Director Lin said that the blood uric acid level is an important indicator to reflect the body's metabolism, and this is one of the routine items of the physical examination.

She pointed out that uric acid is the product of the body's purine metabolism, uric acid levels are too high, the body will be overwhelmed, to a certain extent will induce gout, high uric acid will also make the kidney health is impaired, and even cause a variety of diseases.

High uric acid is not all due to "not controlling your mouth".

When a physical exam reveals high uric acid levels, many people blame themselves for eating too much and feel that their diet triggers high uric acid.

In this regard, Director Lin said that the source of uric acid in the human body in addition to excessive purine intake, more endogenous purines.

Generally speaking, 20% of the body's uric acid comes from diet, such as meat, seafood, alcohol, thick soup, mushrooms, etc., and 80% comes from the body's own metabolism, the final metabolite of purines in the cell nucleus is also uric acid.

Therefore, to control high uric acid, in addition to refusing alcohol, eat less seafood, thick soup, the most important thing is to check whether the metabolic system is out of the problem, if there is a need for timely treatment, in order to solve the problem from the root.

High uric acid from life to regulate

For those who have already found out the high uric acid level in the physical examination, Director Lin suggests that you must drink more water or light tea water in normal times, and control the daily urinary output to about 2000ml. At the same time eat more purple skinned eggplant, lettuce, Shanghai green, it is best not to eat spinach, all beans should be eaten less or not eat, eat more fruit.

Daily habits, may wish to try every day or often with hot water foot soak, each time not less than 20 minutes, can make the whole body slightly sweating best. In addition, you can do some aerobic exercise, not too strenuous, so as not to overwork the joints. The best choice of swimming, tai chi, table tennis and so on.

Older people who find their uric acid level is high, do not panic, pay attention to the combination of work and rest, every six months to check the uric acid, so that the development of the disease can be effectively curbed.

First of all, under normal circumstances, human urine contains a small amount of uric acid, how does it come? First put aside to eat not to talk about, human cells have a variety of nucleic acids, when the cells "old and weak", the body's metabolic "army" will remove these old cells, in the process of removing the nucleic acids contained in it will produce a variety of purine decomposition, and purine after the production of After the purines are produced, the blood will go to the liver as the "large-scale factory" for the next step of processing, with the help of a variety of enzymes to ultimately form uric acid; uric acid and then enter the blood with the flow of blood into the kidneys, and then discharged with the urine under the filtration of the kidneys. Abnormal elevation of blood uric acid in addition to the increase of uric acid itself, but also related to the decline in kidney function, when the kidney function is insufficient, the production of uric acid can not be discharged in a timely manner, which will result in elevated blood uric acid, in addition to the production of blood uric acid may also be caused by the effects of drugs.

Under normal circumstances, uric acid will be discharged from the body with the urine, and the amount is small, but if the "factory" running problems, it may lead to elevated uric acid; in addition, many purines are eaten from the mouth in, this kind of purines accounted for 20% to 30% of the body to eat more uric acid is generated, so you want to control uric acid should be good! Mouth, eat less seafood, animal offal and other high purine-containing foods.

In addition to eating, is to drink. In modern society, human accidents, entertainment is inevitable, many people are busy with work but also need to drink to socialize, no matter what kind of wine, all contain alcohol, and alcohol metabolism needs the liver to help, which greatly increases the "large factory" running burden, and in the kidneys, alcohol discharged overrun the uric acid discharge channel, the more alcohol, the longer the channel is overrun, the higher the accumulation of uric acid. The more alcohol, the longer the channel is occupied, the higher the accumulation of uric acid, so no matter what kind of alcohol, should not drink more!

I have personally seen people around me in their twenties at a young age suffered from gout, action is very inconvenient, is the uric acid this thing caused by! The fourth emperor of the Ming Dynasty, Ming Renzong Zhu Gaoqi, fat and sickly, and mobility, suspected gout, reigning for only 10 months, died at the age of 47.

What is Uric Acid

There is something called purine in the human body, purine is oxidized in the liver to trioxopurine, trioxopurine is uric acid. The so-called purine is the main product of protein metabolism and one of the products of nucleic acid oxidation.

Major sources of uric acid

Through the above introduction, the body of the main sources of uric acid are two: the first is endogenous uric acid, the body of the protein decomposition and metabolism of purines, purine oxidation to form uric acid, this body of synthetic uric acid accounted for the production of uric acid in two thirds; the second is the exogenous uric acid, food proteins, nucleic acids, after digestion and absorption, plus the enzyme action of the formation of uric acid, uric acid from food accounted for one-third of the production of uric acid. The second is exogenous uric acid.

Causes of high uric acid

Uric acid is derived from purines, and in general, the production and excretion of purines in the body is balanced, whether endogenous or exogenous, with one-third of the total amount of uric acid being excreted through the intestines and two-thirds through the kidneys.

Therefore, there are two reasons for high uric acid in the body: first, the body's uric acid production is too high, including food containing too much purine and the body's related enzymes are abnormally active in the production of too much purine; second, the excretion of uric acid is impeded, mostly due to the kidneys will be uric acid out of the body's function is impeded.

Dangers of high uric acid

Excessive levels of uric acid in the blood are responsible for causing ventilation. When the concentration of uric acid is too high, it will be deposited in the form of potassium salts in the joints, cartilage, kidneys and other tissues and organs of the human body, forming uric acid crystals and causing tissue swelling and inflammation, i.e. gouty wind. Hyperuricemia is diagnosed when the level of uric acid in the blood is above 390 micromol/L. Hyperuricemia is a precursor to gout.

Prevention and control measures for ventilation

I have personally seen classmates around me who suffered from gout before they graduated from college and couldn't even walk. Something to keep in mind in your daily life:

1, animal offal, seafood is rich in purine, soy products, eggs, red meat and other protein-rich, these foods should be eaten less 2, do not drink alcohol; 3, try to eat a lighter diet, eat more vegetables; 4, drink more water to promote urination.

That said, whether the blood uric acid is too high or not, even if you are a normal person, eat more vegetables, eat a light diet, do not drink and eat less meat, not good.

Thank you to the Little Secretary of Wukong for the invitation! Before answering this question, we need to understand and know how uric acid is produced and excreted in the body?

I. Sources of Uric Acid

All cells in the human body have a survival period, and different cells have different survival cycles, apoptosis, there are new cell generation, so as to maintain the balance of the body's state, in addition to mature red blood cells and platelets, almost every cell in the human body has a nucleus, the nucleus of the cell there is a substance called nucleic acid, is made up of purines and pyrimidines and deoxyribose, and the metabolism of which the purine of the final uric acid Uric acid is the final product of purine metabolism, and this part of the source of uric acid accounts for about 80 percent of the total uric acid level, also known as endogenous uric acid. The opposite is exogenous uric acid, this part of the uric acid is from food, such as we eat meat, offal, seafood, dried mushrooms and other food is also composed of cells, these cells also have a nucleus, the nucleus of the cell also has a nucleic acid substances, nucleic acid is also the same as humans, by the purines, pyrimidines, ribose, the purines can be metabolized into uric acid, this part of the uric acid accounted for about 20 percent of the total uric acid level. This is about twenty percent of the total uric acid level. Since food-derived uric acid accounts for only 20 percent of total uric acid levels, some cases of hyperuricemia cannot be controlled by diet alone and must be treated with medication.

Second, the excretion of uric acid

Uric acid is soluble in water, so the excretion of uric acid is mainly excreted through the urine, when the kidneys due to various reasons, such as drinking less water, urine is also less, uric acid discharge is also correspondingly less, at the same time, the pH of the urine also affects the amount of uric acid excreted from the kidneys, such as urine PH is less than 5, then uric acid through the urinary excretion of the amount of very little, so some of the patients with high uric acid, I will be given sodium bicarbonate tablets to alkalize the urine, so as to promote the excretion of uric acid from the urine, and the uric acid is also excreted through the urine. Thus, some patients with high uric acid will be given sodium bicarbonate tablets to alkalize the urine, thus promoting the elimination of uric acid from the urine. There is also a small number of patients with uremia, because there is no urine, uric acid can not be excreted, which will cause secondary increase in uric acid.

Third, normally, the production and excretion of uric acid are in a state of equilibrium, and when this equilibrium is disturbed, hyperuricemia occurs, theThe various treatments for hyperuricemia are based on the above principles, through dietary control, reducing exogenous sources of uric acid, drinking plenty of water, alkalizing the urine, benzbromarone are to promote uric acid excretion, allopurinol, febuxostat are to inhibit the activity of two catalytic enzymes of purine metabolism process, and reduce the production of uric acid.It is also based on the principle of uric acid as such, so there is no cure for uric acid gout, through diet plus medication can control the level of uric acid, thus reducing gout attacks and gout stone formation.(This article was originally published by Dr. Fresh in general practice. Welcome to leave a message in the comment section below to express different views and opinions, want to know more about health science knowledge and disease guidance process, please pay attention to your side of the general practitioner, some of the pictures in the text from the network, such as copyright, please contact me in time for deletion)

Hyperuricemia is a disease that many modern people suffer from, it not only brings about gout and arthritis, but also damages one's kidneys and cardiovascular system, causing kidney failure and various cardiovascular diseases. Why a person gets hyperuricemia starts with what is uric acid.

Uric acid is a normal metabolic product of the human body, and the so-called metabolic product can be simply understood as the "waste" produced by the body. These "wastes" are converted from a substance called "purine". "Purines" are essential genetic material in our cells, and when our cells die of aging, "purines" are released.

The source of "purine" substances in our body will not only be released from the aging cells, but also because we eat a high purine content of food in the breakdown. Most of these foods are characterized by relatively dense cells, such as animal offal, shellfish; in addition, "purine" is very easy to water, such as simmering broth and fermentation process made of beer, but also contains a high "purine".

Sometimes, due to certain diseases caused by apoptosis, will also produce a lot of "purine"; strenuous physical activity, will also produce a part of the "purine". Our body "purine" material will not be automatically discharged from the body, must be converted to uric acid through the liver will be discharged through the urine and feces, of which urine is the main way to discharge uric acid.

Why a person will get hyperuricemia, on the one hand, because the excretion is reduced, on the other hand, because the "purine" production is more, the excretion of uric acid obstacles is the main cause of hyperuricemia. Our normal daily production of uric acid is about 750 milligrams, the body's total amount of uric acid is 1200 milligrams. If you cannot excrete this much uric acid every day, you will develop hyperuricemia, which is the cause of about 90% of patients.

There are two main reasons for decreased uric acid excretion: (1), congenital impairment of uric acid clearance; (2), decreased excretion caused by certain diseases, such as diabetes mellitus, thyroid disorders, hypertension, obesity and so on. If you do not have other endocrine and cardiovascular diseases, then most of the elevated uric acid is related to physical obesity.

Hyperuricemia is still very harmful. Because uric acid is mainly discharged from the kidneys through the urine, so uric acid accumulation is the first damage to our kidneys; elevated uric acid in the body, but also lead to blood glucose, dyslipidemia and vascular damage, so people are more prone to diabetes, hyperlipidemia, high blood pressure and a variety of cardiovascular and cerebral vascular diseases; of course, high uric acid anemia will cause gout and joint damage, which is a lot of people's personal experience.

Uric acid lowering treatment, in addition to taking medication, daily life is also very critical. For example, eating less high purine food, controlling weight, not drinking alcohol, eating more fresh vegetables and fruits, drinking more water, etc., can assist in lowering uric acid.

Under normal purine dietary status, men with uric acid level higher than 420umol/L women higher than 360umol/L, that is, hyperuricemia. Many people know that high uric acid is easy to gout, but may not know that high uric acid will also lead to other diseases, such as high uric acid kidney disease, diabetes mellitus, tube coronary heart disease, hypertension, etc. are closely related to high uric acid disease.

1. Gout: As uric acid is too high, it will form crystals in the body, uric acid crystals are deposited in the joint cavity, soft tissues, the more they accumulate to form gout stone, causing irritation to the tissues and joints, generating inflammation and triggering pain.

2. Gout triggers kidney disease. Kidney disease and high uric acid can be said to be the result of mutual promotion, kidney disease will lead to poor uric acid excretion, resulting in high uric acid, in turn, high uric acid, uric acid will be deposited in the kidney tissue, damage to the renal corpuscle, causing small renal arteries and interstitial inflammation.

3. Hypertension and coronary heart disease. High uric acid can induce oxidative stress and endothelial dysfunction, leading to systemic and glomerular hypertension. In addition, it induces mitochondrial calcium overload leading to increased production of superoxide anion, leading to vascular endothelial dysfunction, and vascular endothelial damage is the basis for the formation of coronary atherosclerosis.

4. There is also a close relationship between the development of diabetes mellitus and hyperuricemia, with the risk of new diabetes mellitus increasing by 17% for every 60umol/L rise in uric acid levels.

5. As high uric acid promotes the formation of atherosclerosis as well as hypertension, and hypertension as well as atherosclerosis are important risk factors for the formation of strokes, studies have shown that high uric acid increases the risk of stroke by about 50% compared to normal uric acid.

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High uric acid has followed the three highs (high blood pressure, high blood sugar, high blood cholesterol) to another high, the fourth high! Fourth high! Fourth high!

Hyperuricemia is very harmful, directly related to the occurrence of gout, at the same time, long-term high uric acid will affect kidney function, serious cases of development of renal failure may be in many endocrine metabolism, cardiovascular and cerebrovascular diseases, the occurrence and development of the culprits of the role of the role.

Healthy living habits can effectively control uric acid! Dietary control: do not drink alcohol (beer, liquor), can be appropriate to drink red wine. Avoid eating high purine diet: seafood, animal offal, bone marrow, fish and shrimp, meat, peas, spinach; it is advisable to eat more fruits, vegetables, and other purine-free food. Drinking more water and urinating regularly can not only help the metabolism of uric acid, but also reduce the deposition of uric acid in the joints. It is advisable to drink 2000ml of water daily!

First of all, uric acid is a laboratory indicator, mainly the body's metabolites, once you hear uric acid we all think it is urine, in fact, the urine is mainly urea, contains only a small amount of uric acid, and uric acid is mainly the final metabolite of the body's purine material, uric acid is weakly acidic.

Uric acid in the body under normal circumstances is in the normal value, uric acid is too high is mainly due to → 1, eating food contains a large number of purine substances, 2, there is the body of the purine production and metabolic disorders, in addition to these exogenous and endogenous increase in purine substances. There are also metabolic disorders in the kidneys.

The main causes of renal problems include: 1) abnormal secretion of renal tubules due to renal diseases and various toxic symptoms, which leads to impaired excretion and increased reabsorption of uric acid; 2) glomerular filtration rate dysfunction, mainly due to renal failure and renal insufficiency leading to hyperuricemia; 3) increased reabsorption by renal tubules, which leads to excessive uric acid being absorbed back into the bloodstream instead of excreted; 4) the increase in uric acid absorption; 5) the increase in uric acid absorption; 6) the increase of uric acid absorption; 7) the increase of uric acid absorption.

Excessive uric acid can cause a number of clinical symptoms, including excessive uric acid deposits in the joint cavity, which can release inflammatory factors for various reasons, leading to joint pain and impaired mobility. There is also the most important type of disease "gout", high uric acid is one of the main causes of gout, will appear in the joints of the limbs red, swollen, hot and painful symptoms, but also lead to kidney damage, but also cause high blood pressure and diabetes and other chronic diseases. There is also hyperuricemia without any symptoms, high uric acid, but no clinical symptoms.

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The prevalence of hyperuricemia has been increasing significantly; in the early 1980s, the prevalence of hyperuricemia in China was 1.4% in men and 1.3% in women. In recent years, the prevalence of hyperuricemia in China has ranged from 8.2% to 19.8% in men and 5.1% to 7.6% in women. It is estimated that there are about 120 million hyperuricemia patients in China, accounting for about 10% of the total population. This may be closely related to the irrational dietary structure.

Uric acid is a waste product specific to the bodies of birds and reptiles, and we can categorize purines into endogenous and exogenous purines. Endogenous purines (80% of purine sources): human cells in the process of renewal, the nucleus of the cell nucleus in the breakdown of nucleic acids. Exogenous purines (20% of purine sources): come from daily food containing purines, such as seafood, animal offal. After these purines are metabolized by the human liver, uric acid appears.

The causes of elevated uric acid in the blood: first, less excretion (the main factor), and second, more production. The human body produces about 750 mg of uric acid per day, and under normal circumstances, there is a basic balance between newly produced and excreted uric acid each day. Causes of decreased excretion include genetic factors and acquired factors, and acquired factors include: drugs, metabolic diseases (diabetic ketoacidosis, lactic acidosis, "hypothyroidism", "hyperthyroidism"), hypertension, obesity and so on. The causes of excess uric acid production also include genetic and acquired factors, including acquired factors such as: high purine and sugar diets, strenuous exercise, blood disorders (myelodysplasia), and the use of cytotoxic medications (e.g., chemotherapeutic agents).

If the blood uric acid value exceeds the standard, and at the same time there are coronary heart disease, hypertension, diabetes, obesity and other cardiovascular diseases, hyperlipidemia, or related risk factors, lifestyle should be improved, such as: limiting purine diet, quit smoking and drinking more water, etc., as well as related medication to lower uric acid treatment. If the uric acid value exceeds the standard, but there is no related diseases and risk factors, you can first make lifestyle adjustments, and after 3~6 months, the uric acid value is still high, also need uric acid lowering treatment.

I hope the above answer can help you.

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Uric acid in moderation is good for your health! It has blood pressure maintenance, antioxidant and anti-aging properties. During the evolution of life, due to the need for uprightness, human beings need to maintain a certain amount of uric acid within the blood, so that an enzyme that can break down uric acid into allantoin gradually disappeared, and uric acid becomes the end product of purine metabolism.

However, there is an advantage, there must be a disadvantage, too much uric acid instead of promoting the body's cells easy to oxidize, the probability of arterial vascular sclerosis rose significantly. The risk of metabolic syndrome, diabetes, coronary heart disease and hypertension also rises.

In addition, the production of excessive blood uric acid due to the easy formation of urate crystals deposited in the joints, kidneys and other places leading to arthritis, kidney stones and other diseases.

The study further found that high blood uric acid leads to a state of chronic inflammation in the body! This state is associated with many chronic metabolic diseases. Such as obesity, lupus erythematosus, dermatomyositis and even Alzheimer's disease.

In conclusion, hyperuricemia is associated with many modern chronic diseases and must be taken seriously. Welcome to my headline-Jiangsu Provincial Cancer Hospital Li Feng.