Mr. Chaplin, the famous comedian, is still fit and healthy despite his 88 years of age.

On December 24, 1977, Christmas Eve, Mr. Chaplin hosted a banquet in Vevey, Switzerland, to drink with family and friends. Chaplin, who has always been a good drinker, drank until late into the night.

Back home Chaplin was still very excited and had trouble sleeping, so he took sleeping pills.

Ethanol has a neurological inhibitory effect, it will enhance the inhibition of the central nervous system of some sleeping pills, resulting in lethargy, and in severe cases, coma or even death.

Tragedy struck, and a generation of comedians passed away forever.Almost New Year's Eve, we must pay attention to the safety of drinking, there are data survey, China every year 100,000 people died of alcohol poisoning. I don't know whether this data is accurate or not, but there are people who take the following kinds of medicine should not drink alcohol. I will send the corresponding possible side effects to everyone to see.

Painkillers: hurt your stomach, stomach bleeding; don't take painkillers for a headache after drinking;

Sleeping pills: mentioned earlier.

Antiallergics (e.g., Keratan): similar to sleeping pills;

Antimicrobials (cephalosporins, metronidazole, furazolidone): cause disulfiram-like reactions, headache and dizziness, nausea and vomiting, panic and chest tightness, drop in blood pressure, and in severe cases death;

Glucose-lowering drugs: cause lactic acidosis, hypoglycemic coma, and death;

Antiepileptic drugs: reduce efficacy and induce seizures;

Antianginal drugs: cause severe headache, rapid drop in blood pressure, and shock;

Antihypertensive drugs: cause low blood pressure and even fainting;

Hemostatic and anticoagulant medications: affect the effectiveness of the medication and cause bleeding;

Diuretics: upright defecation;

Antidepressants: intestinal paralysis;

Anti-tuberculosis drugs: injure the liver.

If you can't remember so many kinds, then just remember:

Take pills and don't drink. People who persuade me to drink, knowing I'm on medication, are trying to kill me. I don't want to eat and drink with people like that.

In addition, there are four behaviors in the picture that are legally responsible:
I wish you all a Happy New Year, health and peace of mind.

One of my husband's friends, a cold with a sore throat, taking a cephalosporin, was pulled to the home by classmates to drink. Drink a glass of white wine, and drank a glass of beer, said the heart is difficult, they went to lie down on the sofa, after a while no movement, thought he fell asleep? I thought he was asleep, so I didn't call out to him. Waiting for the guys are finished eating, to go back, called him up to go home, only to find that he has no gas. Rushed to the hospital rescue, the doctor said that people have long been dead, asked the family only to know that he ate a cephalosporin, the doctor said to eat a cephalosporin is not to drink, easy to cause shock, serious death.

Colleagues in the company to get together, a colleague said that the recent flu is more serious, he just came out of the flu army, but still taking medicine. A colleague said that today is rare in the weekend party, we drink some wine together to be happy, we are together in the together and drink. However, something unexpected happened, the one taking medication at the same time was admitted to the hospital. The doctor diagnosed that the colleague was "disulfiram-like reaction".

1. What is a "disulfiram-like reaction"?

Disulfiram is supposed to be an alcohol withdrawal medication, and even small amounts of alcohol consumed after taking the medication can cause discomfort in the body, leading to alcohol withdrawal.

Disulfiram-like reaction - many drugs have effects similar to disulfiram, drinking alcohol after taking drugs will manifest as chest tightness, nausea, shortness of breath, cyanosis of the lips and mouth, dyspnea, drop in blood pressure, weakness of the limbs, convulsions, and even death, and a drop in blood pressure, accelerated heart rate, and electrocardiogram (EKG) changes may be seen on physical examination. The severity is directly proportional to the amount of medication taken and the amount of alcohol consumed, with the elderly, children and people with cardiovascular disease being more sensitive.

2. The drugs that cause "disulfiram-like reactions" are broadly categorized as follows:

Category I: Cefoperazone, cefoperazone sulbactam, ceftriaxone, cefazolin (Pioneer V), cefaclor, etc. in the cephalosporin group. Among them, the use of cefoperazone leads to a larger number of "disulfiram-like reaction" is also more sensitive. The reaction can also occur if the drug is taken with alcohol-centered chocolate and alcohol-containing substances such as patchouli.

Category 2: Nitroimidazoles such as metronidazole and tinidazole.

Category 3: Other antimicrobials such as furazolidone (dysentery) and chloramphenicol.

3. How long after drinking alcohol can I take cephalosporin antibiotics?

Drinking alcohol is sometimes unavoidable, but if you happen to be taking medication that can cause a "disulfiram-like reaction", how long should you drink alcohol before it is safe to take the medication? Studies have found that there is a 99% correlation between cephalosporin antibiotics causing "disulfiram-like reactions" and alcohol consumption. However, due to the differences in each individual, the elimination time is not the same, but the longer the interval between the drinking time and the medication time, the lower the chance of the reaction.

To give you a suggestion, if there is a history of alcohol consumption in the week before the medication, then do not take the drug; if you take the drug, it is recommended to stop drinking for a week before drinking, so that the safety is greatly improved.

4. What should we do in case of a "double-streaming wheel-like reaction"?

As soon as this reaction occurs, you should stop taking the medication and stop drinking alcohol or related products containing alcohol. If the symptoms are mild, they may resolve on their own. If the symptoms are severe, the patient should seek immediate medical attention and talk to the doctor about the medication and the recent consumption of alcohol or alcohol-containing products. In the early stages of the disease, patients may experience nervousness, anxiety, or fear. Family members should remain calm, reassure the patient, and cooperate actively with treatment.

With the recent high incidence of influenza, many people will be taking or injecting some medications. When taking medications, be sure to tell your doctor if you have a history of drug allergies and if you have recently consumed alcohol. Meanwhile, the festive season is approaching, so again, please refrain from drinking alcohol and consuming alcohol-containing products while taking the medication.

Thank you for your question.

(1) Ethanol, which is also a drug in the strictest sense of the word, is a sedative, and after drinking alcohol the body first experiences a state of euphoria and euphoria, followed by a central nervous system depressant effect. Overall, the interaction between ethanol and drugs results in two outcomes: 1) reduced efficacy and interference with drug metabolism in the body; 2) increased incidence of adverse reactions;

(2) Drugs that should not be taken after drinking alcohol are:

(1) antibiotics: cephalosporins, such as cefazolin, cefoperazone, cefoperazone/sulbactam, etc.; macrolide antibiotics, such as erythromycin ethylsuccinate; aminofurans, such as furotoxin, furazolidone; nitroimidazole, such as metronidazole, ornidazole, etc., the interaction of these drugs with ethanol, easy to appear "disulfiram-like reaction";

(2) Sedative-hypnotics/antidepressants: such as barbiturates, sulphasalazine, clonazepam, diazepam, zopiclone, etc., ethanol can increase central inhibition, drowsiness, coma and other adverse reactions;

(3) non-steroidal anti-inflammatory drugs: such as aspirin, indomethacin, ibuprofen, acemetacin, etc., ethanol can stimulate the gastrointestinal mucosa, causing edema, congestion, etc., if the alcohol in the taking of non-steroidal anti-inflammatory drugs, it will increase the stimulation of the mucosa of the gastrointestinal tract, increasing the risk of gastric ulcers, gastric bleeding; alcohol taking acetaminophen to increase the incidence of hepatotoxicity;

(4) oral hypoglycemic drugs: such as glibenclamide, gliquidone, toluene sulfobutylurea, etc., ethanol can reduce blood glucose levels, while aggravating the central inhibitory effect, prone to coma, shock, hypoglycemia and other symptoms;

5) Other drugs: chloroquine, rifampicin, atropine, cetirizine, thioridazine, benzbromarone, memantine, flunarizine, cetirizine, pethidine, nicotinic acid, and so on;

Hints: 1) Alcohol + medicine = poison (most likely); 2) Create a sense of "drink without medicine, take medicine without drinking";

I hope you find it helpful!

The authoritative interpretation of Pharmaceutical Affairs, unauthorized reproduction, plagiarism will be punished.

Thanks for the invite!

It is inevitable to drink alcohol when friends get together and socialize for dinner. However, many people may need to take some drugs for some reasons. But there are some medications that should never be taken after drinking alcohol!

sleeping pill

Alcohol has a depressant effect on human brain stem function. Sleeping pills also inhibit the brain. If a person takes sleeping pills after drinking alcohol, the effect of 1+1 is far greater than 2, which may lead to a long sleep and may kill the person. The famous singer Chan Pak Keung is because of a drink and then take some sleeping pills, the result is not wake up, directly coma, and ultimately lead to death.

cephalosporin antibiotics

After alcohol is absorbed into the body, it is metabolized in the liver to acetaldehyde, which is metabolized to acetic acid, which is eventually metabolized to carbon dioxide and water. Among themAcetaldehyde is toxic to humans. Acetaldehyde is capable of interacting with cephalosporinsdisulfiram reaction (physics), minor symptoms such as raw panic, rapid heartbeat, facial flushing, blurred vision, dizziness, nausea, vomiting, headache, etc., and serious problems such as lowered blood pressure, cardiac infarction, shock, etc., which can be life-threatening. Therefore, cephalosporin antibiotics can not be eaten after drinking alcohol.A safer time is at least 3 days.

gunpowder

Metronidazole is a medication that is often overlooked after drinking alcohol. People with a toothache often go to the pharmacy to buy metronidazole or artificial oxalic metronidazole. Similar to cephalosporins, alcohol can have a disulfiram reaction with metronidazole drugs, which can be hazardous to your health.

In addition to these types of medications, there are others that require special care.

antihypertensive drug

Alcohol can dilate blood vessels on the one hand, and on the other hand, it will also weaken the contraction force of the heart, so it can make the blood pressure lower. Therefore, taking antihypertensive drugs after drinking alcohol requires special attention to blood pressure. Otherwise, blood pressure drops too low, which can lead to insufficient blood supply to the heart and brain, resulting in cardiovascular and cerebrovascular events or even shock.

antihyperglycemic drug

Ethanol inhibits gluconeogenesis and glucose uptake, making it easy for hypoglycemia to occur after heavy drinking. Hypoglycemia due to alcohol consumption is often seen in hospital emergency departments. Hypoglycemia can easily occur when drinking alcohol and taking hypoglycemic drugs to treat diabetes. If you can't avoid it, you need to pay attention to whether symptoms such as panic and sweating occur. If it occurs, you need to measure blood glucose in time and go to the hospital if necessary. In addition, if you take biguanide glucose-lowering drugs, the risk of lactic acidosis will be very high.

Although serious consequences do not happen to everyone, it is important to be very careful with the medications mentioned above for the sake of your health. If you do need to take the medication in question, then try not to drink alcohol, or drink as little as possible.

Hi everyone, I'm Dr. Miao, MD. Thank you all for your support! Follow and like if you like.

Thanks for the invitation!

After drinking alcohol, which drugs can not be taken? Life happens most of the situation should be cephalexin class, commonplace, the various news reports are also a lot of men have a cold, in order to let the cold quickly, will be autonomously required to inject antibiotics, but also crave for alcohol, can not put off the friends of the shouting, so simply go to drink, the results of the problem, shouting to drink, but need to be held accountable, and so on... ...

In addition to the above cephalosporins, metronidazole drugs can not be eaten, metronidazole is mainly used for the treatment and prevention of local infections caused by anaerobic bacteria. Because metronidazole can have been ethanol dehydrogenase, can enhance the role of ethanol, causing disulfiram reaction, so during the period of medication and one week after stopping the medication shall not drink ethanol drinks and drugs.

Again, there are antipyretic, analgesic, and tranquilizer drugs such as ibuprofen, meloxicam, and acetaminophen tablets, which can interact with each other and cause uncomfortable reactions, such as severe irritation of the stomach, which can also lead to stomach bleeding.

In addition, after drinking alcohol, especially fasting, because ethanol can inhibit glucose isomerization, so you can not drink alcohol in the taking of hypoglycemic drugs, can appear hypoglycemia, manifested as pale, confusion or even coma.

For most of you who can drink a couple of drinks, it doesn't hurt to go home for New Year's Eve, take a holiday break, and have a couple of drinks with family and friends.

That's what makes it atmospheric and New Year's Eve!

Whether it's Cao Cao's "Sing a song over wine, what is life like?" I'm not going to be able to do that;

Or Li Bai, "Five-flower horse, a thousand gold furs, call out for a beautiful wine, with you to eliminate all the sorrows of the ages!" I'm not sure if it's the same as Li Bai's;

And then pee in the wine my grandfather made for himself, drink the wine, and sing to my grandma, "Sister you go boldly forward ......"

Even my son's name is Shepherd Boy, "Ask where the tavern is, and the shepherd boy points to the village of apricot blossoms."

But don't drink alcohol after taking the pill!

Alcohol can react with so many medications and even cause life-threatening problems.

What drugs are commonly used that can be dangerous with alcohol?

A. Cephalosporin, this is now basically universal, the vast majority of people already know that do not drink alcohol after taking cephalosporin, it will kill you.

Taking cephalosporin and drinking alcohol can cause chest tightness, shortness of breath, edema of the larynx, cyanosis of the lips and mouth, dyspnea, increased heart rate, decreased blood pressure, hallucinations, trance, and even anaphylactic shock.

B. Sleeping pills After taking sleeping pills such as Valium and drinking alcohol the next day, alcohol excites the central nervous system of the brain first and then inhibits it, which can make the patient suffer from coma, shock, respiratory failure and death.

C. Antipyretic and analgesic such as aspirin and paracetamol. Friends of cardiovascular and cerebrovascular diseases, but also long-term aspirin anti-platelet. This kind of medicine itself has the gastric mucosa has the stimulation and damage effect, and alcohol also hurt the stomach, can cause gastric bleeding and so on.

D. Antihypertensive medication Those who take antihypertensive medication can experience low blood pressure or even shock and life-threatening effects from drinking alcohol.

E. hypoglycemic drugs Diabetics should also pay extra attention to the injection of insulin or oral hypoglycemic drugs during the drinking of alcohol on an empty stomach, it is prone to hypoglycemic reactions.

F. Drugs for Arthritis Commonly known as Cilastatin, Naproxen, Fitalin and so on. Side effects such as ulcers, stomach bleeding and liver damage can be caused when mixed with alcohol.

Wine should be consumed sparingly and things should be known!

Do not use alcohol after taking medication!

Drinking alcohol after taking cephalosporins, nitroimidazole antibiotics, some hypoglycemic drugs and other drugs are prone to disulfiram-like reactions, which are characterized by facial flushing, violent pulsation of the blood vessels in the head and neck or throbbing headache, dizziness, palpitations, chest tightness, chest pain, dyspnea, cold sweating, drop in blood pressure, nausea, vomiting, abdominal pain and other symptoms.

Drugs that may cause a disulfiram-like reaction are:

1. Antimicrobial drugs: (1) cephalosporins: cefoperazone (Pioneer), cefoperazone sulbactam (Sulphadox), cefpiramide, cefamandole, cefmetazole (Pioneer Mactazole), cefmenox, cefmenoxime, cefonicid, ceftimer, cefotetan, cephalothin, cephalothin (Thimerosal), cefazolin (Pioneer V), cefaclor, cefodizime, cefbenzyl cefacil, cefradine, cefoxitin etc.; (2) nitroimidazoles: metronidazole, metronidazole disodium phosphate, tinidazole, ornidazole, sexanidazole, etc.; (3) other antimicrobial drugs: furazolidone, furotoxin, chloramphenicol, ketoconazole, gray penicillin, erythromycin amidosuccinate, sulfamethoxazole and isoniazid.

2. Glucose-lowering drugs: chlorosulfopropamide, methylsulfonylurea, phenelzine, glibenclamide, gliclazide, glipizide, tulasulfonylurea, hexylurea acetate, insulin and so on.

3. Other drugs: warfarin, trifluoperazine, tolazurin, chloral hydrate, etc.

Due to individual differences, the time of alcohol elimination is different for each person, but the longer the interval between the time of alcohol consumption and the time of medication, the lower the incidence of disulfiram-like reactions. A synthesis of the literature reports that no less than 7 days after alcohol consumption should be allowed for the application of the above medications.

It is important to note that disulfiram-like reactions may be triggered not only by alcohol consumption, but also by eating alcohol-centered chocolates, taking medicinal alcohol preparations (e.g., Patchouli Oral Liquid), and by contact with alcohol, such as alcohol-based skin disinfection, alcohol-based baths, and injections of ethanol-solubilized pharmaceutical preparations (e.g., hydrocortisone injections).

There are actually quite a few kinds of drugs that you should never take, but not all of them. However, it is still very troublesome to remember, simply remember: take medicine not to drink, drink not to take medicine.

First of all, cephalosporin antibiotics, metronidazole, most of the drugs in the two categories can not be taken after alcohol, or directly, during the period of taking (including the period of metabolism in the body after taking) is absolutely not allowed to drink alcohol.

This is because these two major classes of drugs produce a disulfiram-like reaction when taken with alcohol.

Disulfiram affects the process of alcohol metabolism in the body by inhibiting the action of the enzyme acetaldehyde dehydrogenase (ALDH) in the liver, resulting in a large concentration of acetaldehyde in the body and toxic effects.

And these two major classes of drugs mentioned above, because of their specific chemical structure, block the process of acetaldehyde metabolism, leading to a bisulfite-like reaction.

Clinical symptoms of disulfiram-like reaction include: chest tightness and shortness of breath, increased heart rate, facial flushing, dyspnea, limb weakness, headache, nausea and other symptoms, and in severe cases, even acute heart failure, convulsions and so on.

Therefore, if you accidentally have a disulfiram reaction, when you go to the hospital, you must take the initiative to explain to the doctor what medications you have recently taken and whether you have been drinking alcohol, how much you have been drinking, as well as your past history of drug allergies. According to clinical observation, the misdiagnosis rate of disulfiram-like reaction is very high, and taking the initiative to explain to the doctor will help to improve the efficiency and accuracy of medical consultation.

Also, disulfiram-like reactions usually last 30-60 minutes and can go away on their own if the symptoms are mild. (This is related to the amount of alcohol consumed.) However, if severe symptoms occur, it is important to go to the hospital in a timely manner!

Of course, if you truly love your body, you should still keep in mind: take your medicine and don't drink!

A special reminder is needed: don't drink alcohol before or after taking the western medicines mentioned below, including all kinds of alcohol, white wine, beer, red wine, medicinal wine, rice wine and so on. Take medicine not drink, healthy New Year!

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It's common knowledge that cephalosporins can't drink alcohol, but disulfiram reactions aren't exclusive to cephalosporins, these meds have them too! Patchouli, for example.

Cold remedies and alcohol can also be reactive and deadly in severe cases!

People with high blood pressure should be even more aware that some antihypertensive medications react with alcohol and can cause large fluctuations in blood pressure, leading to brain hemorrhage and shock!

Healthy New Year's Eve, health first. Drinking comes second. Take care of your health.