

"Heartbreak"

Research has confirmed that even asymptomatic high uric acid, but also hide the "root of the problem" - harm to the heart, can cause high blood pressure, coronary heart disease and heart failure and so on.

So, even if high uric acid is senseless and painless, it's important to actively bring it down!

First of all, adjust the diet: control the intake of meat, seafood and animal offal and other high-purine food, the diet is based on vegetables and fruits; reduce the intake of salt, and ensure that the amount of drinking water is more than 1,500 milliliters per day;

Change bad habits: quit smoking, prohibit alcohol, insist on exercise; obese people should reduce weight, so that weight control in the normal range (BMI less than 24 kg/m2).

If necessary, consult a rheumatologist to see if uric acid-lowering therapy is needed, and also monitor kidney function indicators (e.g., blood creatinine) and urine protein.

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The effects of hyperuricemia on a person's body will mainly bring people gouty arthritis, urinary stones, renal dysfunction, cardiovascular disease and so on.

Most people with hyperuricemia are in an asymptomatic state, and many realize it's all the uric acid that's to blame after a gout attack or urinary tract stone.

People with hyperuricemia should develop good living habits and control their diet. Drink less alcohol, eat more vegetables, and eat less animal offal, fish, shrimp and other foods that are high in purines.

It is important to drink plenty of water and maintain a urine excretion of more than 2,000 milliliters per day.

I am glad to answer your question! Hyperuricemia is a condition in which the level of uric acid in the blood is higher than normal (>420umol/l for men and >360umol/l for women), which can be caused by inborn metabolic disorders or secondary to a variety of acute and chronic diseases. China's hyperuricemia population is very large, every ten people have a person with high uric acid, equivalent to the incidence of hepatitis. So what harm will high uric acid cause to the human body?

What are the possible diseases caused by hyperuricemia?

We all know that.goutIt is caused by the deposition of uric acid, and the higher the blood uric acid level, the more likely people are to get gout. Gout patients often experience redness, swelling, heat and pain in all joints, which are recurrent and cause a great deal of pain to the patient; at the same time, high levels of blood uric acid can irritate and damage the walls of blood vessels, causing or aggravating theCoronary heart disease and hypertensioncardiovascular diseases; people with high uric acid levels are also prone toUric acid stones and gouty nephropathyIf left untreated, it will eventually lead to kidney function damage; in addition, gout also affects glucose metabolism in the body and interferes with insulin formation, which may induce or aggravatediabetes。

To sum up, the impact of high uric acid on the human body is not small, usually should pay attention to low purine diet, eat more vegetables and fruits, if there has been a high uric acidemia and related diseases, should be timely medical treatment to avoid causing more damage to the human body!I hope that my answer will help you! Give me a like if you like it!

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It mainly triggers the danger of gout! It can also cause some neurological functional damage to the body!

High uric acid will cause crystal-related arthritic diseases caused by mononatomic urate deposition, if acute arthritis chronic gout stone should be noted that the heavier can appear joint disability and renal insufficiency, often accompanied by three high.

Live your life with the following in mind.

The first, is to eat less red meat, pork, beef, mutton, ventilation patients generally like to eat these meats, and biased obesity, animal offal is also best not to eat!

The second, eat less fatty food fat itself will hinder the kidney's excretion of uric acid lead to obesity, obesity is one of the reasons that lead to the outbreak of most diseases!

Third, have more grains and potatoes and vegetables,! Fourth, have more fresh fruits!

Fifth, to drink more milk low-fat, a number of studies have shown that eating more low-fat food is conducive to the prevention of gout!

Sixth, patients with gout should quit drinking and smoking sweet drinks and drink more water!

Seventh maintain a moderate amount of exercise! Increase the body's metabolism, gout is scary but manageable!

Eighth regular checkups and treatments in hospitals, and avoid seeking treatment for any illnesses!

With the improvement of people's quality of life, changes in dietary structure, the incidence of patients with hyperuricemia in China has also increased, and gradually younger development. Many people think: it is not just a high point of uric acid, high on the high, not a big problem.

Next, we'll look at what all the dangers of hyperuricemia are for the human body.

Under normal circumstances, more than half of the body's uric acid is excreted through the kidneys, and with the excretion and production of uric acid to maintain a balance. And when excretion decreases or production increases, this balance is disrupted, resulting in too much uric acid in the body and the formation of hyperuricemia. At this point, as the uric acid exceeds the saturated concentration, it will cause urate crystals to precipitate, adhere, and deposit in the joints and surrounding soft tissues, renal tubules and blood vessels. This causes acute and chronic inflammatory damage to articular cartilage, bone, kidneys, and the lining of blood vessels.

The first is an attack of gout, due to the deposition of urate crystals, resulting in gouty arthritis, called gout. It often manifests itself as sudden onset of redness, swelling, heat and pain in single joints such as the first metatarsal toe of the foot, ankle, knee, etc., with attacks most common in the early hours of the morning. And as urate crystals continue to increase, they can also be deposited in the kidneys, leading to kidney stones and even gout stones. Secondly, due to long-term high uric acid, it can also lead to other multi-organ damage and complications such as kidney disease (elevated creatinine), hyperglycemia, dyslipidemia, hypertension, coronary heart disease, cardiac insufficiency and stroke.

Therefore, do not underestimate the harm caused by high uric acid for the human body, from today onwards, we must control the diet, for patients with uric acid greater than 520 to actively carry out drug therapy and with dietary control, a minimum of 2-3L of drinking water per day, to promote the elimination of uric acid from the body.

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Uric acid is a weak acid, which is the final metabolic product of cellular metabolism and purine nucleotides in food in our body, and exists in our body mainly in the form of free urate. Under normal circumstances, the total amount of uric acid in the body is about 1,200 milligrams, the body will produce about 600 milligrams per day, at the same time the body will also excrete about 600 milligrams, when the body is in a normal dynamic balance.

Once we have too much uric acid in our body, the body cannot excrete it in time, it will gather in the body and the symptoms of high uric acid will appear.

Clinically, the normal range of uric acid is 89-357 μmo1/L for women and 149-416 μmol/L for men, which can lead to a series of metabolic disorders once the normal range is exceeded.

Many people think that high uric acid is gout. In fact, it is not, too high uric acid in different stages, there will be different clinical manifestations.

1. Asymptomatic hyperuricemia:This period is generally not easy to detect unless laboratory tests are done, because this period is clinically manifested as an increase in blood uric acid concentration and does not show clinical symptoms, the shortest can last for 10 years, the longest for 20 years, and some people even lifelong without symptoms.

2. Acute hyperuricemic arthritis:It is most common in spring and fall and can develop in all seasons. Patients who have had localized joint injuries, full meals and heavy drinking, excessive fatigue, exposure to cold and dampness, certain medications, infections and surgical procedures can increase the chances of triggering an acute attack. Studies have shown that these factors can cause the formation of crystals of supersaturated uric acid to be deposited in the synovial fluid of the joints, which are regarded as foreign by the body's white blood cells and phagocytosed, and then release inflammatory factors, causing the onset of acute hyperuricosuric arthritis.

3. Uric acid nephropathy:Clinically, the disease is triggered by the increasing concentration of urate in the blood and reaching a certain supersaturated state where the urate crystallizes and deposits in the kidney. Uric acid nephropathy is significantly higher in men than in women, and the average age of its onset is 45 years old, and most of the patients who have suffered from hyperuricemia for more than 10 years will develop uric acid nephropathy.

4. Gouty arthritis:In the early stages of gout, attacks are most often seen in the lower extremities. Gouty arthritis attack sites are generally commonThumb joints, ankles, knees, etc., attacks are often accompanied by redness, swelling, heat, and severe pain.And long-term gout sufferers have attacks in the finger joints and even the auricles containing soft tissue parts.