1. Loratadine, one of the most classic anti-allergy drugs, is used in many of our clinical departments. For example, in respiratory medicine and otorhinolaryngology, it is mainly used to relieve symptoms related to colds or allergic rhinitis, such as sneezing, runny nose, itchy nose, nasal congestion, as well as itchy and burning sensation of the eyes, and the nasal and ocular symptoms and signs can be rapidly relieved after taking loratadine orally; in addition, the dermatology department also often uses loratadine, which is mainly used to relieve the symptoms of chronic urticaria, itchy dermatitis, and other allergic dermatoses.

2, compared with another classic anti-allergy drug paracetamol, loratadine side effects are relatively much smaller, especially in terms of drowsiness adverse reactions. However, since it is a drug, it is impossible to avoid the occurrence of adverse reactions, even the classic drug is no exception. For loratadine, common adverse reactions are weakness, headache, drowsiness, dry mouth, gastrointestinal discomfort, nausea, gastritis, and rash. Rare adverse reactions include alopecia, allergic reactions, liver function abnormalities, tachycardia and palpitations.

3. In addition, there are data reported to cause tearing, salivation, flushing, dulled sensation, impotence, and excessive sweating; angioneurotic edema, weakness, back pain, blurred vision, chest pain, ear pain, eye pain, leg cramps, depression, chills, tinnitus, viral infections, and weight gain; hypertension, hypotension, supraventricular tachyarrhythmia, and fainting; blepharospasms, vertigo, sensory abnormalities, and tremors; and indigestion, bloating, altered taste, decreased appetite, constipation, diarrhea, eructation, increased appetite, toothache, vomiting; however, the incidence of these reactions is also relatively low.

Overall, loratadine is a relatively safe drug, and there are no contraindications to its use that require special attention, unless an allergy occurs with previous use, it can usually be used. Liver and kidney insufficiency, lactation and pregnancy, children and the elderly, please use under the guidance of a pharmacist.

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Loratadine is a drug used to relieve allergic symptoms and is recommended because it does not cause drowsiness, has a long duration of action, and has few central adverse effects.

The role of loratadine:

Loratadine belongs to the second generation of antiallergic drugs (histamine receptor 1 antagonist), the familiar first generation of chlorpheniramine (one of the components of pediatric aminophenol xanthanamine), benadryl (motion sickness drug), etc., and the advantages of the second generation relative to the first generation are: less central nervous system effects, less gastrointestinal adverse reactions, longer duration of action, and does not cause drowsiness.

Therefore, loratadine is used to ① relieve the symptoms of allergic rhinitis, such as sneezing, runny nose, itchy nose, nasal congestion, tearing, itching or burning sensation in the eyes. ② Relief of symptoms of chronic urticaria, pruritic dermatoses and other allergic dermatoses.

Side effects of loratadine

(1) Central nervous system symptoms such as malaise, headache and drowsiness, which are milder than those of the first generation, are usually noticeable in overdose because loratadine differently passes through the brain barrier, rarely enters the brain, and weakly inhibits brain activity.

② Gastrointestinal symptoms such as dry mouth, nausea, anorexia, vomiting, constipation or diarrhea are also significantly weaker than in the first generation.

② Rare side effects include hair loss, allergic reactions (allergic reactions caused by medicines used to treat allergies, which need to be carefully screened), abnormal liver function, tachycardia and palpitations.

In conclusion, loratadine is relatively safe and can be used in children older than 6 months.

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Loratadine is a commonly used anti-allergy drug in our clinic, as a new generation of anti-allergy drugs, it has many advantages over the old generation of anti-allergy drugs (the most common paracetamol tablets): for example, it does not have too obvious side-effects of drowsiness, is long-lasting, and only needs to be taken one tablet a day.

What does Loratadine do?

1. Treatment of rhinitis, can effectively suppress the symptoms of nasal itching, sneezing, running clear nose

2. Treatment of hives. It can quickly reduce swelling and stop itching

3. Treatment of itchy skin from mosquito bites

What are the side effects (adverse reactions) of loratadine?

1. Commonly headache, fatigue, dry mouth, drowsiness, nausea

2. Rare side effects:hair loss, allergies (yes, it can cause allergies even though it is an anti-allergy drug), palpitations, convulsions

Who should not take loratadine and what precautions to take

1. Drinking without drugs, taking drugs without drinking:Drinkers should not take drugs

2. Prohibited for those who are allergic to loratadine.

3. Pregnant women and breastfeeding mothers should be used with caution, preferably under medical supervision

4. Not for patients preparing for a skin test. If you have taken loratadine 48 hours before the skin test, the skin test results are often inaccurate and positive results are often masked. For example, if you are going to have penicillin, you should have a skin test before you have penicillin to see if you are ever allergic to penicillin. If you take loratadine 48 hours before the skin test, then even if you are allergic to penicillin yourself, the skin test won't show it, posing a danger.

5. Patients who are taking ketoconazole, cimetidine and macrolide antibiotics, theophylline these drugs can not be used.

Restorative is the trade name of Loratadine, the original drug is produced by Xi'an Janssen, its effects are mainly used for a variety of allergic diseases or allergic symptoms. For example, sneezing and runny nose, allergic rhinitis, allergic dermatitis, hives, eczema and other itching symptoms.

Its anti-allergic mechanism of action is mainly through the inhibition of histamine release, because the human body will release histamine when allergic, this substance can mediate the allergic reaction, so that the body's capillary permeability is increased, vascular edema, itchy skin.

What are the main adverse effects of loratadine?

Loratadine is a medication that has an overall favorable safety profile with relatively few side effects, and some of the malaise, dry mouth, and gastrointestinal discomfort that usually occurs can be tolerated by patients.

Since it is a third-generation antiallergic drug with no effect on the center, it generally does not cause drowsiness, but some individuals may still have the adverse reaction of drowsiness after using the drug, and this may be related to individual differences.

Some rare serious adverse reactions may occur:

Although the incidence is low, when it occurs, it may be more serious, such as the development of liver function abnormalities, blood pressure drop, seizures, hair loss, tachycardia, etc., and even the possibility of producing rapid-onset allergic reactions. It is important for patients to be aware of these signs of adverse reactions and to stop the medication and seek medical attention if necessary.

Loratadine has no central depressant side effects, so it can be used in children, and there is evidence-based evidence of safety in children over 2 years of age, and there is a lack of clinical information on its use under 2 years of age, so it is usually not recommended for use under 2 years of age.

It should be noted that the drug is contraindicated in people who are allergic to the drug and its components, and that loratadine should be discontinued approximately 48 hours before the skin test is performed, because antihistamines clear or attenuate the positive skin reaction to all allergens.

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Loratadine is a very safe anti-allergy medication now, and the fact that it's OTC, over-the-counter, means it's safe.

The common anti-allergy drugs we used to use are ketotifen, paracetamol, etc. These belong to the first generation of antihistamines (anti-allergy drugs), which have adverse reactions such as drowsiness, dry mouth, etc. The manufacturers have produced and developed the second generation of antihistamines, which are loratadine and cetirizine, to overcome these adverse reactions. In order to overcome these adverse effects, manufacturers have developed second-generation antihistamines such as loratadine and cetirizine. The second generation of these drugs do not have the adverse effects of drowsiness and dry mouth anymore, or they are already very mild, but the anti-allergic efficacy is still good.

The imported drug for loratadine is Merck Sharp & Dohme's Kerratan, and there are many generic drugs in China, and many patients think that the imported ones are about as effective as the generics, while others think that Kerratan is better. But no matter what, loratadine is a good anti-allergy drug.

Adverse reactions are relatively mild, a few patients may experience rash, gastrointestinal symptoms such as nausea and vomiting, but they are rare. It is used with caution in pregnant and breastfeeding women, and must be used in consultation with a doctor. Children are allowed to use loratadine, children can use the syrup, even in infants, just follow the instructions.

Overall, loratadine is still a relatively safe and effective anti-allergy medication.

Loratadine, also known as Keminen, Keratan, etc., is mainly used for allergic rhinitis, acute and chronic urticaria, itchy dermatosis and various other allergic skin diseases, and is commonly used in the clinic as a kind of rapid, potent, and long-lasting anti-defense against allergic reactions.

Pharmacologically, loratadine is highly selective for peripheral histamine H1 receptors, while it has a weak effect on H1 receptors in the central system, and has no effect on AChR receptors and α1-adrenoceptors; therefore, the main adverse reactions that may be induced by loratadine are as follows:

1. Drowsiness, headache, dizziness and other undesirable symptoms may occur with larger single doses (20-40mg). A single dose of 10mg has no symptoms of drowsiness and has no effect on the function of the central nervous system.

2. A very small number of patients may experience skin rashes and gastrointestinal allergic reactions such as nausea, vomiting, diarrhea, etc., in which case the drug should be stopped immediately and symptomatic treatment is required if necessary.

Keep in mind that this product is contraindicated in patients with hypersensitivity to loratadine and in patients with atopic traits.

The following points should be noted when applying loratadine:

1. Use with caution in pregnant women, lactating women and children under 2 weeks of age;

2. Use with caution in patients with impaired hepatic or renal function;

3. Alcohol drinkers, as well as patients taking diazepam-type drugs to assist sleep, should be monitored more closely when the product is first administered, with particular attention to effects on somnolence and the central nervous system.

4. Discontinue use of this product 48h prior to performing skin tests for other drugs, as it may attenuate or even inhibit antigen-positive reactions.

5. Interactions with other drugs: ① caution in combining drugs include: macrolide antibacterial drugs, theophylline, ketoconazole, cimetidine and drugs that inhibit hepatic metabolism; ② other drugs that may interact with loratadine should be consulted with a physician or pharmacist.

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Loratadine is a commonly used antiallergic drug in clinical practice.

Clinical use is mainly for

Relieves symptoms due to allergic rhinitis such as sneezing, runny and itchy nose as well as itchy and burning eyes. Relieves the signs and symptoms of hives and other allergic skin diseases. It is also useful as an adjunctive treatment for delayed phase reactions in bronchial asthma.

Contraindications and adverse reactions

Contraindications:Contraindicated in persons who are hypersensitive to loratadine or in atopic individuals.

The information that can be obtained from the instructions of the drug is that loratadine is an over-the-counter drug, so the application is relatively safe, and the patient should understand that the principle of selection of over-the-counter should be: safe application, precise efficacy, stable quality, and easy to use. So it is generally safer.

Adverse reactions mainly include:Occasionally, adverse reactions such as weakness, dizziness, headache, itching, gastritis, drowsiness, dry mouth and nervousness are observed. Therefore, driving and other maneuvers are not recommended after taking the drug.

Use with caution in the elderly, children, pregnant and lactating women.

If you have liver or kidney insufficiency, it is best to consult your doctor and decide whether to use the drug based on your liver or kidney function.

Loratadine, which is often referred to as Restoril, is a commonly used drug for the treatment of allergic diseases. As the saying goes, all drugs are poisonous, and loratadine is just like any other drug, although it has good therapeutic effects, it is inevitable that taking it also has certain side effects in some aspects.

Antihistamine drugs have H1 receptor antagonist and H2 receptor antagonist two categories, loratadine belongs to the second generation of H1 receptor antagonist, the reason why this kind of drug is better than the first generation is because this kind of drug will not pass the blood-brain barrier, does not affect the center, after taking this drug tiredness and fatigue will not be too obvious, so it is widely used in clinical practice. However, it varies from person to person, and a few patients will still experience significant drowsiness, inability to concentrate, and individuals will experience drowsiness. This is the most common adverse reaction to the application of loratadine. It is best not to engage in things that require concentration after taking loratadine, such as driving, technical operations, etc.

Loratadine has some damage to liver and kidney function, and is prohibited for infants and children under 2 years of age. If the application of anti-allergy drugs is needed, it can be given to loratadine syrup, loratadine oral solution and other drugs specially designed for infants and children. Pregnant women, lactating women and patients with hepatic or renal insufficiency should also use it with caution to avoid irreparable damage. Because of the antihistamine effect of this drug, dilation of blood vessels may also cause a drop in blood pressure. If dizziness or other discomforts occur after use, blood pressure may be measured to clarify the situation.

Although loratadine is an anti-allergic drug, there are patients who are allergic to this drug, if you take this drug and find allergy, you should stop taking it immediately. Although loratadine is effective in treating urticaria, allergic rhinitis, eczema and other allergic diseases, it is still necessary to pay attention to its adverse reactions and contraindications.

Respondent: Donglian Liu, M.S., M.A.

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One of my coworkers suffers from frequent skin allergies and is currently not sure what she is allergic to. When it flares up, there are air masses everywhere, and when it itches, the more you scratch, the more masses you get, and by then it itches even more, a vicious cycle ...... And among the oral medicines, the one that can solve her problem better is loratadine dispersible tablets, which can relieve the symptoms every time you take it, and it doesn't cause drowsiness like paracetamol does.

Loratadine Dispersible Tablets, also known by the trade name Ranine, appearing white to off-white on the surface, is an antihistamine, a long-acting tricyclic antihistamine, which relieves seasonal allergic rhinitis or non-nasal symptoms by selectively antagonizing peripheral H1 receptors.

Loratadine Dispersible Tablets are also used more frequently in clinical practice. It is mainly used for the relief of nasal or non-nasal symptoms of allergic rhinitis, such as sneezing, runny nose, itchy nose, itchy eyes and burning sensation in the eyes. It is also suitable for alleviating the signs and symptoms of chronic urticaria and other allergic skin diseases.

Loratadine is a second-generation anti-allergy drug, safer than first-generation anti-allergy drugs (such as paracetamol), with less central nervous system effects, less digestive upset, generally does not cause drowsiness, and has a longer duration of action. However, even the best medicine will have its side effects, as the saying goes, it is a medicine that is three times poisonous, and its adverse reactions are mainly: common adverse reactions are headache, fatigue, dry mouth, nausea, and skin rashes. Occasionally, drowsiness, amnesia and morning edema of the facial extremities are seen. Rarer adverse reactions include blurred vision, decreased or increased blood pressure, fainting, seizures, mammary gland hyperplasia, alopecia, allergic reactions, liver function abnormalities, tachycardia, palpitations, and jaundice.

Contraindications and precautions for taking loratadine dispersible tablets:

1. It is prohibited for patients who are allergic to any of the components of this product or for patients with idiosyncratic constitution.

2, should be used with caution in patients with cardiac arrhythmia, patients with abnormal liver function and renal function should be used with caution.

3. It is also used with caution in pregnant women. Lactation is prohibited during lactation and should be discontinued while taking it because it can be secreted from breast milk and antihistamines are dangerous to infants, especially newborns and preterm infants.

Regarding the interpretation of loratadine dispersible tablets, Dr. Tsang is here, hoping that you can better understand this medicine, and when you need to take it, you can take it correctly instead of using it blindly to avoid unnecessary accidents.

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Because of the slight differences in the composition of raw materials in different trade names, only Huishutong (loratadine granules) is analyzed here as an example.

First of all, let's take a look at the indications of Huishutong Loratadine Granules: perennial allergic rhinitis, seasonal allergic rhinitis, intractable allergic rhinitis, etc.; urticaria, itchy dermatosis and other allergic dermatoses, etc.; allergic asthma, chilblains, etc.; radiation dermatitis, etc..

Dosage: For children aged 2-12 years. For children weighing more than 30kg, take one sachet (10mg) once a day; for children weighing less than 30kg, take half a sachet (5mg) once a day.

Precautions: 1. Although this product is not cardiotoxic, but occasionally reported arrhythmia, and arrhythmia patients with caution.

2. Boss Ractadine should not be used in the 48 hours prior to the skin test.

3. Dosage should be adjusted for hepatic insufficiency.

4. Use with caution for people working at heights/drivers.

5. It is prohibited for those who have allergic reaction or idiosyncratic constitution to this product.

Adverse effects: drowsiness/mouthfeel/weight gain/weakness; headache and nausea occur less frequently.

Note: When an adverse reaction occurs, follow your doctor's advice on whether you need to suspend the medication.

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