Budesonide formoterol powder inhaler is a very commonly used medication for respiratory patients under the trade name of Cymbicort Dupont. It is mainly used for the treatment of the following diseases: 1, bronchial asthma, is the major asthma guidelines recommended medication, and need to be used for a long time; 2, chronic obstructive pulmonary disease (COPD), especially for patients with recurrent exacerbations of chronic obstructive pulmonary disease for symptomatic treatment, control of the condition, improve the quality of life of patients.

Symbicort Dupont is an inhaled combination formulation consisting of the glucocorticoid budesonide combined with the long-acting beta-blocker formoterol. The two components of the combination therapy have a synergistic effect, both anti-inflammatory and asthmatic, so it has the advantages of fast onset of action, good efficacy and long duration of action. Symbicort can be increased to 2 inhalations twice a day at any time when symptoms are severe. Formoterol works fast, so Cymbicort works fast, within three minutes, and can be carried around for acute exacerbations of bronchial asthma and chronic obstructive pulmonary disease (COPD). However, for emergency use, it is more advantageous to use albuterol aerosol and terbutaline aerosol.

Are there any side effects of Symbicort?

Budesonide formoterol inhaler is a topical drug with minimal systemic side effects and a good safety profile. Due to the hormonal components, there may be adverse reactions such as mild pharyngeal irritation, cough and hoarseness after use. Failure to rinse the mouth after prolonged use may lead to the growth of oral fungi, so it is recommended to rinse the mouth promptly after use. In addition, the most common adverse reactions are the predictable adverse effects that occur with beta2-agonist formoterol treatment, such as tremor, palpitations, and headache, which usually diminish or disappear within a few days of treatment. In a very small number of people, muscle cramps, nervousness, irritability, nausea, vertigo, sleep disturbances, hypokalemia, etc., may occur after prolonged use. The incidence is generally low. Extremely rare adverse reactions, such as the occurrence of paradoxical bronchospasm.

Symbicort Dupont is currently commonly used in clinical asthma and chronic obstructive pulmonary control drugs, mainly for the treatment of stable phase, long-term regular inhalation can significantly improve lung function, reduce the frequency of acute exacerbation of asthma and chronic obstructive pulmonary, reduce hospitalization time, improve exercise endurance, improve the quality of life. It is itself a drug that needs to be used for a long time, so long-term use will not produce dependence, but as far as possible under the premise of controlling the condition to use a lower dose of maintenance dose, in order to reduce the side effects of long-term high-dose hormone. It is important to note that Symbicort DuPont should not be stopped suddenly and the dose should be tapered off gradually before stopping the medication.There is uncertainty regarding the safety of the drug in children under the age of 12 years so it is recommended that the drug should be used in children over the age of 12 years as well as in adults, whereas no dosage adjustment is required for the elderly.

Budesonide formoterol powder inhaler is a compound preparation, the composition of which is budesonide and formoterol, budesonide is an inhaled glucocorticoid with strong local anti-inflammatory and anti-allergic effects, which can relieve bronchial obstruction caused by rapid-onset and delayed-onset allergic reactions. Formoterol is a long-acting bronchodilator with diastolic effects on bronchial smooth muscle and relief of bronchospasm. The bronchodilatory effect is dose-dependent, with an onset of action within 1-3 minutes, and can be sustained for at least 12 hours in a single dose. Budesonide formoterol powder inhaler is a controlled medication for the treatment of bronchial asthma that requires daily use and long-term maintenance therapy. The combination of the two components has synergistic anti-inflammatory and asthmatic effects, which can effectively control airway inflammation, reduce airway hyperresponsiveness, improve asthma symptoms, reduce the frequency of asthma attacks, reduce the severity of attacks, reduce mortality, and significantly improve the therapeutic effect. In addition, because formoterol has a rapid onset of action, budesonide formoterol powder inhaler can also be used as an asthma reliever on an as-needed basis.

Side effects are a kind of adverse reactions, which are harmful effects other than therapeutic effects caused by drugs under normal dosage and usage, and cannot be avoided in the process of medication. The incidence of inhaled budesonide adverse reactions is low, the safety is good, pregnant women can also be used, common local side effects include pharyngeal discomfort, hoarseness, cough and oral candida infection, etc., after inhalation of the drug rinse the mouth with water in time can effectively reduce the occurrence of the above side effects. Side effects such as hand tremor and palpitations are common with formoterol, which are usually mild and short-lived, disappearing within a few days. Long-term clinical studies have shown that low-dose treatment with budesonide formoterol powder inhaler has no significant effect on growth and development and bone metabolism in children, but systemic side effects such as bone metabolism disorders and hypothalamic-pituitary-adrenal axis suppression can also occur if it is used in high doses for a long period of time.

Long-term oral or intravenous use of glucocorticoids can inhibit the hypothalamic-pituitary-adrenal axis through negative feedback, causing insufficient secretion of endogenous glucocorticoids, leading to adrenocortical atrophy and insufficiency, which is manifested as weakness, depression, nausea, vomiting, postural hypotension and so on. In addition, long-term oral or intravenous use of glucocorticoids can produce dependence, and sudden discontinuation or too rapid reduction of the drug can lead to the recurrence or exacerbation of the original disease, known as rebound phenomenon, both of which are systemic side effects of glucocorticoids, and most often occur with prolonged oral or intravenous administration of glucocorticoids. Budesonide formoterol powder inhaler is an inhalation preparation, which mainly acts locally in the airway, and commonly causes local oropharyngeal side effects, rarely causing systemic side effects, but long-term high-dose use does appear to be dependent.

Finally, long-term use of budesonide formoterol powder inhaler is the most effective measure to control asthma and prevent acute asthma attacks, and the safety and tolerability is good, asthma patients should strictly comply with the medical advice, do not reduce the amount of their own or stop the drug, in order to reduce the number of acute attacks of asthma, to protect the lung function, as adherence to the medication is necessary, so the dependence is a reflection of the role of treatment.

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Triple A Hospital Pharmacist, has the answer for you.

Budesonide formoterol powder inhaler, commonly marketed under the trade name "Cymbicort", is used for the long-term maintenance treatment of chronic asthma.

It should be noted in passing that the drug budesonide formoterol powder inhaler is not indicated for acute asthma attacks (for acute asthma attacks you should choose preparations of salbutamol or terbutaline).

What are the side effects of long-term use?

Symbicort Dupro is a combination of budesonide (a glucocorticoid) and formoterol fumarate (a long-acting, selective beta 2 receptor blocker).

The more common adverse effects of long-term use are:

Formoterol causes muscle tremors and shaking, headaches, palpitations (feeling weak, pale, tinnitus sensation, dizziness, etc.);

Hoarseness, cough, oral candida infections caused by the glucocorticoid budesonide (rinsing the mouth after using the drug is recommended).

Specifically, refer to the table.

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Thank you very much for your question, first of all I would like to tell you what is meant by side effects and the concept of side effects. Side effects (Side Effects; Adverse Reactions), refers to the pharmacological effects that occur after the application of a therapeutic amount of medication that have no resemblance to the therapeutic purpose. If you are just worried about the side effects of the drug and do not dare to use the drug, that is to be choked. Sometimes we can only control and live with the side effects of medications, rather than resisting, denying, or fearing them.

So next I am now analyzing this drug budesonide formoterol, he is a mixture of two drugs budesonide and formoterol, so this inhaler will have the adverse effects of both drugs, but there is no increase in the incidence of adverse effects when the two drugs are combined.

Finally, let's talk about dependence. Dependence is a phenomenon that creates physical or mental dependence and needs. Drug dependence generally means that after long-term application of a certain drug, the organism produces physiological or mental dependence and demand for this drug, divided into two kinds of physical dependence and mental dependence. Obviously this drug does not have much mental dependence, if it did, it would have been included in the psychotropic drugs by the Ministry of Health of the People's Republic of China. Then physiological dependence depends on your condition whether you can stop the drug, if the condition has changed or development then you need to adjust the drug, adjust the drug is more complicated, but also depends on whether you are because of asthma or chronic obstructive pulmonary disease, if you are taking for a long time, the need to adjust the drug is recommended to consult a doctor or clinical pharmacist, according to your condition to adjust the drug.

I hope the above answer can help you.

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This is a combination ingredient with the glucocorticoid budesonide and thebeta-blockerComposition!

Since it is a drug, there must be side effects, only because of individual differences in some people react big, some people react light! Since we are talking about long-term use and there are hormone ingredients in the surely will have dependence!

Hormone long-term use will produce dependence, so the condition is controlled in time to reduce the amount!