Recently, "Anacin" is another drug that has been in the limelight after "Saproxil".

The reason is that many of us have eaten as children, "fever-reducing medicine", in the United States has been banned for more than 40 years, has been pulled into the blacklist of more than 30 countries, the reason is that the high probability of the occurrence of side effects of the drug, the second side effects of the reaction is large, the serious can be shock, death. Now it's 2018 and yet we still give it to our children!

The incident began when a mother on Weibo took her child to the doctor, and the doctor prescribed an injection of Anacin for her child.

Let the editor can not help but suck in a breath of cold air, anacin has not been eliminated? A little bit of common sense doctors know that this antipyretic drug has long been banned abroad. After the elimination of commonly used to farm animals to reduce fever, now even veterinarians have called for caution! How can they still prescribe it to our children?

Banned in the U.S. for 40 years and blacklisted in over 30 countries.

The main ingredients of "Anacin" are "aminopyrine and sodium sulfite", and this fever-reducing drug has caused serious adverse reactions and deaths both at home and abroad.

According to the New Beijing News recently disclosed that the information shows that from 1922 to 1934, aminopyralid as a new type of antipyretic and analgesic drugs popular in Europe and the United States, was used to reduce fever and pain. However, it has been found that patients taking this drug will produce a variety of side effects, such as causing a decrease in white blood cells in the peripheral blood, leading to a decline in immunity, and cause a variety of infections.In 1934, 1981 people died of the disease in the United States alone, and more than 200 died in Europe.

Anacin is a compound combining aminopyrine and sodium sulfite, which has a similar effect.

In 1977, the U.S. FDA (U.S. Food and Drug Administration) formally banned anandamide and withdrew the drug from the U.S. market, and the clinical application of a variety of dosage forms was stopped. Subsequently, Japan, Australia, Iran and other successive has been about 30 countries expressly prohibited or restricted the use of anandamide.

Anacin in our country: adults and children are taking it

With regard to the huge side effects and fatal cases of "Anacin", China has also introduced policies to restrict it, but it is still lenient.

On September 4, 1982, the former Ministry of Health issued the "Notice on the Announcement of the Elimination of 127 Types of Drugs", in which the list of eliminated drugs, "Compound Anacin Tablets" was eliminated in the same batch, but left the"Anacin tablets", "Anacin injection", "Anacin injection", "Anacin nasal drops"Equally homogeneous "brothers".

I also checked the latest data, according to the State Drug Administration website data show that as ofJune 22, 2017The country still has1339The number of approval numbers for the manufacture of anandamide.

What is even more embarrassing is that drugs that have been banned in many countries for many years are still widely used in our country, and both children and adults are taking them. Some township hospitals, health centers and even third-level hospitals in prefecture-level cities still prescribe "Anacin" to their patients.

What are the side effects of Anacin?

How big are the side effects of Anacin? Just like it says in the Anacin instructions, the side effects are so big that they are scary.

1. Blood:Can cause granulocyte deficiency, the incidence of about 1.1%, acute onset, the severe cases are fatal, can also cause autoimmune hemolytic anemia, thrombocytopenic purpura, aplastic anemia and so on;

2. Skin aspects:It can cause allergic manifestations such as urticaria, exudative erythema, and in severe cases, exfoliative dermatitis and epidermolysis bullosa;

3. Localized reactions:There may be redness, swelling and pain at the injection site, which will subside only after a few days; some patients show signs of toxemia, with subcutaneous hemorrhagic spots, or purplish-black pus, which often takes several months to heal.

4. Allergic shock:Allergic rash or drug fever, urticaria, severe cases of exfoliative dermatitis, herpetic epidermolysis bullosa leading to death. In individual cases, anaphylactic shock may occur, even leading to death.

As early as 2002, our National Adverse Drug Reaction Monitoring Center collected data on suspected adverse drug reactions caused by anandamide:

There were 11 cases of anaphylaxis, of which7case of death；

There were 16 hematologic reactions, including one death;

There were 31 cases of reactions to the skin and its appendages, including 4 deaths;

There were 17 cases of urinary reactions, including 5 deaths;

There were nine cases of digestive system reactions, including one death;

There were also 8 cases of serious reactions such as respiratory and cardiac arrest and incontinence, of which 1 case died.

(Source: Adverse Drug Reaction Information Circular No. 2)

The above does not include the cases of adverse reactions recorded by local monitoring centers. If the above tragedy were our own children, or the children of our relatives and friends, we would be heartbroken.

These are the only 2 safe and effective antipyretic medicines for children

What should a parent do if the doctor insists on prescribing Anacin to reduce the child's fever?

The answer is simple - just refuse and ask the doctor to switch your child's fever to the following two medications:

"Acetaminophen and ibuprofen.

This is because these are the only 2 fever-reducing medications currently recommended by the World Health Organization (WHO) for children worldwide.

Author Uncle Mi, a veteran media personality, a traveler and scholar in the U.S., has lived in the U.S., Japan and Europe for many years, and is the founder of the self-publishing media "This is America", "This is Japan" and "This is Europe and the United States".

See this news every time is very helpless, do not know the source of the problem out of where, one level up to analyze the last and back to square one, also. Secondly, I found a problem, "each country's food and drug safety level seems to be different", the European Union's level is the most stringent, the year before last, the U.S. FDA has also been sprayed a lot of, such as containing a lot of artificial food coloring, the European Union has been banned chemicals, etc., these foods, medicines are in the U.S. market is still selling, simply all around! It's a pit.

I've been sick for a few years now, and it seems to me that both Chinese and American healthcare have a lot of problems. In the US, the most prominent is that it is expensive, for example, talking to a doctor can cost several hundred dollars. Although these expenses can be paid by the insurance company, you have to pay for the insurance yourself.

When I went abroad, my annual health insurance premium was $1500. As far as I know, most of the schools now offer insurance for international students at the level of 3k to 5k. In fact, students are a low-risk group because they are young. Then for working people and older people, the premiums are obviously much higher.

In addition to health care costs and insurance, it's also true that the way American doctors think about prescribing medication is very different than at home.

For some common illnesses such as colds and fevers (excluding those due to major causes), not only do doctors not prescribe the medicines mentioned in the title, they don't even prescribe them. For example, once I had a fever at night and hung up at the emergency room, after waiting for two hours, the doctor came out and chatted for a few minutes, then gave me a glass of iced orange juice (you read that right, the kind you buy at the supermarket) and sent me back.

Another time my best friend went into the hospital with acute gastroenteritis and vomiting and diarrhea, and the doctor ended up suggesting that he just drink sports drinks and prescribe medication? There is no such thing.

After living in the United States for many years, many people know that if they feel a little sick, they can go to the grocery store or pharmacy and buy over-the-counter medications, as shown below.



In addition, doctors in the United States very much reject the use of antibiotics. A Chinese student once went to see a doctor and I accompanied him as an interpreter. During the visit, the student showed the doctor the medicines he had brought from China, including Cefradine. At that time, the American doctor showed an extremely surprised expression, saying how could you have such medicine and carry it around. In fact, many health organizations in the U.S. have posters on them to limit the use of antibiotics (you can imagine the family planning campaigns in China some years ago).



Finally, compared with the domestic, the United States health care is another major feature is rarely used hanging water (bottles). In China, a small illness, colds and the like, the doctor will let hanging water, many hospitals have hanging water hall. However, in the United States, doctors do not even prescribe medicine, much less water. I asked some of my friends in the U.S., and although all of them have had the experience of going to the hospital, none of them have had the experience of hanging water.

In addition to helplessness, we as parents can only cultivate the habit of children love sports from childhood, to strengthen their own physical fitness and immunity.

Anacin, a familiar and unfamiliar drug, has now become a "net red". Said familiar, because we are 80, 90 years after childhood who is not a fever to eat Anacin; said strange, because now to re-recognize it, it is not what we think of as a "miracle drug", the United States has been banned for 40 years, and some foreign countries have only approved as a veterinary drug, which has a great deal of potential safety problems. The following are the adverse reactions listed in the specification.

[Attention.

① With an incidence of 1.1%, more than one out of 100 people will have a granulomatous defect, which is already quite a high probability, and this is the main reason why it will be eliminated in foreign countries.

② In many manufacturers' instructions, there is an item that reads.

The instructions have shown that it is not appropriate to apply, in the country really still have Anacin injection, Anacin tablets on sale, especially in rural areas, almost become a family drug. The reason is unknown, but also not our people can decide, we can do is not to buy not to use not to promote, children absolutely can not be used, adults also try not to use, there are many medicines can be fever, that is, safe and effective, I believe that smart you know how to choose.

Pharmaceuticals have an "angelic" side - curing illnesses - and a "devilish" side - causing illnesses, just as a person has strengths and weaknesses. It's like a person has advantages and disadvantages. In our work, people often ask, "Is there any side effect of so-and-so drug?" "I want to use the one with no side effect". Sorry, almost all drugs have adverse reactions, adverse reactions are what we do not want to happen, but it is the inherent characteristics of the drug, will not disappear because of our will, we can only try to avoid it, which is how to use the drug safely. What we can do is to utilize its therapeutic effects and reduce its adverse reactions, only when the benefits outweigh the disadvantages, is the rational use of drugs, safe use of drugs, can really give us a cure for disease and bring health.

Let's talk about a real case that happened to me! In my township health center group, the day before yesterday, someone asked the group doctor: "Now someone in the family has a fever of 38.5 ...... I want to go to the pharmacy to buy him some Anacin.......to eat it okay?" The doctor asked and realized that it was for adults. The doctor asked and knew it was for an adult and replied that she could either use Advil, or ibuprofen. As a clinical pharmacist, I immediately advised her not to buy Anacin to avoid unnecessary risks, and in the end, the patient took the advice and took ibuprofen. From this incident, we can see that the people's awareness of drug safety is still very weak, and even certain doctors do not have a good understanding of the safety of drugs, just like the recent online explosion of doctors who prescribe Anadrol, this situation is more common at the grassroots level, and in the first-tier cities, the residents of the safety aspects of the drug is a very high level of concern, and even a lot of patients than specialists are more in-depth study. This is a very good phenomenon. Personally, I suggest that we should gradually cultivate the awareness of safe use of medicines, and we have the right to ask our doctors to change to other safe medicines when it is clearly known that the drugs prescribed have serious adverse reactions, our bodies are our own, and we have to be responsible for ourselves and our families!

Personal opinion, for reference only, not well thought out, please correct me!

Drugs.com authoritative interpretation, unauthorized reproduction, plagiarism will be prosecuted

Speaking of Anacin, I think we are very familiar with it, and many people use this kind of medicine when they are children. Cold, fever, headache, as long as you take Anacin, the fever is not fever, headache is not.

So, why is such a drug classified as a banned drug by the United States? In fact, not only the United States, Anacin has been listed as a banned drug by more than 30 countries. One can imagine how terrible Anacin is.

In fact, the reason why it is classified as a banned drug is that the side effects of anandamide are too terrible. The most serious side effect of Anacin is that it causes a disease called "granulocyte deficiency".

So what is granulocyte deficiency? Granulocytes are an important line of defense for the body against external bacteria and viruses, but Anacin can directly kill these security guards (granulocytes) and kill the value-added granulocyte population. When there are no more security guards in the body, the body becomes extremely susceptible to infections, which can lead to sepsis, shock and other complications. So what are the chances that granulocytopenia will occur when taking Anacin? Surprisingly, it is 1%, which means that for 100 people taking Anacin, granulocyte deficiency will occur in one of the patients.

Moreover, anandamide not only kills granulocytes, but also has a very powerful killing effect on other normal cells in the body, such as for platelets, anandamide can cause aplastic anemia.

Anacin has been banned in the US, Japan and other countries for nearly 40 years

Adverse reactions to anandamide were reported in Sweden in the 1930s. Since then, anandamide has been banned in a number of developed countries.

In 1977, the U.S. FDA (U.S. Food and Drug Administration) officially banned anandamide, and the drug was withdrawn from the U.S. market, and the clinical application of a variety of dosage forms was halted, and anandamide has been banned in the U.S. for 40 years now. Subsequently, Japan, Australia, Iran and other countries have banned or restricted the use of anandamide.

Is Anacin a life-saving drug or a harmful drug?

In 1922, a German chemical and pharmaceutical company developed anandamide and put it into clinical use. Because of its strong antipyretic and analgesic effects, anandamide is widely used in clinical practice.

However, there have been an increasing number of cases of serious side effects with the widespread use of Anacin.From previous reports in the literature, the side effects of this drug are causing a series of complications such as granulocytopenia, thrombocytopenic purpura, autoimmune hemolysis, aplastic anemia, and skin irritation in humans.As you can see, the drug is extremely unsafe for children, especially in cases of granulocytopenia.

As stated in the instructions for Anacin, the probability of it causing granulocyte deficiency is about 1.1%. Granulocytes are a type of white blood cell in the human body, and when there are fewer of these cells, the body's ability to defend itself against external germs is greatly reduced, thus causing the body to be more susceptible to germs.

In addition, when the granulocytes are reduced, the body itself is more likely to develop immune-related diseases, resulting in the body's metabolic waste can not be excreted in a timely manner, which leads to the destruction of the body by disease.So, not only does the use of anandamide not achieve the effect of causing illness and saving lives, but it is harming them.

However, anandamide is still widely used in the country

In 1982, China also phased out the drug "compound anandamide tablets", but left behind "anandamide tablets", "anandamide injection", "Anacin injection" and so on.Until June 22, 2017, there were still 1,339 production approval numbers for Anacin available on the website of our Drug Administration.

What is even more embarrassing is that drugs that have been banned in many countries for many years are still widely used in our country, and both children and adults are taking them. Some township hospitals, health centers and even third-level hospitals in prefecture-level cities still prescribe "Anacin" to their patients.

There are currently only two safe fever-reducing medications recommended by the World Health Organization for children worldwide: acetaminophen and ibuprofen. Please do not take any fever-reducing western medicine other than these.

Acetaminophen can be used for babies older than 2 to 3 months and ibuprofen can be used for babies older than 6 months, and, as long as they are taken in doses, both medications have few side effects on children.

After this Q&A is written, I'm guessing a lot more of my friends will come to disagree with me, but I can't help but want to say it anyway.

There are a lot of antipyretics out there, and it doesn't matter if you feel like banning or not banning them, because it's hard to buy these types of cheap medications at the drugstore.

I don't know if my friends have noticed that the previousparacetamol，Cold and Flu Capsules，VC Yin Qiao Tablet，medicine for coldsThis is the type of medicine that when you go to the drugstore, the clerk will usually recommend something else to replace it with, which happens to me all the time.

When I was young and sick, then basically my mother took me to the injection, a fight is a few days, a few times down to walk and feel the pain is unbearable, especially when sleeping at night, can only choose to sleep on their stomachs, buttocks do not dare to the bed, that taste until now is still remembered by the heart.

Oral medications are few and far between, and the most memorable are"Anacin."和"Paracetamol."These two drugs were not taken at that time, and one other drug was widely used in those days, but later on it caused a lot of trouble to many people like me in the 70's, and as far as I remember it should be the first drug to be completely banned. And that was--"Tetracycline."。

Until I was in middle school and high school I would still feel psychological when I saw my classmates."Tetracycline."It also became a distinctive feature of that era. A lot of girls are obviously very good-looking, but every time you should laugh, you will purse your lips or cover your mouth with your hand. Later inadvertently found that the teeth should be white as jade on a black and brown color, teachers often say, how good-looking children, this is the "tetracycline" harm ah.

with regards to"Tetracycline."I'm not going to put the picture, for fear of causing offense to some friends, if you want to see everywhere on the Internet, absolutely not difficult to find.

The oral cephalosporins were not available at that time."Tetracycline."The use of these medications for broad-spectrum antibacterial effects was so significant that they were used frequently for some time, and were only banned when it was discovered that they had "tetracycline tooth" side effects.

"Anacin."和"Paracetamol."At that time, it was the most common medication to deal with fever and headache, and it was only in recent years that the side effects of "Anacin" were discovered and banned from clinical use.

In fact the efficacy of some of the cold remedies that were popular in previous years was significantly exaggerated, like some of the ones that appear frequently in advertisements for"White Plus Black", "Sanjiu Cold and Flu Spirit", "Feeling Well", Parco, Painkiller TabletsThe main ingredient is paracetamol, which has the same effect on relieving a series of symptoms caused by colds. The original value of only a few cents of the ingredients and packaging, the price can reach hundreds of times the previous price.

Amphenol Flavonoid granules are also known as "medicine for colds","Cold and Flu Capsules"It is one of the most popular cold medicines on the market today, and the main reason why this cold medicine is not recommended for children is that it is also a compound medicine, and its main ingredient for treating cold symptoms is still the antipyretic ingredient "acetaminophen"."Acetaminophen."Although widely used, long-term use can easily cause liver damage.

Cold and flu capsules, a dollar a plate, very cheap.

Therefore, we go to the drugstore to buy drugs when you must pay attention to the ingredients, a little attention will find that the clerk recommended drugs and new drugs are not even close to the edge, only the same ingredients and pharmacology for a good-looking box and packaging only. The reason for recommending to you is not because the drug how effective, but only to sell that kind of drug more profitable.

This is the kind of medicine that diabetics should not try because it has long been eliminated

The other day, a friend brought another new drug that is said to be effective in treating diabetes, saying it's called"Glucose Reduction 5"The price is said to be not high, I deliberately go to check, the above picture of this drug is really not a new drug, but the domestic use has long been banned!"Glibenclamide.", also known as"Eugenol"The side effects are more pronounced than those of the now widely used"Dimethyldouble Melon"The harm is much greater.

My friend was also unhappy with the results and almost fell for the scam. Later in the Internet many times to see people in the promotion of this drug, the efficacy of its blowing God, and said it has no side effects, alas, how to say, anyway, I am very convinced. Eat into the mouth of the things, and for diabetics to take long-term medication so irresponsibly recommended, are they not afraid of retribution?

There are also many parents, listening to people say that Chinese medicine for colds and flu will not produce toxic side effects, so they buy it for their children to eat, and after trying it also have to respond well. I took over a look, "compound" word although small, but not so difficult to see, the main ingredients areCymbopogon flexuosus，aussiella sativa (a type of green leaf), which can't be faulted, it's all about treating colds and flu, but the end of it still made me laugh.acetaminophenYeah, still."Paracetamol."。

Finally, the United States, many friends may not know much about it, but my cousin and friends in the United States. In fact, not only is the banned fever-reducing medicine unavailable there, but many medicines that are very common in China are also unavailable, and going to the hospital is also very inefficient, and for intravenous injections are usually not available. My friend's little granddaughter once had a minor cold that lasted half a month, and in the end it was supposedly her own immune system that did the trick. If you hadn't experienced it yourself, it would be hard to believe that health care in a country as touted as that would be as bad as it is. And the treatment is not as amazing as portrayed in the movie, from the beginning of the examination to make an appointment, if it is a small disease, I guess by the time they have recovered. Do not compare with the United States, a friend's son because of toothache, hard to endure for nearly six months, and finally took the opportunity to return to visit relatives in the country to deal with.

Having said that, I just want to tell you that the most effective way to get sick is to go to the doctor. And if a drug is not effective after 2 days, you should go to the doctor for further diagnosis. Any kind of drug has its inadaptability or side effects, long-term use of drugs or injury to the liver or kidney, must be careful!

A bit of common sense pharmacology people know that different races of people on the same drug effect and reaction is different, for Anacin this kind of drug, white people ate the reaction is very big, was discontinued for many years is also a fact. But this drug has been used in China for decades, there are not many reports of adverse reactions, I myself have taken this drug many times, and did not see any adverse effects, indicating that Anacin is in line with the safety of Chinese people's use of medication, and then again, Anacin is cheap, effective and good, there is really no need to follow the Westerners to ban it.

It's legal to use leptin in the U.S. Why don't you go eat it?

Western medicine produces new drugs every day, and every day they are found to be harmful to human beings, so they are eliminated every day. Many drugs that have been phased out for 50 years are treasured by Chinese interest groups. Thousands of years can not be eliminated Chinese medicine, the Japanese accounted for 95% of world sales, Korea 3%, China only 2%. What's wrong with the Chinese? Western medicine Lindane cream, residual in the earth's environment, Lindane is the active body of the Japanese Rokuroku powder, 30 years to expire.

An still near and go to the pain tablets I have stopped more than ten years, because hours often cold fever and cough, eat still near, toothache eat go to the pain tablets, then there is no pharmacy, to the village to see a doctor, barefoot doctors are prescribed more than a dozen kinds of drugs. Later I grew up and found that ibuprofen tablets can be, also used ibuprofen tablets for many years, and now ibuprofen tablets do not dare to use, the reason is to eat down the stomach pain.